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Targets Recommended: Histone Methyltransferase

抑制剂 & 化合物

化合物库

重组蛋白

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Cat. No.	Product Name
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T60002	DC-S239	Histone Methyltransferase	Chromatin/Epigenetic
	DC-S239 (DC-S239) 是一种选择性的组蛋白甲基转移酶 SETD7 抑制剂 (IC50 = 4.59 μM)，具有抗癌活性。
T10682L	CARM1-IN-1 CARM1-IN-7G	Histone Methyltransferase	Chromatin/Epigenetic
	CARM1-IN-1 (CARM1-IN-7G) 是 CARM1 的选择性抑制剂，IC50 为 8.6 μM。 CARM1-IN-1 对 PRMT1 和 SET7 的活性较弱，IC50 > 600 μM。
T16886	Sinefungin Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP	Others; Histone Methyltransferase; Antibiotic; Antifungal	Chromatin/Epigenetic; Microbiology/Virology; Others
	Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9，通过抑制H3K4甲基化来改善肾纤维化。
T64186	CARM1-IN-1 hydrochloride	Others	Others
	CARM1-IN-1 hydrochloride 是一种高效的、选择性的 CARM1 抑制剂 (IC50: 8.6 μM)，对 PRMT1 和 SET7 抑制作用很低。
T71918	DC-S100	Others	Others
	DC-S100 is a selective histone methyltransferase SET7 inhibitor.
T26188	Setin-1	Others	Others
	Setin-1 is the most potent Set7 inhibitor that acts by inhibiting the KMTase G9a.
T68613	DC-S238	Others	Others
	DC-S238 is a potent and selective histone methyltransferase SET7 inhibitor.
T72013	Epigenetic Multiple Ligand	Others	Others
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.

化合物

DC-S239

Cat.No: T60002

Synonym:

Target: Histone Methyltransferase

CARM1-IN-1

Cat.No: T10682L

Synonym: CARM1-IN-7G

Target: Histone Methyltransferase

Sinefungin

Cat.No: T16886

Synonym: Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP

Target: Others, Histone Methyltransferase, Antibiotic, Antifungal

CARM1-IN-1 hydrochloride

Epigenetic Multiple Ligand

Cat.No: T72013

Synonym:

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01584	PR-Set7 Protein, Human, Recombinant SET8,SET07,PR-Set7	Human	E. coli
	KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re...
TMPY-01229	SETD7 Protein, Human, Recombinant (His) SET7/9,SET domain containing (lys...	Human	E. coli
	Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysi...