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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9518 |
Inarigivir ammonium
ORI-9020 ammonium,SB-9200 ammonium,Inarigivir铵 |
HBV | Microbiology/Virology |
Inarigivir ammonium (SB-9200 ammonium) 是一种二核苷酸抗病毒化合物,可显着降低表达乙型肝炎病毒的转基因小鼠的 HBV DNA。它是一种激活细胞内先天免疫的视黄酸诱导基因-I 激动剂。 | |||
T12516 |
Polyinosinic-polycytidylic acid sodium
双链聚肌胞,Poly(I:C) sodium |
Apoptosis; Others; TLR | Apoptosis; Immunology/Inflammation; Others |
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物,是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂,直接触发癌细胞发生凋亡,还增强先天性和适应性免疫反应,并改变肿瘤的微环境。 | |||
T73486 |
RIG012
|
Others | Others |
RIG012 是一种有效的 RIG-I 抑制剂,用 NADH 偶联 ATPase 测得 IC50 值 为 0.71 μM。RIG012 对 IFN-β 和 ISG hRsad2 表达有抑制作用。 | |||
TP1186 |
Cyclo(Phe-Pro)
六氢-3-(苯基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮,A-64863,Cyclo(phenylalanylprolyl) |
Others | Others |
Cyclo(Phe-Pro) (A-64863) 是创伤弧菌的群体感应分子,能够与 RIG-I 的特异性相互作用,阻碍 RIG-I 的多泛素化,并抑制 IRF-3 的激活和 I 型干扰素的产生。它提高 HCV 和流感病毒的易感性。 | |||
T4027 |
KIN1148
|
Influenza Virus | Microbiology/Virology |
KIN1148 是一种新型小分子佐剂,是IRF3激动剂,用于增强流感疫苗效率。 | |||
T74052 |
Polyinosinic-polycytidylic acid potassium
|
Others | Others |
Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) 是双链 RNA 的合成类似物,是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Polyinosinic-polycytidylic acid potassium 可以用作疫苗佐剂,以增强先天性和适应性免疫反应,并改变肿瘤的微环境,还可以直接触发癌细胞发生凋亡 (Apoptosis)。 | |||
T38329 |
CU-76
|
Others | Others |
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP sy... | |||
T38328 |
CU-32
|
Others | Others |
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas... | |||
T74067 |
Poly (I:C):Kanamycin (1:1) (sodium)
|
Others | Others |
Poly (I:C):Kanamycin (1:1) sodium 是 Poly (I:C) 和 Kanamycin 的等比例复合物。Poly(I:C) sodium 是双链 RNA 的合成类似物,是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Poly(I:C) sodium 可以用作疫苗佐剂,增强先天性和适应性免疫反应,并诱导癌细胞凋亡。Kanamycin 是一种具有口服活性的抗菌剂(革兰氏阴性/阳性细菌),可抑制易位并通过与 70 S 核糖体亚基结合引起错误编码。Kanamycin 对结核分枝杆菌(敏感和耐药)和肺炎克雷伯菌均表现出良好的抑制活性,可用于结核病和肺炎的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00941 |
RIG-I Protein, Human, Recombinant (His)
RIGI,DEAD box protein 58... |
Human | E. coli |
RIG-I Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 53.3 kDa and the accession number is O95786. | |||
TMPH-02736 |
IFIH1 Protein, Mouse, Recombinant (His)
Melanoma differentiation-assoc |
Mouse | E. coli |
IFIH1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q8R5F7. | |||
TMPH-01554 |
IFIH1 Protein, Human, Recombinant (His)
Interferon-induced helicase C dom... |
Human | E. coli |
IFIH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9BYX4. | |||
TMPH-01902 |
DDX60 Protein, Human, Recombinant (His)
Probable ATP-dependent RNA helicase DDX60,DEAD box ... |
Human | E. coli |
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). DDX60 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8IY2... | |||
TMPH-01287 |
TUFM Protein, Human, Recombinant (His)
P43,Elongation factor Tu, mitochondri<... |
Human | E. coli |
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. | |||
TMPH-01247 |
POLR3K Protein, Human, Recombinant (His)
RNA polymerase III subuni |
Human | Baculovirus Insect Cells |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I... | |||
TMPJ-01206 |
Sting Protein, Human, Recombinant (Sumo & His)
TMEM173,Mediator of IRF3 activat<... |
Human | E. coli |
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2,... | |||
TMPH-01246 |
POLR3A Protein, Human, Recombinant (His)
RNA polymerase III subuni |
Human | E. coli |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ... | |||
TMPH-03733 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (His & Myc)
Polymerase cofactor VP35,VP35,Ebola VP35 |
ZEBOV | HEK293 Cells |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPH-03732 |
Zaire ebolavirus (strain Kikwit-95) VP35 Protein (E. col, His & Myc)
Polymerase cofactor VP35,Ebola VP35,VP35 |
ZEBOV | E. coli |
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling. Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes. Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes. Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1. VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between gen... | |||
TMPH-01270 |
TRAIP Protein, Human, Recombinant (His)
E3 ubiquitin-protein l |
Human | E. coli |
E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitm... | |||
TMPH-01552 |
IRF1 Protein, Human, Recombinant (GST & His)
IRF1,Interferon regulatory factor 1 |
Human | Baculovirus Insect Cells |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm... | |||
TMPH-02841 |
Prohibitin Protein, Mouse, Recombinant (His)
Phb1,B-cell receptor-associated protein 32... |
Mouse | E. coli |
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose Homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.; In the mitochondria, together with... |