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Search Results for " raf "

Targets Recommended: Raf Raf

191

抑制剂 & 化合物

15

天然产物

3

化合物库

15

重组蛋白

7

同位素标记化合物

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Cat. No.	Product Name
L2192	抗胰腺癌化合物库		2238 compounds
	2238 种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；

化合物库

抗胰腺癌化合物库

Cat.No: L2192

Compounds: 2238

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

Cat. No.	Product Name	Target	Signaling Pathways
T2074	Raf inhibitor 1 B-Raf inhibitor 1	Raf	MAPK
	Raf inhibitor 1 (B-Raf inhibitor 1)是Raf 激酶抑制剂，对B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T4167	Raf inhibitor 1 dihydrochloride B-Raf inhibitor 1 dihydrochloride	Raf	MAPK
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂，对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T1845	B-Raf IN 1	Raf	MAPK
	B-Raf IN 1 是选择性B-Raf 抑制剂， IC50为 24 nM。
T4194	Raf inhibitor 2 CID-25014542,CID 25014542,CID25014542	Raf	MAPK
	Raf inhibitor 2 (CID 25014542) 是新型 Raf 激酶抑制剂，IC50小于 1.0 μM，可用于癌症研究。
T19802	B-Raf IN 11	Raf	MAPK
	B-Raf IN 11 是一种新型选择性抑制剂。 B-Raf 激酶V600E 突变体的DFG-in 构象优于结肠直肠癌中的DFG-out 构象。
T40284	B-Raf IN 2	Raf	MAPK
	B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.
T63644	Exarafenib RAF/KIN_2787	Raf; p38 MAPK	MAPK
	Exarafenib (RAF/KIN_2787) 是一种有效且可口服的 pan-RAF 抑制剂。Exarafenib 具有抗肿瘤活性，通过抑制下游 MAPK 通路信号来发挥作用。Exarafenib 可用于研究癌症。
T3711	RAF709	Raf	MAPK
	RAF709 是RAF 抑制剂，抑制BRAF 和CRAF，IC50分别为 0.4 和 0.5 nM，具有抗肿瘤活性。
T63333	Uplarafenib B-Raf IN 10	Raf	MAPK
	Uplarafenib (B-Raf IN 10) 是一种强效的 BRAF 抑制剂，其 IC50 在 50-100 nM 之间。B-Raf IN 10 具有抗肿瘤活性，可能不会影响细胞增殖和分化，可用于研究实体瘤。
T6296	RAF265 CHIR-265	Apoptosis; Raf; VEGFR; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	RAF265 (CHIR-265) 是一种 RAF/VEGFR2抑制剂。
T72070	B-Raf IN 14	Bradykinin Receptor	GPCR/G Protein
	B-Raf IN 14是一种 BRAF 抑制剂。
T79830	B-Raf IN 16	Raf	MAPK
	B-Raf IN 16，一种 BRAF 抑制剂，属于环状亚氨基嘧啶衍生物，可用于研究癌症或肿瘤。
T78183	B-Raf IN 15	Raf	MAPK
	B-Raf IN 15 是一种 BRAF 抑制剂，抑制 BRAFWT 和 BRAFV600E，可用于研究黑色素瘤和癌症，可用于优化成效果更好的BRA F抑制剂。
T36642	RAS/RAS-RAF-IN-1	Others	Others
	RAS/RAS-RAF-IN-1 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μμ-15 μμ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity[1]. RAS/RAS-RAF-IN-1 (compound 89; for 4 hours) has an EC50 of 0.5 μμ-5.0 μμ for BRAF-GTP-KRAS-G12C disruption and has an IC50 of 1.0 μμ-10 μμ for pERK inhibition in H358 cells[1]. [1]. Meizhong Jin, et al. Compounds that participate in cooperative binding and uses thereof. WO2020132597A1.
T12685	RAF mutant-IN-1	Others	Others
