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Search Results for " s phase "

Targets Recommended: Apoptosis STAT

87

抑制剂 & 化合物

20

天然产物

1

化合物库

28

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

Cat. No.	Product Name	Target	Signaling Pathways
T6308	Stattic STAT3 Inhibitor V	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Stattic (STAT3 Inhibitor V) 是一种 STAT3 抑制剂 (IC50=5.1 μM)，选择性地抑制 STAT3 活化、二聚化和核转位。Stattic 具有抗肿瘤活性，可诱导细胞凋亡。
T8800	NSAH 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂，无细胞 IC50 为 32 μM，基于细胞的 IC50 约为 250 nM。
T16813	RX-3117 fluorocyclopentenylcytosine,TV-1360	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RX-3117 (fluorocyclopentenylcytosine) 是一种新型的胞苷类似物，在几种癌细胞系中显示出抗癌活性，包括对吉西他滨耐药的变体。
T9003	CVT-11127 N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺	Dehydrogenase	Metabolism
	CVT-11127 是 SCD 抑制剂。它将细胞周期阻滞在 G1/S 期，诱导细胞凋亡。它可用于肺癌的研究。
T64923	Sodium citrate Citrosodine,Natrocitral,柠檬酸钠	Others	Others
	Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。
T73577	TJ08	Apoptosis	Apoptosis
	TJ08 是一种具有抗癌的1,2,5-三取代苯并咪唑衍生物，能够有效诱导G1/S期阻滞，同时促进多种癌细胞的凋亡作用。
T22317	DRB18	transporter	Metabolism
	DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1].
T1272L	Cytarabine hydrochloride Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物，可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成，IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。
TP1828	N-Acetyl-Ser-Asp-Lys-Pro	RAAS	Endocrinology/Hormones
	N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。它抑制多能造血干细胞进入细胞周期的 S 期，并防止小鼠中的 Ara-C 致死性。
T4321	Indisulam E 7070	CDK; Carbonic Anhydrase	Cell Cycle/Checkpoint; Metabolism
	Indisulam (E 7070) 是碳酸酐酶抑制剂。它是细胞周期 G1期的靶向化合物，能够抑制 CDK2及周期蛋白 E 的激活，阻止 G1/S 的转化。它可以募集 DCAF15诱导RBM39降解来靶向剪接，具有抗癌作用。
T2627	Nolatrexed dihydrochloride 盐酸诺拉曲塞,Thymitaq,AG 337	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂，能够在癌细胞 S 期诱导细胞周期停滞，具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用，对人胸苷酸合酶的Ki 值为 11 nM。
T16522	Phenoxodiol 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E	Apoptosis; IAP; Caspase; Topoisomerase; p53	Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
	Phenoxodiol (Idronoxil) 是合成genestein 的类似物，激活线粒体caspase 系统，抑制XIAP，使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II，从而阻止DNA 复制。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T33380	MI-389	PROTACs	PROTAC
	MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T27541	Hexylglutathione NSC 131114,NSC-131114,NSC131114,S-Hexylglutathione
	Hexylglutathione, a glutathione-S-transferase inhibitor, is used to study the effects of phase II enzymes and glutathione.
T34829	Tetrazanbigen TNBG	Others	Others
	Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701.
T28765	SFOM-0046 SFOM 0046	Others	Others
	SFOM-0046 is an anticancer agent. SFOM-0046 arrests the cell cycle in S-phase and causes DNA replication stress, resulting in the phosphorylation of H2AX into gamma-H2AX.
T23817	BPTQ B-P-T-Q	Others	Others
	BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and G2/M phase.
T22490	2,3-DCPE hydrochloride	Others	Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.
T79474	GSPT1 degrader-1	Apoptosis	Apoptosis
	GSPT1 degrader-1 (compound 9q) 是通过泛素蛋白酶体系统有效实现 G1 至 S 相变 1 (GSPT1) 降解的化合物。此外，该化合物能诱导G0/G1 期细胞停滞及细胞凋亡 (apoptosis)。
T61616	Antitumor agent-38	Others	Others
	Antitumor agent-38 is a highly effective antitumor compound that exhibits antiproliferative activity towards cancer cells. It induces cell cycle arrest specifically at the late S and G2/M phase, while not impeding microtubule formation or altering cell morphology [1].
T6051	Orteronel TAK-700,(S)-Orteronel	P450	Metabolism
	(S)-Orteronel ((S)-Orteronel) 是人17，20-裂解酶 (17,20-lyase, CYP17) 选择性抑制剂(IC50:38 nM)，CYP17对(S)-Orteronel 选择性比对 11-hydroxylase 及 CYP3A4 高 1000 多倍。
T68671	Amsacrine Isothionate	Others	Others
	Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T68673	Amsacrine gluconate	Others	Others
	Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T68672	Amsacrine lactate	Others	Others
	Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death.
T63366	Anticancer agent 31	Others	Others
	Anticancer agent 31 是抗癌剂，是1,3-二苯基脲喹喔啉衍生物。Anticancer agent 31 能够将细胞周期阻滞在 S 期，并诱导凋亡 (apoptosis)，表现出抗肿瘤作用。
T62163	Hsp90-IN-15	Others	Others
	Hsp90-IN-15 是一种 Hsp90 抑制剂，具有抗癌作用。Hsp90-IN-15 能够将细胞周期阻滞在 S 期，诱导细胞凋亡 (apoptosis)，并可以减少 Hela 细胞中 Hsp90 的表达水平。
T78686	Apoptosis inducer 11	Apoptosis	Apoptosis
	Apoptosisinducer 11（compound 3u）通过线粒体途径引发细胞凋亡。在非霍奇金淋巴瘤细胞系中，该化合物导致G2/M期停滞和S期显著减少。
T83023	Antiproliferative agent-26	Others	Others
	Antiproliferative agent-26 (compound 4g) 是抗增殖药物，(10 μM) 对多种癌细胞如白血病、中枢神经系统肿瘤、黑色素瘤、肾癌和乳腺癌具有抑制效果。该药物能够阻止集落形成，并在(5 μM) 和 (25 μM) 浓度作用下导致细胞周期在G1期/S期停滞。
T35462	(±)11-HETE	Others	Others
	(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid . The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T36558	(±)9-HETE	Others	Others
	(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid peroxidation using GC/MS.
T79494	VEGFR-2-IN-31	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR-2-IN-31（compound 3i）是一款针对VEGFR-2的高效抑制剂（IC50=8.93 nM），具有抗前列腺癌的活性。该化合物能够导致细胞周期在S期停滞，并诱导细胞发生凋亡（apoptosis）。
T63470	PI3K/mTOR Inhibitor-8	Others	Others
	PI3K/mTOR Inhibitor-8 是 PI3K (PI3Kα IC50: 0.46 nM) 和 mTOR (mTOR IC50: 12 nM) 双重抑制剂。PI3K/mTOR Inhibitor-8 能够将 HCT-116 细胞的细胞周期阻滞在G1/S 期，并诱导其凋亡 (apoptosis)。
