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Search Results for " sh2 "

Targets Recommended: Others

41

抑制剂 & 化合物

22

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82261	Grb2 SH2 domain inhibitor 1	Others	Others
	Grb2 SH2 domain inhibitor 1是构象受限环细胞穿透肽（CPP），主要用作环状肽基抑制剂，包含特定d-Pro-l-Pro基序环（AFΦrpPRRFQ），其中Φ为l-萘基丙氨酸，r为d-精氨酸，p为d-脯氨酸。
T9339	Stafia-1	STAT	JAK/STAT signaling; Stem Cells
	Stafia-1 是STAT5a 抑制剂，Ki 为 10.9 μM，IC50 为 22.2 μM。它与 STAT5b 和其他 STAT 家族成员相比，显示出高选择性。
T77994	Grb2 SH2 domain inhibitor 1 TFA
	Grb2 SH2 domain inhibitor 1 TFA 是构象受限的环细胞穿透肽（CPP），含有d-Pro-l-Pro基序环（AFΦrpPRRFQ），Φ为l-萘基丙氨酸，r为d-精氨酸，p为d-脯氨酸，主要用作环状肽基抑制剂。
T6308	Stattic STAT3 Inhibitor V	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Stattic (STAT3 Inhibitor V) 是一种 STAT3 抑制剂 (IC50=5.1 μM)，选择性地抑制 STAT3 活化、二聚化和核转位。Stattic 具有抗肿瘤活性，可诱导细胞凋亡。
TMAZ-0318A	Anti-CSH2 Monoclonal Antibody-APC
	Anti-CSH2 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-APC can be used FACS.
TMAZ-0318A5	Anti-CSH2 Monoclonal Antibody-AF555
	Anti-CSH2 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-AF555 can be used FACS.
TMAZ-0318B	Anti-CSH2 Monoclonal Antibody-Biotin
	Anti-CSH2 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-Biotin can be used FACS.
TMAZ-0318P	Anti-CSH2 Monoclonal Antibody-PE
	Anti-CSH2 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-PE can be used FACS.
TMAZ-0318A6	Anti-CSH2 Monoclonal Antibody-AF647
	Anti-CSH2 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-AF647 can be used FACS.
TMAZ-0318A4	Anti-CSH2 Monoclonal Antibody-AF488
	Anti-CSH2 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting CSH2. Anti-CSH2 Monoclonal Antibody-AF488 can be used FACS.
T9723	GluR6 antagonist-1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	GluR6 antagonist-1 抑制酪氨酸激酶 p56lck SH2 结构域的 pY 结合位点。
T4216	STAT5-IN-1 STAT5 Inhibitor	STAT	JAK/STAT signaling; Stem Cells
	STAT5-IN-1 (STAT5 Inhibitor) 是STAT5的抑制剂，对 STAT5β 亚型的IC50值为 47 μM。
T14037	3α-Aminocholestane 5α-Cholestan-3α-amine	Phosphatase	Metabolism
	3α-Aminocholestane (5α-Cholestan-3α-amine) 是包含 SH2 结构域的肌醇-5'-磷酸酶 1 (SHIP1) 的有效抑制剂(IC50 ： 2.5 μM)，可用于研究和免疫相关的疾病。
T10877	CPDA	Phosphatase	Metabolism
	CPDA 是新型 SH2 domain-containing inositol phosphatase 2 抑制剂，能够作用于3T3-L1脂肪细胞，改善胰岛素抗性。
T14327	AS1949490	Phosphatase	Metabolism
	AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。
T62491	STAT3-IN-13	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-13 是一种有效的 STAT3 抑制剂。STAT3-IN-13 具有抗增殖和抗癌活性，通过与 STAT3 SH2 结构域结合发挥作用。STAT3-IN-13 抑制 STAT3 Y705 的磷酸化，诱导细胞凋亡，抑制肿瘤细胞的生长和转移。STAT3-IN-13 可用于研究乳腺癌和肝癌。
TQ0003L1	740 Y-P acetate PDGFR 740Y-P Acetate,740YPDGFR acetate,740 Y-P acetate(1236188-16-1 Free base)	PI3K	PI3K/Akt/mTOR signaling
	740 Y-P acetate (740YPDGFR acetate) 是一个有效的且具有细胞渗透性的 PI3K 激活剂。740 Y-P acetate 倾向和含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白结合，但不能单独结合 GST。
TQ0003	740 Y-P 740YPDGFR,PDGFR 740Y-P	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	740 Y-P (740YPDGFR) 是一个细胞渗透性PI3K 激活剂。它能结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白。
T23751	AQX-MN115	Others	Others
	AQX-MN115 is an SH2- containing inositol 5- phosphatase modulator.
