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Search Results for " src "

Targets Recommended: Src Src

205

抑制剂 & 化合物

12

天然产物

2

化合物库

40

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；

化合物库

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

Cat. No.	Product Name	Target	Signaling Pathways
T3593	Src Inhibitor 1 Src Kinase Inhibitor 1,Src-l1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Src Inhibitor 1 (Src Kinase Inhibitor 1) 是一种选择性的、高效的、ATP-竞争性的双位点 Src 酪氨酸激酶抑制剂，能够抑制 Src (IC50:44 nM) 和 Lck (IC50:88 nM)。
TP2289L	RR-src acetate RR-src acetate(81156-93-6 Free base)	Others	Others
	RR-src acetate 是一种合成肽，来源于 pp60src 中磷酸化位点周围的氨基酸序列。
T11745	KB SRC 4	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	KB SRC 4 是一种具有选择性和高效性的 c-Src 抑制剂，具有抗肿瘤活性，可抑制癌细胞生长。
T13000	Src Inhibitor 3	Others; Src	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Src Inhibitor 3 是一种有效的 c-terminal Src 激酶抑制剂（CSK HTRF 中 IC50 <3 nM，Caliper 中 IC50 <4 nM）。 Src Inhibitor 3 增加由 T 细胞受体信号传导诱导的 T 细胞增殖。
TP2137L	pp60 c-src (521-533) (phosphorylated) acetate	Others	Others
	pp60 c-src (521-533) (phosphorylated) acetate 是粘着斑形成和细胞扩散的调节剂。它还调节细胞运动，是由促运动透明质酸受体 RHAMM 触发的信号通路中的关键成分。
T39185	pp60 (v-SRC) Autophosphorylation Site, Phosphorylated pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
	pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate. It serves as a valuable tool for quantifying phosphorylated substrates in screening EGFR Kinase inhibitors.
T1811	WH-4-023 KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	WH-4-023 (Dual LCK/SRC inhibitor) 是选择性Lck 和Src 抑制剂，它们的 IC50 分别为 2 nM、6 nM，对p38α 和 KDR 作用效果稍弱。
T39149	Src Optimal Peptide Substrate
	Src Optimal Peptide Substrate, a highly specific substrate of Src, serves as a reliable indicator of Src activity. It enables accurate assessment of Src kinase function.
TP2289	RR-src	Others	Others
	Tyrosine kinase substrate peptide
T13061	T338C Src-IN-1	Others	Others
	T338C Src-IN-1 is a potent mutant-Src T338C inhibitor(T338C,IC50=111 nM relative to WT c-Src (10-fold increase)).
T13062	T338C Src-IN-2	Others	Others
	T338C Src-IN-2 is a potent mutant inhibitor of c-Src T338C kinase(IC50 of 317 nM). T338C Src-IN-2 also inhibits T338C/V323A and T338C/V323S(IC50 of 57 nM/19 nM,respectively).
TP2137	pp60 c-src (521-533) (phosphorylated)
	Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.
T81106	SRC-1 (686-700)
	SRC-1 (686-700) 是一种含有第二个 LXXLL 基序的生物活性肽，构成自类固醇受体共激活剂 (SRC1) NR 盒 II 的氨基酸 686 至 700 片段。这种共激活蛋白能够以配体依赖的方式与核受体发生相互作用，并增强转录活性。
T76391	p60c-src substrate II
	p60c-src substrate II 是酪氨酸激酶pp60c-src 的高效五肽底物。
T81577	P60v-src(137-157)
	P60v-src(137-157)为合成抑肽，针对p60v-src酪氨酸激酶展现抑制作用(IC50: 7.5 μM)。
T81578	p60c-src substrate II, phosphorylated
	p60c-src substrate II, phosphorylated 是磷酸化的五肽，为 p60c-src substrate II 的磷酸化形式。其代表了蛋白质翻译后修饰的一种，对生物调控具有重要作用。
T8499	eCF506	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	eCF506 是一种高效的、口服具有活力的非受体酪氨酸激酶Src 抑制剂，其IC50<0.5 nM。
T83752	Biotin-SRC-1 (676–700) TFA Biotin-Steroid Receptor Coactivator 1 (676-700)
	Biotin-SRC-1 (676–700)是一种生物素化且缩短的类固醇受体辅助激活蛋白1 (SRC-1)。它已在基于亲和力的报告试验中使用，包括时间分辨荧光共振能量转移 (TR-FRET) 和增强型近距离发光均匀检测法 (ΑLPHASCREEN™)。
