247
76
2
27
6
Cat. No. | Product Name | ||
---|---|---|---|
L8100 | 细胞周期化合物库 | 677 compounds | |
677 种细胞周期相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L5500 | 毒性化合物库 | 262 compounds | |
262 个细胞毒性化合物的特有集合,可用于高通量、高内涵筛选。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36757 |
DMT-dU-CE Phosphoramidite
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DMT-dU-CE Phosphoramidite 是一个核苷分子,通常用于合成 DNA 和 DNA 测序试验。 | |||
T14522 |
Beaucage reagent
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Beaucage reagent 可用于DNA切割。 | |||
T15611 |
JH-RE-06
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
JH-RE-06是一种REV1-REV7互作抑制剂,IC50为0.78 μM,Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1,可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。 | |||
TP1115 |
L-Asparaginase
L-ASNase |
Others | Others |
L-Asparaginase (L-ASNase) 是催化 L-天冬酰胺转化的水解酶,从血浆中去除 L-天冬酰胺,导致 RNA 和 DNA 合成抑制,随后引起细胞凋亡。它用于急性淋巴细胞白血病的研究。 | |||
T12019 |
Methylproamine
|
Others | Others |
Methylproamine是一种与DNA结合的辐射保护剂,可以修复辐射诱导的短暂活性氧。 | |||
T1349 |
5-Fluorouridine
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
5-Fluorouridine 是一种 5-fluorouracil 的代谢物,具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用,其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。 | |||
T6801 |
CeMMEC13
|
Carboxypeptidase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Proteases/Proteasome |
CeMMEC13 是一种异喹啉酮,可选择性抑制 TAF1 的第二个溴结构域,IC50为 2.1 μM。 | |||
T1154 |
Rifaximin
|
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Rifaximin 是一种胃肠道选择性抗生素,与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合,抑制细菌 RNA 合成。与革兰氏阴性菌(MIC:8-50 毫克/毫升)相比,它对革兰氏阳性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。 | |||
T8354 |
Triazavirin
|
Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Triazavirin 是一种核酸的核苷类似物和抗病毒剂,通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。在流感传播阶段,它可作为保护剂。 | |||
T8886 |
NITD-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NITD-2 是一种登革病毒 (DENV) 聚合酶抑制剂,可抑制 DENV RdRp 介导的 RNA 延伸。 | |||
T2037 |
TH588
|
DNA/RNA Synthesis; MTH1 | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TH588 是 nudix 水解酶家族抑制剂,可有效和选择性地参与和抑制细胞中的 MTH1,IC50值 5 nM。 | |||
T2100 |
CX-5461
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
CX5461 是一种口服有效的rRNA 合成抑制剂,可抑制 Pol I 驱动的 rRNA 转录。 | |||
T8955 |
PCNA-I1
|
Others | Others |
PCNA-I1 是PCNA(增殖细胞核抗原)抑制剂。它能够直接与 PCNA 三聚体结合(Kd:0.41 μM),在体内外均表现出抗肿瘤活性。 | |||
T1767 |
BMH-21
BMH21 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BMH-21 是一种小分子 DNA 嵌入剂,可结合核糖体 DNA 并抑制 RNA 聚合酶 I (Pol I) 转录,具有抗癌活性。 | |||
T14501 |
BAY-2402234
|
Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
BAY-2402234 是一种选择性二氢乳清酸脱氢酶的抑制剂,可研究骨髓恶性肿瘤。 | |||
T2410 |
Nedaplatin
奈达铂,NSC 375101D |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Nedaplatin (NSC-375101D) 是顺铂的衍生物,是肿瘤集落形成单位的 DNA 损伤剂,IC50为94 μM。 | |||
T36687 |
Ac-rC Phosphoramidite
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ac-rC Phosphoramidite 可以修饰二硫化磷酸寡核苷酸。 | |||
T40168 |
DHODH-IN-16
|
Dehydrogenase | Metabolism |
DHODH-IN-16 是一种有效的二氢乳清酸脱氢酶抑制剂(DHODH,IC50 = 0.396 nM)。 | |||
T1233 |
Oxolinic acid
Emyrenil,Nidantin,NSC 110364,恶喹酸,Dioxacin,Urinox |
Dopamine Receptor; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology; Neuroscience |
Oxolinic acid (Nidantin) 是一种抗生素,对革兰氏阴性菌和革兰氏阳性菌均有效,可研究急性和慢性尿路感染。它是一种 DNA/RNA 合成抑制剂,也是一种多巴胺摄取抑制剂,能刺激小鼠的活跃过度。 | |||
T36756 |
