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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26744 |
BAY-598 R-isomer
BAY598 R-isomer,BAY 598 R-isomer |
Others | Others |
BAY-598 R-异构体是BAY589的R-异构体,它可用作参考化合物。它是是赖氨酸N-甲基转移酶(SMYD2)的抑制剂,对SMYD2比蛋白酶激活的受体1(PAR1)具有选择性。 | |||
T12617 |
(R)-CR8 trihydrochloride
CR8, (R)-Isomer trihydrochloride |
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) 是一种 CDK1/2/5/7/9 抑制剂,可作为分子胶降解剂,具有神经保护活性,可诱导细胞凋亡。 | |||
T11650 |
INCB3344 R-isomer
|
Others | Others |
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344. | |||
T63166L |
(S, R)-LSN 3318839
(S, R)-LSN 3318839(Isomer-2764704-18-7) |
Glucagon Receptor | GPCR/G Protein |
T70544 |
MKC-963 (R-isomer)
|
Others | Others |
MKC-963 is a platelet aggregation inhibitor and autoinducer of CYP3A4. | |||
T12617L |
(R)-CR8
(R)-CR8,(R)-Isomer,(2R)-2-[[9-异丙基-6-[[[4-(2-吡啶基)苯基]甲基]氨基]-9H-嘌呤-2-基]氨基]-1-丁醇,CR8 |
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
(R)-CR8 ((R)-Isomer) 是 Roscovitine 类似物,是CDK1/2/5/7/9抑制剂。它作为一种分子胶降解剂来消耗细胞周期蛋白 K。它诱导细胞凋亡并具有神经保护作用。 | |||
T71236 |
Oxybutynin R-isomer HCl
|
Others | Others |
Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blo... | |||
T6183 |
ISRIB (trans-isomer)
ISRIB,ISRIB trans-isomer,trans-isomer,trans-ISRIB |
Apoptosis; PERK; Autophagy | Apoptosis; Autophagy |
ISRIB (trans-isomer) (ISRIB trans-isomer)是一种 PERK 的高效抑制剂,可有效逆转 eIF2α 磷酸化的作用,IC50值为 5 nM。 | |||
T33384 |
Midodrine (R-isomer HCl)
ProAmatine,Midodrine,ST-1085,Gutron,Amatine |
Others | Others |
Midodrine is a vasopressor/antihypertensive agent for the treatment of symptomatic postural hypotension. | |||
T69703 |
BAY-6035-R-isomer
|
Others | Others |
BAY-6035 is an inhibitor of the methylation of MEKK2 peptide. | |||
TD0058 |
6-TRITC
四甲基罗丹明-6-异硫氰酸(单一化合物),R isomer [Tetramethylrhodamine-6-isothiocyanate] |
||
6-TRITC can bind to various antibody proteins, and the antibody does not lose its specificity of binding to certain antigens, and has a strong yellow-green fluorescence in alkaline solution. | |||
T5517 |
(R)-Carisbamate
|
Others | Others |
(R)-Carisbamate 是 Carisbamate 的 R-异构体。 Carisbamate 是一种实验性抗惊厥药。 | |||
T26914L |
(R)-AZD 9639
|
Others | Others |
(R)-AZD 9639 是 AZD 9639 的 R型异构体。AZD 9639 是一种新型呼吸道合胞病毒(RSV)融合抑制剂,具有抗病毒活性。 | |||
T22413 |
(R)-Viloxazine Hydrochloride
|
Others; Reductase | Endocrinology/Hormones; Metabolism; Others |
(R)-Viloxazine Hydrochloride是Viloxazine的R型异构体,Viloxazine是一种选择性去甲肾上腺素再摄取抑制剂(NRI),可用作抗抑郁药。 | |||
T50052 |
1,2-diphenylpropan-2-amine
|
Others | Others |
1,2-diphenylpropan-2-amine 是Remacemide 的(S,R)-异构体单盐酸盐代谢产物。1,2-diphenylpropan-2-amine 具有抗惊厥作用。 | |||
T1021 |
(R)-Lansoprazole
Dexlansoprazole,右旋兰索拉唑,T 168390,TAK 390,R-(+)-Lansoprazole |
Proton pump | Membrane transporter/Ion channel |
(R)-Lansoprazole (T 168390) 是Lansoprazole 的R 型异构体。Lansoprazole 是口服有效的质子泵抑制剂,能抑制胃酸生成。Lansoprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂),能透过血脑屏障。 | |||
T72754L |
(R)-JAK2/STAT3-IN-10a
|
