首页工具

登录

搜索结果

Search Results for " rock "

Targets Recommended: ROCK ROCK

92

抑制剂 & 化合物

4

天然产物

1

化合物库

3

重组蛋白

2

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

神经再生化合物库

Cat.No: L7700

Compounds: 524

Cat. No.	Product Name	Target	Signaling Pathways
T12746	ROCK inhibitor-2	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK inhibitor-2 是一种 ROCK1和 ROCK2的选择性双重抑制剂，IC50值分别为 17 nM 和2 nM。
T67748	ROCK-IN-5	ROCK; ERK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Stem Cells
	ROCK-IN-5（化合物I-B-37）是一种有效的蛋白激酶抑制剂，包括ROCK、ERK、GSK 和AGC。ROCK-IN-5在心脏病、增殖性疾病和神经退行性疾病研究方面具有潜力。
TQ0110	ROCK-IN-2 TC-S 7001,Azaindole 1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-2 (Azaindole 1) 是一种选择性，ATP-竞争型的ROCK 抑制剂，对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。
T24725	ROCK-IN-D3 ROCK inhibitor D3,ROCK-inhibitor-D3	Others	Others
	ROCK-IN-D3 is an effective and selective inhibitor of ROCK.
T4095	ZINC00881524 ROCK inhibitor	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ZINC00881524 (ROCK inhibitor)是一种特异性有效 ROCK 抑制剂。
T24723	ROCK-IN-D1 ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1	Others	Others
	ROCK-IN-D1 is an effective and selective inhibitor of ROCK.
T24722	ROCK-IN-32 ROCK-inhibitor-32,ROCK inhibitor 32	Others	Others
	ROCK-IN-32 is an effective Rho-kinase inhibitor.
T24724	ROCK-IN-D2 ROCK inhibitor D2,ROCK IN D2,ROCK-inhibitor-D2	Others	Others
	ROCK-IN-D2 is an effective and selective inhibitor of ROCK.
T6867	Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Belumosudil (Rezurock) 是一种选择性的ROCK2抑制剂，对 ROCK1 和 ROCK2 的IC50值分别为 24 µM 和 105 nM，具有抗纤维化作用。
T12747	ROCK2-IN-2	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-2 是 ROCK2 的特异性抑制剂（IC50 <1 μM）。
T13419	ROCK-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-1 是一种高效的 ROCK 抑制剂，对 ROCK2 介导的信号传导有抑制作用，IC50 值为 1.2 nM。ROCK-IN-1 可用于研究神经系统疾病和炎症相关疾病。
T79809	ROCK-IN-8	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-8 (Example 4) 是ROCK抑制剂，IC50值不足100 nM，并显示出抗炎活性，适用于呼吸系统和胃肠道疾病的研究。
T79077	ROCK-IN-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-6为一有效的ROCK2抑制剂，其IC50值为2.19 nM。该化合物具备用于研究青光眼及视网膜疾病的潜力。
T79905	Akt/ROCK-IN-1	ROCK; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Akt/ROCK-IN-1 (B12) 是Akt和ROCK的双重抑制剂，IC50值分别为0.023 nM和1.47 nM。该化合物对神经母细胞瘤表现出抗肿瘤活性。
T79080	ROCK-IN-7	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-7（compound 9）作为ROCK激酶抑制剂，主要应用于眼部疾病（包括青光眼及视网膜疾病）的研究领域。
T63637	ROCK-IN-4	Others	Others
	ROCK-IN-4 是 ROCK 的有效抑制剂，可维持 NO 释放能力。ROCK-IN-4 能够可逆地解聚 F-肌动蛋白，并阻碍人小梁网 (HTM) 细胞的线粒体呼吸。ROCK-IN-4 能够用于研究青光眼或高眼压。
T84502	ROCK-IN-10	Others	Others
	ROCK-IN-10 (compound 50)，一种高效的ROCK抑制剂，其对ROCK1和ROCK2的IC50值为6 nM和4 nM，对其他激酶的选择性超过100倍。
T79833	ROCK-IN-9	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK-IN-9（Compound T345）为ROCK抑制剂。该化合物在HepG2细胞中表现出IC50为40.8 μM的细胞毒性。在小鼠模型中，ROCK-IN-9展现了良好的药代动力学特性，即使在低剂量下也能获得较高的体内暴露水平及口服生物利用度。