T62916	GEM144	Others	Others
	GEM144 是一种有效的、口服具有活力的 DNA polymerase α(POLA1) 和HDAC 11 双重抑制剂。GEM144 能够诱导 p53 乙酰化、激活 p21，将细胞周期阻滞在 G1/S 期，并诱导细胞凋亡。
T81544	PARP1-IN-16	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-16（化合物12a）是一款高效的PARP1抑制剂，其IC50为1.89 nM。该化合物能够促使细胞周期在S期停滞，并引发HCT-116细胞的凋亡。
T83082	Anticancer agent 168	Others	Others
	Anticanceragent 168（compound d16）是一种DNA2抑制剂。该化合物能够促进细胞凋亡（apoptosis），引起细胞周期在S期显著停滞，并在含mutp53肿瘤中显示出抗癌效应，有助于克服化疗耐药性。
T63144	ZLMT-12	Others	Others
	ZLMT-12 (compound 35) 是他克宁衍生物，是一种有效的 CDK2 (IC50: 0.011 μM) 和 CDK9 (IC50: 0.002 μM) 抑制剂。ZLMT-12 能够较弱的抑制 AChE (IC50: 19.023 μM) 和 BuChE (IC50: 2.768 μM)。ZLMT-12 具抗增殖活性，且细胞毒性较低。ZLMT-12 能够将细胞周期阻滞在 S 期和 G2/M 期，并诱导细胞凋亡。
T73512	ZC0109	Others	Others
	ZC0109 是 IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂，IC50分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累，使细胞周期阻滞于 G1/S 期，导致癌细胞凋亡 (apoptosis)。
T73228	Artonin E 5'-Hydroxymorusin	Others	Others
	Artonin E (5'-Hydroxymorusin) 是一种已知的异戊二烯化类黄酮，可以诱导细胞凋亡 (apoptosis)，使细胞周期停滞在S 期。Artonin E 可以通过线粒体通路失调诱导抗增殖作用，可以用于癌症研究。
T82762	Cdc25A (80-93) (human)
	Cdc25A (80-93) (human)为调控细胞周期蛋白D1及G1/S转换中相关蛋白表达，进而控制细胞增殖与肿瘤发生的多肽。该化合物在癌症研究中具应用价值。
T62934	ZLHQ-5f	Others	Others
	ZLHQ-5f 是一种 CDK2 和 Topo I 双重抑制剂，作用于 CDK2/CycA2 (IC50: 0.145 μM)。ZLHQ-5f 能够将 HCT116 细胞的细胞周期阻滞在 S 期，并诱导其细胞凋亡，具有良好安全性。
T37464	CAY10711	Others	Others
	CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef...
T72436	cis,trans-Germacrone	Others	Others
	cis,trans-Germacrone 是 Germacrone 的异构体。Germacrone 具有广泛的抗肿瘤、抗氧化和抗炎作用。Germacrone 抑制肺癌细胞增殖并改变 Akt/MDM2/p53。Germacrone 还能在 G1/S 期阻滞细胞周期。
T62917	MIR002	Others	Others
	MIR002 是一种有效的、口服具有活力的 DNA polymerase α (POLA1) 和 HDAC 11 双重抑制剂，具有显著的体内抗肿瘤活性。MIR002 能够诱导 p53 乙酰化、激活 p21，将细胞周期阻滞在 G1/S 期，并诱导细胞凋亡。
T64222	Antitumor agent-55	Others	Others
	Antitumor agent-55 (compound 5q) 是一种有效的抗肿瘤剂，能够有效的抑制PC3 (IC50: 0.91 μM)。Antitumor agent-55 能够将 PC3 的细胞周期阻滞 G1/S 期，诱导其凋亡，抑制细胞迁移，阻碍 PC3 的形成。
T61596	EGFR/HER2/DHFR-IN-1	Others	Others
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 μM, 0.108 μM, and 0.291 μM, respectively. Its mechanism of action involves cell cycle arrest at the G1/S phase and induction of apoptosis in cells [1].
T79599	Anti-inflammatory agent 53	COX	Immunology/Inflammation; Neuroscience
	Anti-inflammatory agent 53（compound 7c）是口服有效及选择性的COX-2抑制剂。Anti-inflammatory agent 52展现了抗HT29细胞迁移的特性，能够促使细胞周期在S期与G2/M期停滞。此外，该化合物对大鼠胃肠道安全，对炎症具有中等程度的抑制效应。在携带艾利希实体瘤的小鼠模型中，Anti-inflammatory agent 52能够抑制肿瘤生长，显示出潜在的抗癌活性。
T74859	SLC7A11-IN-1	Others	Others
	SLC7A11-IN-1 是一种有效的 SLC7A11抑制剂。SLC7A11-IN-1 显示出抗增殖活性。SLC7A11-IN-1 抑制细胞侵袭和转移。SLC7A11-IN-1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 S 期。SLC7A11-IN-1 具有抗肿瘤活性。

