289
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Cat. No. | Product Name | ||
---|---|---|---|
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9673 |
RET-IN-3
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
RET-IN-3 是一种具有选择性和高效性的 RETV804M 激酶抑制剂,具有潜在抗癌活性,可用于研究非小细胞肺癌。 | |||
T8467 |
RET V804M-IN-1
RETV804M kinase inhibitor,LUN09945 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
RET V804M-IN-1 (RETV804M kinase inhibitor) 是一种 wt-RET 选择性的RETV804M 激酶抑制剂,其IC50=20 nM。 | |||
T69644 |
DUN73423
RET-IN-21 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
DUN73423 (RET-IN-21) 是一种有效的酪氨酸激酶 (RET) 抑制剂,具有抗肿瘤活性,可用于研究癌症。 | |||
T40097 |
RET-IN-4
|
Others | Others |
RET-IN-4 is a highly effective and specific RET inhibitor that can be administered orally. It demonstrates remarkable potency, with IC50 values of 1.29 nM, 1.97 nM, and 0.99 nM for inhibiting RET variants including RET (WT), RET (V804M), and RET (M918T), respectively. Moreover, RET-IN-4 exhibits superior selectivity towards kinases JAK2 (IC50 of 4.4 nM) and FLT3 (IC50 of 30.8 nM). Additionally, RET-IN-4 possesses pronounced anticancer properties. | |||
T16735 |
RET-IN-1
|
Others | Others |
RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively). | |||
T8222 |
Selpercatinib
LOXO-292 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
Selpercatinib (LOXO-292) 是 RET 激酶抑制剂,抑制 RET (WT)、RET (V804M) 、RET (G810R)的 IC50分别为 14.0 nM、24.1 nM、530.7 nM,具有抗肿瘤活性。 | |||
T73309 |
RET-IN-20
|
Others | Others |
RET-IN-20 是一种有效的RET 抑制剂,IC50值为 13.7 nM。RET-IN-20 降低 p-Ret、p-Shc 蛋白的表达。RET-IN-20 诱导细胞凋亡 (apoptosis)。RET-IN-20 具有抗增殖和抗肿瘤活性。 | |||
T78683 |
RET-IN-22
|
Others | Others |
RET-IN-22(compound 17b)是一种有效且选择性的口服活性RET抑制剂,其对野生型RET和RET-V804M的IC50分别为20.9 nM与18.3 nM。该化合物展现出对多数激酶,特别是EGFR和VEGFR2的高度选择性,表现出抗癌活性。 | |||
T63358 |
RET-IN-15
|
Others | Others |
RET-IN-15 是转染期间重排激酶 (RET) 的抑制剂,能够用于癌症的研究。 | |||
T64103 |
RET-IN-12
|
Others | Others |
RET-IN-12 是一种 RET 抑制剂,能够作用于 RET(WT) (IC50: 0.3 nM) 和 RET(V804M) (IC50: 1 nM)。 | |||
T63468 |
RET-IN-14
|
Others | Others |
RET-IN-14 是 RET 的有效抑制剂,能够作用于 RET (WT) (IC50<0.51 nM)、RET (G810R) (IC50: 9.3 nM)、RET (V804M) (IC50: 1.3 nM)、BTK (C481S) (IC50: 9.2 nM) 和 BTK (C481S) (IC50: 15 nM)。RET-IN-14 表现出潜力进行肿瘤的研究。 | |||
T63837 |
RET-IN-19
|
Others | Others |
RET-IN-19 是 RET 的有效抑制剂,能够作用于 RET-wt (IC50: 6.8 nM) 和 RET V804M (IC50: 13.51 nM),表现出抗癌效果。RET-IN-19 能够用于研究非小细胞肺癌 (NSCLC)。 | |||
T63782 |
RET-IN-10
|
Others | Others |
RET-IN-10 是一种 RET 的有效抑制剂。其中 RET 功能缺失突变会造成先天性巨结肠,而其功能突变获得与多种人类肿瘤有关。RET-IN-10 对癌症疾病表现出研究潜力。 | |||
T79099 |
RET-IN-23
|
Others | Others |
RET-IN-23(化合物17)是一种有效的口服RET抑制剂,其IC50值对应RET-WT为1.32 nM、RET-CCDC6为2.50 nM、RET-V804L为6.54 nM、RET-V804M为1.03 nM及RET-M918T为1.47 nM。该化合物展现出了明显的抗肿瘤活性。 | |||
T63772 |
RET-IN-5
|
Others | Others |
RET-IN-5 是 RET 的有效抑制剂 (IC50: 4.57 nM)。 | |||
T79163 |
RET-IN-24
|
Others | Others |
RET-IN-24(Compound 26)为选择性RET酪氨酸激酶抑制剂,具抗肿瘤活性。 | |||
T79726 |
RET-IN-25
|
Others | Others |
RET-IN-25(化合物6b)是一种具有抗癌活性的RET激酶抑制剂。该化合物能够抑制甲状腺髓样癌(MTC),在TT(C634R) MTC细胞系中的IC50值分别为3.6 μM(3天)和3.0 μM(6天)。 | |||
T63249 |
RET-IN-6
|
Others | Others |
RET-IN-6 是 RET 的有效抑制剂(IC50: 4.57 nM)。 | |||
T63877 |
RET-IN-17
|
Others | Others |
RET-IN-17 是 RET 的有效抑制剂。RET-IN-17 具有潜力进行与 IBS 和其他胃肠道疾病相关的疼痛以及具有组成性 RET 激酶活性的癌症的研究。 | |||
T62877 |
RET-IN-7
|
Others | Others |
RET-IN-7 在体外显示出强大的 RET 激酶抑制作用 ,在体内对 RET 驱动的肿瘤异种移植物具有强大的疗效。 | |||
T63230 |
RET-IN-8
|
Others | Others |
RET-IN-8 是转染期间重排激酶 (RET) 的抑制剂,能够用于癌症的研究。 | |||
T73256 |
RET-IN-16
|
Others | Others |
RET-IN-16 是一种有效且具有选择性的RET 抑制剂,对RET(WT),RET(M918T),RET(V804L),RET(V804M),RET-CCDC6和RET-KIF5B 的IC50分别为 3.98 nM,8.42 nM,15.05 nM,7.86 nM,5.43 nM 和 8.86 nM。RET-IN-16 具有抗癌作用。 | |||
T73248 |
RET-IN-13
|
Others | Others |
RET-IN-13 是一种喹啉化合物,一种有效的 RET 抑制剂,对 RET(WT) 和 RET(V804M) 的 IC50分别为 0.5 nM 和 0.9 nM。RET-IN-13 具有用于与RET 异常激活相关的肿瘤或肠道疾病研究的潜力。 | |||
T63583 |
RET-IN-11
|
Others | Others |
RET-IN-11 是有效的、选择性的 RET 抑制剂,能够作用于 RET (IC50: 6.20 nM) 和 RETV804M (IC50: 18.68 nM)。RET-IN-11 能够诱导细胞凋亡 (apoptosis)。RET-IN-11 在 LC-2/ad 细胞中表现出抗增殖和迁移效果。 | |||
T81296 |
RET-IN-26
|
Others | Others |
RET-IN-26(化合物D5)是一种RET kinase抑制剂,其IC50值为0.33 μM。 | |||
T63183 |
RET-IN-9
|
Others | Others |
RET-IN-9 是一种 RET 的有效抑制剂。其中 RET 激酶是一种单通道跨膜受体酪氨酸激酶,在肾脏和肠神经系统的发育以及维持神经、内分泌、造血和男性生殖系统的体内平衡中发挥着重要作用。RET-IN-9 具有潜力进行 RET 相关疾病的研究(包括非小细胞肺癌和甲状腺髓样癌)。 | |||