T30089	AP-22161 AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161	Others	Others
	AP-22161 selectively binds the Src SH2 domain by targeting highly conserved phosphotyrosine binding to cysteine residues in the pocket. AP-22161 selectively inhibits Src SH2 binding and can be used to inhibit osteoclast absorption.
T38965	EPQpYEEIPIYL
	EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains.
T75841	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA
	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA（化合物1）是一种与srcSH2域具有高亲和性的五肽，IC50约为1 µM。它同样作为srcSH3-SH2：磷酸蛋白相互作用的抑制剂。
T40219	CGP78850	Others	Others
	CGP78850 is a potent and selective Grb2 SH2-phosphopeptide interaction antagonist that holds potential for cancer research.
TP2085	Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
	Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.
TP2084	N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide
	Phosphopeptide; binds to the src SH2 domain.
T21501	5,15-DPP	Others	Others
	5,15-Diphenylporphyrin (5,15-DPP) 是一种选择性STAT3-SH2拮抗剂，其对于STAT3 和 STAT1 的IC50值分别为 0.28 μM 和 10 μM。
T75929	Caffeic acid-pYEEIE TFA
	Caffeic acid-pYEEIE TFA 是一种非磷酸肽抑制剂，对 GST-Lck-SH2 结构域具有强大的结合亲和力。
T27707	K118 K 118,K-118	Others	Others
	K118 is an inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). It reverses diet- and age-associated obesity and metabolic syndrome.
T79186	STAT6-IN-3	STAT	JAK/STAT signaling; Stem Cells
	STAT6-IN-3 (Compound 18a)，一种针对STAT6的Src同源2 (SH2) 结构域的抑制剂，具有44 nM的IC50值。该化合物主要适用于研究哮喘等炎症性疾病。
T75723	740 Y-P TFA
	740 Y-P TFA (740YPDGFR;PDGFR740Y-P) 是一个有效的，具有细胞渗透性的PI3K 激活剂。740 Y-P TFA 很容易结合含有 p85 的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白，但不能单独结合 GST。
T24838	Stafib-1 Stafib 1,Stafib1	STAT	JAK/STAT signaling; Stem Cells
	Stafib-1 是一种特异性的 STAT5β 抑制剂，靶向 SH2 结构域，IC50 为 154 nM，Ki 为 44 nM。
T60765	STAT3-IN-10	Others	Others
	STAT3-IN-10 (A11) 是一种STAT3抑制剂，可直接结合 STAT3 SH2 结构域，抑制肿瘤细胞生长并且诱导肿瘤细胞凋亡 (IC 50 = 5.18 μM)。
TP2053	Caffeic acid-pYEEIE
	Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE,).
T74646	PM-81I	Others	Others
	PM-81I为一种高效STAT6抑制剂（针对SH2结构域），可显著减少STAT6的磷酸化水平。适用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。
T26936	C188 Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188	Others	Others
	C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect agai
T12905	SI-109	STAT	JAK/STAT signaling; Stem Cells
	SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T62724	AQX-435	Others	Others
	AQX-435 是一种有效的 SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1) 激活剂。AQX-435 能够降低 B 细胞受体 (BCR) 下游 PI3K 活性，诱导恶性 B 细胞凋亡，对淋巴瘤生长表现出抑制作用。
T73129	STAT6-IN-1	Others	Others
	STAT6-IN-1（化合物19a）是一种针对STAT6的SH2结构域表现出较高亲和力（IC50=0.028 µM）的STAT6抑制剂。该化合物主要用于研究过敏性肺病、过敏性鼻炎、慢性阻塞性肺病或癌症。
T35429	AC-4-130	Others	Others
	AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].
TP2137	pp60 c-src (521-533) (phosphorylated)
	Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential.
T79662	STAT3-IN-20	STAT	JAK/STAT signaling; Stem Cells
	STAT3-IN-20（Compound 40）是一种选择性地靶向STAT3的SH2结构域，展现了在DU145和MDA-MB-231癌细胞中的抗增殖效果（IC50分别为2.97 μM和3.26 μM），并诱导细胞周期停滞与细胞凋亡。该抑制剂有效抑制了STAT3的磷酸化、核内易位及其下游基因的转录活性（IC50: 0.65 μM）。