	RAF mutant-IN-1 is an inhibitor of RAF kinase(IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively).
T10599	BRAF inhibitor	Raf	MAPK
	BRAF inhibitor 是B-Raf 抑制剂。
T67862	B-Raf IN 13	Raf	MAPK
	B-Raf IN 13 是一种有效的B-Raf 抑制剂，具有抗癌活性。B-Raf IN 13 在 BRAF V600E 酶测定实验中 IC50 为 3.55 nM。
T12556	PROTAC B-Raf degrader 1	Raf; PROTACs	MAPK; PROTAC
	PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T2295	SB-590885	Raf	MAPK
	SB590885 是一种 B-Raf 抑制剂，Ki 值为 0.16 nM，对其选择性是对 c-Raf 的 11 倍多。
T2473	PLX-4720 PLX4720	Raf	MAPK
	PLX-4720 是一种有效且选择性的 B-Raf (V600E) 抑制剂，IC50为 13 nM，与 c-Raf-1（Y340D 和 Y341D 突变）同样有效。
T6318	AZ 628	Apoptosis; Raf	Apoptosis; MAPK
	AZ 628 是一种泛Raf 激酶抑制剂，抑制B-Raf、B-RafV600E 和c-Raf-1，IC50分别为 105、34和 29 nM。
T24437	MCP110 MCP-110,MCP 110	Raf; Ras	GPCR/G Protein; MAPK
	MCP110 是 Ras 与 Raf-1 相互作用的抑制剂，可用于治疗人类肿瘤的研究。
T63365	RAF-IN-1	Others	Others
	RAF-IN-1 是 b/cRAF 的有效抑制剂，能够作用于 cRAF (IC50: 3.8 nM)、bRAFwt (IC50: 36 nM)，bRAFV600E (IC50: 29.4 nM)，能够抑制携带 bRAFV600E 突变的 A375 和 H358 细胞系，其 GI50分别为 3.4 和 2.9 nM。
T64116	B-Raf IN 5	Others	Others
	B-Raf IN 5 是蛋白激酶 B-Raf 的有效抑制剂 (IC50: 2.0 nM)。B-Raf IN 5 可抵抗快速代谢，切不结合二级靶点 PXR。B-Raf IN 5 对癌症疾病表现出研究潜力。
T4133	CCT196969	Raf; Src	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	CCT196969 是泛-Raf 抑制剂，抑制B-Raf、BRafV600E 和CRAF，IC50分别为 0.1、0.04、和 0.01 μM。
T1903	Dabrafenib GSK2118436A,GSK2118436,达拉非尼	Raf	MAPK
	Dabrafenib (GSK2118436A) 是一种 Raf 抑制剂，抑制 C-Raf 和 B-RafV600E (IC50=5/0.6 nM)，具有 ATP 竞争性。Dabrafenib 具有抗肿瘤活性，可用于治疗 B-RafV600E 突变的黑色素瘤。
T1953	L-779450 L 779450	Raf; Autophagy	Autophagy; MAPK
	L-779450 是一种有效的 ATP 竞争性 Raf 激酶抑制剂，IC50为 10 nM，Kd 为 2.4 nM。
T79813	Raf inhibitor 3	Raf	MAPK
	Raf inhibitor3 (Example 30) 作为一种Raf抑制剂，对B-Raf和C-Raf展现出高效抑制作用，其IC50值均小于15 nM，主要应用于癌症研究领域。
T1886	TAK-632	Raf; FGFR; PDGFR; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors
	TAK632 是一种有效的pan-RAF 抑制剂，对CRAF、BRAFV600E 和BRAFWT 的IC50分别为 1.4、2.4 和 8.3 nM。
T9693	TBAP-001	Raf	MAPK
	TBAP-001是RAF 激酶的泛抑制剂，IC50为 62 nM。
T5634	Belvarafenib	Raf	MAPK
	Belvarafenib 是一种有效的泛 RAF 抑制剂，具有抗肿瘤活性，对 B-RAF、B-RAFv600E 和 C-RAF 的 IC50值分别为 56、7 和 5 nM。
T1851	ZM 336372 Zinc00581684	Apoptosis; Raf	Apoptosis; MAPK
	ZM 336372 是一种选择性蛋白激酶 c-Raf 抑制剂。
T60933	B-Raf IN 7	Others	Others
	B-Raf IN 7 (compound 6a) 是 B-Raf 的有效抑制剂，IC50值为 110.23 nM。B-Raf IN 7 对结肠癌细胞(HCT-116)、乳腺癌细胞 (MCF-7)、肝癌细胞 (HEPG-2)、人宫颈癌细胞 (Hela) 和人前列腺癌细胞 (PC-3) 具有抗肿瘤活性。其 IC50值分别为 7.50、9.87、10.57、11.63 和 12.83 μM。
T6487	Encorafenib LGX818	Raf	MAPK
	Encorafenib (LGX818) 是一种可口服的突变型 BRaf V600E 抑制剂，IC50为 0.3 nM，具有潜在的抗肿瘤活性。
T15794	LUT014	Raf	MAPK