DMT-dG(ib) Phosphoramidite
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DMT-dG(ib) Phosphoramidite 可用于 DNA 的合成。 | |||
T13166 |
TK216
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
TK216 是一种口服有效的 E26 转录因子抑制剂,具有抗癌活性。它直接结合 EWS-FLI1 并抑制 EWS-FLI1 蛋白质相互作用,也可阻止 EWS-FLI1 与 RNA 解旋酶 A 的结合。 | |||
T15235 |
Enocitabine
|
Nucleoside Antimetabolite/Analog; HCV Protease; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Enocitabine 是一种核苷类似物,抑制 DNA 复制剂。Enocitabine 抑制人巨细胞病毒的复制,显示出抗白血病和抗病毒活性。 | |||
T8003 |
Methotrexate disodium
|
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate disodium 是一种叶酸类似物代谢抑制剂,具有免疫抑制剂和抗肿瘤特性,用于类风湿关节炎和研究多种癌症。 | |||
T8873 |
Bractoppin
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。 | |||
T35648 |
4-Thiouridine
|
Others | Others |
4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物,广泛用于RNA 分析。 | |||
T26674 |
AT-130
AT 130 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
AT-130 是一种苯基丙烯酰胺衍生物,是乙型肝炎病毒复制的非核苷抑制剂。它抑制病毒 DNA 的合成,EC50为 0.13 μM。 | |||
T7747 |
Datelliptium chloride hydrochloride
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Datelliptium chloride hydrochloride 是一种衍生自玫瑰树碱的 DNA 嵌入剂,具有抗肿瘤活性。 | |||
T12438 |
PfDHODH-IN-1
|
Dehydrogenase; Parasite | Metabolism; Microbiology/Virology |
PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物,具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。 | |||
T38237 |
2′-O-Methylcytidine
|
Nucleoside Antimetabolite/Analog; HCV Protease | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
2'-O-Methylcytidine 是 2'-代核苷,可抑制 HCV 复制。 它在体外抑制 NS5B 催化的 RNA 合成,其抑制方式是与底物核苷三磷酸竞争。 | |||
T16703 |
Quarfloxin
CX-3543 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Quarfloxin (CX-3543) 是一种氟喹诺酮衍生物,具有抗肿瘤活性,可靶向抑制RNA pol I 的活性,在神经母细胞瘤细胞中的 IC50 值在纳摩尔范围内。它破坏核糖体 DNA 模板中核仁蛋白和 G-四链体 DNA 结构之间的相互作用。 | |||
T13659 |
DMTr-LNA-5MeU-3-CED-phosphoramidite
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
DMTr-LNA-5MeU-3-CED-phosphoramidite 是核苷的衍生物。 | |||
T11020 |
DHODH-IN-11
|
Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
DHODH-IN-11 是一种来氟米特衍生物和弱二氢乳清酸脱氢酶 (DHODH) 抑制剂,pKa 为 5.03 | |||
T40661 |
ML-60218
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
ML-60218 是广谱 RNA pol III 抑制剂,对酿酒酵母和人类的 IC50 分别为 32 和 27 μM。 ML-60218 会破坏已组装的病毒质并阻碍新病毒质的形成。 | |||
T9103 |
BVDV-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
BVDV-IN-1 是一种牛病毒性腹泻病毒 (BVDV) 的非核苷抑制剂 (NNI),EC50 为 1.8 μM。它直接与 BVDV RdRp 的疏水口袋结合,对耐 NNI 氨基硫脲 (TSC) 的 BVDV 具有抗病毒活性。 | |||
T2069L |
TH287 hydrochloride
|
DNA/RNA Synthesis; MTH1 | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TH287 hydrochloride 是一种选择性MTH1抑制剂,IC50值为 0.8 nM。它可用于治疗癌症的研究。 | |||
T4345 |
CeMMEC1
CeMMEC1 HCl |
Epigenetic Reader Domain; Carboxypeptidase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
CeMMEC1 是一种 BRD4 抑制剂,对 TAF1 有很好的亲和力,IC50为0.9 μM。 | |||
T8747 |
Levofloxacin hydrochloride
|
DNA gyrase; Topoisomerase | DNA Damage/DNA Repair |
Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素,是氧氟沙星的光学活性 L-异构体,具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶(细菌拓扑异构酶 II)起作用,这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。 | |||
T9121 |
AG-636
|
Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
AG-636 是一种选择性可逆和具有口服活性的二氢乳清酸脱氢酶(DHODH)抑制剂,IC50 为 17 nM,具有很强的抗癌作用。 | |||
T3279 |
Silver sulfadiazine
