Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1519L |
Rimonabant
SR141716,利莫那班 |
Cannabinoid Receptor; Antibacterial; Acyltransferase | GPCR/G Protein; Metabolism; Microbiology/Virology |
Rimonabant (SR141716) 是一种选择性的、能透过血脑屏障的中心大麻素受体 1 拮抗剂, Ki 值为 1.8 nM。它也能够抑制分枝杆菌膜蛋白 3。 | |||
T1519 |
Rimonabant hydrochloride
盐酸利莫那班,SR 151716A,SR 141716A |
Cannabinoid Receptor; Antibacterial | GPCR/G Protein; Microbiology/Virology |
Rimonabant hydrochloride (SR 141716A) 是中心大麻素受体 1 的高效选择性反向激动剂, Ki 值为1.8 nM。它也能够抑制分枝杆菌膜蛋白3。 | |||
T0533 |
N-Aminopiperidine hydrochloride
Piperidin-1-amine hydrochloride,N-氨基哌啶盐酸盐 |
Others | Others |
N-Aminopiperidine hydrochloride (Piperidin-1-amine hydrochloride) 是大麻素受体 1 拮抗剂 Rimonabant(一种抗肥胖剂)的代谢物(M1)。 | |||
T61609 |
CB1-IN-2
|
Others | Others |
CB1-IN-2 (Compound 4g) is a potent and selective inhibitor of the CB1 receptor, exhibiting an IC50 value of 0.644 μM. This compound possesses the ability to penetrate the blood-brain barrier and has the potential to induce central nervous system (CNS) side effects similar to Rimonabant [1]. | |||
T37897 |
AM-6538
|
Others | Others |
AM6538 is a long-acting, high affinity, and pseudo-irreversible cannabinoid antagonist, structurally analogous to rimonabant. It serves as a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. Additionally, AM6538 holds potential for future investigations that necessitate temporary reductions in cannabinoid receptor availability[1]. | |||
T38147 |
(S)-AM1241
(S)-AM1241 |
Others | Others |
(S)-AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors). (S)-1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 (EC50 = 131 nM) than at rat and mouse CB2 receptors (EC50 = 785 and 2,000 nM, respectively). Similar to the racemate AM1241 , (S)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. Th... | |||
T38030 |
(R)-AM1241
(R)-AM1241 |
Others | Others |
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing... |