	LUT014 是B-Raf 抑制剂，IC50值为 11.7 nM，用于减少与 EGFR 抑制剂相关限制剂量的痤疮样病变研究。
T22272	Lifirafenib BGB-283,Beigene-283	EGFR; Raf	Angiogenesis; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	Lifirafenib (Beigene-283) 是新型高效的Raf 激酶和EGFR 抑制剂，对重组BRafV600E 和EGFR 的IC50值分别为 23 和 29 nM。
TQ0048	BI-882370	Raf	MAPK
	BI-882370 是高选择性的RAF 激酶抑制剂，其结合位于 BRAF 激酶的 DFG-out 无活性构象处 (ATP 结合位点)。它抑制 SRC 家族激酶，也抑制 BRAFV600E-mutant、WT BRAF 和 CRAF 激酶，IC50值分别为 0.4、0.8 和 0.6 nM。
T61935	B-Raf IN 9	Others	Others
	B-Raf IN 9 (compound 8b) 是有效的B-Raf 抑制剂（IC50= 24.79 nM）。B-Raf IN 9 将细胞周期阻滞于 G2/M 期，诱导凋亡。B-Raf IN 9 对人前列腺癌 PC-3 细胞表现出较强的抗肿瘤活性（IC50= 7.83 μM）。
T5172	AZ304	c-Fms; Raf; p38 MAPK; Autophagy	Autophagy; MAPK; Tyrosine Kinase/Adaptors
	AZ304 是一种 ATP 竞争性双 BRAF 激酶抑制剂，有效抑制 BRAF (WT)、BRAF (V600E) 和野生型 CRAF，IC50值分别为79、38和68 nM。具有抗肿瘤活性。它对 p38 和 CSF1R 也有抑制作用，IC50值分别为 6 nM 和 35 nM。
T6949	PLX7904 PB04	Raf	MAPK
	PLX7904 (PB04) 是一种有效且选择性的悖论破坏剂 RAF 抑制剂，可抑制突变 BRAF 黑色素瘤细胞中 ERK1/2 的激活。在表达突变体 RAS 的细胞中，对 BRAFV600E 的IC50值约为 5 nM。
T11898	LXH254	Raf	MAPK
	LXH254 是B/C RAF 抑制剂。
T6882	LY3009120 DP-4978	Raf; Autophagy	Autophagy; MAPK
	LY3009120 (DP-4978) 是一种泛RAF 抑制剂，其抑制BRAFV600E、BRAFWT 和CRAFWT 的IC50分别为 5.8、9.1和15 nM。
T63855	B-Raf IN 6	Others	Others
	B-Raf IN 6 是蛋白激酶 B-Raf 的有效抑制剂 (IC50: 1.7 nM)。B-Raf IN 6 不结合二级靶点 PXR，并可抵抗快速代谢。B-Raf IN 6 对癌症疾病表现出研究潜力。
T60727	B-Raf IN 8	Others	Others
	B-Raf IN 8 (compound 7g) 是 B-Raf 的有效抑制剂 (IC50 = 70.65 nM)。B-Raf IN 8 显示出抗肿瘤活性，其对肝细胞癌 (HEPG-2)、结肠癌 (HCT-116)，乳腺癌 (MCF-7) 和人前列腺癌 (PC-3) 细胞的 IC50值分别为9.78、13.78、18.52 和 29.85 μM。
T6320	GDC-0879 GDC 0879,AR-00341677,GDC0879	Raf	MAPK
	GDC-0879 (AR-00341677) 是一种选择性B-Raf 抑制剂，IC50为 0.13 nM。
T41003	KG5	Raf; FLT; PDGFR; c-Kit	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	KG5 是 PDGFRβ 和 B-Raf 的双重变构抑制剂，对 PDGFRβ 和 PDGFRα 的 Kd 分别为 520 nM 和 300 nM。 KG5 抑制 FLT3、KIT 和 c-Raf，具有抗癌和抗血管生成活性。
T8745	PROTAC BRAF-V600E degrader-1 Compound 23	Raf; PROTACs	MAPK; PROTAC
	PROTAC BRAF-V600E degrader-1 (Compound 23) 选择性地诱导 BRAF-V600E 的降解，而不是野生型 BRAF。
T4301	AD80	Raf; c-RET; Src; S6 Kinase	Angiogenesis; Apoptosis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AD80 是多激酶抑制剂，可抑制 RET、RAF、SRC 和 S6K，并大大降低 mTOR 活性。
T63386	Pan-RAF kinase inhibitor 1	Others	Others
	Pan-RAF kinase inhibitor 1 是 Pan-RAF 激酶对有效抑制剂，能够抑制 RAF 激酶，调节 MAPK 信号传导，进而影响 RAS 突变肿瘤细胞的增殖。 Pan-RAF kinase inhibitor 1 对研究癌症疾病表现出研究潜力。
T2070	Agerafenib RXDX-105,CEP 32496,CEP-32496,CEP32496	Raf; c-RET; Bcr-Abl; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	Agerafenib (CEP32496) 是口服高效的 BRAFV600E 抑制剂，Kd 为 14 nM。