T12598 |
Pz-1
|
VEGFR; c-RET | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Pz-1 是 VEGFR2 和 RET 酪氨酸激酶的抑制剂,可阻断 RET 刺激生长所需的血液供应。 | |||
T10624 |
BT-13
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
BT-13 是一种胶质细胞源性神经营养因子 (GDNF) 受体 RET 的选择性激动剂,独立于 GDNF 配体发挥作用,能够促进体外感觉神经元神经突生长,减少大鼠神经病变的发生。 | |||
T16923 |
SPP-86
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
SPP-86 是有效的、选择性的RET 酪氨酸激酶抑制剂,其IC50=8 nM。它能够抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路,也能抑制 RET 诱导的 ERα 磷酸化。 | |||
TQ0277 |
Pralsetinib
普拉替尼,Blu667 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
Pralsetinib (Blu667) 是高效的、选择性的RET 抑制剂。它能够抑制 WT RET (IC50:0.4 nM),RET 突变体 V804L (IC50:0.3 nM),V804M (IC50:0.4 nM),M918T (IC50:0.4 nM) 和 CCDC6-RET (IC50:0.4 nM) 的融合。 | |||
T67733 |
BT44
|
Others | Others |
BT44是一种新的、第二代神经胶质细胞系衍生的神经营养因子模拟物,具有改善的生物活性,是治疗神经退行性疾病的先导化合物。 | |||
T2282 |
RPI-1
|
Others; Phospholipase; c-Met/HGFR; c-RET | Apoptosis; Metabolism; Others; Tyrosine Kinase/Adaptors |
RPI1 是特异性的、口服具有活力的 2-吲哚啉酮Ret 酪氨酸激酶抑制剂,具有抗肿瘤作用。它能够抑制人甲状腺髓样癌 TT 细胞增殖、Ret 酪氨酸磷酸化、Ret 蛋白表达及 PLCgamma、ERKs 和 AKT 的活化。 | |||
T4301 |
AD80
|
Raf; c-RET; Src; S6 Kinase | Angiogenesis; Apoptosis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
AD80 是多激酶抑制剂,可抑制 RET、RAF、SRC 和 S6K,并大大降低 mTOR 活性。 | |||
T5491 |
GSK3179106
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂,对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应,对肠易激综合征具有潜在的应用价值。 | |||
T7418 |
BBT594
NVP-BBT594 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
BBT594 (NVP-BBT594) 是受体酪氨酸激酶 RET 抑制剂,常用于研究癌症。 | |||
T3065 |
TG101209
|
Apoptosis; FLT; c-RET; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG101209 是一种选择性有效的 JAK2抑制剂,IC50值为 6 nM。它能抑制 Flt3和RET 的活性,IC50值分别为 25 nM 和 17 nM。 | |||
T22349 |
JNJ-38158471
CS-2660 |
VEGFR; c-RET; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
JNJ-38158471 (CS-2660) 是一种耐受性好的,有口服活性的、高效的、选择性的 VEGFR-2抑制剂 (IC50:40 nM),还能抑制 Ret (IC50:180 nM) 和 Kit (IC50:500 nM)。 | |||
T1995 |
Fedratinib
TG-101348,SAR 302503 |
Apoptosis; FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Fedratinib (TG-101348) 是一种 JAK2 抑制剂,具有选择性、ATP 竞争性和具有口服活性,抑制 JAK2 和 JAK2V617F 激酶 (IC50=3 nM)。Fedratinib 可诱导肿瘤细胞凋亡,并可用于骨髓增生性疾病的研究。 | |||
T1792L |
Regorafenib monohydrate
|
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib monohydrate 是一种新型口服多激酶抑制剂,对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。 | |||
T6920 |
ON123300
|
FGFR; c-RET; JAK; CDK; PDGFR; Src; AMPK | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
ON123300 是一种可透过血脑屏障的多激酶抑制剂,作用于 CDK4、CDK6、Ark5、PDGFRβ、FGFR1、RET 和 Fyn,IC50值为3.9、9.82、5、26、26、9.2和11 nM。它在脑肿瘤中抑制 Akt 磷酸化及激活 Erk。 | |||
T2032 |
WHI-P180
Janex 3 |
EGFR; VEGFR; c-RET; CDK | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
WHI-P180 (Janex 3) 是 EGFR 和 Cdk2 抑制剂,IC50 分别为 4.0 和 1.0 μM。 | |||
T8402 |
Regorafenib Hydrochloride
瑞戈非尼盐酸盐,BAY73-4506 hydrochloride |
Raf; VEGFR; c-RET; PDGFR; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂,可抑制血管生成、基质和致癌受体酪氨酸激酶,具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1,IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。 | |||
T0520 |
Lenvatinib
仑伐替尼,E7080 |
VEGFR; FGFR; c-RET; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等,具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。 | |||
TD0081 |
EDANS
EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid],EDANS酸,1,5-EDANS,EDANS acid [5-((2-Aminoethyl)amino)napht |
Others | Others |
EDANS (EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid]) 是新型的淬灭荧光底物 (fluorogenic substrate),可利用共振能量转移,分析逆转录病毒蛋白酶。 | |||
T4053 |
AST 487
NVP-AST 487 |
VEGFR; FLT; c-RET; Bcr-Abl; c-Kit | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
AST 487 (NVP-AST 487) 是 RET 激酶抑制剂 (IC50:880 nM),能够抑制 RET 自磷酸化,及下游效应器激活,也抑制 Flt-3 (IC50:520 nM)。 | |||
T2516 |
Amuvatinib
MP470,HPK 56 |
Apoptosis; FLT; c-Met/HGFR; c-RET; DNA/RNA Synthesis; PDGFR; c-Kit | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂,对突变 c-Kit,PDGFRα,Flt3,c-Met 和 c-Ret 具有活性。它还是一种 DNA 修复抑制剂,靶向蛋白 DNA 修复 RAD51,从而破坏 DNA 损伤修复,具有抗肿瘤活性。 | |||
T8541 |
Lenvatinib mesylate
仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼 |
