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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6955 |
Propafenone hydrochloride
Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol |
Sodium Channel | Membrane transporter/Ion channel |
Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效,可用于心房和心室性心律不齐。 | |||
T0866 |
Propafenone
Rythmol,普罗帕酮,Propafenonum |
Potassium Channel; MRP; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel |
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。 | |||
T12811 |
(S)-Propafenone
(S)-SA-79 |
Others | Others |
(S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. It possesses beta-blocking properties and exhibits class 1 antiarrhythmic activity reliant on sodium channel blockade. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12548 |
Propafenone D7 hydrochloride
盐酸普罗帕酮 D7,SA-79 (D7 hydrochloride) |
Others | Others |
Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication. |