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Search Results for " replicase "

Targets Recommended: HCV Protease

2

抑制剂 & 化合物

27

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T26863	BMS-929075 BMS 929075,BMS929075	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	BMS-929075是一种具有口服活性 HCV NS5B 复制酶 (HCV NS5B replicase) 手掌位点变构抑制剂，具有有效性、较高的口服生物利用度和药代动力学参数。BMS-929075 显示出细胞毒性。
T36881	NHC-diphosphate triammonium	Others	Others
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...

化合物

Cat.No: T26863

Synonym: BMS 929075,BMS929075

Target: HCV Protease

NHC-diphosphate triammonium

Cat.No: T36881

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00147	IBV (strain KB8523) Replicase polyprotein 1ab (His) ORF1ab polyprotein,Replicase polyprotein 1ab,rep	IBV	Baculovirus Insect Cells
	The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.; NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. IBV (strain KB8523) Replicase polyprotein 1ab (His) is expressed in Baculo...
TMPJ-01431	SARS-CoV-2 Papain-Like Protease Protein PLpro,PL-PRO,pp1a,Replicase polyprotein 1a,Papain-l...	SARS-CoV-2	E. coli
	Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) sect...
TMPH-03734	Zaire ebolavirus (strain Mayinga-76) L Protein (His) Transcriptase,L,RNA-directed RNA polymerase L,Large structur...	ZEBOV	E. coli
	Zaire ebolavirus (strain Mayinga-76) L Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.9 kDa and the accession number is Q05318.
TMPH-02384	Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) L,Replicase,RNA-directed RNA polymerase L,Transcrip...	MARV	E. coli
	Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.7 kDa and the accession number is P35262.
TMPH-03699	VSIV (strain 94GUB Central America) L Protein (His) RNA-directed RNA polymerase L,Replicase,Transcripta...	VSIV	E. coli
	VSIV (strain 94GUB Central America) L Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.4 kDa and the accession number is Q8B0H0.
TMPH-03735	Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) RNA-directed RNA polymerase L,L,Large structural protein,	ZEBOV	E. coli
	Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q6V1Q2.
TMPK-01352	SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) Plpro,PL2-PRO,pp1a,nsp1,Replicase polyprotein 1a,Pa...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro...
TMPK-01384	SARS PLpro/papain-like protease Protein (His) Papain-like Protease,PL-PRO,Replicase polyprotein 1...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (...
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.8kDa and the accession number is YP_009725301.1.
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.4kDa and the accession number is YP_009725301.1.
TMPY-06009	SARS-CoV-2 NSP7 Protein	SARS-CoV-2	E. coli
	NSP7 is conserved within the coronaviridae. NSP7 is a component of the coronavirus replicase polyprotein to comprise a repilication complex. NSP7 has been shown to interact with NSP10 and NSP1 which indicate that NSP7 has a founction in coronavirus-specific RNA replication mechanisms.
TMPH-00756	Capsid Protein, Escherichia phage MS2, Recombinant (His & Myc) CP,Capsid protein,Coat protein	Escherichia phage MS2	E. coli
	Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. The capsid contains also 1 copy of the A2 maturation protein.; Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is th...
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL-Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5kDa and the accession number is YP_009725301.1.
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) COVID-19,3CL Protease,M Proteinase,3CL Pro,3CL-Mpro,3C-like ...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.79 kDa and the accession number is YP_009725301.1.
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.72 kDa and the accession number is YP_009725301.1.
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant M Proteinase,3CL-Mpro,Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.82 kDa and the accession number is YP_009725301.1.
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant 3CL Protease,3CL-Mpro,Mpro,M Proteinase	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinase,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8kDa and the accession number is YP_009725301.1.
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,3CL Protease,Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.78 kDa and the accession number is YP_009725301.1.
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5 kDa and the accession number is YP_009725301.1.
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL Protease,3CL-Mpro	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,Mpro,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPY-06012	SARS-CoV-2 NSP10 Protein	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and ...
TMPY-06011	SARS-CoV-2 NSP10 Protein (His)	SARS-CoV-2	E. coli
	NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein (His) is expressed in E. coli expression system. The predicted molecular weight is 15.7 ...
TMPJ-01425	SARS-CoV-2 NSP1 Protein (His) SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein	SARS-CoV-2	E. coli
	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close associa...

重组蛋白

IBV (strain KB8523) Replicase polyprotein 1ab (His)

Cat.No: TMPH-00147

Species: IBV

Expression System: Baculovirus Insect Cells

SARS-CoV-2 Papain-Like Protease Protein

Cat.No: TMPJ-01431

Species: SARS-CoV-2

Expression System: E. coli

Zaire ebolavirus (strain Mayinga-76) L Protein (His)

Cat.No: TMPH-03734

Species: ZEBOV

Expression System: E. coli

Lake Victoria marburgvirus (MARV) (strain Popp-67) L Protein (His & Myc)

Cat.No: TMPH-02384

Species: MARV

Expression System: E. coli

VSIV (strain 94GUB Central America) L Protein (His)

Cat.No: TMPH-03699

Species: VSIV

Expression System: E. coli

Zaire ebolavirus (strain Kikwit-95) L Protein (His & Myc)

Cat.No: TMPH-03735

Species: ZEBOV

Expression System: E. coli

SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

Cat.No: TMPK-01352

Species: SARS

Expression System: E. coli

SARS PLpro/papain-like protease Protein (His)

Cat.No: TMPK-01384

Species: SARS

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant

Cat.No: TMPK-01342

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant

Cat.No: TMPK-01347

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP7 Protein

Cat.No: TMPY-06009

Species: SARS-CoV-2

Expression System: E. coli

Capsid Protein, Escherichia phage MS2, Recombinant (His & Myc)

Cat.No: TMPH-00756

Species: Escherichia phage MS2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01344

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)

Cat.No: TMPK-01348

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant

Cat.No: TMPK-01337

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant

Cat.No: TMPK-01340

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant

Cat.No: TMPK-01338

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant

Cat.No: TMPK-01341

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01336

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant

Cat.No: TMPK-01346

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant

Cat.No: TMPK-01339

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01345

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01335

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant

Cat.No: TMPK-01343

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP10 Protein

Cat.No: TMPY-06012

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP10 Protein (His)

Cat.No: TMPY-06011

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP1 Protein (His)

Cat.No: TMPJ-01425

Species: SARS-CoV-2

Expression System: E. coli

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