Silvadene,磺胺嘧啶银,Dermazin,Flamazine |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素,具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用,可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构,阻止细菌 DNA 复制。 | |||
T6357 |
(S)-crizotinib
ent-crizotinib |
Apoptosis; DNA/RNA Synthesis; MTH1 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
(S)-crizotinib (ent-crizotinib) 是一种选择性MTH1(mutT 同源物)抑制剂,IC50为 330 nM。它通过抑制 MTH1 破坏核苷酸库的稳态,诱导 DNA 单链断裂的增加,激活人结肠癌细胞的 DNA 修复,在动物模型中抑制肿瘤生长。 | |||
T3489 |
Dasabuvir
ABT-333,达塞布韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂,是一种 RNA 依赖性 RNA 聚合酶,具有抗 HCV 的潜在活性。 | |||
T11546 |
hDHODH-IN-1
|
Dehydrogenase | Metabolism |
hDHODH-IN-1 是有效的人二氢乳清酸脱氢酶抑制剂, 显示出抗炎作用。 | |||
T2069 |
TH287
TH287 hydrochloride |
DNA/RNA Synthesis; MTH1 | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TH287 是一种选择性的MTH1抑制剂,对 MTH1 具有高度选择性,可用于治疗癌症的研究。 | |||
T12718L |
RG7800
RO6885247 |
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
RG7800 (RO6885247) 是一种 SMN2 拼接修饰剂,有用于治疗脊髓性肌萎缩的研究潜力。 | |||
T16961 |
Supinoxin
RX-5902 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂,是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长,IC50的范围为 10 nM 至 20 nM。 | |||
T27135 |
DDD85646
DDD 85646,DDD-85646 |
Parasite | Microbiology/Virology |
DDD85646 是 T. brucei N-myristoyltransferase 的抑制剂,Ki 为 1.44 nM,IC50 为 2 nM,EC50 为 2 nM。 hNMT 的 IC50 为 4 nM。 | |||
T40192 |
dGTP
2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate |
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
dGTP(2'-Deoxyguanosine-5'-triphosphate)作为脱氧核糖核酸(DNA)合成的基本单元,属于鸟苷核苷酸,对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。 | |||
T15793 |
Lurbinectedin
卢比克替定,PM01183 |
Others | Others |
Lurbinectedin (PM01183) 是一种 DNA 小沟共价粘合剂,可抑制 RMG1和 RMG2,IC50值分别为1.25和1.16 nM。它具有高效的抗肿瘤活性。 | |||
T4356 |
POL1-IN-1
Compound 3A |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂,IC50值低于 0.5 uM。 它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。 | |||
T0164 |
Oxaliplatin
L-OHP,奥沙利铂 |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Oxaliplatin (L-OHP) 是一种 DNA 烷化剂,一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤,阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13969 |
Xanthopterin (hydrate)
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Xanthopterin hydrate 是东方大黄蜂翅膀中黄色颗粒的主要成分,是一种非共轭的蝶啶天然产物,在 386/456 nm 处产生特征性的激发光。 它可抑制 RNA 合成,引起大鼠肾脏生长和肥大。 | |||
T40179 |
Sodium Camptothecin
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Sodium Camptothecin 是一种植物生物碱,具有抗肿瘤活性。它是可逆 RNA 合成抑制剂,可以抑制腺病毒的复制。它能抑制 DNA 合成,并引起细胞内预形成的病毒 DNA 断裂。 | |||
T7520 |
Deoxycytidine triphosphate
|
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Deoxycytidine triphosphate 是一种核苷三磷酸,是合成 DNA 的原料,可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。 | |||
T5270 |
5-Methylcytosine
|
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
5-Methylcytosine 是一种存在于真核 DNA 中的甲基化核苷酸碱基。它是由 DNA 甲基转移酶作用形成的表观遗传修饰。 | |||
T2S1635 |
3-Isomangostin
|
MTH1 | DNA Damage/DNA Repair |
3-Isomangostin 可从莽吉柿壳中提取的一种天然产物,是一种乙酰胆碱酯酶选择性抑制剂,也是一种有效的人醛糖还原酶抑制剂,IC50 为 3.48 uM。它抑制 MutT 同源物 1 (MTH1),IC50 为 52 nM。它具有清除自由基、抗疟原虫和抗癌的活性。 | |||
TN1134 |
Euscaphic acid
|
Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling |
Euscaphic acid 是来源于枣的一种三萜,是DNA 聚合酶抑制剂,可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。 | |||
T5901 |
3-Hydroxy-2-methylpyridine
|
Others | Others |
3-Hydroxy-2-methylpyridine 是分离自可可碱提取物,可用于合成嘧啶。 | |||
T21498 |
Phleomycin
|
