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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78345 |
Ribonuclease A
EC 3.1.27.5,RNase A |
||
Ribonuclease A (RNase A) 是一种有效的内切核糖核酸酶 ,可在dna和蛋白质的制备过程中去除RNA。 | |||
T76112 |
Ribonuclease H
|
Others | Others |
Ribonuclease H 是一种降解 DNA-RNA 杂交体 RNA 部分的酶。 | |||
T73609 |
Ribonuclease T1
|
Others | Others |
Ribonuclease T1 (Rnase T1),常用于生化研究。Ribonuclease T1 是一种内切酶,可特异性降解单链 RNA。Ribonuclease T1 能够形成核苷 2′,3′-环磷酸中间体,以切割 3′-鸟苷残基与邻近核苷 5′-OH 基团之间的磷酸二酯键,产生 3′-GMP 末端寡核苷酸。 | |||
T64750 |
Deoxyribonuclease I
DNase I |
Others | Others |
Deoxyribonuclease I (DNase I) 是提纯蛋白质常用的一种酶,具有潜在的抗炎和抗癌活性,可用于研究细菌感染和真菌感染。 | |||
T28859 |
ß-Thujaplicinol
|
HBV | Microbiology/Virology |
ß-Thujaplicinol 是一种从西部红雪松心材中分离出的羟基化托泊酮,具有抗病毒活性,通过阻断病毒核糖核酸酶 H 活性来抑制乙型肝炎病毒复制,可用于研究病毒感染。 | |||
T8333 |
Aurintricarboxylic acid
ATA,NSC-4056,NSC4056,金精三羧酸,NSC 4056 |
Apoptosis; P2X Receptor; Influenza Virus; Topoisomerase | Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Aurintricarboxylic acid (NSC-4056) 是高效的αβ-亚甲基-ATP 敏感选择性P2X1Rs 和P2X3Rs 变构拮抗剂。 它是核糖核酸酶和拓扑异构酶 II 的有效抑制剂,可阻止核酸与酶结合。 | |||
T24113 |
GSK5750
GSK-5750,GSK 5750 |
Others | Others |
GSK5750 is the ribonuclease H activity inhibitor. | |||
T79488 |
RNase L-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RNase L-IN-1(compound 17a)为RNase L的特异性抑制剂,能有效地防止该酶降解RNA,从而抑制病毒复制,并对先天性免疫反应及炎症过程具调控作用。 | |||
T78055 |
MYC-RIBOTAC
|
c-Myc | Cell Cycle/Checkpoint |
MYC-RIBOTAC 是一种针对MYC内部核糖体进入位点(IRES)的核糖核酸酶靶向降解剂(RIBOTAC)。该化合物结合了MYC mRNA的靶向组分以及一种可招募并激活RNA酶L1的小分子。通过降低MYC的mRNA和蛋白质表达水平,MYC-RIBOTAC诱导细胞发生凋亡,应用于抗肿瘤治疗的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74516 |
CI-39
|
Others | Others |
CI-39 是一种抗病毒天然产物。CI-39 是一种 NNRTI (非核苷类逆转录酶抑制) 抗病毒剂,对野生型HIV 的EC50为 3.40 µM,CC50>30 µM。CI-39 抑制HIV-1RT DNA 聚合酶和核糖核酸酶 H 活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00156 |
Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His)
Barnase,Ribonuclease,RNase Ba |
Bacillus amyloliquefaciens | E. coli |
Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates. Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 13.3 kDa and the accession number is P00648. | |||
TMPH-03615 |
Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO)
rnj,Ribonuclease J |
Synechocystis | E. coli |
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 86.4 kDa and the accession number is P54123. | |||
TMPH-02047 |
Ribonuclease H1 Protein, Human, Recombinant (His)
RNASEH1,Ribonuclease H type II,Ribonuclease |
Human | E. coli |
Ribonuclease H1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-00120 |
Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc)
cla,Ribonuclease clavin |
Aspergillus clavatus | E. coli |
Clavin has the same substrate specificity as alpha-sarcin. It is specific for purines in both single- and double-stranded RNA. Its toxic action on eukaryotic cells is the result of cleavage of a single phosphodiester bond in the 60S subunit of ribosomes. Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.5 kDa and the accession number is P0CL71. | |||
TMPH-02045 |
Ribonuclease 4 Protein, Human, Recombinant (His & Myc)
Ribonuclease 4,RNASE4 |
Human | Baculovirus Insect Cells |
Ribonuclease 4 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPY-03180 |
Ribonuclease A Protein, Human, Recombinant (His)
RNS1,ribonuclease, RNase A family, 1 (pancreatic),R... |
Human | HEK293 Cells |
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ... | |||
TMPH-02466 |
Ribonuclease MC Protein, Momordica charantia, Recombinant (His & Myc)
MC1,Ribonuclease MC |
Momordica charantia | E. coli |
Ribonuclease MC Protein, Momordica charantia, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is P23540. | |||
TMPH-00131 |
Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc)
Ribonuclease mitogillin,Restrictocin,ret |
Aspergillus restrictus | E. coli |
This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.9 kDa and the accession number is P67876. | |||
TMPH-02046 |
Ribonuclease 7 Protein, Human, Recombinant (His)
RNASE7,Skin-derived antimicrobial protein 2,Ribonuclease... |
Human | E. coli |
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Ribonuclease 7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted... | |||
TMPH-03055 |
Ribonuclease mitogillin Protein, Neosartorya fumigata, Recombinant (His & Myc & SUMO)
Major allergen Asp f 1,Allergen Asp f I,Ribonuclease |
Neosartorya fumigata | E. coli |
This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. | |||
TMPH-00847 |
2-5A-dependent Rnase Protein, Human, Recombinant (Myc)
Ribonuclease L,RNASEL,Ribonuclease 4,2-5A-... |
Human | E. coli |
2-5A-dependent Rnase Protein, Human, Recombinant (Myc) is expressed in E. coli expression system with C-Myc tag. The predicted molecular weight is 85.1 kDa and the accession number is Q05823. | |||
