40
3
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8591 |
RNase L-IN-2
5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one |
Others | Others |
RNase L-IN-2 是 RNase L 的激活剂,EC50 为 22 uM;对多种类型的 RNA 病毒(包括人类病原体人类副流感病毒 3 型)具有广谱抗病毒活性,在有效浓度下没有细胞毒性。 | |||
T78345 |
Ribonuclease A
EC 3.1.27.5,RNase A |
||
Ribonuclease A (RNase A) 是一种有效的内切核糖核酸酶 ,可在dna和蛋白质的制备过程中去除RNA。 | |||
T79488 |
RNase L-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RNase L-IN-1(compound 17a)为RNase L的特异性抑制剂,能有效地防止该酶降解RNA,从而抑制病毒复制,并对先天性免疫反应及炎症过程具调控作用。 | |||
T2096 |
Framycetin sulfate
Neomycin Sulphate B,硫酸新霉素B,Framycetin sulphate |
Antibacterial; Antibiotic | Microbiology/Virology |
Framycetin sulfate (Neomycin Sulphate B) 是一种氨基糖苷类抗生素,是 RNase P 裂解活性抑制剂,Ki 为 35 μM。它抑制锤头状核酶,Ki 值为 13.5 μM,可用于肝性脑病和肠致病性大肠杆菌感染的研究。 | |||
TMAZ-0365A6 |
Anti-RNASE3 Monoclonal Antibody-AF647
|
||
Anti-RNASE3 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-AF647 can be used FACS. | |||
TMAZ-0365A |
Anti-RNASE3 Monoclonal Antibody-APC
|
||
Anti-RNASE3 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-APC can be used FACS. | |||
TMAZ-0365B |
Anti-RNASE3 Monoclonal Antibody-Biotin
|
||
Anti-RNASE3 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-Biotin can be used FACS. | |||
TMAZ-0365P |
Anti-RNASE3 Monoclonal Antibody-PE
|
||
Anti-RNASE3 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-PE can be used FACS. | |||
TMAZ-0365A5 |
Anti-RNASE3 Monoclonal Antibody-AF555
|
||
Anti-RNASE3 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-AF555 can be used FACS. | |||
TMAZ-0365A4 |
Anti-RNASE3 Monoclonal Antibody-AF488
|
||
Anti-RNASE3 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting RNASE3. Anti-RNASE3 Monoclonal Antibody-AF488 can be used FACS. | |||
TMAZ-0268A6 |
Anti-RNASET2 Monoclonal Antibody-AF647
|
||
Anti-RNASET2 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-AF647 can be used FACS. | |||
TMAZ-0268A5 |
Anti-RNASET2 Monoclonal Antibody-AF555
|
||
Anti-RNASET2 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-AF555 can be used FACS. | |||
TMAZ-0268A |
Anti-RNASET2 Monoclonal Antibody-APC
|
||
Anti-RNASET2 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-APC can be used FACS. | |||
TMAZ-0268B |
Anti-RNASET2 Monoclonal Antibody-Biotin
|
||
Anti-RNASET2 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-Biotin can be used FACS. | |||
TMAZ-0268A4 |
Anti-RNASET2 Monoclonal Antibody-AF488
|
||
Anti-RNASET2 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-AF488 can be used FACS. | |||
TMAZ-0268P |
Anti-RNASET2 Monoclonal Antibody-PE
|
||
Anti-RNASET2 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting RNASET2. Anti-RNASET2 Monoclonal Antibody-PE can be used FACS. | |||
T6363 |
4μ8C
IRE1 Inhibitor III |
IRE1 | Cell Cycle/Checkpoint |
4μ8C (IRE1 Inhibitor III) 是一种有效且特异性的 IRE1α 抑制剂。 | |||
T15594 |
MKC8866
|
IRE1 | Cell Cycle/Checkpoint |
MKC8866 是一种选择性IRE1 RNase 抑制剂,在体外的IC50为 0.29 μM,是水杨醛类似物。 它抑制乳腺癌细胞中的 IRE1 RNase,导致促肿瘤因子的产生减少,并且可以抑制前列腺癌 (PCa) 肿瘤的生长。它强烈抑制二硫苏糖醇诱导的 XBP1s 表达,EC50为 0.52 μM。 | |||
T11762L |
Kira8
AMG-18 |
IRE1 | Cell Cycle/Checkpoint |
Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂,可变构减弱 IRE1α RNase 活性,IC50为 5.9 nM。 | |||
T14847 |
B I09
|
Others; IRE1 | Cell Cycle/Checkpoint; Others |
B I09是一种 IRE-1 RNase 抑制剂,IC50为1230 nM,对人 WaC3细胞中 XBP1 mRNA 的剪接和 LPS 刺激的 B 细胞中 xbp -1的表达有抑制作用。B I09可用于 CLL 细胞模拟XBP-1缺陷的研究。 | |||
T11488 |
GSK2850163
|
IRE1 | Cell Cycle/Checkpoint |
GSK2850163 是新型的肌醇需要酶-1α (IRE1α) 抑制剂,抑制 IRE1α 激酶活性的 IC50为 20nM,对 RNA 酶活性也有抑制活性,IC50为200 nM。 | |||
TQ0076 |
KIRA6
|
IRE1 | Cell Cycle/Checkpoint |
KIRA6 是一种 IRE1α RNase 激酶的有效抑制剂,IC50为0.6 µM。它可以触发细胞凋亡反应。 | |||
T3654 |
APY29
|
IRE1 | Cell Cycle/Checkpoint |