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Phleomycin 是在链霉菌中发现的,引起 DNA 切割的抗癌糖肽抗生素之一。 它类似于博来霉素,它结合并插入 DNA 以破坏双螺旋的完整性。 | |||
T1068 |
Dithranol
1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin |
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Dithranol (cignoline) 是蒽醌衍生物,可破坏线粒体功能和结构,用于治疗皮肤病。 | |||
T37101 |
1-Hydroxyanthraquinone
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
1-Hydroxyanthraquinone 是口服有效的天然产物,来源于植物 Tabebuia avellanedae,显示出致癌活性。 | |||
T35455 |
N-Nitrosodiethylamine
Diethylnitrosamine,NDEA |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
N-Nitrosodiethylamine (NDEA) 是致癌物质二烷基硝胺。它主要存在于水、烟草烟雾、腌制食品、油炸食品以及许多酒精饮料中。它与 DNA 修复/复制相关的核酶的变化相关。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T6S0232 |
Eriodictyol
圣草酚,Huazhongilexone |
Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物,具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 18 nM。它可诱导Nrf2信号通路。 | |||
T6S0139 |
Neobavaisoflavone
|
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。 | |||
T1465 |
Mupirocin
Pseudomonic acid,莫匹罗星,BRL-4910A |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Mupirocin (BRL-4910A) 是从Pseudomonas fluorescens 中分离得到的一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA,并抑制细菌蛋白和RNA 的合成起抗菌作用。 | |||
T16674 |
Pseudouridine
|
Endogenous Metabolite | Metabolism |
Pseudouridine 是非编码 RNA 中丰富的修饰核苷,通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。 | |||
T4593 |
ISOPIMPINELLIN
5,8-Dimethoxypsoralen,异茴芹内酯,4,9-Dimethoxypsoralen |
Antiviral; DNA/RNA Synthesis; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology |
Isopimpinellin (4,9-Dimethoxypsoralen) 是从 Pimpinella saxifrage 根部分离得到的一种天然产物,具有抗病毒和抗利什曼病活性。 | |||
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
TN2132 |
Quinizarin
1,4-Dihydroxyanthraquinone,1,4-二羟基蒽醌 |
Others; DNA/RNA Synthesis; Antifungal | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Quinizarin (1,4-Dihydroxyanthraquinone) 是一种杀菌剂和杀虫剂,可抑制肿瘤细胞生长。 | |||
T2998 |
Dihydromyricetin
Ampelopsin,Ampeloptin,二氢杨梅素 |
Influenza Virus; GABA Receptor; DNA/RNA Synthesis; mTOR; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling |
Dihydromyricetin (Ampelopsin) 是一种来自 Ampelopsis Grossedentata 的天然抗氧化剂类黄酮,是二氢嘧啶酶抑制剂,IC50 为 48 μM。它通过抑制mTOR 信号从而激活自噬。它还是流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 22 μM。 | |||
T8148 |
Mupirocin calcium hydrate
莫匹罗星钙,Mupirocin calcium |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Mupirocin calcium hydrate 是从Pseudomonas fluorescens 中分离得到的,一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA,并抑制细菌蛋白和RNA 的合成起到抗菌作用。 | |||
T13791 |
N2-methylguanine
6-羟基-2-氨甲基嘌呤 |
DNA/RNA Synthesis; Endogenous Metabolite; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
N2-methylguanine (N2-methylguanine) 是一种在人体体液中发现的内源性甲基化核苷,是一种修饰的核苷。 | |||
TWP2911 |
Thymidine
beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin |
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
Thymidine (DThyd) 是一种细胞同步剂,是脱氧核糖核酸的特殊前体。它可在 DNA 复制前在 G1/S 边界阻滞细胞,是DNA 合成抑制因子。 | |||
T0064 |
Adenine
Vitamin B4,腺嘌呤,6-Aminopurine |
DNA/RNA Synthesis; Endogenous Metabolite; AChR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Neuroscience |
Adenine (6-Aminopurine) 是一种嘌呤衍生物,是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用,作为 DNA 和 RNA 的化学成分。 | |||
TN1097 |
β-Boswellic acid
Beta-boswellic acid,β-乳香酸 |
Lipoxygenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
