Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T70946 |
SC 51316
|
Others | Others |
SC 51316 is a nonpeptidic angiotensin II (AII) receptor antagonist. | |||
T70944 |
Carotegrast methyl HCl
|
Others | Others |
Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice. |