Antiviral | Immunology/Inflammation |
(R)-JAK2/STAT3-IN-10a 是 JAK2/STAT3-IN-1 的R型异构体。JAK2/STAT3-IN-1 是一种 GP130 D1 结构域抑制剂,具有抗肿瘤活性,抑制 JAK2 和 STAT3 磷酸化。(R)-JAK2/STAT3-IN-1 对 GP130 蛋白的 KD 值为3.8μM。 | |||
T68002L |
(R)-Naroparcil
|
Others | Others |
(R)-Naroparcil 是 Naroparcil 的异构体。 Naroparcil 是一种4-甲基伞形酮基 β-D-木糖苷类似物,与血管平滑肌细胞增殖有关,在 Wessler 淤滞模型中抑制血栓的形成。 | |||
T63898 |
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-是一种PPARα/γ双激动剂,EC50 分别为 0.358μM 和1.21μM。Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-是Aleglitazar 的R 型异构体。 | |||
T29905 |
Alprenolol tartrate, (R)-
|
Others | Others |
Alprenolol tartrate, (R)-, is the R isomer of Alprenolol tartrate. | |||
T12611 |
R 80123
|
Others | Others |
R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595 | |||
T13442 | (R)-BAY1238097 | Others | Others |
(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a selective BET inhibitor. | |||
T21265 |
(R)-Amlodipine
D-Amlodipine,(R)-(+)-Amlodipine,(+)-Amlodipine |
Others | Others |
(R)-Amlodipine is the R isomer of Amlodipine, a medication used to prevent chest pain and lower blood pressure. | |||
T17307 |
(R)-Ofloxacin
DR3354,D-Ofloxacin,DR-3354,DR 3354,(R)-氧氟沙星,(R)-(+)-Ofloxacin,(+)-Ofloxacin |
Others | Others |
(R)-Ofloxacin is a R-isomer of Ofloxacin, an antibiotic used to treat a number of bacterial infections. | |||
T70780 |
BW 737C89
|
Others | Others |
BW 737C89 is a highly potent dopamine D1 receptor antagonist; BW-737C is the (S)-isomer; BW-736C is the (R)-isomer. | |||
T12621 |
(R)-FT671
|
Others | Others |
(R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective inhibitor of USP7 (IC50 of 52 nM) | |||
T29671 |
Adrafinil, (R)-
UNII-Z61JQF40LJ,Adrafinil (R)-,R-(+)-Adrafinil |
Others | Others |
Adrafinil, (R)- is the R isomer of Adrafinil -- a eugeroic that was formerly used to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly. | |||
T31176 |
Dabelotine, (R)-
UNII-3NZJ1HNE7Y |
Others | Others |
Dabelotine, (R)- 是 Dabelotine 的 R 型异构体。Dabelotine 是一种肾上腺素能受体激动剂,可用于研究痴呆症。 | |||
T84578 |
15(R)-15-methyl Prostaglandin F2α
15(R)-15-methyl PGF2α |
Others | Others |
15(R)-15-methyl PGF2α, a metabolically stable analog of PGF2α, is an inactive, prodrug PGF agonist intended for activation by gastric acid through oral administration. This transformation involves acid-catalyzed epimerization that converts 15(R)-15-methyl PGF2α into its active counterpart, the 15(S)-isomer. Upon conversion, the 15(S)-isomer has been shown to induce luteolysis in rhesus monkeys following an approximately 12 mg/animal dosage, a response not observed with the 15(R)-isomer. | |||
T26266 |
TH-162
L-PIA,(R)-PIA,(R)- PIA,(R)-PIA,L-2-N6-(Phenylisopropyl)adenosine |
Others | Others |
TH-162, also known as (R)-PIA and Adenosine, N-(1-methyl-2-phenylethyl)-, (R)-, is an agonist of the A1 adenosine receptor. Affinity for adenosine receptors is approx. 100× that of the (+)-isomer. | |||
T21234 |
(R)-Dihydrolipoic acid
|