β-Boswellic acid (Beta-boswellic acid) 是从乳香的树胶脂中分离出来的一种天然产物。它是 5-脂氧合酶(5-LO) 产物形成的非还原型抑制剂,其直接与 5-LO 相互作用或阻断其易位。具有抗癌、抗肿瘤和抗高血脂活性。 | |||
T20945 |
2,4-D
Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 | |||
T7004 |
Tubercidin
结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine |
Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素,抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂,并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。 | |||
T6116 |
Bleomycin Sulfate
Blenoxane,硫酸博来霉素,硫酸博莱霉素,NSC125066 |
DNA/RNA Synthesis; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Bleomycin Sulfate (Blenoxane) 是一种糖肽抗生素,一种 DNA 合成抑制剂。Bleomycin Sulfate 可以引起 DNA 链断裂而不引起 RNA 链断裂。Bleomycin Sulfate 具有抗肿瘤活性。 | |||
T3343 |
5-methoxyflavone
5-methoxy-2-phenylchromen-4-one,5-甲氧基黄酮 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
5-methoxyflavone (5-methoxy-2-phenylchromen-4-one) 是一种类黄酮,是DNA 聚合酶 β 的抑制剂和 β-淀粉样蛋白毒性的神经保护剂。它通过调控嗜离子 GABAA 受体,起到镇静中枢神经系统的作用。 | |||
T6758 |
Anisomycin
茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK; Microbiology/Virology |
Anisomycin (Flagecidin) 属于细菌抗生素,是一种蛋白合成抑制剂和一种 JNK 激活剂。Anisomycin 通过抑制肽基转移酶或 80S 核糖体系统来干扰蛋白质和 DNA 的合成。 | |||
T17143 |
Toyocamycin
丰加霉素,Vengicide |
Apoptosis; Others; IRE1; Antibiotic; Antifungal | Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others |
Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物,为 X 盒结合蛋白 1 (XBP1) 抑制剂,抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂,IC50值为 80 nM。它还诱导凋亡。 | |||
TN2111 |
Prunin
Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷 |
Phosphatase; Anti-infection; Virus Protease | Metabolism; Microbiology/Virology |
Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B,IC50值为 5.5 μM。 | |||
T7174 |
Urolithin A
尿石素A,3,8-二羟基-6H-二苯并[B,D]吡喃-6-酮 |
Apoptosis; Reactive Oxygen Species; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; Drug Metabolite | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB |
Urolithin A 是一种鞣花酸的肠道微生物代谢产物,可诱导自噬和凋亡,抑制细胞周期进程,抑制DNA 合成,具有抗炎、抗增殖和抗氧化的特性。 | |||
T6194 |
Fidaxomicin
非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101 |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂,具有窄谱活性。它选择性地根除致病性艰难梭菌,对构成正常健康肠道菌群的多种细菌影响很小。 | |||
T38427 |
dUTP trisodium
2'-Deoxyuridine-5'-triphosphate trisodium salt,Deoxyuridine triphosphate |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
dUTP trisodium (Deoxyuridine triphosphate) 是在 5'-位具有三磷酸基团的脱氧尿苷磷酸盐,可用于 PCR。 | |||
T6567 |
Levofloxacin
Levaquin,Cravit,Tavanic,Fluoroquinolone,左氧氟沙星,(-)-Ofloxacin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Levofloxacin (Fluoroquinolone) 是合成的氟喹诺酮类抗生素,有抑制细菌DNA 旋转酶的超螺旋活性的作用,能阻止DNA 复制。 | |||
T0062 |
Folic acid
Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folic acid (Vitamin B9) 是维生素B9,是合成DNA/RNA,新细胞产生和维持的必要成分。 | |||
T6225 |
Adenine hydrochloride
Adenine HCl,腺嘌呤盐酸盐,6-Aminopurine hydrochloride |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Adenine hydrochloride (6-Aminopurine hydrochloride) 是一种嘌呤,是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用,作为 DNA 和 RNA 的化学成分。 | |||
T40426 |
Cytidine 5'-diphosphate trisodium salt
CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐 |
Others | Others |
Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T6369 |
Adenine hemisulfate