化合物

Grb2 SH2 domain inhibitor 1

Cat.No: T82261

Target: Others

Cat.No: T9339

Target: STAT

Grb2 SH2 domain inhibitor 1 TFA

Cat.No: T77994

Cat.No: T6308

Synonym: STAT3 Inhibitor V

Target: Apoptosis, STAT

Anti-CSH2 Monoclonal Antibody-APC

Cat.No: TMAZ-0318A

Anti-CSH2 Monoclonal Antibody-AF555

Cat.No: TMAZ-0318A5

Anti-CSH2 Monoclonal Antibody-Biotin

Cat.No: TMAZ-0318B

Anti-CSH2 Monoclonal Antibody-PE

Cat.No: TMAZ-0318P

Anti-CSH2 Monoclonal Antibody-AF647

Cat.No: TMAZ-0318A6

Anti-CSH2 Monoclonal Antibody-AF488

Cat.No: TMAZ-0318A4

GluR6 antagonist-1

Cat.No: T9723

Target: Src

Cat.No: T4216

Synonym: STAT5 Inhibitor

Target: STAT

3α-Aminocholestane

Cat.No: T14037

Synonym: 5α-Cholestan-3α-amine

Target: Phosphatase

Cat.No: T10877

Target: Phosphatase

Cat.No: T14327

Target: Phosphatase

Cat.No: T62491

Target: STAT

740 Y-P acetate

Cat.No: TQ0003L1

Synonym: PDGFR 740Y-P Acetate,740YPDGFR acetate,740 Y-P acetate(1236188-16-1 Free base)

Target: PI3K

Cat.No: TQ0003

Synonym: 740YPDGFR,PDGFR 740Y-P

Target: PI3K, Autophagy

Cat.No: T23751

Target: Others

Cat.No: T30089

Synonym: AP22161,G7VE62573J,UNII-G7VE62573J,SCHEMBL7243003,AP 22161

Target: Others

Cat.No: T38965

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA

Cat.No: T75841

Cat.No: T40219

Target: Others

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH

Cat.No: TP2085

Synonym: N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu

N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide

Cat.No: TP2084

Cat.No: T21501

Target: Others

Caffeic acid-pYEEIE TFA

Cat.No: T75929

Cat.No: T27707

Synonym: K 118,K-118

Target: Others

Cat.No: T79186

Target: STAT

Cat.No: T75723

Cat.No: T24838

Synonym: Stafib 1,Stafib1

Target: STAT

Cat.No: T60765

Target: Others

Caffeic acid-pYEEIE

Cat.No: TP2053

Cat.No: T74646

Target: Others

Cat.No: T26936

Synonym: Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188

Target: Others

Cat.No: T12905

Target: STAT

Cat.No: T62724

Target: Others

Cat.No: T73129

Target: Others

Cat.No: T35429

Target: Others

pp60 c-src (521-533) (phosphorylated)