Others | Others |
(R)-Dihydrolipoic acid is a R-isomer of Dihydrolipoic acid. It is optically active, but only the R-enantiomer is biochemically significant. The lipoic acid/dihydrolipoic acid pair participate in a variety of biochemical transformations. | |||
T37227 |
(±)8(9)-DiHET
|
Others | Others |
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor. | |||
T17951 |
Fmoc-Gly-Gly-D-Phe-OtBu
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Fmoc-Gly-Gly-D-Phe-OtBu, an ADC cleavable linker, is utilized in the synthesis of antibody-drug conjugates. It is the R-isomer of Fmoc-Gly-Gly-Phe-OtBu [1]. | |||
T72820 |
(R)-Casopitant
(R)-GW679769 |
Others | Others |
(R)-Casopitant ((R)-GW679769) 是Casopitant 的异构体。Casopitant 是一种 NK(1)-受体拮抗剂。Casopitant 可用于化疗引起的恶心和呕吐的研究。 | |||
T61309 |
(R)-Oxybutynin
|
Others | Others |
(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3]. | |||
T72913 |
(R)-MLN-4760
|
Others | Others |
(R)-MLN-4760 是 MLN-4760 的活性较低的 R 型异构体,是一种ACE2抑制剂,IC50值为 8.4 μM。 | |||
T36840 |
(R)-Omeprazole (sodium salt)
|
Others | Others |
(R)-Omeprazole is the inactive isomer of omeprazole , a gastric proton-pump inhibitor. A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer . (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 μM). | |||
T38031 |
(R)-KT109
(R)-KT109 |
Others | Others |
(R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol . It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 . | |||
T84559 |
15(S)-Fluprostenol
|
Others | Others |
15(S)-Fluprostenol, an isomer of the FP receptor agonist fluprostenol, serves as a potential active metabolite of 15(S)-fluprostenol isopropyl ester. It can function as an agonist at FP receptors, though with lower potency compared to its 15(R) epimer, fluprostenol. | |||
T84624 |
8-iso-15(R)-Prostaglandin F2α
8-iso-15-epi PGF2α |
Others | Others |
8-iso-15(R)-Prostaglandin F2α (8-iso-15(R) PGF2α) is a chemically distinct member within a broad group of prostaglandin-like eicosanoids, produced through the free radical peroxidation of arachidonic acid contained in membrane phospholipids. It represents the C-15 epimer of 8-isoPGF2α, distinguished as the sole isoprostane isomer extensively examined across numerous biological systems. | |||
T62881 |
(R)-BAY-899
|
Others | Others |
(R)-BAY-899 是一种 BAY-899 的 R 型异构体。其中 BAY-899 是一种选择性的、口服具有活力的促黄体生成激素受体 (LH-R) 拮抗剂,作用于 hLH (人 LH) (IC50: 185 nM) 和 rLH (大鼠 LH) (IC50: 46 nM)。 | |||
T35467 |
(±)18-HETE
|
Others | Others |
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure. 18-HETE has negligible effects on ATPase activity. 18(R)-HETE at 1 μM completely blocks 20-HETE-induced vasoconstriction of renal arterioles. | |||
T71736 |
AMG-628, (R)-
|
Others | Others |
AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. | |||
T70430 |
XK469
|
Others | Others |
XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. | |||
T73507 |
NS1219
(R)-SPD502 |
Others | Others |