T0152	Bosutinib 伯舒替尼,SKI-606	Bcr-Abl; Src; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Bosutinib (SKI-606) 是一种合成的喹诺酮衍生物和双激酶抑制剂，靶向 Abl 和 Src 激酶的 IC50分别为 1 nM 和 1.2 nM。
T17267	XL228	IGF-1R; Bcr-Abl; Src; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	XL228 是一种多靶点酪氨酸激酶抑制剂，对 Bcr-Abl、Aurora A、IGF-1R、Src 和 Lyn 的 IC50 分别为 5、3.1、1.6、6.1和 2 nM。
T3063	PD173955 PD-173955,PD 173955	Apoptosis; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PD173955是一种Src 激酶家族选择性抑制剂，对Src、Yes 和Abl 激酶IC50值约为22nM，对 FGFRα 的效力较低，对InsR 和PKC 无活性。
T4470	Pyridostatin TFA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T6078	Saracatinib AZD0530,塞卡替尼	EGFR; Src; BTK; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Saracatinib (AZD0530) 是一种有效的 Src 抑制剂，抑制 c-Src、Lck、c-YES、Lyn、Fyn、Fgr 和 Blk 的 IC50值在 2.7 到 11 nM 之间，对其他酪氨酸激酶具有选择性。
T13186	TL02-59	Apoptosis; Src; Hck	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	TL02-59 是 Src 家族激酶中 Fgr 的特异性抑制剂 (IC50 = 0.03 nM)。 TL02-59 抑制 Lyn 和 Hck，IC50 分别为 0.1 nM 和 160 nM。 TL02-59 有效抑制急性髓性白血病细胞的生长。
T4301	AD80	Raf; c-RET; Src; S6 Kinase	Angiogenesis; Apoptosis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AD80 是多激酶抑制剂，可抑制 RET、RAF、SRC 和 S6K，并大大降低 mTOR 活性。
T16760	RK-24466 KIN 001-51	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	RK-24466 (KIN 001-51) 是高效的、选择性的 Lck 抑制剂，对 Lck (64-509) 和 LckCD 亚型的 IC50 值分别为小于 1 和2 nM。
T6594	MNS	Syk; Src; p97	Angiogenesis; Tyrosine Kinase/Adaptors; Ubiquitination
	MNS 是一种酪氨酸激酶抑制剂和广谱抗血小板药物，是一种 β-硝基苯乙烯衍生物。它完全抑制 U46619 (IC50:2.1 μM)、ADP (IC50:4.1 μM)、花生四烯酸 (IC50:5.8 μM)、胶原 (IC50:7.0 μM)和凝血酶 (IC50:12.7 μM)诱导的血小板聚集，并抑制 Src (IC50:27.3 μM)、Syk (IC50:2.8 μM) 和 FAK (IC50:97.6 μM)。
T4597	UM-164 UM164,DAS-DFGO-II	p38 MAPK; Src; Autophagy	Angiogenesis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	UM-164 (DAS-DFGO-II) 是一种高效的c-Src 抑制剂，Kd 为 2.7 nM。它还抑制p38α和p38β活性。
T11538	Hck-IN-1	HIV Protease; Src; Hck	Angiogenesis; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Hck-IN-1 是二苯基吡唑啉化合物，选择性的 Nef 依赖性 Hck 抑制剂。它是广泛的 HIV-1 Nef 直接拮抗剂，对于野生型 HIV-1 复制的IC50为 100-300 nM。它结合口袋残基 Asn126，具有抗逆转录病毒活性。
T6345	Tirbanibulin KX2-391,KX-01	Microtubule Associated; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tirbanibulin (KX2-391) 是一种高度选择性的 Src 激酶抑制，靶向 Src 的多肽底物结合位点，对多种癌症有疗效。
T1812	KX1-004 KX1 004,KX1004	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	KX1-004 是非 ATP 竞争性 Src-PTK 抑制剂，IC50=40 μM。它能够保护耳蜗，使其免受有害噪音的影响，并防止噪音引起的听力损失 (NIHL)。
T2153	1-NM-PP1 PP1 Analog II,1 nM-PP1	Serine/threonin kinase; CDK; Src	Angiogenesis; Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	1-NM-PP1 (PP1 Analog II) 是一种有效的Src 家族激酶抑制剂，是一种细胞渗透性 PP1 类似物，对 v-Src-as1 与 c-Fyn-as1 的IC50值分别为 4.3 nM、3.2 nM。
T6997	SU6656	FAK; Akt; Src	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。
T7123	AMG-47a	VEGFR; p38 MAPK; JAK; Src	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
	AMG-47a 是具有口服活性的 Lck 抑制剂，IC50值为 0.2 nM。它具有抗炎作用，对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。
T13194	CSF1R-IN-2	c-Fms; c-Met/HGFR; Src	Angiogenesis; Tyrosine Kinase/Adaptors
	CSF1R-IN-2 是一种口服具有活力的、有效的 SRC，MET 和 c-FMS 抑制剂，它们的 IC50 值分别为 0.12 nM，0.14 nM 和 0.76 nM。