Cat.No: TP2137

Cat.No: T79662

Target: STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00870	NCK1 Protein, Human, Recombinant (His) SH2/SH3 Adaptor Protein NCK-α,	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing...
TMPJ-01050	GRB2 Protein, Human, Recombinant (His) Growth Factor Receptor-Bound Protein 2,SH<...	Human	E. coli
	As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti...
TMPH-01189	CISH Protein, Human, Recombinant (GST) Suppressor of cytokine signaling,Cytokine-inducible SH	Human	E. coli
	CISH Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 55.7 kDa and the accession number is Q9NSE2.
TMPY-02440	SAP/SH2D1A Protein, Human, Recombinant (His) XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2...	Human	E. coli
	SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell...
TMPJ-01096	SLP-76 Protein, Human, Recombinant (His) LCP2,SH2 domain-containing leukoc...	Human	E. coli
	Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation ...
TMPH-01330	FCRL3 Protein, Human, Recombinant (His) MAIA,IFGP family protein 3,Fc receptor homolog 3,Immune rece...	Human	E. coli
	FCRL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 67.4 kDa and the accession number is Q96P31.
TMPH-02304	Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) Vasohibin-2,VASH2,Vasohibin-like ...	Human	E. coli
	Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST) FCC1,COCA1,HNPCC1,HNPCC,LCFS2,mutS homolog 2	Human	Baculovirus Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch r...
TMPH-02105	ASH2L Protein, Human, Recombinant (His & SUMO) ASH2-like protein,ASH2L,...	Human	E. coli
	Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May p...
TMPH-01087	CSH2 Protein, Human, Recombinant (GST & His) Chorionic somatomammotropin hormone 2,Lactogen,Chor...	Human	E. coli
	Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. CSH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 53.8 kDa and the accession number is P0DML3.
TMPJ-00387	IL-4R alpha Protein, Mouse, Recombinant (hFc) Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol...	Mouse	HEK293 Cells
	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ...
TMPJ-00465	PTP1C Protein, Human, Recombinant (His) HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH	Human	E. coli
	Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter...
TMPJ-00226	SLAMF1 Protein, Mouse, Recombinant (His) signaling lymphocytic activation molecule,SLAM family member...	Mouse	HEK293 Cells
	Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been...
TMPY-03510	Cbl-c Protein, Human, Recombinant (His & GST) Cbl proto-oncogene C, E3 ubiquitin protein ligase,CBL-SL,CBL...	Human	Baculovirus Insect Cells
	CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c g...
TMPJ-00961	STAT1 Protein, Human, Recombinant Transcription Factor ISGF-3 Components p91/p84,STAT1,Signal ...	Human	E. coli
	Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellul...
TMPY-03296	SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST) SH-PTP1,Hcph,70Z-SHP,Ptp1C,protein tyrosin...	Mouse	Baculovirus Insect Cells
	PTPN6 is an enzyme that belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an ...
TMPY-02194	SOCS3 Protein, Human, Recombinant (His & Trx) SOCS-3,SSI-3,ATOD4,Cish3,SSI3,suppressor of cytokin...	Human	E. coli
	Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. ...
TMPJ-00307	BLK Protein, Human, Recombinant (His) Tyrosine-Protein Kinase Blk,BLK,B Lymphocyte Kinase,p55-Blk	Human	E. coli
	Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B t...
TMPJ-00455	SLAMF5 Protein, Mouse, Recombinant (His) CD84 molecule,SLAM family member 5,Leukocyte differentiation...	Mouse	HEK293 Cells
	CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST) HsT441,c-yes,YES proto-oncogene 1, Src family tyrosine kinas...	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase i...
TMPY-02388	SIRP beta 1 Protein, Mouse, Recombinant (His) SIRP-beta,SIRP-β,99327N5Rik,Sirpb,Sirpb1,Sirpb1a,SI...	Mouse	HEK293 Cells
	SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or...
TMPY-02191	BLNK Protein, Human, Recombinant (His) BLNK-S,bca,SLP-65,B-cell linker,LY57,SLP65,AGM4,BASH	Human	HEK293 Cells
	B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small inte...

重组蛋白

NCK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00870

Species: Human

Expression System: E. coli

GRB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01050

Species: Human

Expression System: E. coli

CISH Protein, Human, Recombinant (GST)

Cat.No: TMPH-01189

Species: Human

Expression System: E. coli

SAP/SH2D1A Protein, Human, Recombinant (His)

Cat.No: TMPY-02440

Species: Human

Expression System: E. coli

SLP-76 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01096

Species: Human

Expression System: E. coli

FCRL3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01330

Species: Human

Expression System: E. coli

Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02304

Species: Human

Expression System: E. coli

MSH2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04267

Species: Human

Expression System: Baculovirus Insect Cells

ASH2L Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02105

Species: Human

Expression System: E. coli

CSH2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01087

Species: Human

Expression System: E. coli

IL-4R alpha Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00387

Species: Mouse

Expression System: HEK293 Cells

PTP1C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00465

Species: Human

Expression System: E. coli

SLAMF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00226

Species: Mouse

Expression System: HEK293 Cells

Cbl-c Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03510

Species: Human

Expression System: Baculovirus Insect Cells

STAT1 Protein, Human, Recombinant

Cat.No: TMPJ-00961

Species: Human

Expression System: E. coli

SHP-1 Protein, Mouse, Recombinant (aa 207-597, His & GST)

Cat.No: TMPY-03296

Species: Mouse

Expression System: Baculovirus Insect Cells

SOCS3 Protein, Human, Recombinant (His & Trx)

Cat.No: TMPY-02194

Species: Human

Expression System: E. coli

BLK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00307

Species: Human

Expression System: E. coli

SLAMF5 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00455

Species: Mouse

Expression System: HEK293 Cells

YES1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04411

Species: Human

Expression System: Baculovirus Insect Cells

SIRP beta 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02388

Species: Mouse

Expression System: HEK293 Cells

BLNK Protein, Human, Recombinant (His)

Cat.No: TMPY-02191

Species: Human

Expression System: HEK293 Cells

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