NS1219 ((R)-SPD502) 是 NS 1209 的异构体。NS1209 是一种选择性AMPA 受体拮抗剂,具有神经保护活性。NS1209 可用于中风、神经性疼痛和癫痫的研究。 | |||
T72663 |
(Rac)-Etavopivat
(Rac)-FT-4202 |
Others | Others |
(Rac)-Etavopivat((Rac)-FT-4202) 是Etavopivat 异构体。Etavopivat 是一种具有口服活性的的红细胞丙酮酸激酶-R (PKR) 激活剂,可以用于镰状细胞病和其他血红蛋白疾病研究。 | |||
T38148 |
(S)-KT109
(S)-KT109 |
Others | Others |
(S)-KT109 is the (S) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 . (S)-KT109 is a less potent inhibitor of DAGLβ (IC50 = 39.81 nM), DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM), and α/β-hydrolase domain-containing protein 6 (ABHD6; IC50 = 630.9 nM) than (R)-KT109 . | |||
T36608 |
(±)8-HEPE
|
Others | Others |
(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.[1][2] Reference:[1]. Shing, T.K.M., Gibson, K.H., Wiley, J.R., et al. First total synthesis of a barnacle hatching factor 8(R)-hydroxy-eicosa-5(Z),9(E),11(Z)-pentaenoic acid. Tetrahedron Letters 35, 1067-1070 (1994).[2]. Hill, E... | |||
T71483 |
Streptonigrin (racemate)
|
Others | Others |
Streptonigrin is an aminoquinone antitumor and antibacterial antibiotic produced by Streptomyces flocculus. Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells. Streptonigrin induces delayed chromosomal instability involving interstitial telomeric sequences in Chinese hamster ovary cells. Note: Streptonigrin from natural resource is (-)-rotation, has CAS#3930-19-6 and is a R-isomer. | |||
T84598 |
15(R),19(R)-hydroxy Prostaglandin F2α
15(R),19(R)-hydroxy PGF2α |
Others | Others |
19(R)-Hydroxylated prostaglandins (PGs) are present at µg/ml concentrations in the semen of some mammalian species, notably primates, with the majority being from the PGE series and featuring a 15(S),19(R) hydroxyl stereochemistry. These compounds are also observed in marsupials' seminal plasma, where F-type 1 and 2-series compounds are predominant. The 15(R)-hydroxy epimer represents the inverse or "unnatural" isomer at C-15 for these 19-hydroxylated PGs. Although the biological function of 19(... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5302 |
(R)-pyrrolidine-2-carboxylic acid
D-脯氨酸,D-Proline |
Others; Endogenous Metabolite | Metabolism; Others |
(R)-pyrrolidine-2-carboxylic acid (D-Proline) 是天然氨基酸 L -脯氨酸的异构体。D -氨基酸在人类血浆和唾液中含量相对较高。这些氨基酸可能是细菌来源,但也有证据表明它们是通过氨基酸消旋酶活性内源性产生的。 | |||
TN7295 |
(R)-(+)-Tetrahydroberberine
(R)-(+)-Canadine,(+)-Canadine |
Others | Others |
(R)-(+)-Tetrahydroberberine 为 (S)-(-)-Tetrahydroberberine 的非活性异构体,常用作实验对照物。其中,(S)-(-)-Tetrahydroberberine 是生物碱种类,作为小檗碱生物合成路径中的中间体,具备杀虫作用。 | |||
T74193 |
(R)-IDHP
|
Others | Others |
(R)-IDHP为IDHP异构体,属于丹参代谢物。该化合物能通过抑制血管平滑肌细胞电压依赖性钙通道与受体操作钙通道的Ca2+释放和Ca2+内流,发挥血管松弛作用,适用于心脑血管疾病研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0187 |
Dexlansoprazole-d4
(R)-Lansoprazole-d4 |
||
Dexlansoprazole-d4 是 Dexlansoprazole 的氘代化合物。Dexlansoprazole 的 CAS 号为 138530-94-6。(R)-Lansoprazole 是Lansoprazole 的R型异构体。Lansoprazole 是口服有效的质子泵抑制剂,能抑制胃酸生成。Lansoprazole 是中性鞘磷脂酶(N-SMase)的抑制剂(外泌体抑制剂),能透过血脑屏障。 |