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Search Results for " ripk1 "

Targets Recommended: RIP kinase

35

抑制剂 & 化合物

1

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12730	RIPK1-IN-4	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-4 是有效的 II 型激酶受体相互作用蛋白1 (RIP1) 激酶抑制剂，并且与 DL1-out 无活性形式的 RIP1 结合。RIPK1-IN-4抑制 RIP1 和 ADP-Glo 激酶，IC50 分别是 16 nM 和 10 nM。
T12731	RIPK1-IN-7	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂，Kd 值为 4 nM，IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。
T63055	RIPK1-IN-9	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-9是是一种强效且具有选择性的 RIPK1抑制剂，是一种二氢萘酮化合物。RIPK1-IN-9对 U937细胞和 L929细胞具有抑制作用，IC50分别为2 nM 和1.3 nM。
T12729	RIPK1-IN-3	Others	Others
	RIPK1-IN-3 is a RIPK1 inhibitor, with anti-inflammatory proprieties.
T62499	RIPK1-IN-14	Others	Others
	RIPK1-IN-14 (Compound 41) 是一种 RIPK1 的有效抑制剂 (IC50: 92 nM)。RIPK1-IN-14 在 U937 细胞的坏死性凋亡模型中具有明显的抗坏死性凋亡效果。
T60862	RIPK1-IN-15	Others	Others
	RIPK1-IN-15 (Compound 2.5) 是 RIPK1 的有效抑制剂，在神经退行性疾病、自身免疫性疾病和炎症性疾病研究中具有潜力。
T61887	RIPK1-IN-13	Others	Others
	RIPK1-IN-13 (Compound 8) 是一种有效的RIPK1抑制剂（IC50= 1139 nM）。通过抑制 RIPK1，RIPK1-IN-13 能够阻断坏死性凋亡途径的激活。RIPK1-IN-13 在炎症性疾病中具有研究潜力。
T62723	RIPK1-IN-12
	RIPK1-IN-12 是一种 RIPK1 的有效抑制剂。RIPK1-IN-12 对人和小鼠细胞的坏死性凋亡表现出抑制作用，EC50 值分别为 1.6 和 2.9 nM.
T64064	RIPK1-IN-10	Others	Others
	RIPK1-IN-10 是 RIPK1 的有效抑制剂。
T81269	RIPK1-IN-16	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-16是口服活性的RIPK1抑制剂，有效阻断RIPK1介导的necroptosis，抑制炎症反应。在小鼠模型中，RIPK1-IN-16通过抵御TNF引发的全身性炎症综合症和败血症来展现保护作用。
T62762	RIPK1-IN-11	Others	Others
	RIPK1-IN-11 是一种口服具有活力的 RIPK1 抑制剂，其 Kd 值为 9.2 nM，IC50 值为 67 nM。RIPK1-IN-11 能够抑制人和小鼠细胞坏死，表现出抗炎作用。
T81268	RIPK1-IN-17	RIP kinase	Apoptosis; NF-κB
	RIPK1/3-IN-1（Compound 10）是RIPK1与RIPK3的抑制剂，其通过抑制RIPK1、RIPK3及MLKL的磷酸化作用，特异性地抑制坏死性凋亡。
T63469	RIPK1-IN-8	Others	Others
	RIPK1-IN-8 是一种氨基咪唑并吡啶，是选择性的 RIPK1 有效抑制剂 (IC50: 4 nM)。RIPK1-IN-8 对炎症性疾病具有研究潜力。
T12493	PK68	Others; RIP kinase	Apoptosis; NF-κB; Others
	PK68 是 II 型受体相互作用激酶 1 (RIPK1, IC50 = 90 nM) 的有效特异性抑制剂。 PK68可用于治疗炎症性疾病和癌症转移的研究。
T9079	Apostatin-1 Apt-1	Others	Others
	Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。
T9095	Necrostatin-34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase	Apoptosis; NF-κB
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) 是一种 RIPK1 激酶抑制剂，通过在激酶结构域中占据一个独特的结合口袋，将 RIPK1 激酶稳定在非活性构象中。
T7504	Necrostatin 2 racemate 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate	RIP kinase	Apoptosis; NF-κB
	Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂，是一种稳定型 Nec-1。
T8931L	ICCB-19 hydrochloride ICCB-19 HCl（750621-52-4 free base）	Apoptosis; Others; Autophagy; RIP kinase	Apoptosis; Autophagy; NF-κB; Others
	ICCB-19 hydrochloride (ICCB-19 HCl) 是RIPK1激酶活性的间接抑制剂。它是一种 TRADD 抑制剂，可与 TRADD 的 N 端结构域结合，破坏其与 TRADD-C 和 TRAF2 的结合，诱导自噬和长寿命蛋白质的降解。