APY29 是 IRE1α 的变构调节剂;抑制 IRE1α 自磷酸化,IC50值为 280 nM,并激活 IRE1α RNase 活性。 | |||
T9564 |
IRE1α kinase-IN-1
|
IRE1 | Cell Cycle/Checkpoint |
IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM),对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化,并抑制 IRE1α RNase 活性 (IC50=80 nM)。 | |||
T65118 |
DEPC
Diethyl pyrocarbonate |
Others | Others |
DEPC (Diethyl pyrocarbonate) 是一种有效的、不可逆的含有组氨酸残基的 RNase 抑制剂。DEPC 可用碳氧基化修饰组氨酸残基从而导致酶失活,可用于防止RNA 酶降解RNA。DEPC 对兔子的中枢化学敏感性具有抑制作用。DEPC 可以修饰 His,Tyr,Ser 和 Thr 残基。 | |||
T0374 |
Sunitinib Malate
苏尼替尼苹果酸盐,Sutent,SU 11248 (Malate),SU 11248,Sunitinib |
Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
Sunitinib Malate (Sunitinib) 是一种基于吲哚酮的酪氨酸激酶抑制剂,抑制 VEGFR2和 PDGFRβ的 IC50分别为80 nM 和 2 nM。它是 ATP 竞争性抑制剂,可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制 Ire1α的磷酸化。 | |||
T11762 |
Kira8 Hydrochloride
AMG-18 Hydrochloride |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. | |||
T84372 |
G-9807
|
Others | Others |
G-9807 通过稳定活性二聚体单元,充当 RNase 的变构激活,显著提高 IRE1-KR-0P 的 RNase 活性。 | |||
T84373 |
G-1749
|
Others | Others |
G-1749 不改变 IRE 的单体-二聚体平衡,可刺激未磷酸化的 IRE1 (IRE1-0P) 的 RNase 活性,并抑制 IRE1-3P,显著提高 IRE1-KR-0P 的 RNase 活性。 | |||
T15664 |
KIRA-7
|
Others | Others |
KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity. | |||
T63591 |
HIV-1 inhibitor-45
|
Others | Others |
HIV-1 inhibitor-45 是 HIV-1 RNase H 的有效抑制剂 (IC50: 0.067 μM),具有抗病毒效果。 | |||
TP1803 |
S Tag Peptide
|
||
S Tag Peptide is a 15 amino acid peptide derived from RNase A. | |||
T62156 |
HIV-1 integrase inhibitor 9
|
Others | Others |
HIV-1 integrase inhibitor 9 (compound 8a) 是一种 HIV-1 RNase H 的有效抑制剂 (IC50: 12.3 μM),具有抗病毒作用。 | |||
T85002 |
Cytidine 3'-monophosphate
3'-CMP |
Others | Others |
Cytidine 3'-monophosphate, a ribonucleotide, results from the hydrolysis of cytidine 2’,3’-cyclic monophosphate via RNase—a process that cytidine 3'-monophosphate itself inhibits. Additionally, it can be dephosphorylated to cytidine by 3’-nucleotidase. | |||
T64183 |
PAIR2
|
Others | Others |
PAIR2 是一种有效和选择性的 IRE1α RNase 的部分拮抗剂。PAIR2 可以完全占据细胞中 IRE1α 的 ATP 结合位点,并阻断强效 KIRA 抑制 XBP1 剪接的能力。 | |||
T39498 |
Tofersen
BIIB067,ISIS-SOD1Rx |
Others | Others |
Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compound holds potential for amyotrophic lateral sclerosis (ALS) research. | |||
T73609 |
Ribonuclease T1
|
Others | Others |
Ribonuclease T1 (Rnase T1),常用于生化研究。Ribonuclease T1 是一种内切酶,可特异性降解单链 RNA。Ribonuclease T1 能够形成核苷 2′,3′-环磷酸中间体,以切割 3′-鸟苷残基与邻近核苷 5′-OH 基团之间的磷酸二酯键,产生 3′-GMP 末端寡核苷酸。 | |||
T62506 |
3,6-DMAD dihydrochloride
|
Others | Others |
3,6-DMAD dihydrochloride 是一种吖啶衍生物,是一种 IRE1α-XBP1s 通路的有效抑制剂。3,6-DMAD dihydrochloride 可以利用 IRE1α-XBP1s 通路,诱导 IL-6 分泌。3,6-DMAD dihydrochloride 对 IRE1α 寡聚化和核糖核酸内切酶 (RNase) 活性具有抑制作用。3,6-DMAD dihydrochloride 能够用于研究癌症。 | |||
T27768 |
L-696229
L696,229,L-696,229,L 696229,L696229,L 696,229 |
Others | Others |
L-696229 is a specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). L-696229 inhibited RT activity in a mutually exclusive manner with respect to either phosphonoformate or azidothymidine triphosphate and was a weak | |||
T78055 |
MYC-RIBOTAC
|
c-Myc | Cell Cycle/Checkpoint |
MYC-RIBOTAC 是一种针对MYC内部核糖体进入位点(IRES)的核糖核酸酶靶向降解剂(RIBOTAC)。该化合物结合了MYC mRNA的靶向组分以及一种可招募并激活RNA酶L1的小分子。通过降低MYC的mRNA和蛋白质表达水平,MYC-RIBOTAC诱导细胞发生凋亡,应用于抗肿瘤治疗的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6600 |
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside 是一种吡喃葡萄糖苷,对 HIV-2 RNase H 具有抑制作用,IC50 为 5.19 μM。 | |||
T81965 |
Laccaic acid C
|
||
Laccaic acid C,以8.1 μM的IC50有效抑制RNase H并能阻止病毒在细胞内的增殖。 | |||
TN5717 |
6'-O-Galloylsalidroside
|
Antiviral; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
6'-O-Galloylsalidroside 具有抗病毒活性,对HIV 具有抑制作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01258 |