VEGFR; FGFR; c-RET; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Lenvatinib mesylate (E7080 (mesylate)) 是一种口服具有活力的,多靶点酪氨酸激酶抑制剂,能够抑制血管内皮生长因子受体(VEGFR1-3),成纤维细胞生长因子受体(FGFR1-4),干细胞因子受体(KIT),血小板衍生生长因子受体(PDGFR),转染期间重排(RET),具有效抗癌作用。 | |||
T9251 |
Fedratinib hydrochloride hydrate
TG-101348 hydrochloride hydrate,SAR 302503 hydrochloride hydrate |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) 是一种选择性的,ATP 竞争性和具有口服活性的JAK2抑制剂,对于JAK2和JAK2V617F 激酶的IC50均为 3 nM。它可诱导癌细胞凋亡,可研究骨髓增生性疾病。 | |||
T1792 |
Regorafenib
BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼 |
Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂,抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM),具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。 | |||
T6028 |
PF 477736
PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 |
c-Fms; VEGFR; FGFR; FLT; c-RET; Chk; CDK; Src; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
PF 477736 (PF-736,PF-00477736) 是一种特异性、有效且具有 ATP 竞争性的 Chk1 抑制剂,Ki 值为0.49 nM。它也是Chk2抑制剂,Ki 值为 47 nM。它还抑制VEGFR2、Fms、Yes、Aurora-A、FGFR3、Flt3和Ret。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7090 |
Coretinphencone
|
Others | Others |
Coretinphencone 是一种从金鸡菊花蕾中分离出来的天然产物。 | |||
TJS2190 |
Nordihydroguaiaretic acid
去甲二氢愈创木酸,NDGA,Dihydronorguaiaretic Acid |
Antioxidant; Ferroptosis; Lipoxygenase; Autophagy | Apoptosis; Autophagy; Metabolism; oxidation-reduction |
Nordihydroguaiaretic acid (NDGA) 是从极叉开拉瑞阿提取出的一种天然产物,是脂氧合酶抑制剂,具有抗氧化和清除自由基的特性。 | |||
T2924 |
Phloretin
根皮素,Dihydronaringenin,NSC 407292,RJC 02792 |
SGLT; transporter; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。 | |||
TN2148 |
Retusin
5-Hydroxy-3,7,3',4'-tetramethoxyflavone,Quercetin-3,7,3',4'-tetramethyl ether |
ATPase; Free radical scavengers; Tyrosinase | Membrane transporter/Ion channel; oxidation-reduction; Proteases/Proteasome |
Retusin 是从 Talinum triangulare 的叶子中提取的。 Retusin Retusin 可用于作为芽前和芽后除草剂的研究。 | |||
T1059 |
Retinyl palmitate
Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate,维生素A棕榈酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Retinyl palmitate (Vitamin A palmitate) 是酯化的视黄醇,是表皮中维生素 A 的主要形式,在药品和化妆品中有广泛应用。 | |||
T1611 |
Isotretinoin
13-cis-Retinoic acid,异维A酸 |
Retinoid Receptor; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸,具有潜在的抗肿瘤活性。 它结合并激活核视黄酸受体 (RAR), 活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物,用于治疗严重的痤疮和某些形式的皮肤、头颈癌。 | |||
T7408 |
all-trans-4-Oxoretinoic acid
4-KETO全反式维甲酸,all-trans 4-Keto Retinoic Acid |
Endogenous Metabolite | Metabolism |
all-trans-4-Oxoretinoic acid (all-trans 4-Keto Retinoic Acid) 是一种维生素A 的特性代谢物,能够通过作用核维甲酸受体(RARs) 来诱导基因转录。 | |||
T5256 |
All-trans-retinal
视黄醛,All trans-Retinal,Retinaldehyde,Vitamin A aldehyde |
Others; Endogenous Metabolite | Metabolism; Others |
All-trans-retinal (Vitamin A aldehyde) 是视网膜中维生素A 代谢物之一。 生理条件下,它再生为视觉发色团,11-顺式-视黄醛。 | |||
T6212 |
Combretastatin A4
CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09 |
Microtubule Associated | Cytoskeletal Signaling |
Combretastatin A4 (CA4) 是一种微管靶向剂,可结合 β-tubulin,Kd 值为 0.4 μM。 | |||
TN7082 |
demethyldaphnoretin-7-O-glucoside
|
Others | Others |
demethyldaphnoretin-7-O-glucoside 是从 Daphne oleoides Schreber subsp. 中分离出来的天然产物。在土耳其传统医学中,它的地上部分已被用于治疗疟疾、风湿病和伤口愈合。 | |||
T2842 |
Tangeretin
NSC53909,Tangeritin,NSC618905,桔皮素 |
Apoptosis; Gamma-secretase | Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells |
Tangeretin (NSC-618905) 是一种来自柑橘类水果果皮的类黄酮,是一种Notch-1抑制剂,具有抗炎,保护神经等作用。 | |||
T0051 |
Urethane
Ethyl carbamate,Ethylurethane,Carbamic acid ethyl ester,氨基甲酸乙酯 |
Chloride channel; GABA Receptor; Antibacterial; GluR; NMDAR; AChR; Parasite | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Urethane (Ethylurethane) 是多种食品中发酵形成的副产物,是氨基甲酸的乙酯,具有抑制细菌、海胆卵、原生动物和植物组织生长的作用。 | |||
TN1733 |
Hesperetin 7-O-glucoside
|
Anti-infection; Antibacterial; HMG-CoA Reductase | Metabolism; Microbiology/Virology |
Hesperetin 7-O-glucoside 是通过 Hesperidin 的酶促转化产生的一种人 HMG-CoA 还原酶抑制剂,具有降压作用,可抑制幽门螺杆菌的生长。 | |||
T1330 |
Acitretin
阿曲汀,Ro 10-1670,Etretin |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
Acitretin (Ro 10-1670) 是一种维甲酸,可用于银屑病和阿尔兹海默症的研究。 | |||
T1051 |
Retinoic acid
维生素A酸,Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin |
Retinoid Receptor; Endogenous Metabolite; PPAR; Autophagy | Autophagy; DNA Damage/DNA Repair; Metabolism |