硫酸腺嘌呤,Diadenine sulphate,Adenine sulfate,Adeninsulfat,1H-嘌呤-6-胺硫酸盐 |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Adenine hemisulfate (Diadenine sulphate) 是一种嘌呤,是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用,作为 DNA 和 RNA 的化学成分。 | |||
T1507 |
Streptozocin
STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889 |
DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Streptozocin (NSC-85998) 是一种抗生素,可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性,常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定,建议现配现用。 | |||
T1272 |
Cytarabine
阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Cytarabine (Ara-C) 是一种核苷类似物,一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶,诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。 | |||
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T4706 |
Uridine-5'-diphosphate disodium salt
UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd,尿苷-5'-二磷酸二钠盐 |
DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Uridine-5'-diphosphate disodium salt (UDP disodium salt) 是一种选择性 P2Y6受体激动剂,EC50为300 nM,对人 P2Y6受体的 pEC50为6.52。它可刺激炎症介质的产生、吞噬作用和血管收缩,催化多种底物的葡糖醛酸糖化反应,用于核酸生物合成。 | |||
T2A2537 |
Guanine
鸟嘌呤;2-氨基次黄嘌呤;2-氨基-6-羟基嘌呤;鸟便嘌呤;鸟粪素;海鸟粪碱;鸟粪环;亚氨基二氧化嘌呤,Pearl essence,Mearlmaid,鸟嘌呤,2-Aminohypoxanthine |
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
Guanine (2-Aminohypoxanthine) 是一种嘌呤碱基,是核酸中核苷酸的组成部分,由具有共轭双键的稠合嘧啶 - 咪唑环系统组成。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T3376 |
Cynaroside
朝蓟糖甙,Luteoloside,Luteolin 7-β-D-Glucopyranoside,Luteolin 7-O-Glucoside,Luteolin 7-O-β-D-glucoside,木犀草苷,Luteolin 7-glucoside |
Others; Influenza Virus; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Cynaroside (Luteolin 7-O-Glucoside) 是一个抗氧化类黄酮。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂,IC50为 32 nM。 | |||
T1511 |
Daunorubicin hydrochloride
Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin |
Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类化合物,一种拓扑异构酶 II (Topo II) 抑制剂。Daunorubicin hydrochloride 可以抑制 DNA 和 RNA 的合成,具有抗肿瘤活性。 | |||
T9086 |
Deoxythymidine-5'-triphosphate trisodium
dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一,用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05749 |
SARS-CoV-2 NSP8 Protein (Avi)
|
SARS-CoV-2 | E. coli |
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num... | |||
TMPY-05024 |
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His)
|
ZIKV | Baculovirus Insect Cells |
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase. | |||
TMPY-06416 |
SARS-CoV-2 NSP8 Protein
|
SARS-CoV-2 | E. coli |
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is... | |||
TMPH-02383 |
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)
Polymerase cofactor VP35,VP35,Marburg VP35 |
MARV | E. coli |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. | |||
TMPH-03055 |
Ribonuclease mitogillin Protein, Neosartorya fumigata, Recombinant (His & Myc & SUMO)
Major allergen Asp f 1,Allergen Asp f I,Ribonuclease mitogil... |
Neosartorya fumigata | E. coli |
This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. | |||
TMPH-03732 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
Polymerase cofactor VP35,Ebola VP35,VP35 |
ZEBOV | E. coli |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPH-00131 |
Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc)
Ribonuclease mitogillin,Restrictocin,ret |
Aspergillus restrictus | E. coli |