化合物

Raf inhibitor 1

Cat.No: T2074

Synonym: B-Raf inhibitor 1

Target: Raf

Raf inhibitor 1 dihydrochloride

Cat.No: T4167

Synonym: B-Raf inhibitor 1 dihydrochloride

Target: Raf

Cat.No: T1845

Target: Raf

Raf inhibitor 2

Cat.No: T4194

Synonym: CID-25014542,CID 25014542,CID25014542

Target: Raf

Cat.No: T19802

Target: Raf

Cat.No: T40284

Target: Raf

Cat.No: T63644

Synonym: RAF/KIN_2787

Target: Raf, p38 MAPK

Cat.No: T3711

Target: Raf

Cat.No: T63333

Synonym: B-Raf IN 10

Target: Raf

Cat.No: T6296

Synonym: CHIR-265

Target: Apoptosis, Raf, VEGFR, Autophagy

Cat.No: T72070

Target: Bradykinin Receptor

Cat.No: T79830

Target: Raf

Cat.No: T78183

Target: Raf

RAS/RAS-RAF-IN-1

Cat.No: T36642

Target: Others

RAF mutant-IN-1

Cat.No: T12685

Target: Others

Cat.No: T10599

Target: Raf

Cat.No: T67862

Target: Raf

PROTAC B-Raf degrader 1

Cat.No: T12556

Target: Raf, PROTACs

Cat.No: T2295

Target: Raf

Cat.No: T2473

Synonym: PLX4720

Target: Raf

Cat.No: T6318

Target: Apoptosis, Raf

Cat.No: T24437

Synonym: MCP-110,MCP 110

Target: Raf, Ras

Cat.No: T63365

Target: Others

Cat.No: T64116

Target: Others

Cat.No: T4133

Target: Raf, Src

Cat.No: T1903

Synonym: GSK2118436A,GSK2118436,达拉非尼

Target: Raf

Cat.No: T1953

Synonym: L 779450

Target: Raf, Autophagy

Raf inhibitor 3

Cat.No: T79813

Target: Raf

Cat.No: T1886

Target: Raf, FGFR, PDGFR, Aurora Kinase

Cat.No: T9693

Target: Raf

Cat.No: T5634

Target: Raf

Cat.No: T1851

Synonym: Zinc00581684

Target: Apoptosis, Raf

Cat.No: T60933

Target: Others

Cat.No: T6487

Synonym: LGX818

Target: Raf

Cat.No: T15794

Target: Raf

Cat.No: T22272

Synonym: BGB-283,Beigene-283

Target: EGFR, Raf

Cat.No: TQ0048

Target: Raf

Cat.No: T61935

Target: Others

Cat.No: T5172

Target: c-Fms, Raf, p38 MAPK, Autophagy

Cat.No: T6949

Synonym: PB04

Target: Raf

Cat.No: T11898

Target: Raf

Cat.No: T6882

Synonym: DP-4978

Target: Raf, Autophagy

Cat.No: T63855

Target: Others

Cat.No: T60727

Target: Others

Cat.No: T6320

Synonym: GDC 0879,AR-00341677,GDC0879

Target: Raf

Cat.No: T41003

Target: Raf, FLT, PDGFR, c-Kit

PROTAC BRAF-V600E degrader-1

Cat.No: T8745

Synonym: Compound 23

Target: Raf, PROTACs

Cat.No: T4301

Target: Raf, c-RET, Src, S6 Kinase

Pan-RAF kinase inhibitor 1

Cat.No: T63386

Target: Others

Cat.No: T2070

Synonym: RXDX-105,CEP 32496,CEP-32496,CEP32496

Target: Raf, c-RET, Bcr-Abl, PDGFR, Src, c-Kit

Cat. No.	Product Name	Target	Signaling Pathways
T3S0309	D(+)-Raffinose pentahydrate D-Raffinose pentahydrate,Raffinose,D(+)-五水棉子糖,五水棉子糖	Others; Endogenous Metabolite	Metabolism; Others