Retinoic acid (Tretinoin) 是维生素 A 的代谢产物,是一种视黄酸受体 RAR 的天然激动剂,激动 RARα/β/γ (IC50=14 nM)。Retinoic acid 可以诱导细胞分化、减少细胞增殖和抑制肿瘤发生。 | |||
T4S1335 |
Daphnoretin
Dephnoretin,西瑞香素,Thymelol |
Influenza Virus; Caspase; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物,具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T1183 |
Retinol
all-trans-Retinol,视黄醇,Vitamin A,Vitamin A1,Alphalin |
Others | Others |
Retinol (Vitamin A) 属于天然维生素,具有脂溶性。Retinol 在视网膜的代谢功能、上皮组织的生长和分化、骨骼的生长、生殖和免疫反应中起重要作用。 | |||
T4955 |
saponaretin
Isovitexin,Apigenin-6-C-glucoside,异牧荆素 |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
saponaretin 是许多中药的活性成分,具有多种活性,如抗氧化、抗炎、抗阿尔茨海默病(AD)作用等。 | |||
T6272 |
Fosbretabulin Disodium
Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂,是 Combretastatin A4 前药,可选择性靶向内皮细胞,诱导新生肿瘤新血管消退,减少肿瘤血流量并引起中央肿瘤坏死。 | |||
T2565 |
Hesperetin
橙皮素 |
Apoptosis; p38 MAPK; 5-HT Receptor; Autophagy; TGF-beta/Smad | Apoptosis; Autophagy; GPCR/G Protein; MAPK; Neuroscience; Stem Cells |
Hesperetin 是一种天然黄烷酮类物质,是人UGT 的广谱抑制剂,可诱导凋亡。 | |||
TQ0280 |
Feretoside
|
HSP | Cytoskeletal Signaling; Metabolism |
Feretoside 是分离自杜仲树皮的一种酚类化合物。它是 HSP 诱导剂,可作为细胞保护剂。 | |||
T0685 |
Retinyl acetate
Vitamin A acetate,Retinyl (Retinol) Acetate,视黄醇乙酸酯(维生素A醋酸酯),Retinol acetate,视黄醇乙酸酯 |
||
Retinyl acetate (Vitamin A acetate) 是一种视黄醇的合成乙酸酯形式衍生物,有抗肿瘤和化学预防活性的潜能。 | |||
T8152 |
6-Demethoxytangeretin
|
MAPK; ALK | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
6-Demethoxytangeretin 是一种从柑橘分离的黄酮。它能够促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。它具有抗炎和抗过敏作用,通过间变性淋巴瘤激酶和丝裂原活化蛋白激酶途径抑制人肥大细胞中 IL-6 的产生和基因表达。 | |||
TN3312 |
9-Angeloylretronecine N-oxide
|
Others | Others |
9-Angeloylretronecine N-oxide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3312,CAS号为 27773-86-0。 | |||
TN1581 |
Dihydroguaiaretic acid
二氢愈创木酸 |
COX; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. | |||
T28021 |
meso-Dihydroguaiaretic acid
|
||
meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells. | |||
T19169 |
9-cis-Retinal
|
Others | Others |
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in r | |||
T81015 |
Terretonin A
|
||
Terretonin A为一类萜化合物,可从Aspergillus terreus中分离获得。 | |||
T83401 |
2′-O-Methylphloretin
|
Others | Others |
2′-O-Methylphloretin是一种从Melodorum siamensis叶子中分离出的类黄酮衍生物,具有抑制肿瘤细胞系复制的生物活性。 | |||
TN4206 |
Hesperetin 5-O-glucoside
|
Others | Others |
Hesperetin 5-O-glucoside has hypocholesterolemic effect. | |||
TN5127 |
Tereticornate A
|
Others | Others |
Tereticornate A是一种天然产物,属于桃金娘科桉属,其产品编号为 TN5127,CAS号为 149751-81-5。Tereticornate A可用作对照参考。 | |||
T79973 |
Dehydrodiscretamine chloride
|
Others | Others |
Dehydrodiscretamine chloride作为AChE和BChE的双重抑制剂,展现了其抑制效力,其中对AChE的IC50为17.8 μM,对BChE的IC50为118.8 μM。此外,该化合物具备抗氧化活性,并可被应用于阿尔茨海默病相关研究。 | |||
TN7510 |
all-trans-13,14-Dihydroretinol
|
Others | Others |
All-trans-13,14-Dihydroretinol, a metabolite of all-trans-retinoic acid, is synthesized through the enzymatic action of retinol saturase on all-trans-retinoic acid. | |||
TN4278 |
Isodaphnoretin B
|
Others | Others |
Isodaphnoretin B is a natural product from Stellera chamaejasme. | |||
TN2146 |
Retronecine N-oxide
倒千里光碱氮氧化物 |
Others | Others |
Retronecine N-oxide is a natural product | |||
T81291 |
Retrofractamide A
|
||
Retrofratamide A为源自Piper chaba果实的酰胺,能够促进3T3-L1细胞的脂肪生成。 | |||
T83581 |
(±)-Reticuline
|
Others | Others |
(±)-Reticuline(化合物3f),波尔多叶(Peumus boldus Molina)中的天然产物,用于合成S-Reticuline。 | |||
T40665 |
Uvaretin
|
Others | Others |
Uvaretin demonstrates potent antibacterial activity against B. subtilis (EC50: 8.7 μM) and S. epidermidis (IC50: 7.9 μM). | |||
T32198 |
Retrorsine N-oxide
Isatidine |
Others | Others |
Isatidine is a pyrrolizidine alkaoid. | |||
TN7552 |
Luteoreticulin
Griseulin |
Others | Others |
Luteoreticulin, a nitro-containing bacterial metabolite first isolated from S. luteoreticuli, exhibits mosquitocidal activity against A. aegypti at a concentration of 6.25 mg/L and nematocidal activity against C. elegans. | |||
T12667 |
(Rac)-Hesperetin
|
Others | Others |
(Rac)-Hesperetin is the racemate form of of Hesperetin. Hesperetin is a natural flavanone compound, and it exhibits potent inhibitory effects against human UGT activity, making it a broad-spectrum inhibitor. Furthermore, Hesperetin induces apoptosis through the activation of p38 MAPK. | |||
TN2572 |
