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Search Results for " scd1 "

Targets Recommended: Dehydrogenase

18

抑制剂 & 化合物

2

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38683	SCD1 inhibitor-3 SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a	Dehydrogenase	Metabolism
	SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物，可以抑制SCD1，且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常，以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。
T10525	SCD1 inhibitor-4	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	SCD1 inhibitor-4 是一种具有口服活性的 stearoylCoA desaturase-1 抑制剂，可用于研究糖尿病。
T71175	SCD1 Inhibitor	Others	Others
	SCD1 Inhibitor is a novel stearoyl-CoA desaturase1 (SCD1) inhibitor.
T12863	SCD1 inhibitor-1	Others	Others
	SCD1 inhibitor-1 is a potent and liver-selective inhibitor of stearoyl-CoA desaturase-1 (SCD1).
T84804	SCD1/5-IN-1	Others	Others
	SCD1/5-IN-1 (Compound 10) 作为一种SCD1/5抑制剂，适用于神经系统疾病的研究。
T61841	SCD1-IN-1	Others	Others
	SCD1-IN-1, a potent inhibitor of SCD1 (IC50: 5.8 nM), is valuable in dermatologic research [1].
T2650	MK-8245	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MK8245 是肝靶向的硬脂酰 -CoA 去饱和酶(SCD)抑制剂，对人 SCD1 和鼠 SCD1 的IC50值分别为 1 nM 和 3 nM，具有抗糖尿病和抗血脂异常的作用。
T4515	A939572	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	A939572 是口服具有活性的硬脂酰 CoA 去饱和酶 1SCD1抑制剂，对mSCD1和hSCD1的IC50分别为 <4 nM 和 37 nM。
T16068	MF-438	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	MF-438 是一种口服具有活力的 stearoyl-CoA desaturase 1 抑制剂，其对 rSCD1 的 EC50值为 2.3 nM。
T13356	XEN723	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	XEN723 是新型的硬脂酰辅酶 A 去饱和酶的噻唑基咪唑烷酮抑制剂，能够抑制小鼠和 HepG2 细胞的活性，它们的 IC50值分别为 45 和 524 nM。
T9003	CVT-11127 N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺	Dehydrogenase	Metabolism
	CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期，诱导细胞凋亡。它可用于肺癌的研究。
T1869	PluriSIn 1 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1	Apoptosis; Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Apoptosis; Metabolism
	PluriSIn 1 (NSC 14613) 是一种酰基-辅酶 A 去饱和酶抑制剂，是一种多能细胞特异性的抑制剂。
T14878	CAY10566	Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Metabolism
	CAY10566 是选择性的、口服具有活性的硬脂酰辅酶 A 去饱和酶 1 抑制剂，在小鼠和人酶测定中IC50分别为 4.5 和 26 nM。它具有显著的细胞活性，可阻断 HepG2 细胞中饱和长链脂肪酸-CoAs (LCFA-CoAs) 向单不饱和 LCFA-CoAs 的转化。
T9722	YTX-465	Stearoyl-CoA Desaturase (SCD)	Metabolism
	YTX-465 是有效的硬脂酰辅酶 A 去饱和酶 (Ole1/SCD) 抑制剂，抑制 Ole1 和 SCD1的IC50=分别为 0.039 μM 和 30.4 μM。YTX-465在帕金森病和其他突触核蛋白病领域有研究的价值。
T7294	Aramchol C20-FABAC	Others	Others
	Aramchol (C20-FABAC) 是一种胆酸和花生酸的结合物，能够降低硬脂酰辅酶 A 去饱和酶 1 (SCD1) 的活性。它具有用于非酒精性脂肪性肝病 (NAFLD) 和非酒精性脂肪性肝炎 (NASH) 的潜能。
T38844	MK-8245 Trifluoroacetate	Others	Others
	MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK...
T79262	SSI-4	Stearoyl-CoA Desaturase (SCD)	Metabolism
	SSI-4为SCD1 (硬脂酰辅酶A去饱和酶1) 抑制剂，能够通过11C标记，用于SCD1体内小动物PET/CT成像的配体。
T85282	trans-Petroselinic Acid trans-6-Octadecenoic Acid,Δ6-trans-Octadecenoic Acid,Petroselaidic Acid	Others	Others
	Trans-Petroselinic acid, the trans isomer of petroselinic acid and an isomer of oleic acid, is detected in the milk fat of cows, goats, and ewes, as well as human breast milk. In HepG2 cells, when treated with trans-petroselinic acid (100 μM), there is an increase in the cellular content of triacylglycerols and cholesterol esters. Additionally, it upregulates the transcription of genes associated with fatty acid synthesis (SREBP-1c, ACACA, FASN, SCD1) and cholesterol synthesis (HMGCR, HMGCS1, FD...

化合物

SCD1 inhibitor-3

Cat.No: T38683

Synonym: SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a

Target: Dehydrogenase

SCD1 inhibitor-4

Cat.No: T10525

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

SCD1 Inhibitor

Cat.No: T71175

Target: Others

SCD1 inhibitor-1

Cat.No: T12863

Target: Others

Cat.No: T84804

Target: Others

Cat.No: T61841

Target: Others

Cat.No: T2650

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T4515

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T16068

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T13356

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T9003

Synonym: N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺

Target: Dehydrogenase

Cat.No: T1869

Synonym: 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1

Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T14878

Target: Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Cat.No: T9722

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T7294

Synonym: C20-FABAC

Target: Others

MK-8245 Trifluoroacetate

Cat.No: T38844

Target: Others

Cat.No: T79262

Target: Stearoyl-CoA Desaturase (SCD)

trans-Petroselinic Acid

Cat.No: T85282

Synonym: trans-6-Octadecenoic Acid,Δ6-trans-Octadecenoic Acid,Petroselaidic Acid

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T41253	Sterculic acid	Others	Others
	Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 剂量依赖性抑制 delta-9 去饱和酶 (Δ9D) 活性，IC50值为 0.9 μM。
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Cat.No: T41253

Target: Others

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02491	SCD1 Protein, Mouse, Recombinant (His & Myc) Stearoyl-CoA desaturase 1,Scd1,De...	Mouse	E. coli
	SCD1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.4 kDa and the accession number is P13516.

重组蛋白

SCD1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02491

Species: Mouse

Expression System: E. coli

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