18
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3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6877 |
LJH685
|
Apoptosis; S6 Kinase | Apoptosis; MAPK; PI3K/Akt/mTOR signaling |
LJH685 是一种选择性,ATP-竞争性的RSK 抑制剂, 抑制 RSK1/2/3 生物活性,IC50为 6、5、4 nM。 | |||
T22422 |
S6K-18
|
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
S6K-18 是一种高度选择性的 S6K1 抑制剂,抑制 S6K1,IC50 为 52nM。 | |||
T5428 |
BIX 02565
|
LRRK2; S6 Kinase | Autophagy; MAPK; PI3K/Akt/mTOR signaling |
BIX 02565 是核糖体 S6 激酶 2 (RSK2) 抑制剂,IC50为 1.1 nM。 | |||
T2002 |
PF-4708671
PF4708671 |
S6 Kinase; Autophagy | Autophagy; MAPK; PI3K/Akt/mTOR signaling |
PF-4708671 是一种可渗透细胞的 p70 核糖体 S6 激酶抑制剂,对 S6K1的Ki 为 20 nM,IC50为 160 nM。 | |||
T14779 |
BRD7389
|
SGK; FLT; Pim; CDK; S6 Kinase; DAPK | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
BRD7389 是一种 RSK 家族激酶抑制剂,对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。 | |||
T4301 |
AD80
|
Raf; c-RET; Src; S6 Kinase | Angiogenesis; Apoptosis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
AD80 是多激酶抑制剂,可抑制 RET、RAF、SRC 和 S6K,并大大降低 mTOR 活性。 | |||
T6304 |
AT7867
|
Akt; PKA; S6 Kinase | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
AT7867 是 ATP 竞争性的Akt1/Akt2/Akt3和p70S6K/PKA 抑制剂,IC50分别为 32、17、47 和 85、20 nM。 | |||
T6171 |
BI-D1870
|
S6 Kinase; Autophagy | Autophagy; MAPK; PI3K/Akt/mTOR signaling |
BI-D1870 是一种可渗透细胞和透过血脑屏障的的 ATP 竞争性核糖体 S6 激酶抑制剂,抑制 RSK1、RSK2、RSK3和 RSK4 的 IC50值分别为 31 nM、24 nM、18 nM 和15 nM。 | |||
T6878 |
LJI308
|
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
LJI308 是泛RSK 抑制剂,对 RSK1、RSK2 和 RSK3 的IC50分别为 6、4 和 13 nM。它抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。 | |||
T6948 |
Pluripotin
SC1 |
ERK; Raf; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
Pluripotin (SC1) 是ERK1和RasGAP 的双重抑制剂,KD 分别为 98 和 212 nM。它还抑制RSK1、RSK2、RSK3和RSK4,IC50分别为 0.5、2.5、3.3 和 10.0 μM。 | |||
T2482 |
AT13148
|
ROCK; SGK; Akt; PKA; S6 Kinase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
AT13148 是一种 ATP 竞争性 AGC 激酶口服抑制剂,能够抑制 Akt1/Akt2/Akt3、p70S6K、PKA 和 ROCKI/ROCKII 的活性,IC50值分别为 38/402/50、8、3 和 6 nM/4 nM。 | |||
T4488 |
GSK-25
GSK25 |
ROCK; S6 Kinase; mTOR | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
GSK-25 是一种选择性的,具有口服活性的 ROCK1抑制剂。它对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性,RSK1的 IC50 为 398 nM,p70S6K 的 IC50 为 1000nM。它可抑制 P450,对 CYP2C9、CYP2D6和 CYP3A4的 IC50分别为2.5、5.2和2.5 μM。 | |||
T6159 |
LY-2584702 free base
|
S6 Kinase; mTOR | MAPK; PI3K/Akt/mTOR signaling |
LY-2584702 free base 是一种选择性的 ATP 竞争性 p70S6K 抑制剂,IC50为 4 nM,对S6K1的IC50为 2 nM,用于研究癌症治疗的试验。 | |||
T7790 |
Bisindolylmaleimide V
双吲哚马来酰亚胺 V,双吲哚马来酰亚胺 |
PKC; S6 Kinase | Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Bisindolylmaleimide V 是一种弱蛋白激酶 C (PKC) 抑制剂( IC50 >100 µM)。 | |||
T1746 |
LY-2584702 tosylate salt
LY2584702 tosylate |
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
LY-2584702 tosylate salt 是一种选择性的 ATP 竞争性 p70S6K 抑制剂,IC50为 4 nM,对S6K1的IC50为 2 nM,用于研究癌症治疗的试验。 | |||
T8978 |
DD1
3,3'-Diamino-4'-methoxyflavone,HUN85111 |
Proteasome | Proteases/Proteasome; Ubiquitination |
DD1 (HUN85111) 是一种蛋白酶体抑制剂,可诱导人髓系肿瘤选择性凋亡。 | |||
T19913 |
CKI-7
CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl |
ROCK; SGK; Casein Kinase; CDK; S6 Kinase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂,IC50为 6 μM,Ki 为 8.5 μM。它选择性抑制 Cdc7激酶,还抑制 SGK,S6K1以及 MSK1。 | |||
T11310 |
FMK-MEA
|
Others | Others |
FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3836 |
Eudesmin
|
MAPK; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
Eudesmin 通过抑制S6K1信号通路来干扰成脂分化,具有抗肿瘤、抗炎和抗菌活性。 | |||
T6S1302 |
Carnosol
|
Nrf2; Endogenous Metabolite; S6 Kinase | Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Carnosol 是 Nrf2激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1(HMOX1) 表达。它是核糖体 S6激酶(RSK2)抑制剂,可用于胃癌相关研究,IC50值约为 5.5 μM。 | |||
T2871 |
Quercitrin
Sophoretin,3-rhamnosyl quercetin,Quercetin 3-rhamnoside,Xanthaurine,槲皮苷,Meletin |
Reactive Oxygen Species; S6 Kinase; Autophagy | Autophagy; Immunology/Inflammation; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Quercitrin (3-rhamnosyl quercetin) 是苦荞麦中的一种天然产物,具有抗炎作用,有用于心血管疾病的研究潜力。 | |||
T0335 |
Sodium salicylate
水杨酸钠,Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt |
Apoptosis; NF-κB; COX; S6 Kinase; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; MAPK; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling |
Sodium salicylate (2-Hydroxybenzoic acid sodium salt) 是一种S6K 的抑制剂,可抑制COX-2活性。它还是一种NF-κB 抑制剂,可降低炎症基因的表达,促进老化肌肉的修复。 | |||
T16896 |
SL 0101-1
SL0101 |
S6 Kinase | MAPK; PI3K/Akt/mTOR signaling |
SL 0101-1 (SL0101) 是一种可透过细胞膜且具有选择性、高效性、可逆性、ATP竞争性的 p90核糖体S6激酶(RSK) 的抑制剂,对 RSK 的 IC50 值为 89 nM。SL 0101-1 (SL0101) 也是一种有效的 RSK1/2 抑制剂,其 Ki 值为 1 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04357 |
RSK4 Protein, Human, Recombinant (GST)
RSK4,ribosomal protein S6 kin... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2... | |||
TMPY-04392 |
RSK3 Protein, Human, Recombinant (GST)
HU-2,ribosomal protein S6 kinase,... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a... | |||
TMPY-04540 |
S6K1/RPS6KB1 Protein, Human, Recombinant (GST)
p70(S6K)-alpha,PS6K,p70-alpha,p70(S6 |
Human | Baculovirus Insect Cells |
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is disso... |