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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9271 |
RAD51-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51-IN-1 是 B02 的衍生物,是一种RAD51的有效抑制剂,可研究癌症。 | |||
T4656 |
RAD51 Inhibitor B02
B02 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51 Inhibitor B02 (B02) 是一种人 RAD51的抑制剂,IC50值为27.4 μM。 | |||
T39824 |
RAD51-IN-3
RAD51-IN-3 |
Others | Others |
RAD51-IN-3 is a Rad51 inhibitor. | |||
T12682 |
Emzadirib
CYT-0851,RAD51-IN-2 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Emzadirib (RAD51-IN-2) 是一种有效的 RAD51 抑制剂,具有潜在的抗癌活性,可用于研究 DNA 损伤修复。 | |||
T2276 |
RI-1
RI-1; 3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮,RI1,RAD51 inhibitor 1 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RI-1 (RAD51 inhibitor 1) 是一种选择性 RAD51的抑制剂,IC50值为 5-30 μM,可以破坏人类细胞中的同源重组。它在半胱氨酸 319 处与 RAD51 蛋白表面共价结合,并通过直接结合到 RAD51 细丝中蛋白质亚基之间的界面的蛋白质表面来灭活 RAD51。 | |||
T61469 |
RAD51-IN-8
|
Others | Others |
RAD51-IN-8,一种新型 RAD51 结合剂,是一种RAD51-BRCA2抑制剂,可在微摩尔范围内抑制 RAD51-BRCA2 蛋白的相互作用。RAD51-IN-8 也是一种蛋白质-蛋白质相互作用 (PPI) 抑制剂。RAD51-IN-8 对 H4A4 具有抑制活性,EC50值为19 μM。 | |||
T63728 |
RAD51-IN-7
|
Others | Others |
RAD51-IN-7 是 RAD51 的有效抑制剂。其中 RAD51 是一种真核生物基因。RAD51-IN-7 对线粒体缺陷病症表现出研究潜力。 | |||
T63892 |
RAD51-IN-5
|
Others | Others |
RAD51-IN-5 是 RAD51 有效的抑制剂。其中 RAD51 是一种真核生物基因。RAD51-IN-5 对线粒体缺陷病症表现出研究潜力。 | |||
T2628 |
RI-2
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RI-2 是一种可逆的RAD51抑制剂,IC50值为 44.17 μM,可抑制人体细胞中的同源重组修复。 | |||
T63883 |
RAD51-IN-6
|
Others | Others |
RAD51-IN-6 是 RAD51 的有效抑制剂。其中 RAD51 是一种真核生物基因。RAD51-IN-6 对线粒体缺陷病症表现出研究潜力。 | |||
T73107 |
RAD51-IN-4
|
Others | Others |
RAD51-IN-4 是一种有效的RAD51抑制剂。RAD51是一种真核生物基因。RAD51-IN-4 具有研究线粒体缺陷病症的潜力。 | |||
T6972 |
RS-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RS-1 是一种 RAD51 的激活剂,同时可增强 CRISPR/Cas9 的活性。 | |||
T11600 |
IBR2
Isoquinoline |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
IBR2(Isoquinoline)是一种针对RAD51的强效特异性抑制剂,通过干预RAD51多聚体形成,加速蛋白酶体介导的RAD51蛋白降解,抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。 | |||
T8873 |
Bractoppin
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。 | |||
T9168 |
NSC 617145
NSC617145,NSC-617145 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂,IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶,并诱导双链断裂和染色体异常。 | |||
T2516 |
Amuvatinib
MP470,HPK 56 |
Apoptosis; FLT; c-Met/HGFR; c-RET; DNA/RNA Synthesis; PDGFR; c-Kit | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂,对突变 c-Kit,PDGFRα,Flt3,c-Met 和 c-Ret 具有活性。它还是一种 DNA 修复抑制剂,靶向蛋白 DNA 修复 RAD51,从而破坏 DNA 损伤修复,具有抗肿瘤活性。 | |||
T60006 |
Aromatase inhibitor 23
|
Others | Others |
Aromatase inhibitor 23 是一种针对 RAD51 重组酶家族中蛋白质-蛋白质相互作用的抑制剂。 | |||
T6960L |
PU-H71 HCl
PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl |
HSP; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism |
PU-H71 HCl (Zelavespib HCl) 是一种新型Hsp90抑制剂,是一种新型嘌呤基类似物,也是一种可能是CIRT的一种有前途的放射增敏剂。PU-H71 HCL 在许多恶性肿瘤临床前模型中显示出抗肿瘤活性。PU-H71 HCL 对 Rad51 和Ku70 的蛋白表达水平有抑制作用,这可能与双链断裂修复的同源重组途径和非同源末端连接途径有关。 | |||
T10936 |
D-I03
DI03 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
D-I03 是一种选择性的RAD52 抑制剂,Kd 为 25.8 µM。D-I03 抑制 RAD52 依赖性单链退火 (SSA) 和 D 环形成,IC50 分别为 5 µM 和 8 µM。D-I03 抑制 BRCA1 和 BRCA2 缺陷细胞的生长,并抑制顺铂诱导的 RAD52 病灶形成,但对 RAD51 无影响。 | |||
T41211 |
CAM 833
|
Others | Others |