TQ0132	A 419259 trihydrochloride RK 20449 trihydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	A 419259 trihydrochloride (RK 20449 trihydrochloride) 是一种 Src 家族激酶抑制剂，能够抑制 Src (IC50:9 nM)、Lck (IC50:3 nM)、Lyn (IC50:3 nM)。
T2640	Rebastinib DCC2036,DCC 2036,DCC-2036	Apoptosis; FLT; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Rebastinib (DCC-2036) 是一种口服有效的，非 ATP 竞争性的 Bcr-Abl 抑制剂，作用于 Abl1WT 和 Abl1T315I，IC50分别为 0.8 nM 和 4 nM，还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2，对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T6311	Bafetinib NS-187,巴氟替尼,INNO-406	Bcr-Abl; Src; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Bafetinib (INNO-406) 是一种特异性双重 Bcr-Abl/Lyn 抑制剂，IC50值为5.8和19 nM。
T1448	Dasatinib BMS-354825,达沙替尼	Apoptosis; Bcr-Abl; Src; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Dasatinib (BMS-354825) 是一种酪氨酸激酶抑制剂，抑制 Src 和 Bcr-Abl (Ki=16/30 pM)，具有口服活性和 ATP 竞争性。Dasatinib 具有抗肿瘤活性，用于治疗白血病和淋巴瘤等。
T15675	Tirbanibulin Mesylate KX2-391 Mesylate,KX01 Mesylate	Microtubule Associated; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tirbanibulin Mesylate (KX01 Mesylate) 是一种 Src 抑制剂，靶向 Src 的肽底物位点。在肿瘤细胞中，GI50值为 9-60 nM。
T6196	PP1 EI 275,AGL 1872	Apoptosis; EGFR; Bcr-Abl; Src; c-Kit	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PP1 (AGL 1872) 是一种选择性有效 Src 家族抑制剂，抑制 Lck 和Fyn，IC50分别为 5 和 6 nM。
T0948	Adrenalone hydrochloride Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Adrenalone hydrochloride (Adrenalone HCl) 是一种多巴胺β氧化酶 (dopamine β oxidase) 抑制剂，结构与去甲肾上腺素转运蛋白 (NET) 配体相似，IC50=36.9 μM。它是一种肾上腺素能 (adrenergic) 激动剂，用作局部血管收缩剂和止血剂。
T8976	PD-089828	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-089828 是受体酪氨酸激酶 FGFR1、PDGFRβ 和 EGFR 的竞争性抑制剂，IC50分别为0.15、1.76 和 5.47 µM。它也是非受体酪氨酸激酶 c-Src 的非竞争性抑制剂，IC50 为 0.18 µM。
T2327	Pelitinib 培利替尼,EKB-569,WAY-EKB 569	EGFR; Raf; MEK; Src	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	Pelitinib (EKB-569) 是一种可逆的EGFR 抑制剂，IC50值为38.5 nM。它也抑制Src、MEK/ERK 和 ErbB2，IC50值分别为282、800 和 1255 nM。
T8719	SC99	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SC99 是一种口服有效选择性STAT3抑制剂，靶向 JAK2-STAT3 途径，抑制血小板活化和聚集，有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中，抑制 JAK2 和 STAT3 的磷酸化。
T11826	LCH-7749944 GNF-PF-2356	Apoptosis; PAK	Apoptosis; Cytoskeletal Signaling
	LCH-7749944 (GNF-PF-2356) 是一种 PAK4抑制剂，IC50为 14.93 μM。它通过下调 PAK4/c-Src/EGFR/cyclin D1 途径有效抑制人胃癌细胞的增殖，并诱导凋亡。
T6896	Tolimidone 托利咪酮,NSC 314335,MLR-1023,CP-26154	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Tolimidone (NSC 314335) 是选择性的 Lyn kinase 变构激活剂，其 EC50=63 nM。
T6266	PP2 AGL 1879,AG 1879,AGL 1879	EGFR; Tyrosine Kinases; JAK; Src	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	PP2 (AG 1879,AGL 1879) 是 Lck/Fyn 抑制剂 (IC50:4/5 nM)，对 EGFR 的效力降低约 100 倍，对 ZAP-70、PKA 和 JAK2 无活性。
T2358	ENMD-2076	Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	ENMD2076是一种多靶点激酶抑制剂，抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。
T2609	Masitinib AB1010,马赛替尼	Apoptosis; FAK; c-Fms; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Hck	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。它有抗增殖，促凋亡活性，且毒性低。