	D(+)-Raffinose pentahydrate (D-Raffinose pentahydrate) 是果糖，半乳糖和葡萄糖组成的三糖，天然存在于各种蔬菜和谷物中。D(+)-Raffinose pentahydrate 是一种功能性低聚糖。
T5S1000	Sophoraflavanone G Kushenol F,槐黄烷酮 G,Vexibinol	Apoptosis	Apoptosis
	Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡，具有抗肿瘤和抗炎特性。
T8144	Raffinose Melitose,Melitriose,棉子糖	Others; Endogenous Metabolite	Metabolism; Others
	Raffinose (Melitriose) 是不能够消化的短链寡糖，是由半乳糖，葡萄糖和果糖组成的三糖，能够在许多植物中找到。它能够被 α-半乳糖苷酶 (α-GAL) 水解为 D-半乳糖和蔗糖。
TN5038	Sophoraflavanone I	Others	Others
	Sophoraflavanone I is a natural product from Sophora moorcroftiana.
TN7429	Sophoraflavone A	Others	Others

TN5037	Sophoraflavanone H	Others	Others
	Sophoraflavanone H is a natural product from Sophora moorcroftiana.
TN4865	Putraflavone	Beta Amyloid; BACE	Neuroscience
	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN3726	Cudraflavone B	IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
T16011	Manumycin A	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A acts as a selective, competitive inhibitor of
TN2114	Pseudoginsenoside Rh2 拟人参皂苷RH2,拟人参皂苷 Rh2	ERK; Raf; p53	Apoptosis; MAPK
	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity.
TN4166	Griffipavixanthone	ERK; Raf; ROS; MEK; Caspase	Apoptosis; Immunology/Inflammation; MAPK; Proteases/Proteasome
	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
T72803	Norartocarpetin	Others	Others
	Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
T35577	Phosphatidylserines (bovine)	Others	Others
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...
T14055	5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2	VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src	Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors
	5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂，不可逆的选择性抑制 TAK1和 VEGF-R2，IC50值分别为 8 nM 和 52 nM。

天然产物

D(+)-Raffinose pentahydrate

Cat.No: T3S0309

Synonym: D-Raffinose pentahydrate,Raffinose,D(+)-五水棉子糖,五水棉子糖

Target: Others, Endogenous Metabolite

Sophoraflavanone G

Cat.No: T5S1000

Synonym: Kushenol F,槐黄烷酮 G,Vexibinol

Target: Apoptosis

Cat.No: T8144

Synonym: Melitose,Melitriose,棉子糖

Target: Others, Endogenous Metabolite

Sophoraflavanone I

Cat.No: TN5038

Target: Others

Sophoraflavone A

Cat.No: TN7429

Target: Others

Sophoraflavanone H

Cat.No: TN5037

Target: Others

Cat.No: TN4865

Target: Beta Amyloid, BACE

Cat.No: TN3726

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

Cat.No: T16011

Target: Prostaglandin Receptor

Pseudoginsenoside Rh2

Cat.No: TN2114

Synonym: 拟人参皂苷RH2,拟人参皂苷 Rh2

Target: ERK, Raf, p53

Griffipavixanthone

Cat.No: TN4166

Target: ERK, Raf, ROS, MEK, Caspase

Norartocarpetin

Cat.No: T72803

Target: Others

Phosphatidylserines (bovine)

