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Search Results for " shp2 "

Targets Recommended: PROTACs

59

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T40121	SHP2-D26 SHP2-D26	PROTACs	PROTAC
	SHP2-D26 is a highly potent and effective SHP2 degrader. Its mechanism of action involves the induction of SHP2 degradation through binding to VHL-1 and SHP2 proteins. Additionally, the degradation of SHP2 induced by SHP2-D26 is dependent on neddylation and proteasome activity.
T39640	JAB-3068 SHP2-IN-6	Phosphatase	Metabolism
	JAB-3068 (SHP2-IN-6) 是一种高效的 SHP2 抑制剂，具有抗癌抗肿瘤活性，可用于研究乳腺癌肺癌和食道癌。
T40250	SHP2 protein degrader-1 SHP2 protein degrader-1	Others	Others
	SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying diseases associated with SHP2.
T39658	RMC-4630 SHP2-IN-7,RMC-4630	Phosphatase	Metabolism
	RMC-4630 (SHP2-IN-7) 是 SHP2 的抑制剂。
T39641	SHP2-IN-6 hydrochloride SHP2-IN-6 hydrochloride	Others	Others
	SHP2-IN-6 hydrochloride is a highly potent inhibitor of SHP2 with an IC50 of 25.8 nM.
T12903	SHP2 IN-1	Others	Others
	SHP2 IN-1 is an allergic SHP2 (PTPN11) inhibitor(IC50 : 3 nM).
T63993	SHP2 inhibitor LY6	Others	Others
	SHP2 inhibitor LY6 (LY6) 是一种有效的、选择性的 SHP2 抑制剂 (IC50: 9.8 μM)。SHP2 inhibitor LY6 能够阻碍 SHP2 介导的细胞信号传导和增殖。
T81162	SHP2-IN-20	Others	Others
	SHP2-IN-20 (compound 193)为SHP2抑制剂，具有3 nM的IC50值，适用于胶质母细胞瘤研究。
T79108	SHP2-IN-14	Others	Others
	SHP2-IN-14 (compound 27) 为一种口服生效SHP2变构抑制剂（IC50=7 nM），展示抗肿瘤作用。该化合物能够有效抑止小鼠NCI-H358肿瘤模型生长，且具备优良药代动力学属性和安全性。
T74430	SHP2 protein degrader-2	PROTACs	PROTAC
	SHP2protein degrader-2 (SHP2-D26) 是一种SHP2蛋白PROTAC 降解剂。SHP2protein degrader-2 可降低各种癌细胞中SHP2的表达水平。
T61891	SHP2-IN-8	Others	Others
	SHP2-IN-8 是一种可逆、非竞争性、选择性、高效性的变构SHP2抑制剂（IC50= 23 nM，Ki= 22 nM），在细胞中也有效果。SHP2-IN-8 能引起显著的热位移（ΔTm = 7.01 ℃）。SHP2-IN-8 可抑制AKT 的磷酸化，诱导 Hela 细胞凋亡 (apoptosis)。
T79412	SHP2-IN-16	Others	Others
	SHP2-IN-16（化合物222）作为SHP2抑制剂，具有1 nM的IC50值，适用于胶质母细胞瘤研究。
T78896	SHP2-IN-22	Others	Others
	SHP2-IN-22 作为变构抑制剂，靶向SHP2，具有 17.7 nM 的 IC50。该化合物能够有效抑制MIA PaCa-2胰腺癌细胞的增殖、迁移和侵袭行为。SHP2-IN-22 主要用于研究含Kirsten大鼠肉瘤病毒癌基因(KRAS)突变型的癌症。
T78611	SHP2-IN-5	Others	Others
	SHP2-IN-5（化合物1）为SHP2抑制剂，IC50为97 nM。SHP2，一种非受体型蛋白酪氨酸磷酸酶，与细胞生长及增殖紧密相关。SHP2-IN-5可能对抑制癌症和其他与SHP2有关的疾病具有治疗潜力。
T81161	SHP2-IN-21	Others	Others
	SHP2-IN-21（化合物208）是一种SHP2抑制剂，其IC50为3 nM，适用于胶质母细胞瘤研究。
T78694	SHP2-IN-13	Others	Others
