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Search Results for " scap "

Targets Recommended: Others

6

抑制剂 & 化合物

6

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T81104	SREBP/SCAP-IN-2	Others	Others
	SREBP/SCAP-IN-1（compound 13）为选择性SREBP/SCAP抑制剂。
T81105	SREBP/SCAP-IN-1	Others	Others
	SREBP/SCAP-IN-1（compound 10b）为一选择性SREBP/SCAP抑制剂。
T123857	Euscaphin B	Others	Others
	Euscaphin B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123857。
T125313	Euscapholide	Others	Others
	Euscapholide 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125313。
T9266	Fatostatin	Lipid; Fatty Acid Synthase	Metabolism
	Fatostatin A 是一种SREBP 活化的特异性抑制剂，能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性，能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。

化合物

SREBP/SCAP-IN-2

Cat.No: T81104

Target: Others

SREBP/SCAP-IN-1

Cat.No: T81105

Target: Others

Cat.No: T123857

Target: Others

Cat.No: T125313

Target: Others

Cat.No: T9266

Target: Lipid, Fatty Acid Synthase

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Cat. No.	Product Name	Target	Signaling Pathways
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T3242	Breviscapin Scutellarin,红盏花素,Scutellarin B	Others	Others
	Breviscapin (Scutellarin) 是从Erigeron breviscapus 全草中提取的总黄酮成分(含量≥85%)。
TN2543	1β-Hydroxyeuscaphic acid 1beta-Hydroxyeuscaphic acid	Others	Others
	1beta-Hydroxyeuscaphic acid demonstrates notable hepatoprotective activity, effectively minimizing the leakage of intracellular enzymes, attenuating protein oxidation, and reducing apoptosis rates.
TN5941	2,3-O-Isopropylidenyl euscaphic acid 蔷薇酸丙酮化物,Euscaphic acid acetonide
	2,3-O-Isopropylidenyl euscaphic acid shows good hepatoprotective effect,the EC50 value of 88.36±3.25 uM in Hep G2 cells.
T27305	Fascaplysin chloride NSC622398,NSC 622398,Fascaplysin,NSC-622398	Others	Others
	Fascaplysin is a cyclin D kinase 4/ cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.

天然产物

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T3242

Synonym: Scutellarin,红盏花素,Scutellarin B

Target: Others

1β-Hydroxyeuscaphic acid

Cat.No: TN2543

Synonym: 1beta-Hydroxyeuscaphic acid

Target: Others

2,3-O-Isopropylidenyl euscaphic acid

Cat.No: TN5941

Synonym: 蔷薇酸丙酮化物,Euscaphic acid acetonide

Fascaplysin chloride

Cat.No: T27305

Synonym: NSC622398,NSC 622398,Fascaplysin,NSC-622398

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02363	TROSPA Protein, Ixodes scapularis, Recombinant (His) Tick receptor for ospA,TROSPA	Ixodes scapularis	Baculovirus Insect Cells
	Serves as a receptor for ospA protein of B.burgdorferi, the Lyme disease agent. Required for spirochetal colonization. Essential for pathogen adherence to the vector. TROSPA Protein, Ixodes scapularis, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 21.7 kDa and the accession number is Q5SDL7.
TMPH-01535	INSIG2 Protein, Human, Recombinant (His & Myc) Insulin-induced gene 2 protein,INSIG2	Human	E. coli
	Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycho...

重组蛋白

TROSPA Protein, Ixodes scapularis, Recombinant (His)

Cat.No: TMPH-02363

Species: Ixodes scapularis

Expression System: Baculovirus Insect Cells

INSIG2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01535

Species: Human

Expression System: E. coli

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