Cat.No: T35577

Target: Others

5Z-7-Oxozeaenol

Cat.No: T14055

Synonym: FR148083,L783279,LL-Z 1640-2

Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01995	RAF1 Protein, Human, Recombinant (His & SUMO) RAF1,Raf-1,Proto-oncogene c-RAF,<...	Human	E. coli
	RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kinase,C...	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...
TMPH-03745	TNF-alpha Protein, Zebrafish, Recombinant (His) Lymphotoxin-alpha,tnfa,Tumor necrosis factor ligand superfam...	Danio rerio (Zebrafish)	E. coli
	TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3.
TMPH-02208	TRAF3 Protein, Human, Recombinant LMP1-associated protein 1,TNF receptor-associated factor 3,R...	Human	E. coli
	Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga...
TMPY-03632	EFNB2A Protein, Danio rerio (zebrafish), Recombinant (hFc) EFNB2A,efnb2,id:ibd572	Danio rerio (zebrafish)	HEK293 Cells
	EFNB2A Protein, Danio rerio (zebrafish), Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is O73874.
TMPY-03633	EFNB2A Protein, Danio rerio (zebrafish), Recombinant (His) efnb2,EFNB2A,id:ibd572	Danio rerio (zebrafish)	HEK293 Cells
	EFNB2A Protein, Danio rerio (zebrafish), Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.3 kDa and the accession number is O73874.
TMPH-03744	IL-1 beta Protein, Zebrafish, Recombinant (His & Myc) Interleukin-1,il1b	Danio rerio (Zebrafish)	E. coli
	IL-1 beta Protein, Zebrafish, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.9 kDa and the accession number is E6N152.
TMPH-03743	IL-1 beta Protein, Zebrafish, Recombinant (His) il1b,Interleukin-1	Danio rerio (Zebrafish)	E. coli
	IL-1 beta Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.9 kDa and the accession number is E6N152.
TMPH-02209	TRAF5 Protein, Human, Recombinant (His & SUMO) TRAF5,RING finger protein 84,TNF receptor-associate...	Human	E. coli
	Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
TMPH-02210	TRAF6 Protein, Human, Recombinant (His & SUMO) RING finger protein 85,E3 ubiquitin-protein ligase TRAF<...	Human	E. coli
	TRAF6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 75.6 kDa and the accession number is Q9Y4K3.
TMPY-03080	VEGF165 Protein, Danio rerio (zebrafish), Recombinant 血管内皮生长因子,vascular endothelial growth factor A	Danio rerio (zebrafish)	Baculovirus Insect Cells
	VEGF165 Protein, Danio rerio (zebrafish), Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.2 kDa and the accession number is O73682.
TMPH-02207	TRAF3 Protein, Human, Recombinant (His) TRAF3,RING-type E3 ubiquitin transferase TRAF	Human	E. coli
	TRAF3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is Q13114.
TMPY-03297	BMP-2 Protein, Danio rerio (zebrafish), Recombinant bone morphogenetic protein 2	Danio rerio (zebrafish)	E. coli
	BMP-2 Protein, Danio rerio (zebrafish), Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.2 kDa and the accession number is B3DI86.
TMPY-00146	RKIP/PEBP1 Protein, Human, Recombinant PBP,HEL-S-34,PEBP,RKIP,HCNP,PEBP-1,phosphatidylethanolamine ...	Human	E. coli
	Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that monitor cell proliferation and differentiation. PEBP1 in many cells interacts with several pathways, namely MAPK, GRK2, NF-small ka, CyrillicB, etc. that keeps the cell proliferation and differentiation in check. This protein is expressed by many cells in humans, including neurons w...
TMPY-04411	YES1 Protein, Human, Recombinant (His & GST) HsT441,c-yes,YES proto-oncogene 1, Src family tyrosine kinas...	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase i...