RNASE6 Protein, Human, Recombinant (His)
RNS6,Ribonuclease K6,RNase K6,RNASE6 |
Human | HEK293 Cells |
Ribonuclease K6 (RNASE6) is a secreted protein that belongs to the pancreatic ribonuclease family. Human RNASE6 is synthesized as a 150 amino acid precursor that contains a 23 amino acid signal sequence, and a 127 amino acid mature chain. RNASE6 is expressed in many tissues, with high expression levels in the lung, with lower expression levels in the heart, placenta, kidney, pancreas, liver, brain, and skeletal muscle. It is also detected in monocytes and neutrophils. RNASE6 may have a role in h... | |||
TMPJ-00574 |
RNASE3 Protein, Human, Recombinant (His)
RNase 3,RNS3,ECP,Eosinophil Cationic Protein,RN... |
Human | HEK293 Cells |
Ribonuclease 3 (RNASE3) is a basic protein that is localized to the eosinophil primary matrix and belongs to the pancreatic ribonuclease family. RNASE3 is released during degranulation of eosinophils. RNASE3 possesses a wide variety of biological activities. RNASE3 interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). RNASE3 exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. It p... | |||
TMPH-01779 |
RNASE2 Protein, Human, Recombinant (His)
Ribonuclease US,Eosinophil-derived neurotoxin,Non-secretory ... |
Human | E. coli |
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. RNASE2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.5 kDa and the accession number is P10153. | |||
TMPH-00156 |
Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His)
Barnase,Ribonuclease,RNase Ba |
Bacillus amyloliquefaciens | E. coli |
Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates. Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 13.3 kDa and the accession number is P00648. | |||
TMPH-02506 |
ANG Protein, Mouse, Recombinant (His)
ANG,Angiogenin,Ribonuclease 5,RNase 5 |
Mouse | E. coli |
ANG Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.9 kDa and the accession number is P21570. | |||
TMPH-00934 |
ANG Protein, Human, Recombinant (His)
RNase 5,ANG,Angiogenin,Ribonuclease 5 |
Human | E. coli |
ANG Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00763 |
ANG Protein, Human, Recombinant
RNASE5,ANG,Angiogenin,Ribonuclease 5,血管生成素,RNas... |
Human | E. coli |
Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin... | |||
TMPY-03180 |
Ribonuclease A Protein, Human, Recombinant (His)
RNS1,ribonuclease, RNase A family, 1 (pancreatic),R... |
Human | HEK293 Cells |
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ... | |||
TMPH-00847 |
2-5A-dependent Rnase Protein, Human, Recombinant (Myc)
Ribonuclease L,RNASEL,Ribonuclease 4,2-5A-dependent... |
Human | E. coli |
2-5A-dependent Rnase Protein, Human, Recombinant (Myc) is expressed in E. coli expression system with C-Myc tag. The predicted molecular weight is 85.1 kDa and the accession number is Q05823. | |||
TMPY-02769 |
RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2 |
Human | Baculovirus Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPH-02046 |
Ribonuclease 7 Protein, Human, Recombinant (His)
RNASE7,Skin-derived antimicrobial protein 2,Ribonuc... |
Human | E. coli |
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. Ribonuclease 7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted... | |||
TMPH-03615 |
Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO)
rnj,Ribonuclease J |
Synechocystis | E. coli |
An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 86.4 kDa and the accession number is P54123. | |||
TMPH-00848 |
OASL Protein, Human, Recombinant (His)
59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid re... |
Human | E. coli |
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646. |