化合物

Cat.No: T6308

Synonym: STAT3 Inhibitor V

Target: Apoptosis, STAT

Cat.No: T8800

Synonym: 2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide

Target: DNA/RNA Synthesis

Cat.No: T16813

Synonym: fluorocyclopentenylcytosine,TV-1360

Target: Nucleoside Antimetabolite/Analog

Cat.No: T9003

Synonym: N-[2-[6-[[(3,4-二氯苯基)甲基]氨基]-2-(4-甲氧基苯基)-3-氧代-3,4-二氢吡啶并[2,3-B]吡嗪-4-基]乙基]乙酰胺

Target: Dehydrogenase

Cat.No: T64923

Synonym: Citrosodine,Natrocitral,柠檬酸钠

Target: Others

Cat.No: T73577

Target: Apoptosis

Cat.No: T22317

Target: transporter

Cytarabine hydrochloride

Cat.No: T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

N-Acetyl-Ser-Asp-Lys-Pro

Cat.No: TP1828

Target: RAAS

Cat.No: T4321

Synonym: E 7070

Target: CDK, Carbonic Anhydrase

Nolatrexed dihydrochloride

Cat.No: T2627

Synonym: 盐酸诺拉曲塞,Thymitaq,AG 337

Target: DNA/RNA Synthesis

Cat.No: T16522

Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Cat.No: T33380

Target: PROTACs

Hexylglutathione

Cat.No: T27541

Synonym: NSC 131114,NSC-131114,NSC131114,S-Hexylglutathione

Cat.No: T34829

Synonym: TNBG

Target: Others

Cat.No: T28765

Synonym: SFOM 0046

Target: Others

Cat.No: T23817

Synonym: B-P-T-Q

Target: Others

2,3-DCPE hydrochloride

Cat.No: T22490

Target: Others

GSPT1 degrader-1

Cat.No: T79474

Target: Apoptosis

Antitumor agent-38

Cat.No: T61616

Target: Others

Cat.No: T6051

Synonym: TAK-700,(S)-Orteronel

Target: P450

Amsacrine Isothionate

Cat.No: T68671

Target: Others

Amsacrine gluconate

Cat.No: T68673

Target: Others

Amsacrine lactate

Cat.No: T68672

Target: Others

Anticancer agent 31

Cat.No: T63366

Target: Others

Cat.No: T62163

Target: Others

Apoptosis inducer 11

Cat.No: T78686

Target: Apoptosis

Antiproliferative agent-26

Cat.No: T83023

Target: Others

Cat.No: T35462

Target: Others

Cat.No: T36558

Target: Others

Cat.No: T79494

Target: VEGFR

PI3K/mTOR Inhibitor-8

Cat.No: T63470

Target: Others

Cat.No: T62916

Target: Others

Cat.No: T81544

Target: PARP

Anticancer agent 168

Cat.No: T83082

Target: Others

Cat.No: T63144

Target: Others

Cat.No: T73512

Target: Others

Cat.No: T73228

Synonym: 5'-Hydroxymorusin

Target: Others

Cdc25A (80-93) (human)

Cat.No: T82762

Cat.No: T62934

Target: Others

Cat.No: T37464

Target: Others

cis,trans-Germacrone

Cat.No: T72436

Target: Others

Cat.No: T62917

Target: Others

Antitumor agent-55

Cat.No: T64222

Target: Others

EGFR/HER2/DHFR-IN-1

Cat.No: T61596

Target: Others

Anti-inflammatory agent 53

Cat.No: T79599

Target: COX

Cat.No: T74859

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5669	Citric acid monohydrate	Others	Others
	Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T1270	Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Vincristine sulfate (Leurocristine sulfate) 是一种抗肿瘤长春花生物碱。在细胞周期的 S 期不可逆地与微管(Ki: 85 nM) 和纺锤体蛋白结合，并干扰有丝分裂纺锤体的形成。
T3S2325	Ardisiacrispin A 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin	HSV	Microbiology/Virology
	Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷，来自于紫金牛属物种。它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性，如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。
T3398	Icaritin Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin	Apoptosis; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。
TN2272	Tigloylgomisin H	Nrf2	Immunology/Inflammation
	Tigloylgomisin H 是分离自S. chinensis 果实中的木酚素。Tigloylgomisin H 能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶活性。Tigloylgomisin H 是单功能诱导剂，通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1。Tigloylgomisin H 是潜在的肝癌预防剂。
T0486L	Irinotecan Hydrochloride 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride	Topoisomerase; Autophagy	Autophagy; DNA Damage/DNA Repair
	Irinotecan Hydrochloride (CPT-11 hydrochloride) 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。
T1591	Ancitabine hydrochloride NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。
T3339	Sophoridine 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物，诱导细胞凋亡。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T81818	Metachromins X
	Metachromins X，一倍半萜醌类化合物，能阻碍HeLa/Fucci2细胞在S/G2/M期的细胞周期。
TN4913	Riddelline	VEGFR; DNA/RNA Synthesis	Angiogenesis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arre
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
TN5336	9-Oxo-10,11-dehydroageraphorone 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha
TN7550	Bostrycin Rhodosporin	Others	Others
	Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis ...
T79941	Antimycin A2c	Apoptosis	Apoptosis
	Anticanceragent 141（compound AE）是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能，诱导caspase依赖性细胞凋亡，并激活ROS介导的泛素依赖性蛋白酶体系统，进而引起E6/E7癌蛋白的降解。
T72803	Norartocarpetin	Others	Others
	Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
T36954	Nemorosone	Others	Others
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Citric acid monohydrate