化合物

Src Inhibitor 1

Cat.No: T3593

Synonym: Src Kinase Inhibitor 1,Src-l1

Target: Src

RR-src acetate

Cat.No: TP2289L

Synonym: RR-src acetate(81156-93-6 Free base)

Target: Others

Cat.No: T11745

Target: Src

Src Inhibitor 3

Cat.No: T13000

Target: Others, Src

pp60 c-src (521-533) (phosphorylated) acetate

Cat.No: TP2137L

Target: Others

pp60 (v-SRC) Autophosphorylation Site, Phosphorylated

Cat.No: T39185

Synonym: pp60 (v-SRC) Autophosphorylation Site, Phosphorylated

Cat.No: T1811

Synonym: KIN112,KIN001-112,Dual LCK/SRC inhibitor

Target: Src

Src Optimal Peptide Substrate

Cat.No: T39149

Cat.No: TP2289

Target: Others

T338C Src-IN-1

Cat.No: T13061

Target: Others

T338C Src-IN-2

Cat.No: T13062

Target: Others

pp60 c-src (521-533) (phosphorylated)

Cat.No: TP2137

SRC-1 (686-700)

Cat.No: T81106

p60c-src substrate II

Cat.No: T76391

P60v-src(137-157)

Cat.No: T81577

p60c-src substrate II, phosphorylated

Cat.No: T81578

Cat.No: T8499

Target: Src

Biotin-SRC-1 (676–700) TFA

Cat.No: T83752

Synonym: Biotin-Steroid Receptor Coactivator 1 (676-700)

