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Search Results for " raf1 "

Targets Recommended: Apoptosis Raf

8

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6525	GW 5074 GW5074,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,Raf1 Kinase Inhibitor I	Apoptosis; Raf	Apoptosis; MAPK
	GW 5074 (Raf1 Kinase Inhibitor I) 是一种有效且特异性的 c-Raf 抑制剂，IC50值为 9 nM。它对 JNK1/2/3、MEK1、MKK6/7、CDK1/2、c-Src、p38 MAP、VEGFR2 或 c-Fms 的活性没有影响。
T8823	Locostatin	Raf	MAPK
	Locostatin 是一种有效的细胞渗透性 Raf 激酶抑制剂蛋白 (RKIP)/Raf1 激酶相互作用抑制剂和细胞迁移抑制剂。
T1876	Kobe0065	Apoptosis; Raf; Ras	Apoptosis; GPCR/G Protein; MAPK
	Kobe0065 是一种新型 Ras-Raf 相互作用抑制剂，可完全抑制 H-Ras·GTP 与 c-Raf-1 RBD 的结合，Ki 值为 46±13 μM。
T68383	BIIB028	Others	Others
	BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o...
T6318	AZ 628	Apoptosis; Raf	Apoptosis; MAPK
	AZ 628 是一种泛Raf 激酶抑制剂，抑制B-Raf、B-RafV600E 和c-Raf-1，IC50分别为 105、34和 29 nM。
T2473	PLX-4720 PLX4720	Raf	MAPK
	PLX-4720 是一种有效且选择性的 B-Raf (V600E) 抑制剂，IC50为 13 nM，与 c-Raf-1（Y340D 和 Y341D 突变）同样有效。
T3641	NVP-BAW2881 BAW2881	Raf; VEGFR; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	NVP-BAW2881 (BAW2881) 是一种选择性的 VEGFR2抑制剂，其 IC50=9 nM。
T2382	Vemurafenib RO5185426,RG7204,维罗非尼,PLX4032	Raf; MAPK; ACK; Src; Autophagy	Angiogenesis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Vemurafenib (RG7204) 是一种 B-RAF 抑制剂，可以抑制 RAFV600E 和 c-RAF-1 (IC50=31/48 nM)，具有选择性和有效性。Vemurafenib 具有抗肿瘤活性，用于 BRAF V600E 突变阳性的黑色素瘤治疗。

化合物

Cat.No: T6525

Synonym: GW5074,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,Raf1 Kinase Inhibitor I

Target: Apoptosis, Raf

Cat.No: T8823

Target: Raf

Cat.No: T1876

Target: Apoptosis, Raf, Ras

Cat.No: T68383

Target: Others

Cat.No: T6318

Target: Apoptosis, Raf

Cat.No: T2473

Synonym: PLX4720

Target: Raf

Cat.No: T3641

Synonym: BAW2881

Target: Raf, VEGFR, Bcr-Abl

Cat.No: T2382

Synonym: RO5185426,RG7204,维罗非尼,PLX4032

Target: Raf, MAPK, ACK, Src, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01995	RAF1 Protein, Human, Recombinant (His & SUMO) RAF1,Raf-1,Proto-oncogen...	Human	E. coli
	RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kin...	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor,Stem cell factor...	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

RAF1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01995

Species: Human

Expression System: E. coli

RAF1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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