重组蛋白

RAF1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01995

Species: Human

Expression System: E. coli

RAF1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

TNF-alpha Protein, Zebrafish, Recombinant (His)

Cat.No: TMPH-03745

Species: Danio rerio (Zebrafish)

Expression System: E. coli

TRAF3 Protein, Human, Recombinant

Cat.No: TMPH-02208

Species: Human

Expression System: E. coli

EFNB2A Protein, Danio rerio (zebrafish), Recombinant (hFc)

Cat.No: TMPY-03632

Species: Danio rerio (zebrafish)

Expression System: HEK293 Cells

EFNB2A Protein, Danio rerio (zebrafish), Recombinant (His)

Cat.No: TMPY-03633

Species: Danio rerio (zebrafish)

Expression System: HEK293 Cells

IL-1 beta Protein, Zebrafish, Recombinant (His & Myc)

Cat.No: TMPH-03744

Species: Danio rerio (Zebrafish)

Expression System: E. coli

IL-1 beta Protein, Zebrafish, Recombinant (His)

Cat.No: TMPH-03743

Species: Danio rerio (Zebrafish)

Expression System: E. coli

TRAF5 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02209

Species: Human

Expression System: E. coli

TRAF6 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02210

Species: Human

Expression System: E. coli

VEGF165 Protein, Danio rerio (zebrafish), Recombinant

Cat.No: TMPY-03080

Species: Danio rerio (zebrafish)

Expression System: Baculovirus Insect Cells

TRAF3 Protein, Human, Recombinant (His)

Cat.No: TMPH-02207

Species: Human

Expression System: E. coli

BMP-2 Protein, Danio rerio (zebrafish), Recombinant

Cat.No: TMPY-03297

Species: Danio rerio (zebrafish)

Expression System: E. coli

RKIP/PEBP1 Protein, Human, Recombinant

Cat.No: TMPY-00146

Species: Human

Expression System: E. coli

YES1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04411

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T12976	Sorafenib-d4 Sorafenib (D4),Bay 43-9006 (D4)	Others	Others
	Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC50s of 6 nM, 20 nM, and 22 nM, respectively).
TMIJ-0124	Regorafenib-13C-d3
	Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂，对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。
TMIJ-0125	Regorafenib-13C-d3 N-Oxide
	Regorafenib-13C-d3 N-Oxide 是 Regorafenib N-Oxide 的 13C 和氘代化合物。Regorafenib N-Oxide 的 CAS 号为 835621-11-9。Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂，包括VEGFR1/2/3，PDGFRβ，Kit，RET 和 Raf-1 ， IC50分别是 13/4.2/46，22，7，1.5 和 2.5 nM。
T38755	Rafoxanide 13C6 雷复尼特13C6
	Rafoxanide 13C6 is a labeled Rafoxanide . Rafoxanide is a salicylanilide used as an antiparasitic agent.
T12698	Regorafenib-d3 Regorafenib D3,BAY 73-4506 D3	Others	Others
	Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.
TMIJ-0037	Sarafloxacin-d8 Hydrochloride
	Sarafloxacin-d8 Hydrochloride 是 Sarafloxacin Hydrochloride 的氘代化合物。Sarafloxacin Hydrochloride 的 CAS 号为 91296-87-6。Sarafloxacin hydrochloride是一种抗菌化合物。
T16909	Donafenib Sorafenib (D3),Bay 43-9006 (D3),Sorafenib-d3	Raf; VEGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	Donafenib (Bay 43-9006 (D3)) 是一种氘标记的 Sorafenib，Sorafenib 是一种多激酶抑制剂(对 Raf-1、B-Raf 和 VEGFR-3 的 IC50 分别为 6 nM、20 nM 和 22 nM)。

同位素标记化合物

Cat.No: T12976

Synonym: Sorafenib (D4),Bay 43-9006 (D4)

Target: Others

Regorafenib-13C-d3

Cat.No: TMIJ-0124

Regorafenib-13C-d3 N-Oxide

Cat.No: TMIJ-0125

Rafoxanide 13C6

Cat.No: T38755

Synonym: 雷复尼特13C6

Cat.No: T12698

Synonym: Regorafenib D3,BAY 73-4506 D3

Target: Others

Sarafloxacin-d8 Hydrochloride

Cat.No: TMIJ-0037

Cat.No: T16909

Synonym: Sorafenib (D3),Bay 43-9006 (D3),Sorafenib-d3

Target: Raf, VEGFR

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