Cat.No: T5669

Target: Others

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Vincristine sulfate

Cat.No: T1270

Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱

Target: Apoptosis, Microtubule Associated

Ardisiacrispin A

Cat.No: T3S2325

Synonym: 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin

Target: HSV

Cat.No: T3398

Synonym: Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin

Target: Apoptosis, JAK, STAT, Autophagy

Tigloylgomisin H

Cat.No: TN2272

Target: Nrf2

Irinotecan Hydrochloride

Cat.No: T0486L

Synonym: 盐酸伊立替康,伊立替康盐酸盐,Camptothecin 11 hydrochloride,CPT-11 hydrochloride

Target: Topoisomerase, Autophagy

Ancitabine hydrochloride

Cat.No: T1591

Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

Cat.No: T3339

Synonym: 5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine

Target: Apoptosis, Topoisomerase

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T81818

Cat.No: TN4913

Target: VEGFR, DNA/RNA Synthesis

Cat.No: TN6591

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

9-Oxo-10,11-dehydroageraphorone

Cat.No: TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮

Cat.No: TN7550

Synonym: Rhodosporin

Target: Others

Cat.No: T79941

Target: Apoptosis

Norartocarpetin

Cat.No: T72803

Target: Others

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Cat.No: T36954

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05642	SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated S-phase kinase-ass	Human	E. coli
	SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 22 kDa and the accession number is P63208.
TMPH-01308	GSPT1 Protein, Human, Recombinant (His & Myc) GSPT1,Eukaryotic peptide chain release fac...	Human	P. pastoris (Yeast)
	Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. GSPT...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO) S-phase kinase-ass	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPH-01733	DDAH2 Protein, Human, Recombinant (GST & His) Inactive dimethylarginine dimethylaminohydrolase 2,...	Human	E. coli
	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 61.2 kDa and the accession number is O95865.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-02543	PCNA Protein, Human, Recombinant (His) ATLD2,proliferating cell nuclear antigen	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic...
TMPH-01526	KMT2E Protein, Human, Recombinant (His & Myc) Inactive histone-lysine N-methyltrans<...	Human	E. coli
	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPK-01386	TK1 Potein, Canine, Recombinant (His) thymidine kinase-1,EC 2.7.1.21,Thymidine kinas<...	Canine	E. coli
	Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle.
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) GROES,Hsp10,Chaperonin 10,HSPE1,E...	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated Hsp10,Chaperonin 10,HSPE1,GROES,E...	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His) water dikinase 1,SELD,Selenopho	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP....
TMPJ-00721	ZBED1 Protein, Human, Recombinant (His) TRAMP,dREF Homolog,ALTE,DREF,ZBED1,Zinc Finger BED Domain-Co...	Human	E. coli
	Zinc Finger BED Domain-Containing Protein 1 (ZBED1) contains one BED-type zinc finger and is found in the cell nucleus. ZBED1 is widely expressed, highly in heart, skeletal muscle, spleen and placenta. The expression of ZBED1 is usually linked to the cell cycle. During the G1/S phase, the expression is increasing. During the S/G2 phage, the expression reaches to the highest, and then decreasing. ZBED1 exists in homodimer forms, which can bind to 5’-TGTCCG[CT]GA[CT]A-3’ DNA elements, that can be ...
TMPK-00044	SKP1 Protein, Human, Recombinant (His, Avi) OCP-II,TCEB1L,SIII,p19A,OCP-2,EMC19,OCP2,S...	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi) is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21.43 kDa and the...
TMPY-03603	AHSP Protein, Human, Recombinant ERAF,alpha hemoglobin stabilizing protein,α hemoglo...	Human	E. coli
	AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globin. It rapidly binds to ferrous α with association (k'(AHSP)) and dissociation (k(AHSP)) rate constants of ≈1 μm(-1) s(-1) and .2 s(-1), respectively, at pH 7.4 at 22 ℃. A small slow phase was observed when AHSP binds to excess ferrous αCO. This slow phase appears to be due to cis...
TMPK-00045	SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated SIII,OCP-2,TCEB1L,EMC19,OCP-II,OCP2,SKP1A,...	Human	HEK293 Cells
	The S-phase Kinase-Associated Protein 1 (SKP1) is a core component of the SKP1, Cullin 1, F-box protein (SCF) complex, an E3 ubiquitin ligase that serves to poly-ubiquitinate a vast array of protein targets as a signal for their proteasomal degradation, thereby playing a critical role in the regulation of downstream biological processes. SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His and C-Avi tag. The predicted molecular weight is 21....
TMPJ-00053	PRL-2 Protein, Human, Recombinant (His) HU-PP-1,Protein tyrosine phosphatas	Human	E. coli
	PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran...
TMPJ-00907	GADD45A Protein, Human, Recombinant (His) GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible...	Human	E. coli
	Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ...
TMPY-03287	RRM1 Protein, Human, Recombinant (His & GST) ribonucleotide reductase M1,R1,RR1,RIR1	Human	Baculovirus Insect Cells
	RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocort...
TMPJ-01241	DTD1 Protein, Human, Recombinant (His) DUE-B,D-tyrosyl-tRNA(Tyr) deacylase 1,DNA-...	Human	HEK293 Cells
	D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defens...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His) DOC-1R,p14,cyclin-dependent kinase 2 as	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las...
TMPH-01240	MCM2 Protein, Human, Recombinant (His) DNA replication licensing factor MCM2,Nuclear prote...	Human	E. coli
	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active ...
TMPJ-00769	TK1 Protein, Human, Recombinant (His) cytosolic,Thymidine kinase,TK1	Human	HEK293 Cells
	Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this protein have been identified in animal cells, one in cytosol TK1 and one in mitochondria TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA. Activity of the cytosolic enzyme...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His) cyclin A1,CT146	Human	Baculovirus Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the...
TMPY-02402	WTAP Protein, Human, Recombinant (GST) Mum2,Wilms tumor 1 associated pro...	Human	E. coli
	Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, ...
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His) antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col...	Mouse	HEK293 Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End...
TMPY-01332	HIST1H3A Protein, Human, Mouse, Recombinant Histone H3.1,histone cluster 1, H...	Human,Mouse	E. coli
	Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during the S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby pla...