Cat.No: T0152

Synonym: 伯舒替尼,SKI-606

Target: Bcr-Abl, Src, Autophagy

Cat.No: T17267

Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase

Cat.No: T3063

Synonym: PD-173955,PD 173955

Target: Apoptosis, Bcr-Abl, Src

Pyridostatin TFA

Cat.No: T4470

Target: DNA/RNA Synthesis

Cat.No: T6078

Synonym: AZD0530,塞卡替尼

Target: EGFR, Src, BTK, Autophagy

Cat.No: T13186

Target: Apoptosis, Src, Hck

Cat.No: T4301

Target: Raf, c-RET, Src, S6 Kinase

Cat.No: T16760

Synonym: KIN 001-51

Target: Src

Cat.No: T6594

Target: Syk, Src, p97

Cat.No: T4597

Synonym: UM164,DAS-DFGO-II

Target: p38 MAPK, Src, Autophagy

Cat.No: T11538

Target: HIV Protease, Src, Hck

Cat.No: T6345

Synonym: KX2-391,KX-01

Target: Microtubule Associated, Src

Cat.No: T1812

Synonym: KX1 004,KX1004

Target: Src

Cat.No: T2153

Synonym: PP1 Analog II,1 nM-PP1

Target: Serine/threonin kinase, CDK, Src

Cat.No: T6997

Target: FAK, Akt, Src

Cat.No: T7123

Target: VEGFR, p38 MAPK, JAK, Src

Cat.No: T13194

Target: c-Fms, c-Met/HGFR, Src

A 419259 trihydrochloride

Cat.No: TQ0132

Synonym: RK 20449 trihydrochloride

Target: Src

Cat.No: T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Cat.No: T6311

Synonym: NS-187,巴氟替尼,INNO-406

Target: Bcr-Abl, Src, Autophagy

Cat.No: T1448

Synonym: BMS-354825,达沙替尼

Target: Apoptosis, Bcr-Abl, Src, c-Kit, Autophagy

Tirbanibulin Mesylate

Cat.No: T15675

Synonym: KX2-391 Mesylate,KX01 Mesylate

Target: Microtubule Associated, Src

Cat.No: T6196

Synonym: EI 275,AGL 1872

Target: Apoptosis, EGFR, Bcr-Abl, Src, c-Kit

Adrenalone hydrochloride

Cat.No: T0948

Synonym: Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮

Target: Adrenergic Receptor

Cat.No: T8976

Target: EGFR, FGFR, PDGFR, Src

Cat.No: T2327

Synonym: 培利替尼,EKB-569,WAY-EKB 569

Target: EGFR, Raf, MEK, Src

Cat.No: T8719

Target: Apoptosis, JAK, STAT

Cat.No: T11826

Synonym: GNF-PF-2356

Target: Apoptosis, PAK

Cat.No: T6896

Synonym: 托利咪酮,NSC 314335,MLR-1023,CP-26154

Target: Src

Cat.No: T6266

Synonym: AGL 1879,AG 1879,AGL 1879

Target: EGFR, Tyrosine Kinases, JAK, Src

Cat.No: T2358

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

Cat.No: T2609

Synonym: AB1010,马赛替尼

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

Cat. No.	Product Name	Target	Signaling Pathways
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T3319	Scutellarein 野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin	SARS-CoV; Src; Autophagy	Angiogenesis; Autophagy; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Scutellarein (6-Hydroxyapigenin) 是一种天然黄酮，具有抗炎功效。
T7345	7-Hydroxy-4H-chromen-4-one 7-羟基色原酮,7-hydroxy-4-benzopyrone,7-Hydroxy-4-chromone,7-Hydroxychromone	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	7-Hydroxy-4H-chromen-4-one (7-hydroxy-4-benzopyrone) 是 Src 激酶抑制剂，其 IC50<300 μM。
TQ0169	Inulicin 1-O-Acetylbritannilactone,旋覆花内酯	FAK; NF-κB; COX; Src	Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Inulicin (1-O-Acetylbritannilactone) 是从欧亚旋覆花中提取的一种天然产物，可抑制 VEGF 介导的Src 和FAK 活化，抑制NF-κB 活化和易位，以及抑制 LPS 诱导的PGE2产生和COX-2表达。
T3S2390	Caftaric acid trans-Caftaric acid,单咖啡酰洒石酸	Others	Others
	Caftaric acid (trans-Caftaric acid) 是一种具有抗氧化和抗炎作用的天然产物，具有抗致突变性，也是Src 家族激酶介导的蛋白质-蛋白质相互作用的抑制剂。
TN1892	Lusianthridin	Others; c-Myc	Cell Cycle/Checkpoint; Others
	Lusianthridin 是来自石斛 Dendrobium venustum 的天然产物。 Lusianthridin 在无毒浓度下表现出抗迁移特性。 Lusianthridin 通过抑制 Src-STAT3 信号传导增强 c-Myc 降解。
TN1244	3'-Demethylnobiletin	LDL; NF-κB; Integrin; Lipoxygenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; NF-κB
	3'-Demethylnobiletin 是样一种存在于柑橘类水果中的多甲氧基黄酮类化合物，是一种 Nobiletin 的衍生物。N 其中 obiletin 能够调节 Src，FAK 和 STAT3 信号传导来抗肿瘤，并能够抑制肿瘤血管生成。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
T14055	5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2	VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src	Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors
	5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂，不可逆的选择性抑制 TAK1和 VEGF-R2，IC50值分别为 8 nM 和 52 nM。