	SHP2-IN-13是一种针对SHP2“tunnel site” 的变构抑制剂，具备高选择性及口服活性，IC50值为83.0 nM。该化合物可作为研究潜力药物，用于治疗携带RTK致癌驱动因素的癌症以及SHP2相关疾病。
T81163	SHP2-IN-19	Others	Others
	SHP2-IN-19（compound 183），作为SHP2抑制剂，展现出3 nM的IC50值，主要应用于胶质母细胞瘤研究。
T81165	SHP2-IN-17	Others	Others
	SHP2-IN-17（化合物192）作为SHP2抑制剂，具有2 nM的IC50值，适用于胶质母细胞瘤研究。
T72839	SHP2/HDAC-IN-1	Others	Others
	SHP2/HDAC-IN-1 是一种变构的 SHP2/HDAC 双重抑制剂，IC50值分别为 20.4 nM (SHP2) 和 25.3 nM ( HDAC1)。SHP2/HDAC-IN-1 通过激活 T 细胞、增强抗原呈递功能和促进细胞因子分泌来触发抗肿瘤免疫反应。SHP2/HDAC-IN-1 可用于癌症的免疫治疗研究。
T72836	SHP2/CDK4-IN-1	Others	Others
	SHP2/CDK4-IN-1（化合物10）是一种针对SHP2和CDK4的口服双重抑制剂，具有IC50值分别为4.3和18.2 nM。该化合物能有效引起G0/G1期阻滞，抑制TNBC细胞的增殖，并在EMT6同源小鼠模型中展现出明显的抗肿瘤活性，适用于三阴性乳腺癌（TNBC）的研究。
T61701	SHP2-IN-9	Others	Others
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
T81164	SHP2-IN-18	Others	Others
	SHP2-IN-18（化合物183）作为SHP2抑制剂，具有3 nM的IC50。该化合物适用于胶质母细胞瘤研究。
T4340	SPI-112	Phosphatase	Metabolism
	SPI 112 是一种选择性的、有效的、竞争性的SHP2 (PTPN11)抑制剂，对SHP2，蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的IC50分别为 1 μM，18.3 μM 和 14.5 μM。
T13176	TNO155 Batoprotafib	Phosphatase	Metabolism
	TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤（尤其是晚期实体瘤）的潜力。
T9196	IACS-13909 BBP-398	Phosphatase	Metabolism
	IACS-13909 (BBP-398) 是具有口服活性的、选择性的 SHP2变构抑制剂，其 IC50=15.7 nM，Kd=32 nM。与其他磷酸酶相比，它对 SHP2的选择性更高。它能够抑制受体酪氨酸激酶 (RTK)/MAPK 途径的信号传导，并具有抗癌作用。
T28410	PHPS1 PHPS-1,PHPS 1	Phosphatase	Metabolism
	PHPS1 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T22276	Bis(maltolato)oxovanadium(IV) 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase; Others	Metabolism; Others
	Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂，也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA，PTP1B，HPTPβ和SHP2的IC50分别为 126 nM，109 nM，26 nM 和 201 nM。
T68409	SHP244	Others	Others
	SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme.
T3544	SHP099 hydrochloride	Phosphatase; Others	Metabolism; Others
	SHP099 hydrochloride 是一种有效的、选择性的、口服生物可利用的、有效的 SHP2 抑制剂。
T16350	NSC-87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 是一种Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。它还抑制双特异性磷酸酶26。
T16762	RMC-4550	Phosphatase	Metabolism
	RMC-4550 是选择性的蛋白酪氨酸磷酸酶 2 的变构抑制剂，其IC50=0.583 nM。
T3564	SHP099 SHP099 free base,SHP 099,SHP-099	Phosphatase; PERK	Apoptosis; Metabolism
	SHP099 (SHP099 free base) free base 是一种选择性的，有效的，有口服活性的 SHP2抑制剂，IC50=70 nM。
T73552	BPDA2	Phosphatase	Metabolism