10-O-Caffeoyl-6-epiferetoside
|
Others | Others |
10-O-Caffeoyl-6-epiferetoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2572,CAS号为 83348-22-5。 | |||
TN6497 |
Hesperetin-7-methyl ether
|
||
Hesperetin-7-methyl ether is a natural prooduct from Citrus maxima. | |||
TN3718 |
Creticoside C
|
Others | Others |
Creticoside C 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3718,CAS号为 53452-34-9。 | |||
TN3221 |
7-Angeloylretronecine
|
Antifection | Microbiology/Virology |
7-Angeloylretronecine may have antibacterial effects. | |||
TN4640 |
Neophellamuretin
|
Others | Others |
Neophellamuretin is a natural product from Akschindlium godefroyanum (Kuntze) H. Ohashi. | |||
TN4930 |
Rutaretin
|
Others | Others |
Rutaretin是一种天然产物,属于芸香科芸香属,其产品编号为 TN4930,CAS号为 13895-92-6。Rutaretin可用作对照参考。 | |||
TN2145 |
Retronecine
|
Others | Others |
Retronecine acts as the better competitor for the competitive inhibition of antibodies to Retronecine. | |||
T83917 |
6-O-Methylreticulol
8-hydroxy-6,7-dimethoxy-3-methyl Isocoumarin |
Others | Others |
6-O-Methylreticulol是一种异香豆素(isocoumarin)及真菌代谢产物,已在S. mobaraensis中被发现。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02270 |
RET Protein, Human, Recombinant (His)
MTC1,PTC,HSCR1,RET51,ret proto-oncogene,CD... |
Human | HEK293 Cells |
RET Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.1 kDa and the accession number is P07949-1. | |||
TMPY-04418 |
RET Protein, Human, Recombinant (aa 658-1114, His & GST)
HSCR1,RET51,CDHR16,RET-ELE1,ret p... |
Human | Baculovirus Insect Cells |
RET Protein, Human, Recombinant (aa 658-1114, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.7 kDa and the accession number is P07949-1. | |||
TMPH-00131 |
Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc)
Ribonuclease mitogillin,Restrictocin,ret |
Aspergillus restrictus | E. coli |
This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. Ribonuclease mitogillin Protein, Aspergillus restrictus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.9 kDa and the accession number is P67876. | |||
TMPJ-00290 |
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
TRNR2,GDNFR-beta,TGF-β-related neurotrophic factor receptor ... |
Human | HEK293 Cells |
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kina... | |||
TMPY-01756 |
Transthyretin Protein, Human, Recombinant (His)
PALB,HEL111,CTS,transthyretin,CTS1,HsT2651,TBPA |
Human | HEK293 Cells |
Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36. | |||
TMPY-04675 |
SG3/Secretogranin 3, Mouse, Recombinant (His)
AI385542,SgIII,1B1075,Chgd,secretogranin III |
Mouse | HEK293 Cells |
SG3/Secretogranin 3, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is P47867-1. | |||
TMPY-02182 |
CD4 Protein, Ferret, Recombinant (His)
CD4 molecule |
Ferret | HEK293 Cells |
CD4 Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is I6LI22. | |||
TMPK-01090 |
Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)
Prealbumin,TBPA,CTS,HEL111,Transthyretin,TTR,ATTR,C... |
Cynomolgus | HEK293 Cells |
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue. | |||
TMPY-00086 |
Reticulocalbin 3/RCN3 Protein, Rat, Recombinant (His)
reticulocalbin 3, EF-hand calcium binding domain |
Rat | HEK293 Cells |
Reticulocalbin 3/RCN3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is I6L9G5. | |||
TMPY-03968 |
Secretogranin II Protein, Human, Recombinant (His)
EM66,SgII,SN,CHGC,secretogranin II |
Human | HEK293 Cells |
Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel... | |||
TMPY-03994 |
SG3/Secretogranin 3 Protein, Human, Recombinant (His)
secretogranin III,SGIII,UNQ2502/PRO5990 |
Human | HEK293 Cells |
SG3/Secretogranin 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.4 kDa and the accession number is AAH14539.1. | |||
TMPH-02559 |
Calreticulin Protein, Mouse, Recombinant (GST)
ERp60,Calreticulin,Endoplasmic reticulum r... |
Mouse | E. coli |
Calreticulin Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 73.3 kDa and the accession number is P14211. | |||
TMPH-02069 |
Secretogranin-2 Protein, Human, Recombinant (GST & His)
Secretogranin-2,Chromogranin-C,Secretogran... |
Human | E. coli |
Secretogranin-2 Protein, Human, Recombinant (GST & His) is expressed in E. coli. | |||
TMPH-02027 |
RETNLB Protein, Human, Recombinant (His)