This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.9 kDa and the accession number is P67876. | |||
TMPH-03733 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
Polymerase cofactor VP35,VP35,Ebola VP35 |
ZEBOV | HEK293 Cells |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPH-01843 |
Human parainfluenza 4b virus (HPIV-4b) Nucleoprotein/NP Protein (His)
Nucleoprotein,Nucleocapsid protein,N |
HPIV-4b | E. coli |
Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. Human parainfluenza 4b virus (HPIV-4b) Nucleoprotein/NP Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 68.5 ... | |||
TMPH-03729 |
Zaire ebolavirus (strain Kikwit-95) VP30 Protein (His)
Transcriptional activator VP30,EbolaVP30,Minor nucleoprotein... |
ZEBOV | E. coli |
Multifunctional protein that acts as a viral transcriptional activator. Promotes read-through of an RNA hairpin in the NP open reading frame to enhance viral transcription. Mechanistically, nonphosphorylated VP30 hexamers form a ternary complex with the viral leader RNA. Clamps the RNA template and the complex VP35-polymerase L together, thereby increasing the polymerase affinity for the RNA template to increase transcription initiation despite the presence of RNA secondary structures. Assists a... | |||
TMPJ-01428 |
SARS-CoV-2 NSP8 Protein (His)
SARS-CoV 2 nsp8 |
SARS-CoV-2 | E. coli |
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependen... | |||
TMPH-01841 |
Human parainfluenza 1 virus (HPIV-1) Nucleoprotein/NP Protein (His)
Nucleoprotein,Nucleocapsid protein,N |
HPIV-1 | E. coli |
Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. Human parainfluenza 1 virus (HPIV-1) Nucleoprotein/NP Protein (His) is expressed in E. coli expression system with N-10xHis tag. T... | |||
TMPJ-01436 |
MKI67 Protein, Human, Recombinant (GST)
Ki-67,Antigen Ki67,MKI67,KIA,antigen KI-67,MIB-1,MIB-,Ki67,P... |
Human | E. coli |
MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferation. MKI67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, MKI67 qualifies as a cell proliferation marker. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition... | |||
TMPH-00729 |
RpoH Protein, E. coli, Recombinant (His & Myc)
RNA polymerase sigma-32 factor,Heat shock regulator... |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane... | |||
TMPH-03582 |
MazF Protein, S. epidermidis, Recombinant (His)
Endoribonuclease MazF,mRNA interferase MazF,mazF,To... |
Staphylococcus epidermidis | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.0 kDa and the acce... | |||
TMPH-00756 |
Capsid Protein, Escherichia phage MS2, Recombinant (His & Myc)
CP,Capsid protein,Coat protein |
Escherichia phage MS2 | E. coli |
Capsid protein self-assembles to form an icosahedral capsid with a T=3 symmetry, about 26 nm in diameter, and consisting of 89 capsid proteins dimers (178 capsid proteins). Involved in viral genome encapsidation through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome. The capsid contains also 1 copy of the A2 maturation protein.; Acts as a translational repressor of viral replicase synthesis late in infection. This latter function is th... | |||
TMPH-03565 |
MazF Protein, S. aureus, Recombinant (His)
Toxin MazF,mRNA interferase MazF,mazF,Endoribonucle... |
Staphylococcus aureus | E. coli |
