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TMPY-06986
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FGF-8b Protein, Human, Recombinant
NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8...
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Human
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E. coli
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In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... |
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TMPY-00005
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FGF-8a Protein, Human, Recombinant
fibroblast growth factor 8 (androgen-induced),FGF-8,AIGF,NEW...
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Human
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E. coli
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In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... |
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TMPY-01101
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Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10
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Human
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Baculovirus Insect Cells
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Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... |
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TMPY-01104
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Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI
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Human
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HEK293 Cells
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Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... |
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TMPK-01276
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CD161 Protein, Cynomolgus, Recombinant (His & Avi)
HNKR-P1a,NKRP1,KLRB1,Ly59,NKRP1ANKR,NKR-P1,CLEC5B,NKR,CD161,...
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Cynomolgus
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HEK293 Cells
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CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.5 kDa and the accession number is XP_005570142.1. |
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TMPY-04773
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TPK1 Protein, Human, Recombinant (His)
THMD5,PP20,HTPK1,thiamin pyrophosphokinase 1
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Human
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E. coli
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Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans. |
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TMPY-04510
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PSAP/Prosaposin Protein, Human, Recombinant (His)
prosaposin,SAP1,GLBA
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Human
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HEK293 Cells
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Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... |
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TMPK-00956
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CD161 Protein, Human, Recombinant (His)
KLRB1,NKRP1ANKR,CD161,NKRP1A,NKR-P1A,NKR-P1,CLEC5B,Ly59,HNKR...
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Human
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HEK293 Cells
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CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 19.6 kDa and the accession number is Q12918-1. |
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TMPK-00955
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CD161 Protein, Human, Recombinant (His & Avi), Biotinylated
NKRP1,HNKR-P1a,NKRP1A,CD161,NKR-P1A,Ly59,NKRP1ANKR,NKR,NKR-P...
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Human
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HEK293 Cells
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CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.4 kDa and the accession number is Q12918-1. |
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TMPK-01277
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CD161 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
Ly59,CLEC5B,NKRP1A,CD161,HNKR-P1a,NKRP1,NKR,KLRB1,NKRP1ANKR,...
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Cynomolgus
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HEK293 Cells
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|
CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. CD161 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 21.5 kDa and the accession number is XP_005570142.1. |
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TMPY-00452
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SBDS Protein, Mouse, Recombinant (His)
4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s...
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Mouse
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E. coli
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The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His ta... |
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TMPY-00518
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SBDS Protein, Human, Recombinant (His)
CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS
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Human
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E. coli
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The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His ta... |
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TMPJ-01287
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Sialidase-1 Protein, Human, Recombinant (His)
NEU1,NANH,Lysosomal Sialidase,G9 Sialidase,Sialidase-1,N-Ace...
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Human
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HEK293 Cells
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Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosi... |
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TMPY-00209
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PSAP/Prosaposin Protein, Rat, Recombinant (His)
prosaposin
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Rat
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HEK293 Cells
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Prosaposin (PSAP) gene mutations, affecting saposin B (Sap-B) domain, cause a rare metachromatic leukodystrophy (MLD) variant in which arylsulfatase A (ARSA) activity is normal. The human prosaposin gene (PSAP) was previously localized to 10q21-->q22 by isotopic in situ hybridization using a human prosaposin cDNA as a probe. Using fluorescence in situ hybridization with a mouse genomic prosaposin fragment as probe, confirms the localization of PSAP and precisely maps it to band 10q22.1. PSAP/Pro... |
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TMPU-00002
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SOS1-Cat Protein, Human, Recombinant (His)
SOS-1,Son of sevenless homolog 1
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Human
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E. coli
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Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid... |
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TMPY-04930
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Notch 2 Protein, Human, Recombinant (His)
AGS2,HJCYS,hN2,notch 2
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Human
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Baculovirus Insect Cells
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NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced express... |
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TMPY-04633
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Frizzled 2 Protein, Mouse, Recombinant (hFc)
AW456835,AL033370,Fz10,frizzled class receptor 2,Fzd10,Mfz10...
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Mouse
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HEK293 Cells
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FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and characterized by facial dysmorphism and shortness of the upper extremities and first metacarpal bones, and heterozygous FZD2 mutations may be disease-causing for OMOD2. heterozygous de novo mutation (G434V) in the frizzled class receptor 2 (FZD2) gene in a patient with distinct facial features including hypertelorism, bilateral cleft li... |
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TMPJ-00813
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QDPR Protein, Human, Recombinant (His)
Dihydropteridine Reductase,QDPR,DHPR,HDHPR,Quinoid Dihydropt...
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Human
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HEK293 Cells
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Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals i... |
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TMPY-00131
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Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)
NPC,Niemann-Pick disease, type C1
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Human
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HEK293 Cells
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Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty... |
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TMPY-02552
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Adenylosuccinate Lyase Protein, Human, Recombinant (His)
ASL,adenylosuccinate lyase,ASASE,AMPS
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Human
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E. coli
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Adenylosuccinate lyase, also known as adenylosuccinase, ADSL or ASL, is an enzyme implicated in the reaction of adenylosuccinat converting to AMP and fumarate as part of the purine nucleotide cycle. The two substates of adenylosuccinate lyase (ADSL) are dephosphorylated derivatives of SAICA ribotide (SAICAR) and adenylosuccinate (S-AMP), which catalyzes an important reaction in the de novo pathway of purine biosynthesis. ADSL catalyzes two distinct reactions in the synthesis of purine nucleotide... |
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TMPJ-00873
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CCL3L1 Protein, Human, Recombinant (His)
CCL3L3,G0S19-2,CCL3L1,Tonsillar Lymphocyte LD78 β,PAT 464.2,...
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Human
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HEK293 Cells
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C-C Motif Chemokine 3-Like 1 (CCL3L1) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. CCL3L1 is a ligand for CCR1, CCR3 and CCR5. CCL3L1 binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The processed form LD78-beta (3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor o... |
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TMPY-02300
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BIN1 Protein, Human, Recombinant (His)
AMPHL,bridging integrator 1,AMPH2,SH3P9
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Human
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E. coli
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Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased... |
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TMPY-02043
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PARK7/DJ-1 Protein, Human, Recombinant (His)
DJ1,HEL-S-67p,DJ-1,parkinson protein 7
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Human
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E. coli
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Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress... |
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TMPY-02000
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UNG Protein, Human, Recombinant (GST)
uracil-DNA glycosylase,HIGM4,UNG15,UNG1,DGU,UNG2,HIGM5,UDG
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Human
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E. coli
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Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil... |
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TMPY-01585
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SOD1 Protein, Human, Recombinant (His)
SOD,homodimer,ALS,hSod1,IPOA,superoxide dismutase 1, soluble...
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Human
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E. coli
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SOD1 belongs to the Cu-Zn superoxide dismutase family. It binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis.... |
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TMPY-02220
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HRAS Protein, Human, Recombinant (His)
HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...
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Human
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Baculovirus Insect Cells
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HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase... |
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TMPY-02014
|
Coagulation factor VII/F7 Protein, Human, Recombinant (His)
coagulation factor VII (serum prothrombin conversion acceler...
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Human
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HEK293 Cells
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Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is ... |
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