	BPDA2 是一种具有选择性和高效性的 SHP2 抑制剂，对 SHP2、SHP1、SHP1B 的 IC50 值分别为 92.0 nM、33.39 μM、40.71 μM。DBDA2 具有抗癌抗肿瘤活性，以浓度依赖性方式抑制乳腺癌细胞的锚定非依赖性生长和癌症干细胞特性。BPDA2 可用于研究乳腺癌。
T4627	SPI--112Me	Others	Others
	SPI--112Me 是 SPI-112 的前药，在无细胞试验中，它优先抑制 Shp2 的 PTPase 活性超过 Shp1 和 PTP1B 20 倍。
T6911	NSC-87877 disodium NSC87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。
T16878	SHP836	Others	Others
	SHP836 is an inhibitor of SHP2 allosteric (IC50: 12 μM for the full-length SHP2).
T16877	SHP394	Others	Others
	SHP394 is an orally efficacious inhibitor of protein tyrosine phosphatase SHP2 (IC50: 23 nM).
T39726	SHP389 SHP389	Others	Others
	SHP389 is an allosteric SHP2 inhibitor, with an IC 50 of 36 nM for both SHP2 and p-ERK.
T39167	GS-493	Others	Others
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.
T25953	PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt	Others	Others
	PHPS1 sodium 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T70919	NAT6-297775	Others	Others
	NAT6-297775 is a SHP2 inhibitor with IC50 =2.47uM.
T73477	SHP844	Others	Others
	SHP844为一SHP2抑制剂，IC50值为18.9 µM。SHP2为蛋白酪氨酸磷酸酶(PTP)，调控酪氨酸磷酸化水平，影响细胞增殖、分化及存活。
T62798	GDC-1971	Others	Others
	GDC-1971 (compound 199) 是一种 SHP2 的抑制剂。
T69835	Plasiatine	Others	Others
	Plasiatine is a novel potent activator of the nonreceptor protein tyrosine phosphatase shp2
T69125	NSC-13030	Others	Others
	NSC-13030 is a Potent SHP2 Inhibitor with Anti-Proliferative Activity in Breast Cancer Cell Lines
T27591	II-B08 II-B 08,FAP1 Inhibitor,II-B-08,LMWPTP Inhibitor,Lyp Inhibitor III,CD45 Inhibitor V	Others	Others
	II-B08 is a cell-permeable SHP2 inhibitor (IC50 = 5.5 µM). II-B08 blocks growth factor stimulated ERK1/2 activation and hematopoietic progenitor proliferation.
T62657	SHP504	Others	Others
	SHP504 是一种 SHP2 磷酸酶的抑制剂，能够作用于 SHP21–525 (IC50: 21 μM)。
T39999	IACS-15414	Others	Others
	IACS-15414 is a potent SHP2 inhibitor that is effective when administered orally, demonstrating an IC50 value of 122 nM.
T79311	CNBCA	Others	Others
	CNBCA是一种有效的SHP2酶抑制剂，具有选择性和竞争性，IC50值为0.87 μM。该化合物可结合SHP2全长蛋白并抑制其酶活性，进而阻止Akt和ERK1/2的磷酸化，以及抑制BT474和MDA-MB468乳腺癌细胞的生长。CNBCA主要用于乳腺癌的研究。
T39221	RMC-3943	Others	Others
	RMC-3943 is a highly potent allosteric inhibitor of full-length SHP2, as demonstrated by its remarkable activity in a biochemical assay, with an IC50 value of 2.19 nM.