重组蛋白

SKP1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05642

Species: Human

Expression System: E. coli

GSPT1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01308

Species: Human

Expression System: P. pastoris (Yeast)

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

DDAH2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01733

Species: Human

Expression System: E. coli

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

PCNA Protein, Human, Recombinant (His)

Cat.No: TMPY-02543

Species: Human

Expression System: Baculovirus Insect Cells

KMT2E Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01526

Species: Human

Expression System: E. coli

TK1 Potein, Canine, Recombinant (His)

Cat.No: TMPK-01386

Species: Canine

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

Cat.No: TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00988

Species: Human

Expression System: HEK293 Cells

ZBED1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00721

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi)

Cat.No: TMPK-00044

Species: Human

Expression System: HEK293 Cells

AHSP Protein, Human, Recombinant

Cat.No: TMPY-03603

Species: Human

Expression System: E. coli

SKP1 Protein, Human, Recombinant (His, Avi), Biotinylated

Cat.No: TMPK-00045

Species: Human

Expression System: HEK293 Cells

PRL-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00053

Species: Human

Expression System: E. coli

GADD45A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00907

Species: Human

Expression System: E. coli

RRM1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03287

Species: Human

Expression System: Baculovirus Insect Cells

DTD1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01241

Species: Human

Expression System: HEK293 Cells

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

CDK2AP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02921

Species: Human

Expression System: E. coli

MCM2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01240

Species: Human

Expression System: E. coli

TK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00769

Species: Human

Expression System: HEK293 Cells

Cyclin A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01401

Species: Human

Expression System: Baculovirus Insect Cells

WTAP Protein, Human, Recombinant (GST)

Cat.No: TMPY-02402

Species: Human

Expression System: E. coli

Endostatin Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00948

Species: Mouse

Expression System: HEK293 Cells

HIST1H3A Protein, Human, Mouse, Recombinant

Cat.No: TMPY-01332

Species: Human,Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0078	Irinotecan-d10 Hydrochloride
	Irinotecan-d10 Hydrochloride 是 Irinotecan Hydrochloride 的氘代化合物。Irinotecan Hydrochloride 的 CAS 号为 100286-90-6。Irinotecan Hydrochloride 是喜树碱半合成衍生物的盐酸盐，是一种拓扑异构酶 I 抑制剂，可研究结肠癌和直肠癌。

同位素标记化合物

Irinotecan-d10 Hydrochloride

Cat.No: TMID-0078

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