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Search Results for " recombination and repair protein "

Targets Recommended: HSP DNA/RNA Synthesis

2

抑制剂 & 化合物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6960L	PU-H71 HCl PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl	HSP; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism
	PU-H71 HCl (Zelavespib HCl) 是一种新型Hsp90抑制剂，是一种新型嘌呤基类似物，也是一种可能是CIRT的一种有前途的放射增敏剂。PU-H71 HCL 在许多恶性肿瘤临床前模型中显示出抗肿瘤活性。PU-H71 HCL 对 Rad51 和Ku70 的蛋白表达水平有抑制作用，这可能与双链断裂修复的同源重组途径和非同源末端连接途径有关。
T81640	NSC15520	Others	Others
	NSC15520是一种小分子RPA抑制剂，特异性结合RPA的N端DNA结合域(DBD)，阻断其与p53或RAD9的相互作用。它还能够抑制双链DNA(dsDNA)寡核苷酸的螺旋不稳定性，影响DNA复制、修复、重组及损伤反应信号。

化合物

Cat.No: T6960L

Synonym: PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl

Target: HSP, DNA/RNA Synthesis

Cat.No: T81640

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00528	Recombination and repair protein Protein, Enterobacteria phage T4, Recombinant (His) UVSX,Recombination and repair	Enterobacteria phage T4	E. coli
	Important in genetic recombination, DNA repair, and replication. Possesses pairing and strand-transfer activity. Interacts with dda and gene 32 proteins.
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) RAD52,DNA repair and recombination	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778.
TMPJ-01179	SWSAP1 Protein, Human, Recombinant (His) SWS1-associated protein 1,SWIM-type zinc finger 7-a...	Human	E. coli
	SWSAP1 is a nucleus ATPase protein, interacts with ZSWIM7 and forms a functional complex. The complexs involved in homologous recombination repair and stabilizes each other. SWS1AP1 also interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3. It involves in homologous recombination repair. ATPase is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). SWSAP1 has a DNA-binding activity which is independent of its ATPase activity.
TMPH-01244	POLM Protein, Human, Recombinant (His) DNA-directed DNA/RNA polymerase mu,Terminal transferase,POLM	Human	E. coli
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPH-01431	HELQ Protein, Human, Recombinant (His & Myc) Mus308-like helicase,POLQ-like helicase,HELQ,Helicase POLQ-l...	Human	E. coli
	Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. HELQ Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 4...
TMPH-01245	POLM Protein, Human, Recombinant (His & Myc) DNA-directed DNA/RNA polymerase mu,POLM,Terminal transferase	Human	Baculovirus Insect Cells
	Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination. POLM Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 58.8 kDa and the accession number is Q9NP87.
TMPJ-00918	HMGB2 Protein, Human, Recombinant (His) High Mobility Group Protein B2,HMG2,High Mobility G...	Human	HEK293 Cells
	High Mobility Group Protein B2 (HMGB2) belongs to the non-histone chromosomal high-mobility group protein family. Members of this family are chromatin-associated and widely spread in the nucleus of higher eukaryotic cells. HMGB2 contains 2 HMG box DNA-binding domains. It is associated with chromatin and has the ability to bend DNA, preferentially single-stranded DNA. It is shown that HMGB2 is able to efficiently bend DNA and form DNA circles. In addition, HMGB2 is involved in the final ligation ...
TMPH-00531	SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO) Single-stranded DNA-binding protein,Gene p...	Enterobacteria phage T7	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST) FCC1,COCA1,HNPCC1,HNPCC,LCFS2,mutS homolog 2	Human	Baculovirus Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch r...
TMPH-00530	SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc) Gp32,Helix-destabilizing protein,Single-strand<...	Enterobacteria phage T4	E. coli
	Single-stranded DNA-binding protein that participates in viral DNA replication, recombination, and repair (Probable). Coats the lagging-strand ssDNA as the replication fork advances. Stimulates the activities of viral DNA polymerase and DnaB-like SF4 replicative helicase, probably via its interaction with the helicase assembly factor. Together with DnaB-like SF4 replicative helicase and the helicase assembly factor, promotes pairing of two homologous DNA molecules containing complementary single...
TMPH-00532	SSB Protein, Enterobacteria phage T7, Recombinant Gene product 2.5,Single-stranded DNA-binding pr...	Enterobacteria phage T7	P. pastoris (Yeast)
	Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks. Coats the lagging-strand ssDNA as the replication fork advances and stimulates the activities of viral DNA polymerase and primase/helicase. Coordinates simultaneous synthesis of leading- and lagging-strands. Together with DNA primase/helicase, promotes pairing of two homologous DNA molecules containing complementary single-stranded regions ...
TMPJ-01450	SARS-CoV-2 Helicase Protein (His & MBP) SARS-CoV 2 nsp13,SARS-CoV 2 Helicase	SARS-CoV-2	E. coli
	The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nu...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc) ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa...	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP) Nuclear factor IV,Lupus Ku autoantigen protein p86,...	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...

重组蛋白

Recombination and repair protein Protein, Enterobacteria phage T4, Recombinant (His)

Cat.No: TMPH-00528

Species: Enterobacteria phage T4

Expression System: E. coli

RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)

Cat.No: TMPH-03440

Species: Saccharomyces cerevisiae

Expression System: E. coli

SWSAP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01179

Species: Human

Expression System: E. coli

POLM Protein, Human, Recombinant (His)

Cat.No: TMPH-01244

Species: Human

Expression System: E. coli

HELQ Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01431

Species: Human

Expression System: E. coli

POLM Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01245

Species: Human

Expression System: Baculovirus Insect Cells

HMGB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00918

Species: Human

Expression System: HEK293 Cells

SSB Protein, Enterobacteria phage T7, Recombinant (His & SUMO)

Cat.No: TMPH-00531

Species: Enterobacteria phage T7

Expression System: E. coli

MSH2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04267

Species: Human

Expression System: Baculovirus Insect Cells

SSB Protein, Enterobacteria phage T4, Recombinant (His & Myc)

Cat.No: TMPH-00530

Species: Enterobacteria phage T4

Expression System: E. coli

SSB Protein, Enterobacteria phage T7, Recombinant

Cat.No: TMPH-00532

Species: Enterobacteria phage T7

Expression System: P. pastoris (Yeast)

SARS-CoV-2 Helicase Protein (His & MBP)

Cat.No: TMPJ-01450

Species: SARS-CoV-2

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

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