T70937	ROCK-IN-(R)14f	Others	Others
	ROCK-IN-(R)14f is a potent ROCK inhibitor.
T9797	ROCK2-IN-10	Others	Others
	Benzenamine, 2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)- 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T9797，CAS号为 1072906-07-0。
T2011	RKI1313 RKI 1313,RKI-1313	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI1313 (RKI-1313) 是一种选择性抑制剂，可抑制 ROCK 依赖性信号传导、细胞骨架变化、不依赖锚定的集落形成、迁移和侵袭。
T2155	Thiazovivin	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Thiazovivin 是一种ROCK 抑制剂，能提高 iPSC 的生成效率，对人胚胎干细胞具有保护作用。
T7301	BDP5290	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	BDP5290 是一种有效 ROCK 和 MRCK 抑制剂，对 ROCK1、ROCK2、MRCKα 和 MRCKβ 的 IC50 分别为 5、50 、10 和 100 nM。
T7391	SAR407899	ROCK; Rho	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	SAR407899 是一种选择性的 ATP 竞争性ROCK 抑制剂，对ROCK-2的IC50值为 135 nM，对人和大鼠ROCK-2的Ki 值分别为 36 和 41 nM。它是 Rho 激酶抑制剂，有效抑制 endothelin-1 诱导的肾阻力动脉收缩。
T3513	GSK180736A GSK180736	ROCK; GRK; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells; Tyrosine Kinase/Adaptors
	GSK180736A 是 Rho 相关卷曲螺旋激酶 1 (ROCK1) 抑制剂，IC50值为 100 nM。它也是选择性的ATP-竞争性 G 蛋白偶联受体激酶 2 抑制剂，IC50值为 0.77 μM，其选择性比其他 GRK 高 100 倍以上。
T15798	LX7101	ROCK; LIM Kinase; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
	LX7101是 LIMK 和ROCK2高效抑制剂，对LIMK1/2、ROCK、PKA 的IC50分别为24、1.6、10 和小于1 nM。
T14989	CMPD101	ROCK; GRK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	CMPD101 是膜透性的 GRK2/3高选择性小分子抑制剂，IC50分别为 18 nM 和 5.4 nM。它针对 GRK1、GRK5 ROCK-2 和 PKCα 的选择性较小，IC50值分别为 3.1 μM，2.3 μM，1.4 μM 和 8.1 μM，可研究心衰疾病。
T1870	Y-27632	ROCK; Apoptosis	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-27632 是一种 ROCK-I 和 ROCK-II 抑制剂，具有口服有效性、ATP 竞争性。Y-27632 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。
T14960	Chroman 1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Chroman 1 是高效的的ROCK 选择性抑制剂，对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK 也有抑制作用，IC50为 150 nM。
T2633	GSK429286A RHO-15	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	GSK429286A (RHO-15) 是一种选择性ROCK1/2抑制剂，IC50值为14 和 63 nM。
T7885	Afuresertib hydrochloride	ROCK; Akt; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Afuresertib hydrochloride 是一个口服有效的，ATP 竞争性的选择性泛Akt 抑制剂，作用于Akt1、Akt2和Akt3，Ki 值分别为 0.08、2和 2.6 nM。
TQ0187	SR-3677	ROCK; Autophagy	Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	SR-3677 是一种有效且特异性的 ROCK2 抑制剂，IC50值为3 nM。
T1898	RKI-1447 RKI1447	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI-1447 是一种高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5和6.2 nM。
T4488	GSK-25 GSK25	ROCK; S6 Kinase; mTOR	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-25 是一种选择性的，具有口服活性的 ROCK1抑制剂。它对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性，RSK1的 IC50 为 398 nM，p70S6K 的 IC50 为 1000nM。它可抑制 P450，对 CYP2C9、CYP2D6和 CYP3A4的 IC50分别为2.5、5.2和2.5 μM。