T9702	Eclitasertib	RIP kinase	Apoptosis; NF-κB
	Eclitasertib 是一种受体相互作用蛋白激酶1抑制剂，IC50 <1 µΜ。
T15437	GSK3145095	RIP kinase	Apoptosis; NF-κB
	GSK3145095 是一种口服有效的 RIPK1 抑制剂，IC50 为 5 nM，具有潜在的免疫调节活性和抗肿瘤活性。
T9305	Necroptosis-IN-1	RIP kinase	Apoptosis; NF-κB
	Necroptosis-IN-1 是一种 RIPK1 坏死性凋亡抑制剂。它是 Necrostatin-1 的类似物。
T63544	RIPK3-IN-1	Apoptosis; c-Met/HGFR; RIP kinase	Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	RIPK3-IN-1 是一种具有选择性和高效性的 RIPK3 抑制剂（IC50为 9.1 nM），抑制 c-Met 激酶、RIPK1 和 RIPK2 的活性。RIPK3-IN-1 具有潜在的看肿瘤活性，可用于研究细胞凋亡。
T7151	GSK2982772	RIP kinase	Apoptosis; NF-κB
	GSK2982772 是一种受体相互作用丝氨酸/苏氨酸激酶 1 (RIPK1) 的抑制剂，对人和猴 RIP1 的 IC50 值分别为 16 nM 和 20 nM。
T73511	SZM679	RIP kinase	Apoptosis; NF-κB
	SZM679是一种口服有效的选择性RIPK1抑制剂，其对RIPK1的Kd值为8.6 nM，而对RIPK3的Kd值则大于5000 nM。该化合物能够逆转肿瘤坏死因子诱导的全身炎症反应，并在海马和皮质中降低Tau蛋白的过度磷酸化、神经炎症以及RIPK1磷酸化水平。SZM679可用于阿尔茨海默病（AD）的研究。
T73373	TP-030-2	Others	Others
	TP-030-2 是一种 RIPK1抑制剂 (humanKi=0.43 nM ; mouseIC50=100 nM)。
T73382	SZM-1209	RIP kinase	Apoptosis; NF-κB
	SZM-1209是一种口服活性且特异性RIPK1抑制剂，具有85 nM的Kd值。该化合物展现出对抗坏死性凋亡（necroptosis）高效活性（EC50=22.4 ± 8.1 nM），并能抵抗SIRS（全身炎症反应综合征）及ALI（急性肺损伤）。
T73374	TP-030-1	Others	Others
	TP-030-1 是 RIPK1的抑制剂。TP-030-1 抑制 hRIPK1 的 Ki 值为 3.9 nM，抑制 mRIPK1 的 IC50值为 4.2 μM。TP-030-1 可用于炎症性疾病和神经退行性疾病的研究。
T68520	Cl-Necrostatin-1	Others	Others
	Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase. It inhibits RIPK1 activity.
T74801	KWCN-41	Others	Others
	KWCN-41, 一种选择性且高效的RIPK1激酶抑制剂，具有88 nM的IC50值，能特异性抑制细胞坏死而不影响细胞凋亡，并表现出抗炎作用。
T73493	RI-962	RIP kinase	Apoptosis; NF-κB
	RI-962 是一种针对受体相互作用蛋白激酶 1 (RIPK1) 的高效选择性抑制剂，具有35.0 nM的IC50。本化合物主要用于神经系统疾病和炎症性疾病研究领域。
T12203L	Necrostatin 2	Others	Others
	Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
T74642	DB1113	PROTACs	PROTAC
	DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解 ABL1，ABL2，BLK，CDK11B，CDK4，CSK，EPHA3，FER，GAK，LIMK1，MAP3K20，MAP4K1，MAP4K2，MAP4K3，MAP4K5，MAPK14，MAPK7，MAPK8，MAPK9，MAPKAPK2，MAPKAPK3，NLK，PDIK1L，PTK2B，RIPK1，RPS6KA1，RPS6KA3，SIK2，SIK3，STK35，TNK2 和 ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。
T60316	AV123	Others	Others
	AV123 (化合物 12) 是一种无细胞毒性的RIPK1抑制剂，IC50值为12.12 μM。AV123 阻断 TNF-α 诱导的坏死性细胞死亡，EC50值为1.7 μM，但不阻断凋亡性细胞的死亡。AV123 可用于脑、心和肾的缺血再灌注损伤等慢性坏死性病症、炎症性疾病、神经退行性疾病和感染性疾病的研究。
T74644	DB0614	PROTACs	PROTAC
	DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解ABL1，ABL2，BLK，CDK11B，CDK4，CSK，EPHA3，FER，GAK，LIMK1，MAP3K20，MAP4K1，MAP4K2，MAP4K3，MAP4K5，MAPK14，MAPK7，MAPK8，MAPK9，MAPKAPK2，MAPKAPK3，NLK，PDIK1L，PTK2B，RIPK1，RPS6KA1，RPS6KA3，SIK2，SIK3，STK35，TNK2 和ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。
T79041	RIP1 kinase inhibitor 4	RIP kinase	Apoptosis; NF-κB
	RIP1 kinase inhibitor 4 (compound 3)为一高效RIP1K抑制剂，其EC50值 ≤ 1000 nM[1]。