天然产物

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T3319

Synonym: 野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin

Target: SARS-CoV, Src, Autophagy

7-Hydroxy-4H-chromen-4-one

Cat.No: T7345

Synonym: 7-羟基色原酮,7-hydroxy-4-benzopyrone,7-Hydroxy-4-chromone,7-Hydroxychromone

Target: Src

Cat.No: TQ0169

Synonym: 1-O-Acetylbritannilactone,旋覆花内酯

Target: FAK, NF-κB, COX, Src

Cat.No: T3S2390

Synonym: trans-Caftaric acid,单咖啡酰洒石酸

Target: Others

Cat.No: TN1892

Target: Others, c-Myc

3'-Demethylnobiletin

Cat.No: TN1244

Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

5Z-7-Oxozeaenol

Cat.No: T14055

Synonym: FR148083,L783279,LL-Z 1640-2

Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04384	Src Protein, Human, Recombinant (His & GST) c-SRC,p60-Src,ASV,SRC1,SRC	Human	Baculovirus Insect Cells
	Src Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is P12931-1.
TMPH-01977	Src Protein, Human, Recombinant (His) Proto-oncogene c-Src,Proto-oncogene tyrosine-protei...	Human	E. coli
	Src Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-04434	Src Protein, Mouse, Recombinant (His & GST) SRC proto-oncogene, non-receptor tyrosine kinase,AW...	Mouse	Baculovirus Insect Cells
	Src Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is NP_001020566.111.
TMPY-04383	CSK Protein, Human, Recombinant (GST) c-src tyrosine kinase	Human	Baculovirus Insect Cells
	CSK Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 77 kDa and the accession number is P41240.
TMPY-04760	CSK Protein, Mouse, Recombinant c-src tyrosine kinase,AW212630,p50CSK	Mouse	Baculovirus Insect Cells
	CSK Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 50.9 kDa and the accession number is P41241.
TMPY-04444	CSK Protein, Mouse, Recombinant (His & GST) AW212630,p50CSK,c-src tyrosine kinase	Mouse	Baculovirus Insect Cells
	CSK Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 78.5 kDa and the accession number is P41241.
TMPY-04388	BLK Protein, Human, Recombinant (GST) MODY11,BLK proto-oncogene, Src family tyrosine kina...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST) HsT441,c-yes,YES proto-oncogene 1, Src family tyros...	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase i...
TMPH-02275	Lck Protein, Human, Recombinant (His) Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,T...	Human	E. coli
	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules...
TMPJ-00712	MPZL1 Protein, Human, Recombinant (His) FLJ96614,mRNA,Myelin protein zero-like 1,cDNA FLJ78597,cDNA,...	Human	HEK293 Cells
	Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin...
TMPY-02511	PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST) LRP,PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His...	Human	Baculovirus Insect Cells
	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and anima...
TMPH-00376	IL-8/CXCL8 Protein, Chicken, Recombinant CEF-4,Embryo fibroblast protein 1,Chemokine (C-X-C motif) li...	Chicken	E. coli
	May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. IL-8/CXCL8 Protein, Chicken, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9.4 kDa and the accession number is P08317.
TMPH-02278	PTPN5 Protein, Human, Recombinant (His & SUMO) PTPN5,Neural-specific protein-tyrosine phosphatase,Tyrosine-...	Human	E. coli
	May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P54829.
TMPH-00375	IL-8/CXCL8 Protein, Chicken, Recombinant (His) Embryo fibroblast protein 1,Interleukin-8,Chemokine (C-X-C m...	Chicken	E. coli
	May be an autocrine factor that promotes the growth of fibroblasts and is involved in the neoplastic transformation of fibroblasts by v-Src. Chemotactic for peripheral blood mononuclear cells as well as for heterophils. IL-8/CXCL8 Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is P08317.
TMPH-01428	TRAP1 Protein, Human, Recombinant (GST) TNFR-associated protein 1,Tumor necrosis factor type 1 recep...	Human	E. coli
	Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. TRAP1 Protein, Human, Recombinant (GST) is expressed in E. coli expressi...
TMPH-01581	KRT1 Protein, Human, Recombinant (His) Keratin, type II cytoskeletal 1,67 kDa cytokeratin,Keratin-1...	Human	E. coli
	May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. KRT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9 kDa and the accession number is P04264.
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST) Cbl proto-oncogene C, E3 ubiquitin protein ligase,CBL-SL,CBL...	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g...
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc) CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3.1.3.48	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577...