T70935	Phenoxan	Others	Others
	Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase.
T7648	HA-100	Myosin; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	HA-100 是蛋白激酶和ROCK 抑制剂，抑制PKG，PKA，PKC 和MLC 激酶的IC50值分别为 4、8、12 和 240 μM。
T13384L	Y-33075 dihydrochloride	CaMK; ROCK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Neuroscience; Stem Cells
	Y-33075 dihydrochloride 是一种选择性ROCK 抑制剂，IC50为 3.6 nM。
T23308	SAR407899 hydrochloride 6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	SAR407899 hydrochloride 是一种选择性，ATP 竞争性的ROCK 抑制剂，对人和大鼠ROCK2的Ki 值分别为 36 和 41 nM，对ROCK2的IC50值为 135 nM。
T2482	AT13148	ROCK; SGK; Akt; PKA; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AT13148 是一种 ATP 竞争性 AGC 激酶口服抑制剂，能够抑制 Akt1/Akt2/Akt3、p70S6K、PKA 和 ROCKI/ROCKII 的活性，IC50值分别为 38/402/50、8、3 和 6 nM/4 nM。
T7764	CCG-222740	ROCK; Rho; Ras	Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells
	CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂，可减少皮肤纤维化并阻止黑色素瘤转移。
T4276L	Hydroxyfasudil Hydroxy-Fasudil,HA-1100,羟基法舒地尔	ROCK; PKA	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Hydroxyfasudil (Hydroxy-Fasudil) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50分别为 0.73 和 0.72 μM。
T1911	Afuresertib GSK2110183C,GSK2110183	ROCK; Akt; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Afuresertib (GSK2110183) 是一个选择性，ATP 竞争性，口服有效的泛 Akt 抑制剂，作用于 Akt1、Akt2和 Akt3，Ki 值分别为 0.08、2、2.6 nM。
T78205	ROCK2-IN-6 hydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。
T79832	ROCK2-IN-6	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-6 (Comp A) 是一種选择性针对ROCK2的抑制剂，适用于研究ROCK介导的病症、自身免疫性疾病以及炎症。
T3518	GSK269962A GSK269962B,GSK 269962,GSK269962A HCl	ROCK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	GSK269962A (GSK269962A HCl) 是一种有效的ROCK 抑制剂，具有抗炎和血管舒张作用。它作用于重组人ROCK1和ROCK2，IC50分别为 1.6 和 4 nM。
T73117	ROCK2-IN-5	Others	Others
	ROCK2-IN-5是一种复合型化合物，融合了Rho激酶抑制剂fasudil以及NRF2诱导剂咖啡酸和阿魏酸的结构元素。该化合物展示了优秀的多靶点作用特性和较高的耐受性。ROCK2-IN-5在针对SOD1基因变异型ALS研究中具备应用潜力。
T81261	ROCK2-IN-7	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	ROCK2-IN-7是针对ROCK2的激酶抑制剂，能够抑制ROCK2/pSTAT3信号通路。该化合物在治疗银屑病模型中有着明显效果，通过抑制全身免疫激活，从而减轻炎症。
T4276	Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,羟基法舒地尔盐酸盐,RHO-激酶抑制剂,HA 1100 hydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) 是一种ROCK 抑制剂，对ROCK1和ROCK2的IC50值分别为 0.73 和 0.72 μM。
T1725	Y-27632 dihydrochloride 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl	ROCK; Apoptosis	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂，具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。
T7552	H-1152	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	H-1152 是一种膜通透的选择性ROCK 抑制剂，Ki 为 1.6 nM，对ROCK2的IC50为 12 nM。