CAM 833 是一种有效的正位抑制剂,对 BRCA2 和 RAD51 之间相互作用具有抑制作用,对 ChimRAD51 蛋白的 Kd 为 366 nM。 CAM833 抑制 RAD51 的寡聚,促进 G2/M 阻滞细胞的凋亡 (apoptosis) 进程。 | |||
T27526 |
Halenaquinone
|
Others | Others |
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells. | |||
T28536 |
RI(dl)-2 TFA
RI(dl)-2 |
Others | Others |
RI(dl)-2 TFA 是一种有效的选择性 RAD51 介导的 D 环形成 (RAD51-mediated D-loop formation) 抑制剂,IC50为 11.1 μM,并抑制人细胞中的同源重组 (HR) 活性,IC50为 3.0 μM。 | |||
T63717 |
CAM833
|
Others | Others |
CAM833 是有效的抑制 BRCA2 和 RAD51 之间相互作用的正位抑制剂,也能够抑制 RAD51 的寡聚,能够作用于 ChimRAD51 蛋白 (Kd: 366 nM)。 | |||
T14282 |
Amuvatinib hydrochloride
HPK 56 hydrochloride,MP470 hydrochloride |
Others | Others |
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret and is also a DNA repair suppressor through suppression of DNA repai | |||
T20694 |
DIDS
|
Others | Others |
DIDS, an anion exchange inhibitor, acts by blocking reversibly and later irreversibly, exchangers such as chloride-bicarbonate exchanger. It is also a RAD51 inhibitor. | |||
T36703 |
CAY10760
|
Others | Others |
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 μM. CAY10760 (20 μM) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib . 1.Bag... | |||
T74501 |
NHEJ inhibitor-1
|
Others | Others |
NHEJ inhibitor-1 (Compound C2) 是一种三功能 Pt(II) 复合物,可缓解非同源末端连接 (NHEJ)/同源重组 (HR) 相关的双链断裂 (DSB) 修复,从而避免非小细胞肺对顺铂的耐药性。NHEJ inhibitor-1 抑制损伤修复蛋白 Ku70 和 Rad51,从而使肿瘤对活性分子重新敏感。NHEJ inhibitor-1 还诱导 ROS 产生和MMP 降低。 | |||
T83854 |
BRC4wt TFA
|
||
BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽,并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时,BRC4wt缩短了体外DNA复制轨迹长度,并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率,同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡,但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。 | |||
T36701 |
Phosphoramide mustard (cyclohexanamine)
|
Others | Others |
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01179 |
SWSAP1 Protein, Human, Recombinant (His)
SWS1-associated protein 1,SWIM-type zinc finger 7-associated... |
Human | E. coli |
SWSAP1 is a nucleus ATPase protein, interacts with ZSWIM7 and forms a functional complex. The complexs involved in homologous recombination repair and stabilizes each other. SWS1AP1 also interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3. It involves in homologous recombination repair. ATPase is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). SWSAP1 has a DNA-binding activity which is independent of its ATPase activity. | |||
TMPH-03440 |
RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)
RAD52,DNA repair and recombination protein RAD<... |
Saccharomyces cerevisiae | E. coli |
Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778. | |||
TMPH-01237 |
POLQ Protein, Human, Recombinant (E. coli, His)
DNA polymerase eta,POLQ,DNA polymerase theta |
Human | E. coli |
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul... | |||
TMPH-01238 |
POLQ Protein, Human, Recombinant (His)
DNA polymerase eta,POLQ,DNA polymerase theta |
Human | Baculovirus Insect Cells |
DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul... | |||
TMPH-01267 |
RNF13 Protein, Human, Recombinant (His & Myc)
RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,... |
Human | E. coli |
E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist... |