化合物

Cat.No: T12730

Target: RIP kinase

Cat.No: T12731

Target: RIP kinase

Cat.No: T63055

Target: RIP kinase

Cat.No: T12729

Target: Others

Cat.No: T62499

Target: Others

Cat.No: T60862

Target: Others

Cat.No: T61887

Target: Others

Cat.No: T62723

Cat.No: T64064

Target: Others

Cat.No: T81269

Target: RIP kinase

Cat.No: T62762

Target: Others

Cat.No: T81268

Target: RIP kinase

Cat.No: T63469

Target: Others

Cat.No: T12493

Target: Others, RIP kinase

Cat.No: T9079

Synonym: Apt-1

Target: Others

Cat.No: T9095

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase

Necrostatin 2 racemate

Cat.No: T7504

Synonym: 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate

Target: RIP kinase

ICCB-19 hydrochloride

Cat.No: T8931L

Synonym: ICCB-19 HCl（750621-52-4 free base）

Target: Apoptosis, Others, Autophagy, RIP kinase

Cat.No: T9702

Target: RIP kinase

Cat.No: T15437

Target: RIP kinase

Necroptosis-IN-1

Cat.No: T9305

Target: RIP kinase

Cat.No: T63544

Target: Apoptosis, c-Met/HGFR, RIP kinase

Cat.No: T7151

Target: RIP kinase

Cat.No: T73511

Target: RIP kinase

Cat.No: T73373

Target: Others

Cat.No: T73382

Target: RIP kinase

Cat.No: T73374

Target: Others

Cl-Necrostatin-1

Cat.No: T68520

Target: Others

Cat.No: T74801

Target: Others

Cat.No: T73493

Target: RIP kinase

Cat.No: T12203L

Target: Others

Cat.No: T74642

Target: PROTACs

Cat.No: T60316

Target: Others

Cat.No: T74644

Target: PROTACs

RIP1 kinase inhibitor 4

Cat.No: T79041

Target: RIP kinase

Cat. No.	Product Name	Target	Signaling Pathways
T6S1255	Ophiopogonin-D 麦冬皂苷D	ROS	Immunology/Inflammation
	Ophiopogonin-D 通过 RIPK1 显着抑制前列腺细胞的体外和体内生长，OPD 可能被开发为潜在的抗前列腺癌药物。

天然产物

Cat.No: T6S1255

Synonym: 麦冬皂苷D

Target: ROS

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His) Cell death protein RIP,Receptor-interacting protein 1	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...
TMPH-02007	RIPK1 Protein, Human, Recombinant (His & Myc) Receptor-interacting protein 1,Receptor-interacting...	Human	E. coli
	RIPK1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q13546.
TMPY-02213	RAIDD Protein, Human, Recombinant (His) RAIDD,MRT34,CASP2 and RIPK1 domain contain...	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains oneCARD domain and onedeath domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the ...
TMPY-01654	ITCH Protein, Human, Recombinant (aa 526-903) itchy E3 ubiquitin protein ligase,NAPP1,dJ468O1...	Human	E. coli
	E3 ubiquitin-protein ligase Itchy homolog, also known as Atrophin-1-interacting protein 4, NFE2-associated polypeptide 1, NAPP1, and ITCH, is a cell membrane protein that contains one C2 domain, one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and contains four WW domains. ITCH acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-...
TMPH-01531	IKBKB Protein, Human, Recombinant (His) Serine/threonine protein kinase IKBKB,Nuclear factor NF-kapp...	Human	Baculovirus Insect Cells
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...
TMPJ-01328	ZBP1 Protein, Human, Recombinant (His) Tumor Stroma and Activated Macrophage Protein DLM,DLM1	Human	E. coli
	Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream ...
TMPH-01532	IKBKB Protein, Human, Recombinant (E. coli, His) Nuclear factor NF-kappa-B inhibitor kinase beta,Serine/threo...	Human	E. coli
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu...
TMPH-02194	TAB2 Protein, Human, Recombinant (His & Myc) Mitogen-activated protein kinase kinase kinase 7-interacting...	Human	Baculovirus Insect Cells
	Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to ...

重组蛋白

RIPK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02876

Species: Mouse

Expression System: E. coli

RIPK1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02007

Species: Human

Expression System: E. coli

RAIDD Protein, Human, Recombinant (His)

Cat.No: TMPY-02213

Species: Human

Expression System: E. coli

ITCH Protein, Human, Recombinant (aa 526-903)

Cat.No: TMPY-01654

Species: Human

Expression System: E. coli

IKBKB Protein, Human, Recombinant (His)

Cat.No: TMPH-01531

Species: Human

Expression System: Baculovirus Insect Cells

ZBP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01328

Species: Human

Expression System: E. coli

IKBKB Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01532

Species: Human

Expression System: E. coli

TAB2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02194

Species: Human

Expression System: Baculovirus Insect Cells

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