Colon carcinoma-related gene protein,Colon and small intesti... |
Human | E. coli |
Probable hormone. RETNLB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is Q9BQ08. | |||
TMPY-03664 |
IFN gamma Protein, Ferret, Recombinant (His)
interferon, gamma,interferon, γ,IFN γ,干扰素 |
Ferret | HEK293 Cells |
IFN gamma Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.4 kDa and the accession number is A4PIZ9. | |||
TMPY-06948 |
Influenza A H1N1 (A/New Caledonia/20/1999) Hemagglutinin/HA-specific B cell probe (Y108F, and aa 339-342 SIQS→QRET, His & Avi), Biotinylated
Harvey rat sarcoma viral oncogene homolog |
H1N1 | Baculovirus Insect Cells |
Influenza A H1N1 (A/New Caledonia/20/1999) Hemagglutinin/HA-specific B cell probe (Y108F, and aa 339-342 SIQS→QRET, His & Avi), Biotinylated is expressed in Baculovirus insect cells with His and Avi tag. The predicted molecular weight is 59.79 kDa and the accession number is AAP34324.1. | |||
TMPY-04672 |
Reticulocalbin 3/RCN3 Protein, Mouse, Recombinant (His)
D530026G20Rik,6030455P07Rik,D7Ertd671e,RLP49,reticu... |
Mouse | HEK293 Cells |
Reticulocalbin 3/RCN3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.9 kDa and the accession number is Q8BH97. | |||
TMPY-03259 |
Calreticulin Protein, Human, Recombinant (His)
HEL-S-99n,cC1qR,SSA,CRT,RO,calreticulin |
Human | HEK293 Cells |
Calreticulin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is P27797. | |||
TMPY-03181 |
Reticulocalbin 3/RCN3 Protein, Human, Recombinant (His)
RLP49,reticulocalbin 3, EF-hand calcium binding dom... |
Human | HEK293 Cells |
Reticulocalbin 3/RCN3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q96D15. | |||
TMPY-03258 |
Calreticulin Protein, Human, Recombinant (hFc)
RO,cC1qR,HEL-S-99n,CRT,calreticulin,SSA |
Human | HEK293 Cells |
Calreticulin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73 kDa and the accession number is P27797. | |||
TMPK-00583 |
TNF alpha Protein, Ferret, Recombinant (His)
TNF-α,DIF,TNFα,TNF-alpha,TNF α,Cachectin,APC1 protein,TNF,TN... |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1. | |||
TMPH-02242 |
Transthyretin Protein, Human, Recombinant (hFc & Myc)
TTR,ATTR,Transthyretin,Prealbumin,TBPA |
Human | HEK293 Cells |
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. | |||
TMPH-02034 |
Retinoschisin Protein, Human, Recombinant (His)
Retinoschisin,X-linked juvenile retinoschi... |
Human | E. coli |
Retinoschisin Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-02226 |
TNF alpha Protein, Ferret, Recombinant
tumor necrosis factor,肿瘤坏死因子,TNF-α |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1. | |||
TMPY-06327 |
Calreticulin Protein, Human, Recombinant
HEL-S-99n,calreticulin,cC1qR,CRT,RO,SSA |
Human | HEK293 Cells |
Calreticulin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.99 kDa and the accession number is P27797. | |||
TMPK-00673 |
SG3/Secretogranin 3 Protein, Cynomolgus, Recombinant (His)
SCG3,Secretogranin-3,UNQ2502/PRO5990,SGIII,Secr... |
Cynomolgus | HEK293 Cells |
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs. SG3/Secretogranin 3 Protein, Cynomolgus... | |||
TMPH-00034 |
ASFV (isolate Tick/South Africa/Pretoriuskop Pr4/1996) p12 Protein (His)
Protein p12,Pret-110,Inner membrane protein p12 |
ASFV | E. coli |
Virus attachment protein. ASFV (isolate Tick/South Africa/Pretoriuskop Pr4/1996) p12 Protein (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 12.7 kDa and the accession number is P0C9Y3. | |||
TMPH-03105 |
Calreticulin Protein, Pig, Recombinant (His)
Endoplasmic reticulum resident protein 60,CRP55,CRT... |
Sus scrofa (Pig) | P. pastoris (Yeast) |
Calreticulin Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P28491. | |||
TMPH-02558 |
Calreticulin Protein, Mouse, Recombinant (His)
ERp60,CRP55,CRT,CALR,Calregulin,Calreticulin,Endopl... |
Mouse | P. pastoris (Yeast) |
Calreticulin Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.3 kDa and the accession number is P14211. | |||
TMPH-00319 |
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His)
yscF |
Burkholderia thailandensis | P. pastoris (Yeast) |
Type III secretion system needle Protein, Burkholderia thailandensis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 11.9 kDa and the accession number is Q2T727. | |||