TMPH-02048 |
RNH1 Protein, Human, Recombinant (His & Myc)
RNH1,Ribonuclease/angiogenin inhibitor 1,Placental ... |
Human | E. coli |
RNH1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-01779 |
RNASE2 Protein, Human, Recombinant (His)
Ribonuclease US,Eosinophil-derived neurotoxin,Non-s... |
Human | E. coli |
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. RNASE2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.5 kDa and the accession number is P10153. | |||
TMPH-00155 |
Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc)
Barstar,Ribonuclease inhibitor |
Bacillus amyloliquefaciens | E. coli |
Inhibitor of the ribonuclease barnase. Forms a one-to-one non-covalent complex. Barstar Protein, Bacillus amyloliquefaciens, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.7 kDa and the accession number is P11540. | |||
TMPH-03653 |
RNU2 Protein, Ustilago sphaerogena, Recombinant (B2M & His)
Ribonuclease U2,RNU2 |
Ustilago sphaerogena | E. coli |
N/A. RNU2 Protein, Ustilago sphaerogena, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 26.4 kDa and the accession number is P00654. | |||
TMPY-02769 |
RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2 |
Human | Baculovirus Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... | |||
TMPH-01883 |
PARN Protein, Human, Recombinant (His)
PARN,Polyadenylate-specific ribonuclease,Deadenylat... |
Human | E. coli |
PARN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 77.5 kDa and the accession number is O95453. | |||
TMPH-02506 |
ANG Protein, Mouse, Recombinant (His)
ANG,Angiogenin,Ribonuclease 5,RNase 5 |
Mouse | E. coli |
ANG Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.9 kDa and the accession number is P21570. | |||
TMPH-00934 |
ANG Protein, Human, Recombinant (His)
RNase 5,ANG,Angiogenin,Ribonuclease 5 |
Human | E. coli |
ANG Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-02063 |
SLFN12 Protein, Human, Recombinant (His)
Ribonuclease SLFN12,Schlafen family member 12,SLFN1... |
Human | E. coli |
SLFN12 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system. | |||
TMPJ-01258 |
RNASE6 Protein, Human, Recombinant (His)
RNS6,Ribonuclease K6,RNase K6,RNASE6 |
Human | HEK293 Cells |
Ribonuclease K6 (RNASE6) is a secreted protein that belongs to the pancreatic ribonuclease family. Human RNASE6 is synthesized as a 150 amino acid precursor that contains a 23 amino acid signal sequence, and a 127 amino acid mature chain. RNASE6 is expressed in many tissues, with high expression levels in the lung, with lower expression levels in the heart, placenta, kidney, pancreas, liver, brain, and skeletal muscle. It is also detected in monocytes and neutrophils. RNASE6 may have a role in h... | |||
TMPJ-00763 |
ANG Protein, Human, Recombinant
RNASE5,ANG,Angiogenin,Ribonuclease 5,血管生成素,RNase 5 |
Human | E. coli |
Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin... | |||
TMPJ-00574 |
RNASE3 Protein, Human, Recombinant (His)
RNase 3,RNS3,ECP,Eosinophil Cationic Protein,RNASE3,Ribo... |
Human | HEK293 Cells |
Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It p... | |||
TMPJ-01007 |
HRSP12 Protein, Human, Recombinant (His)
p14.5,UK114 Antigen Homolog,Heat-Responsive Protein 12,R... |
Human | E. coli |
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels ... | |||
TMPH-03094 |
Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO)
Pollen allergen Phl p 5b,Allergen Phl p Vb |
Phleum pratense | E. coli |
Has ribonuclease activity. May be involved in host-pathogen interactions. Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.1 kDa and the accession number is Q40963. | |||
TMPH-02508 |
Angiogenin-4 Protein, Mouse, Recombinant (His & SUMOstar)
Ang4,Angiogenin-4,EC:3.1.27.- |
Mouse | P. pastoris (Yeast) |
Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro). Angiogenin-4 Protein, Mouse, Recombinant (His & SUMOstar) is expressed in yeast with N-6xHis-sumostar tag. The predicted molecular weight is 29.9 kDa and the accession number is Q3TMQ6. | |||
TMPH-02507 |
Angiogenin-4 Protein, Mouse, Recombinant (His & Myc & SUMO)
EC:3.1.27.-,Angiogenin-4,Ang4 |
Mouse | E. coli |
Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro). Angiogenin-4 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO and C-Myc tag. The predicted molecular weight is 31.4 kDa and the accession number is Q3TMQ6. | |||
TMPY-02491 |
LRRN3 Protein, Human, Recombinant (His)
NLRR3,FIGLER5,leucine rich repeat neuronal 3,NLRR-3 |
Human | Baculovirus Insect Cells |
Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. Leucine-rich repeats are short sequence motifs present in some proteins with diverse functions and cellular locations. All proteins containing these repeats are thought to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor protein has revealed th... |