化合物

Cat.No: T40121

Synonym: SHP2-D26

Target: PROTACs

Cat.No: T39640

Synonym: SHP2-IN-6

Target: Phosphatase

SHP2 protein degrader-1

Cat.No: T40250

Synonym: SHP2 protein degrader-1

Target: Others

Cat.No: T39658

Synonym: SHP2-IN-7,RMC-4630

Target: Phosphatase

SHP2-IN-6 hydrochloride

Cat.No: T39641

Synonym: SHP2-IN-6 hydrochloride

Target: Others

Cat.No: T12903

Target: Others

SHP2 inhibitor LY6

Cat.No: T63993

Target: Others

Cat.No: T81162

Target: Others

Cat.No: T79108

Target: Others

SHP2 protein degrader-2

Cat.No: T74430

Target: PROTACs

Cat.No: T61891

Target: Others

Cat.No: T79412

Target: Others

Cat.No: T78896

Target: Others

Cat.No: T78611

Target: Others

Cat.No: T81161

Target: Others

Cat.No: T78694

Target: Others

Cat.No: T81163

Target: Others

Cat.No: T81165

Target: Others

SHP2/HDAC-IN-1

Cat.No: T72839

Target: Others

SHP2/CDK4-IN-1

Cat.No: T72836

Target: Others

Cat.No: T61701

Target: Others

Cat.No: T81164

Target: Others

Cat.No: T4340

Target: Phosphatase

Cat.No: T13176

Synonym: Batoprotafib

Target: Phosphatase

Cat.No: T9196

Synonym: BBP-398

Target: Phosphatase

Cat.No: T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Bis(maltolato)oxovanadium(IV)

Cat.No: T22276

Synonym: 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

Cat.No: T68409

Target: Others

SHP099 hydrochloride

Cat.No: T3544

Target: Phosphatase, Others

Cat.No: T16350

Target: Apoptosis, Phosphatase

Cat.No: T16762

Target: Phosphatase

Cat.No: T3564

Synonym: SHP099 free base,SHP 099,SHP-099

Target: Phosphatase, PERK

Cat.No: T73552

Target: Phosphatase

Cat.No: T4627

Target: Others

NSC-87877 disodium

Cat.No: T6911

Synonym: NSC87877

Target: Apoptosis, Phosphatase

Cat.No: T16878

Target: Others

Cat.No: T16877

Target: Others

Cat.No: T39726

Synonym: SHP389

Target: Others

Cat.No: T39167

Target: Others

Cat.No: T25953

Synonym: PHPS1 Na,PHPS1 Sodium salt

Target: Others

Cat.No: T70919

Target: Others

Cat.No: T73477

Target: Others

Cat.No: T62798

Target: Others

Cat.No: T69835

Target: Others

Cat.No: T69125

Target: Others

Cat.No: T27591

Synonym: II-B 08,FAP1 Inhibitor,II-B-08,LMWPTP Inhibitor,Lyp Inhibitor III,CD45 Inhibitor V

Target: Others

Cat.No: T62657

Target: Others

Cat.No: T39999

Target: Others

Cat.No: T79311

Target: Others

Cat.No: T39221

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T79985	Cryptosporioptide A	Phosphatase	Metabolism
	Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂，针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用，其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。

天然产物

Cryptosporioptide A

Cat.No: T79985

Target: Phosphatase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03125	SHP-2 Protein, Mouse, Recombinant (His) SAP-2,Syp,PTP1D,SH-PTP2,SH-PTP3,SHP	Mouse	HEK293 Cells
	SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation. SHP2 is widely expressed, with highest levels in heart, brain, and skeletal muscle. SHP2 acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participat...
TMPJ-00537	Siglec-3/CD33 Protein, Human, Recombinant (hFc & His) Myeloid Cell Surface Antigen CD33,CD33,Siglec-3,SIGLEC3,gp67...	Human	HEK293 Cells
	CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c...

重组蛋白

SHP-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03125

Species: Mouse

Expression System: HEK293 Cells

Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00537

Species: Human

Expression System: HEK293 Cells

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