Toxic component of a type II toxin-antitoxin (TA) system. Ribosome-independent, sequence-specific endoribonuclease that cleaves mRNA, thus inhibiting protein synthesis and inducing bacterial stasis. It cuts between the first and nucleotides of 5'-UACAU-3' in single-stranded RNA. Neutralized by coexpression with cognate antitoxin MazE. MazF Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.4 kDa and the accession... | |||
TMPH-00561 |
30S ribosomal protein S4 Protein, E. coli, Recombinant (His)
Small ribosomal subunit protein uS4,ramA,rpsD,30S ribosomal ... |
E. coli | E. coli |
One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).; Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity c... | |||
TMPH-01248 |
ADAR Protein, Human, Recombinant (His & SUMO)
ADAR1,IFI-4,136 kDa double-stranded RNA-binding pro... |
Human | E. coli |
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences duri... | |||
TMPJ-01007 |
HRSP12 Protein, Human, Recombinant (His)
p14.5,UK114 Antigen Homolog,Heat-Responsive Protein 12,Ribon... |
Human | E. coli |
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels ... | |||
TMPH-02396 |
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)
RING finger protein Z,Z,Zinc-binding protein |
LASV | E. coli |
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins in... | |||
TMPH-03289 |
EIF3I Protein, Rat, Recombinant (E. coli, His)
eIF3 p36,eIF3i,eIF-3-beta,Eukaryotic translation initiation ... |
Rat | E. coli |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPH-02349 |
Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)
Non-structural protein 1,NS,NS1A |
H1N1 | E. coli |
Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also ... | |||
TMPY-02402 |
WTAP Protein, Human, Recombinant (GST)
Mum2,Wilms tumor 1 associated protein |
Human | E. coli |
Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, ... | |||
TMPY-03105 |
Ki67/MKI67 Protein, Human, Recombinant (GST)
MIB-1,PPP1R105,marker of proliferation Ki-67,MIB-,KIA |
Human | E. coli |
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu... | |||
TMPH-03288 |
EIF3I Protein, Rat, Recombinant (His)
eIF3i,Eif3s2,eIF-3-beta,Eukaryotic translation initiation fa... |
Rat | Baculovirus Insect Cells |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPH-01689 |
PLD6 Protein, Human, Recombinant (His)
Mitochondrial phospholipase,Choline phosphatase 6,Protein zu... |
Human | E. coli |
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMID-0227 |
Rifabutin-d7
|
||
Rifabutin-d7 是 Rifabutin 的氘代化合物。Rifabutin 的 CAS 号为 72559-06-9。Rifabutin是半合成的安莎霉素抗生素,抑制 DNA 依赖性 RNA 聚合酶,有抗分枝杆菌作用。 | |||
TMID-0286 |
Rifaximin-d6
|
||
Rifaximin-d6 是 Rifaximin 的氘代化合物。Rifaximin 的 CAS 号为 80621-81-4。Rifaximin是一种胃肠道选择性抗生素,与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合,抑制细菌 RNA 合成。与革兰氏阴性菌(MIC:8-50 毫克/毫升)相比,它对革兰氏阳性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。 | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
||
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. | |||
TMID-0065 |
Adenine-2-d1
|
||
Adenine-2-d1 是 Adenine 的氘代化合物。Adenine 的 CAS 号为 73-24-5。Adenine 是一种嘌呤衍生物,是一种核碱基。它在细胞呼吸、以富含能量的 ATP 和 NAD 和 FAD 的形式和蛋白质合成作用,作为 DNA 和 RNA 的化学成分。 | |||
TMID-0242 |
Capecitabine-d11
|
||
Capecitabine-d11 是 Capecitabine 的氘代化合物。Capecitabine 的 CAS 号为 154361-50-9。Capecitabine 是一种可口服的前药,可由胸苷磷酸化酶催化转变为其活性代谢物 Fluorouracil。 | |||
T71401 |
Oxaliplatin-d10
|
||
Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.... |