Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12832 |
Amcenestrant
SAR439859 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Amcenestrant (SAR439859) 是一种有效的 ER 拮抗剂,具有 ER 降解活性,EC50为 0.2 nM。它是一种具有口服活性,非甾体和选择性雌激素受体降解剂 (SERD)。它可在 ER+乳腺癌中表现出强大的抗肿瘤功效和有限的交叉耐药性。 | |||
T9997 |
GLL 398
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
GLL 398 是一种具有口服活性的选择性雌激素受体降解剂,IC50 为 1.14 nM。 GLL 398 在异种移植乳腺癌模型中阻断肿瘤生长。 | |||
T2243 |
Serdemetan
JNJ-26854165,N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺 |
Apoptosis; Mdm2; E1/E2/E3 Enzyme; p53 | Apoptosis; Ubiquitination |
Serdemetan (JNJ-26854165) 是一种 HDM2泛素连接酶拮抗剂,能诱导 p53野生型细胞的早期凋亡。 | |||
T39727 |
ERα degrader-2
|
ERK | MAPK |
ERα degrader-2 是一种具有选择性和有效性的雌激素受体 (SERD)降解剂,具有抗癌活性,抑制 ERα,对雌激素受体降解的 EC50 值为 0.3 nM。ERα degrader-2 可用于预防和治疗 HER 阳性乳腺癌。 | |||
T13674 |
Elacestrant
依拉司群,RAD1901 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Elacestrant (RAD1901) 是一种具有口服活性的、选择性的雌激素受体 (ER) 降解剂 (SERD),能够作用于 ERα (IC50:48 nM)和 ERβ (IC50:870 nM)。 | |||
T13675 |
Elacestrant dihydrochloride
RAD1901 dihydrochloride |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD),能够作用于 ERα (IC50:48 nM) 和 ERβ (IC50:870 nM)。 | |||
T70179 |
THIQ-40
|
Others | Others |
THIQ-40 is a novel potent erα antagonist and selective estrogen receptor degrader (serd), exhibiting good oral bioavailability, antitumor efficacy, and serd activity in vivo | |||
T39499 |
Rintodestrant
G1T48 |
Others | Others |
Rintodestrant (G1T48) is an orally active, non-steroidal, selective estrogen receptor degrader (SERD) that also functions as a CDK4/6 inhibitor. | |||
T77724 |
OBHSA
Oxabicycloheptane sulfonamide |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
OBHSA(Oxabicycloheptane sulfonamide) 是一种新型选择性雌激素受体降解剂 (SERD),可用于研究乳腺癌。 | |||
T74593 |
Taragarestrant meglumine
|
Others | Others |
Taragarestrant meglumine (D-0502) 是一种口服有效、选择性的雌激素受体 (estrogen receptor) 降解剂,展现了对各种ER+乳腺癌细胞系及移植模型的强大活性。 | |||
T63674 |
Imlunestrant
|
Others | Others |
Imlunestrant 是选择性的、口服具有活力的雌激素受体的降解剂(SERD),能够用于 ER+ 和HER2 乳腺癌的研究。 | |||
T39118 |
AZD9496 maleate
|
Others | Others |
AZD9496 maleate is a highly potent and selective antagonist of the estrogen receptor alpha (ERα), exhibiting an IC50 value of 0.28 nM. This compound, AZD9496 maleate, is an orally bioavailable selective estrogen receptor degrader (SERD). | |||
T39368 |
GNE-149
|
Others | Others |
GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds potential for research in the field of breast cancer. | |||
T74415 |
Imlunestrant tosylate
|
Others | Others |
Imlunestrant (LY-3484356) tosylate 是口服有效且选择性的雌激素受体(estrogen receptor, ER)降解剂(SERD),具纯拮抗性。该化合物能持续抑制ER依赖的基因转录与细胞生长,适用于研究ER阳性(ER+)晚期乳腺癌(aBC)与子宫内膜样癌(EEC)。 | |||
T27289 |
Etacstil
GW 5638,GW-5638,GW5638,DPC974,DPC 974,DPC-974 |
Others | Others |
GW5638 is a estrogen receptor ligand. GW5638 is a prodrug of its active metabolite GW7604. GW5638 appears to act as an antagonist in these in vitro systems, although in a manner distinct from other known ER modulators. GW5638 is also classified as a pseud |