TMPK-00423	CD45 Protein, Human, Recombinant (His & Avi) CD45R,LY5,EC 3.1.3.48,B220,CD45,T200,L-CA,GP180,LCA,PTPRC	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPY-02761	Rack1 Protein, Human, Recombinant (His & MBP) PIG21,Gnb2-rs1,H12.3,RACK1,HLC-7	Human	E. coli
	The scaffolding protein, Rack1, is a seven-WD-domain-containing protein that has been implicated in binding to integrin beta subunit cytoplasmic domains and to members of two kinase families (src and protein kinase C, PKC) that mediate integrin bidirectional signaling.Rack1 may link protein kinase C directly to integrins and participate in the regulation of integrin functions.Rack1 regulates the localization of an essential PCP protein and acts as a molecular switch to promote PCP signaling.
TMPJ-00396	SEMA4D Protein, Human, Recombinant (aa 22-734, His) A8,BB18,Semaphorin-4D,GR3,CD100	Human	HEK293 Cells
	Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells, regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/P...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosine phosphatase, non...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...
TMPK-00424	CD45 Protein, Human, Recombinant (His & Avi), Biotinylated LCA,LY5,EC 3.1.3.48,CD45,L-CA,T200,CD45R,PTPRC,B220,GP180	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi...
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His) MET,oncogene MET,cMET,SF receptor,HGF/SF receptor,AUTS9,Met ...	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPJ-00326	CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated IL-2R subunit beta,High affinity IL-2 receptor subunit β,Int...	Human	HEK293 Cells
	Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit c...
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi) cMET,Met (c-Met),MET,HGF/SF receptor,SF receptor,RCCP2,AUTS9...	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPY-02191	BLNK Protein, Human, Recombinant (His) BLNK-S,bca,SLP-65,B-cell linker,LY57,SLP65,AGM4,BASH	Human	HEK293 Cells
	B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small inte...
TMPH-01297	DDR1 Protein, Human, Recombinant (aa 21-417, His) EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...	Human	HEK293 Cells
	Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell...
TMPJ-00534	hFcgR4 Protein, Mouse, Recombinant (His) Low Affinity Immunoglobulin γ Fc Region Receptor IV,FcgR4,Lo...	Mouse	HEK293 Cells
	Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc γ receptors (FcR), and they are Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity ...
TMPJ-00329	CD19 Protein, Rhesus macaque, Recombinant (hFc) B-Lymphocyte Antigen CD19,CD19,Differentiation Antigen CD19,...	Rhesus	HEK293 Cells
	CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Sr...
TMPJ-00155	Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated Polymorphic epithelial mucin,KL-6,Cancer antigen 15-3,PEMT,P...	Human	HEK293 Cells
	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane ...
TMPY-01831	SLAMF8 Protein, Mouse, Recombinant (His) Blame,SBBI42,SLAM family member 8,5830408F06Rik	Mouse	HEK293 Cells
	The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associ...
TMPJ-01137	MIA Protein, Human, Recombinant (His) MIA,Melanoma Inhibitory Activity Protein,Melanoma-Derived Gr...	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au...
TMPY-02440	SAP/SH2D1A Protein, Human, Recombinant (His) XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2 domain containing 1A,LYP,S...	Human	E. coli
	SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell...
TMPJ-00395	SEMA4D Protein, Mouse, Recombinant (hFc) Semacl2,Sema J,Semaphorin-C-like 2,Semaj,CD100,Semaphorin-4D...	Mouse	HEK293 Cells
	SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. S...
TMPY-02032	FLRT1 Protein, Human, Recombinant (His) SPG68,fibronectin leucine rich transmembrane protein 1	Human	HEK293 Cells
	The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation ...
TMPH-02549	FHIT Protein, Mouse, Recombinant (His) Adenylylsulfatase,Adenylylsulfate-ammonia adenylyltransferas...	Mouse	E. coli
	Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monop...
TMPY-04084	ANGPTL1 Protein, Canine, Recombinant (hFc) angiopoietin-like 1	Canine	HEK293 Cells
	Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC).The downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decre...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST) PKCI,nPKC-iota,protein kinase C, ι,DXS1179E,nPKC-ι,protein k...	Human	Baculovirus Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ...

重组蛋白

Src Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04384

Species: Human

Expression System: Baculovirus Insect Cells

Src Protein, Human, Recombinant (His)

Cat.No: TMPH-01977

Species: Human

Expression System: E. coli

Src Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04434

Species: Mouse

Expression System: Baculovirus Insect Cells

CSK Protein, Human, Recombinant (GST)

Cat.No: TMPY-04383

Species: Human

Expression System: Baculovirus Insect Cells

CSK Protein, Mouse, Recombinant

Cat.No: TMPY-04760

Species: Mouse

Expression System: Baculovirus Insect Cells

CSK Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04444

Species: Mouse

Expression System: Baculovirus Insect Cells

BLK Protein, Human, Recombinant (GST)

Cat.No: TMPY-04388

Species: Human

Expression System: Baculovirus Insect Cells

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

YES1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04411

Species: Human

Expression System: Baculovirus Insect Cells

Lck Protein, Human, Recombinant (His)

Cat.No: TMPH-02275

Species: Human

Expression System: E. coli

MPZL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00712

Species: Human

Expression System: HEK293 Cells

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Cat.No: TMPY-02511

Species: Human

Expression System: Baculovirus Insect Cells

IL-8/CXCL8 Protein, Chicken, Recombinant

Cat.No: TMPH-00376

Species: Chicken

Expression System: E. coli

PTPN5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02278

Species: Human

Expression System: E. coli

IL-8/CXCL8 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00375

Species: Chicken

Expression System: E. coli

TRAP1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01428

Species: Human

Expression System: E. coli

KRT1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01581

Species: Human

Expression System: E. coli

Cbl-c Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03510

Species: Human

Expression System: Baculovirus Insect Cells

CD45 Protein, Human, Recombinant (aa 26-577, hFc)

Cat.No: TMPK-00447

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00423

Species: Human

Expression System: HEK293 Cells

Rack1 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-02761

Species: Human

Expression System: E. coli

SEMA4D Protein, Human, Recombinant (aa 22-734, His)

Cat.No: TMPJ-00396

Species: Human

Expression System: HEK293 Cells

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

CD45 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00424

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00499

Species: Cynomolgus

Expression System: HEK293 Cells

CD122/IL2RB Protein, Human, Recombinant (aa 27-239, His & Avi), Biotinylated

Cat.No: TMPJ-00326

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00457

Species: Human

Expression System: HEK293 Cells

BLNK Protein, Human, Recombinant (His)

Cat.No: TMPY-02191

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (aa 21-417, His)

Cat.No: TMPH-01297

Species: Human

Expression System: HEK293 Cells

hFcgR4 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00534

Species: Mouse

Expression System: HEK293 Cells

CD19 Protein, Rhesus macaque, Recombinant (hFc)

Cat.No: TMPJ-00329

Species: Rhesus

Expression System: HEK293 Cells

Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated

Cat.No: TMPJ-00155

Species: Human

Expression System: HEK293 Cells

SLAMF8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01831

Species: Mouse

Expression System: HEK293 Cells

MIA Protein, Human, Recombinant (His)

Cat.No: TMPJ-01137

Species: Human

Expression System: E. coli

SAP/SH2D1A Protein, Human, Recombinant (His)

Cat.No: TMPY-02440

Species: Human

Expression System: E. coli

SEMA4D Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00395

Species: Mouse

Expression System: HEK293 Cells

FLRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02032

Species: Human

Expression System: HEK293 Cells

FHIT Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02549

Species: Mouse

Expression System: E. coli

ANGPTL1 Protein, Canine, Recombinant (hFc)

Cat.No: TMPY-04084

Species: Canine

Expression System: HEK293 Cells

PKC iota Protein, Human, Recombinant (GST)

Cat.No: TMPY-04455

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T10962	Dasatinib-d8 BMS-354825 D8	Others	Others
	Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
T12521	Ponatinib-d8 AP24534 D8	Others	Others
	Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase(Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively).
TMID-0288	Apatinib-d8
	Apatinib-d8 是 Apatinib 的氘代化合物。Apatinib 的 CAS 号为 811803-05-1。Apatinib 是一种口服生物可利用的特异性 VEGFR2 抑制剂 (IC50: 1 nM)。此外，该试剂温和地抑制 c-Kit 和 c-SRC 酪氨酸激酶。
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

同位素标记化合物

Cat.No: T10962

Synonym: BMS-354825 D8

Target: Others

Cat.No: T12521

Synonym: AP24534 D8

Target: Others

Cat.No: TMID-0288

Acalabrutinib-d4

Cat.No: TMIH-0065

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