化合物

ROCK inhibitor-2

Cat.No: T12746

Target: ROCK

Cat.No: T67748

Target: ROCK, ERK

Cat.No: TQ0110

Synonym: TC-S 7001,Azaindole 1

Target: ROCK

Cat.No: T24725

Synonym: ROCK inhibitor D3,ROCK-inhibitor-D3

Target: Others

Cat.No: T4095

Synonym: ROCK inhibitor

Target: ROCK

Cat.No: T24723

Synonym: ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1

Target: Others

Cat.No: T24722

Synonym: ROCK-inhibitor-32,ROCK inhibitor 32

Target: Others

Cat.No: T24724

Synonym: ROCK inhibitor D2,ROCK IN D2,ROCK-inhibitor-D2

Target: Others

Cat.No: T6867

Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119

Target: ROCK

Cat.No: T12747

Target: ROCK

Cat.No: T13419

Target: ROCK

Cat.No: T79809

Target: ROCK

Cat.No: T79077

Target: ROCK

Akt/ROCK-IN-1

Cat.No: T79905

Target: ROCK, ADC Cytotoxin

Cat.No: T79080

Target: ROCK

Cat.No: T63637

Target: Others

Cat.No: T84502

Target: Others

Cat.No: T79833

Target: ROCK

ROCK-IN-(R)14f

Cat.No: T70937

Target: Others

Cat.No: T9797

Target: Others

Cat.No: T2011

Synonym: RKI 1313,RKI-1313

Target: ROCK

Cat.No: T2155

Target: ROCK

Cat.No: T7301

Target: ROCK

Cat.No: T7391

Target: ROCK, Rho

Cat.No: T3513

Synonym: GSK180736

Target: ROCK, GRK, PKA

Cat.No: T15798

Target: ROCK, LIM Kinase, PKA

Cat.No: T14989

Target: ROCK, GRK, PKC

Cat.No: T1870

Target: ROCK, Apoptosis

Cat.No: T14960

Target: ROCK

Cat.No: T2633

Synonym: RHO-15

Target: ROCK

Afuresertib hydrochloride

Cat.No: T7885

Target: ROCK, Akt, PKC

Cat.No: TQ0187

Target: ROCK, Autophagy

Cat.No: T1898

Synonym: RKI1447

Target: ROCK

Cat.No: T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

Cat.No: T70935

Target: Others

Cat.No: T7648

Target: Myosin, PKA, PKC

Y-33075 dihydrochloride

Cat.No: T13384L

Target: CaMK, ROCK, PKC

SAR407899 hydrochloride

Cat.No: T23308

Synonym: 6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐

Target: ROCK

Cat.No: T2482

Target: ROCK, SGK, Akt, PKA, S6 Kinase

Cat.No: T7764

Target: ROCK, Rho, Ras

Cat.No: T4276L

Synonym: Hydroxy-Fasudil,HA-1100,羟基法舒地尔

Target: ROCK, PKA

Cat.No: T1911

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

ROCK2-IN-6 hydrochloride

Cat.No: T78205

Target: ROCK

Cat.No: T79832

Target: ROCK

Cat.No: T3518

Synonym: GSK269962B,GSK 269962,GSK269962A HCl

Target: ROCK, S6 Kinase

Cat.No: T73117

Target: Others

Cat.No: T81261

Target: ROCK

Hydroxyfasudil Hydrochloride

Cat.No: T4276

Synonym: Hydroxyfasudil (HA-1100) HCl,羟基法舒地尔盐酸盐,RHO-激酶抑制剂,HA 1100 hydrochloride

Target: ROCK

Y-27632 dihydrochloride

Cat.No: T1725

Synonym: 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl

Target: ROCK, Apoptosis

Cat.No: T7552

Target: ROCK

Cat. No.	Product Name	Target	Signaling Pathways
TQ0183	Narciclasine 水仙环素,Lycoricidinol	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Narciclasine (Lycoricidinol) 是一种植物生长调节剂。它通过调节Rho/Rho 激酶/LIM 激酶/cofilin 信号传导途径，大大增加GTP 酶RhoA 活性以及以RhoA 依赖性方式诱导肌动蛋白应力纤维形成。
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
TN1533	Cucurbitacin A	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

天然产物

Cat.No: TQ0183

Synonym: 水仙环素,Lycoricidinol

Target: ROCK

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: TN1533

Target: ROCK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03265	CMKLR2 Protein, Rat, Recombinant (His) Chemerin chemokine-like receptor 2,Gpr1,Chemokine-like recep...	Rat	E. coli
	Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway.
TMPH-01805	ODAM Protein, Human, Recombinant (His) ODAM,Apin,Odontogenic ameloblast-associated protein	Human	E. coli
	Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. ODAM Protein, Human, Recombinant (His) is expressed in E. col...
TMPH-02697	GNA12 Protein, Mouse, Recombinant (His & Myc) Guanine nucleotide-binding protein subunit alpha-12,Gna12	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by ac...

重组蛋白

CMKLR2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03265

Species: Rat

Expression System: E. coli

ODAM Protein, Human, Recombinant (His)

Cat.No: TMPH-01805

Species: Human

Expression System: E. coli

GNA12 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02697

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0428	Pentanoic-d9 Acid
	Pentanoic-d9 Acid 是 Pentanoic Acid 的氘代化合物。Pentanoic Acid 的 CAS 号为 109-52-4。Valeric acid 是存在于缬草的一种短链脂肪酸，也是细菌代谢产物，能够激活ROCK信号通路，可研究过敏性皮肤病。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Pentanoic-d9 Acid

Cat.No: TMIJ-0428

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