2
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0349 |
Riluzole
PK 26124,RP-54274,利鲁唑 |
GABA Receptor; Sodium Channel; NMDAR | Membrane transporter/Ion channel; Neuroscience |
Riluzole (RP-54274) 是一种谷氨酸拮抗剂,用作抗惊厥药并延长肌萎缩侧索硬化症患者的生存期。它还抑制 GABA 摄取,IC50值为 43 μM。 | |||
T41265 |
Riluzole hydrochloride
AQST-117 hydrochloride,PK 26124 hydrochloride |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Riluzole hydrochloride (PK 26124 hydrochloride) 是一种抗惊厥化合物,属于钠通道阻滞剂家族,抑制 GABA 摄取。Riluzole hydrochloride是钠-谷氨酸拮抗剂,具有抗癌和神经保护活性,可用于研究肌萎缩侧索硬化症和神经系统疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
||
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... |