首页工具

登录

搜索结果

Search Results for " rsl3 "

Targets Recommended: Ferroptosis GPX Glutathione Peroxidase

11

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T3646	RSL3 RSL3 1S,1S,3R-RSL3	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	RSL3 (RSL3 1S) 是一种 GPX4 的抑制剂，抑制阻断 GSH 合成的 system xc- (IC50=100 nM)。RSL3 是一种不依赖 VDAC 的铁死亡激活剂，对携带致癌 RAS 的肿瘤细胞具有选择性。
T41203	1R,3R-RSL3 1R,3R-RSL3	Others	Others
	1R,3R-RSL3 is a negative control for1S, 3R-RSL3.
T11631	iFSP1	Ferroptosis	Apoptosis
	iFSP1 是一种强效、选择性和谷胱甘肽独立的铁死亡抑制蛋白 1 (FSP1) (AIFM2) 抑制剂，具有EC50 为 103 nM。它能够使多种人类癌细胞系对铁死亡诱导剂敏感，例如 (1S,3R)-RSL3。它在过表达 FSP1 的 GPX4 敲除细胞中选择性地诱导铁死亡。
T2376	Liproxstatin-1	Ferroptosis	Apoptosis
	Liproxstatin-1 是一种铁死亡抑制剂 (IC50=22 nM)，具有强效性和选择性。Liproxstatin-1 可以保护细胞免受铁死亡诱导剂 (如 Erastin、RSL3) 诱导的铁死亡。
T84370	(R)-HTS-3	Acyltransferase	Metabolism
	(R)-HTS-3 是一种溶血磷脂酰胆碱酰基转移酶3 (LPCAT3) 抑制剂，可重塑人体细胞的多不饱和磷脂含量，降低了 RSL3 诱导的癌细胞发生铁死亡现象。
T79294	NC-R17	Glutathione Peroxidase	Metabolism
	NC-R17是一种衍生自RSL3的非共价GPX4降解剂，涉及铁死亡(Ferroptosis)过程。该化合物展现出抗肿瘤活性，用于非共价GPX4 PROTAC的设计。
T82408	Ferroptosis-IN-3	Ferroptosis	Apoptosis
	Ferroptosis-IN-3（Compound 25）是一款抑制RSL3引起的铁死亡（HT-1080细胞中EC50为8.6nM）的铁死亡抑制剂。此外，Ferroptosis-IN-3能有效清除DPPH和ABTS自由基（EC50分别为3.94μM与6.3μM），并且能降低脂质过氧化水平。
T83780	GPX4 24 Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24	Others	Others
	GPX4 24是(1S,3R)-RSL3的衍生物，具有抑制谷胱甘肽过氧化物酶4（GPX4）的作用。它能够在浓度依赖的方式中与4T1小鼠乳腺癌细胞中的GPX4形成共价结合。在GPX4依赖的HT-1080成纤维细胞中，GPX4 24诱导铁死亡（EC50 = 0.16 µM）。当以200 mg/kg剂量给予小鼠时，它能够增加小鼠肾脏和血浆中丙二醛（MDA）的水平。
T36516	RC574 RC574	Others	Others
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T37487	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE	Others	Others
	1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
T36515	RC363	Others	Others
	RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT2...

化合物

Cat.No: T3646

Synonym: RSL3 1S,1S,3R-RSL3

Target: Ferroptosis, GPX, Glutathione Peroxidase

Cat.No: T41203

Synonym: 1R,3R-RSL3

Target: Others

Cat.No: T11631

Target: Ferroptosis

Cat.No: T2376

Target: Ferroptosis

Cat.No: T84370

Target: Acyltransferase

Cat.No: T79294

Target: Glutathione Peroxidase

Ferroptosis-IN-3

Cat.No: T82408

Target: Ferroptosis

Cat.No: T83780

Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

Target: Others

Cat.No: T36516

Synonym: RC574

Target: Others

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE

Cat.No: T37487

Target: Others

Cat.No: T36515

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1983	Neoisoastilbin	IL Receptor; TNF; NO Synthase	Apoptosis; Immunology/Inflammation
	Neoisoastilbin 具有抗炎、抗氧化、抗尿酸过多等生物特性。
T5262	trans-3-Indoleacrylic acid (E)-3-吲哚丙烯酸,反式-3-吲哚丙烯酸,trans-IAA	Others; Ferroptosis; Endogenous Metabolite	Apoptosis; Metabolism; Others
	trans-3-Indoleacrylic acid 是内源性代谢产物的一种，抑制RSL3 诱导的铁死亡，可用于研究结直肠癌。

天然产物

Cat.No: TN1983

Target: IL Receptor, TNF, NO Synthase

trans-3-Indoleacrylic acid

Cat.No: T5262

Synonym: (E)-3-吲哚丙烯酸,反式-3-吲哚丙烯酸,trans-IAA

Target: Others, Ferroptosis, Endogenous Metabolite

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