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Search Results for " rheumatic diseases "

Targets Recommended: Apoptosis GPR Rho

9

抑制剂 & 化合物

4

天然产物

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1237	Azathioprine 硫唑嘌呤,BW 57-322	Apoptosis; GPR; Rho	Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein
	Azathioprine (BW 57-322) 是一种免疫抑制剂。
T26926	Butibufen FF 105,FF-106,FF 106,FF106	Lipoxygenase	Metabolism
	Butibufen (FF-106) 是一种具有口服活性的非甾体抗炎化合物，是潜在的环氧合酶抑制剂，具有止痛和解热活性，抑制尿素合成。Butibufen 可用于研究风湿性疾病。
T40888	3-Acetamidocoumarin	Others	Others
	3-Acetamidocoumarin, a compound significant in biology and medicine, exhibits physiological effects and is utilized in treating various conditions, including burns, brucellosis-rheumatic diseases, and cancer.
T21074	Dexamethasone acetate Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron	Others	Others
	Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics
T25959	Pipebuzone LD-4644,LD 4644,LD4644,Pipebuzonum	Others	Others
	Pipebuzone 是一种抗炎、解热、镇痛药，用于治疗各种风湿性疾病。它在临床和病理上都具有良好的耐受性，并具有可靠的抗炎作用。
T62363	Salazopyridazine	Others	Others
	Salazopyridazine 是一种抗菌剂，可以抑制溃疡性结肠炎。Salazopyridazine 能够用于研究风湿病。
T62913	Piroxicam cinnamate	Others	Others
	Piroxicam cinnamate (Cinnoxicam) 是一种环氧合酶 (COX) 抑制剂，表现出抗炎作用。Piroxicam cinnamate 能够用于研究炎症退行性骨关节疾病，风湿性疾病和精索静脉曲张 (VC) 相关性少弱精子症。
T71420	RO314724	Others	Others
	RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.
T37419	Zetomipzomib	Others	Others
	KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhib...

化合物

Cat.No: T1237

Synonym: 硫唑嘌呤,BW 57-322

Target: Apoptosis, GPR, Rho

Cat.No: T26926

Synonym: FF 105,FF-106,FF 106,FF106

Target: Lipoxygenase

3-Acetamidocoumarin

Cat.No: T40888

Target: Others

Dexamethasone acetate

Cat.No: T21074

Synonym: Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron

Target: Others

Cat.No: T25959

Synonym: LD-4644,LD 4644,LD4644,Pipebuzonum

Target: Others

Salazopyridazine

Cat.No: T62363

Target: Others

Piroxicam cinnamate

Cat.No: T62913

Target: Others

Cat.No: T71420

Target: Others

Cat.No: T37419

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2967	Stigmasterol Stigmasterin,beta-Stigmasterol,豆甾醇	MMP; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Stigmasterol (Stigmasterin) 是一种植物性甾醇，具有抑制胆固醇的特性，此外在风湿性疾病的研究中被评价为抗硬化因子。
T0320	Colchicine 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。
T4S0536	Bullatine A	Apoptosis; P2X Receptor	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Bullatine A 是一种有效的 P2X7拮抗剂，可抑制 ATP 诱导的细胞凋亡和 P2X 受体介导的炎症反应。它是乌头属的二萜生物碱，能缓解过敏反应，具有抗风湿、抗炎和抗伤害作用，可用于治疗关节炎等神经退行性疾病。
TN5498	6,7,4'-Trihydroxyflavanone	Others	Others
	6,7,4'-Trihydroxyflavanone 具有多种药理活性，包括抗风湿、抗缺血、抗炎、抗破骨细胞和对 METH 诱导的 T 细胞失活的保护作用。 6,7,4'-三羟基黄烷酮可用于研究治疗患有神经退行性疾病的 METH 成瘾者。

天然产物

Cat.No: T2967

Synonym: Stigmasterin,beta-Stigmasterol,豆甾醇

Target: MMP, Endogenous Metabolite

Cat.No: T0320

Synonym: 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol

Target: Apoptosis, Microtubule Associated, Autophagy

Cat.No: T4S0536

Target: Apoptosis, P2X Receptor

6,7,4'-Trihydroxyflavanone

Cat.No: TN5498

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T13155	Tiaprofenic acid D3	Others	Others
	Tiaprofenic acid D3 is a deuterium-labeled Tiaprofenic acid. Tiaprofenic acid is a nonsteroidal anti-inflammatory drug and treatment of rheumatic diseases.

同位素标记化合物

Tiaprofenic acid D3

Cat.No: T13155

Target: Others

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