TMPH-00813 |
Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)
Protein ORF2,Pro-secreted protein ORF2 |
HEV-1 | Baculovirus Insect Cells |
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation. Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes. Hepatitis E virus gen... | |||
TMPH-02068 |
Secretogranin-1 Protein, Human, Recombinant (GST & His)
Secretogranin I,Chromogranin-B,Secretogran... |
Human | E. coli |
Secretogranin-1 Protein, Human, Recombinant (GST & His) is expressed in E. coli. | |||
TMPH-02946 |
Transthyretin Protein, Mouse, Recombinant (His & SUMO)
Transthyretin,Prealbumin,Ttr |
Mouse | E. coli |
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.6 kDa and the accession number is P07309. | |||
TMPH-02926 |
TRET Protein, Mouse, Recombinant (His & SUMO)
Telomerase catalytic subunit,Telomerase reverse transcriptas... |
Mouse | E. coli |
TRET Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.1 kDa and the accession number is O70372. | |||
TMPY-02165 |
CD8 alpha Protein, Ferret, Recombinant (His)
CD8a molecule,CD8 α |
Ferret | HEK293 Cells |
CD8 alpha Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.5 kDa and the accession number is I6LI23. | |||
TMPY-04919 |
Transthyretin Protein, Mouse, Recombinant (His)
AI787086,prealbumin,D17860,AA408768,transthyretin |
Mouse | HEK293 Cells |
Transthyretin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P07309. | |||
TMPY-02218 |
CD20 Protein, Ferret, Recombinant (His)
membrane-spanning 4-domains, subfamily A, member 1 |
Ferret | HEK293 Cells |
CD20 Protein, Ferret, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa. | |||
TMPK-01122 |
SG3/Secretogranin 3 Protein, Human, Recombinant (aa 20-468, His)
SCG3,Secretogranin III,UNQ2502/PRO5990,Secret |
Human | HEK293 Cells |
Secretogranin III (Scg3) is a member of the granin protein family that regulates the biogenesis of secretory granules. Scg3 was recently discovered as an angiogenic factor, expanding its functional role to extrinsic regulation. Unlike many other known angiogenic factors, the pro-angiogenic actions of Scg3 are restricted to pathological conditions. Among thousands of quantified endothelial ligands, Scg3 has the highest binding activity ratio to diabetic vs. SG3/Secretogranin 3 Protein, Human, Rec... | |||
TMPH-00436 |
Calreticulin Protein, Cricetulus griseus, Recombinant (His)
ERp60,Calreticulin,Calregulin,CRT,CRP55,HACBP,CALR,... |
Chinese hamster | P. pastoris (Yeast) |
Calreticulin Protein, Cricetulus griseus, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 48.1 kDa and the accession number is Q8K3H7. | |||
TMPH-03368 |
SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)
Scg3,1B1075,Secretogranin-3,Secretogranin ... |
Rat | E. coli |
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.2 kDa and the accessio... | |||
TMPH-02030 |
Reticulocalbin-1/RCN1 Protein, Human, Recombinant (His)
Reticulocalbin-1,RCN1 |
Human | P. pastoris (Yeast) |
Reticulocalbin-1/RCN1 Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-02947 |
Transthyretin Protein, Mouse, Recombinant
Prealbumin,Transthyretin,Ttr |
Mouse | E. coli |
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.5 kDa and the accession number is P07309. | |||
TMPH-00757 |
Reticuline oxidase Protein, Eschscholzia californica, Recombinant (His)
BBE1,Tetrahydroprotoberberine synthase,Berberine bridge-form... |
Eschscholzia californica | E. coli |
Essential to the formation of benzophenanthridine alkaloids in the response of plants to pathogenic attack. Catalyzes the stereospecific conversion of the N-methyl moiety of (S)-reticuline into the berberine bridge carbon of (S)-scoulerine. | |||
TMPH-03247 |
Artemin Protein, Rat, Recombinant (His & Myc)
Artemin,Artn |
Rat | E. coli |
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Artemin Protein, Rat, Recombinant (His & Myc) is expressed in E. coli ... | |||
TMPH-02842 |
CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)
CD133,Prom1,Prominin-like protein 1,Prom,Proml1,Antigen AC13... |
Mouse | E. coli |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. | |||
TMPK-00109 |
Artemin Protein, Human, Recombinant (hFc)
ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN |
Human | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. | |||
