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Search Results for " rd5 "

Targets Recommended: Others

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T67901	SRD5A1-IN-1	Others	Others
	SRD5A1-IN-1 是类固醇 5α-还原酶 1 型的抑制剂（SRD5A1，IC50 = 1.44 µM）。 SRD5A1-IN-1 可降低二氢睾酮的产生并显着降低 SRD5A1 蛋白表达。
T30582	BRD56491 BRD-56491,BRD 56491	Others	Others
	BRD56491 is a non-toxic reactive oxygen species (ROS) enhancer that strongly elevates markers of oxidative stress without causing cell death.
T10608	BRD5648 (R)-BRD0705	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	BRD5648 是 BRD0705 的阴性对照，BRD0705 是旁系选择性和口服有效的 GSK3α 抑制剂，Kd为 4.8 μM，IC50为 66 nM。与 GSK3β (IC50为 515 nM) 相比，BRD0705 对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。
T10607	BRD5631	Autophagy	Autophagy
	BRD5631 是一种自噬 (autophagy) 增强剂，通过与 mTOR 无关的通路来增强自噬。BRD5631 能够影响先前与自噬相关的几种细胞疾病表型，包括蛋白聚集、细胞存活、细菌复制和炎性因子的产生。BRD5631可以作为一种有价值的工具，用于研究自噬在细胞稳态和疾病中的作用。
T39756	BRD5018	Others	Others
	BRD5018 is an antimalarial agent.
T26899	BRD50837 BRD-50837,BRD 50837	Others	Others
	BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T70040	BRD5814	Others	Others
	BRD5814 is a highly brain penetrant β-arrestin biased D2R antagonist.
T30581	BRD5459 BRD-5459,BRD 5459	Others	Others
	BRD5459 is a kind of reactive oxygen species enhancer that is non-toxic or leads to genotype selective cell death. Brd5459 can selectively kill cancer cells in various in vitro and in vivo models.
T14777	BRD5529	Others	Others
	BRD5529 is a selective inhibitor of CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction (IC50: 8.6 μM). BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and activation of CARD9.

化合物

Synonym: BRD-56491,BRD 56491

Target: Others

BRD5648

Cat.No: T10608

Synonym: (R)-BRD0705

Target: Autophagy

Synonym: BRD-50837,BRD 50837

Synonym: BRD-5459,BRD 5459

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00895	Tubby Protein, Human, Recombinant (His) TUB,RD5,RDOB	Human	E. coli
	Tubby is the founding member of the tubby-like family of proteins. Tubby-like proteins (TLPs) possess a highly conserved closed β barrel tubby domain at C-terminal and N-terminal F-box.Tubby plays a critical role in trafficking select GPCRs to the cilia.