TMPY-04207 |
Motilin Protein, Human, Recombinant (His)
MLN,Motilin |
Human | HEK293 Cells |
MLN (Motilin) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. The encoded protein belongs to the motilin family. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). MLN plays an important role in the regulation of Interdigestive... | |||
TMPJ-00100 |
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin |
Human | E. coli |
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... | |||
TMPH-00001 |
CD133/PROM1 Protein-VLP, Human, Recombinant (His)
Proml1,Prom1,CD133,Prominin-like protein 1,Antigen AC133 hom... |
Human | HEK293 Cells |
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. CD133/PROM1 Protein... | |||
TMPJ-01414 |
GDF-15 Protein, Mouse, Recombinant (His & Flag)
Growth Differentiation Factor 15, Macrophage inhibitory cyto... |
Mouse | HEK293 Cells |
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0039 |
Norethindrone Acetate-2,2,4,6,6,10-d6
|
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Norethindrone Acetate-2,2,4,6,6,10-d6 是 Norethindrone Acetate 的氘代化合物。Norethindrone Acetate 的 CAS 号为 51-98-9。Norethindrone acetate 是一种雌性激素,对青少年月经和肝腺瘤有抑制作用,常与孕激素联合使用,可用于研究子宫内膜异位症。 | |||
TMIH-0470 |
R-(-)-Tretoquinol Hydrochloride-d9
|
||
R-(-)-Tretoquinol Hydrochloride-d9 是 R-(-)-Tretoquinol Hydrochloride 的氘代化合物。 | |||
TMIH-0510 |
S-(-)-Tretoquinol Hydrochloride-d9
|
||
S-(-)-Tretoquinol Hydrochloride-d9 是 S-(-)-Tretoquinol Hydrochloride 的氘代化合物。 | |||
TMID-0131 |
Norethindrone-2,2,4,6,6,10-d6
|
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Norethindrone-2,2,4,6,6,10-d6 是 Norethindrone 的氘代化合物。Norethindrone 的 CAS 号为 68-22-4。Norethindrone 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 | |||
TMIJ-0382 |
Norethindrone (Ethynyl-13C2)
|
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Norethindrone (Ethynyl-13C2) 是 Norethindrone 的 13C 的标记化合物。Norethindrone 的 CAS 号为 68-22-4。Norethindrone 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 | |||
T19088 |
13-cis Acitretin D3
Isoacitretin D3,13-cis Acitretin D3 |
Others | Others |
13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid. | |||
T67921 |
Retinoic acid-d5
all-trans-Retinoic acid-d5,Isotretinoin-d5,Vitamin A acid-d5,Accutane-d5,ATRA-d5 |
Retinoid Receptor | Metabolism |
Retinoic acid-d5 (Vitamin A acid-d5)是视黄酸的氘标记形式。视黄酸是一种天然的RAR 核受体激动剂, 对 RARα/β/γ 的 IC50 为 14 nM,与 PPARβ/δ 结合的Kd 为 17 nM。视黄酸是维生素a 的代谢物,在细胞生长、分化和器官发育中起着重要作用。视黄酸通过激活视黄酸受体α作为转录因子Nrf2的抑制剂来发挥作用。 | |||
TMIJ-0074 |
Retigabine-d4
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Retigabine-d4 是 Retigabine 的氘代化合物。Retigabine 的 CAS 号为 150812-12-7。Retigabine dihydrochloride 是一种抗惊厥药,用作有治疗经验的成年患者部分性癫痫的辅助治疗。作用机制涉及神经元 K(V)7.2-7.5(以前的 KCNQ2-5)电压激活 K(+) 通道的开放。 | |||
TMIJ-0108 |
rac-Hesperetin-13C-d3
rac-Diosmin EP Impurity G-13C-d3 |
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rac-Hesperetin-13C-d3 是 rac-Hesperetin 的 13C 和氘代化合物。rac-Hesperetin 的 CAS 号为 69097-99-0。 | |||
TMIJ-0360 |
Urethane-d5
|
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Urethane-d5 是 Urethane 的氘代化合物。Urethane 的 CAS 号为 51-79-6。Urethane 是多种食品中发酵形成的副产物,是氨基甲酸的乙酯,具有抑制细菌、海胆卵、原生动物和植物组织生长的作用。 | |||
TMIJ-0443 |
3-Keto Fenretinide-d4
|
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3-Keto Fenretinide-d4 是 3-Keto Fenretinide 的氘代化合物。3-Keto Fenretinide 的 CAS 号为 865536-65-8。4-Oxofenretinide 是一种最近发现的 fenretinide 代谢物,可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。 | |||
TMIJ-0125 |
Regorafenib-13C-d3 N-Oxide
|
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Regorafenib-13C-d3 N-Oxide 是 Regorafenib N-Oxide 的 13C 和氘代化合物。Regorafenib N-Oxide 的 CAS 号为 835621-11-9。Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂,包括VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 , IC50分别是 13/4.2/46,22,7,1.5 和 2.5 nM。 | |||
TMIJ-0124 |
Regorafenib-13C-d3
|
||
Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂,对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。 | |||
TMIJ-0154 |
Lenvatinib-d4
|
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Lenvatinib-d4 是 Lenvatinib 的氘代化合物。Lenvatinib 的 CAS 号为 417716-92-8。Lenvatinib 是一种口服具有活性的,多靶点酪氨酸激酶抑制剂,能够抑制血管内皮生长因子受体(VEGFR1-3),成纤维细胞生长因子受体(FGFR1-4),干细胞因子受体(KIT),血小板衍生生长因子受体(PDGFR),转染期间重排(RET),具有效抗癌的作用。 |