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Targets Recommended: Dopamine Receptor 5-HT Receptor Adrenergic Receptor AChR Histamine Receptor

抑制剂 & 化合物

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0162	Quetiapine ICI204636,Quetiapin,喹硫平	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Quetiapine (ICI204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂，对人5-HT1A 的 pEC50值为 4.77，对人 D2的 pIC50值为 6.33。它用于治疗精神分裂症，以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人 D2、HT1、5-HT2A、5-HT2C 受体具有中高等亲和力，pKi 值为 7.25、5.74、7.54和5.55。
T6241	Quetiapine hemifumarate Quetiapine Fumarate,ICI-204636,富马酸喹硫平	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Quetiapine hemifumarate (ICI-204636) 是5-HT 受体激动剂和多巴胺受体拮抗剂，对人5-HT1A 和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。
T12619	Quetiapine sulfoxide Quetiapine S-oxide	Others	Others
	Quetiapine sulfoxide is a main Quetiapinem metabolite. Quetiapine is a agonist of 5-HT receptors and a antagonist of dopamine receptor.Quetiapine is a second-generation antipsychotic.
T12619L	Quetiapine sulfoxide dihydrochloride Quetiapine S-oxide dihydrochloride,喹硫平亚砜双盐酸盐	Others	Others
	Quetiapine sulfoxide dihydrochloride is a main Quetiapinem metabolite. Quetiapine is a agonist of 5-HT receptors and a antagonist of dopamine receptor.Quetiapine is a second-generation antipsychotic.
T12619L2	Quetiapine sulfoxide hydrochloride Quetiapine S-oxide hydrochloride,Quetiapine sulfoxide hydrochloride (329216-63-9 free base)	Others	Others
	Quetiapine sulfoxide hydrochloride is a main metabolite of Quetiapinem. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
T125035	Quetiapine hydroxy impurity	Others	Others
	Quetiapine hydroxy impurity 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125035，CAS号为 329216-67-3。
T84947	Desethoxy Quetiapine hydrochloride O-Desalkylquetiapine	Others	Others
	Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg/kg mitigates dopamine receptor agonist apomorphine-induced climbing behavior and ameliorates swimming deficits in mice, showcasing its potential modulatory effects on dopamine-mediated behaviors.
T68706	Olanzapine HCl	Others	Others
	Olanzapine HCl is an atypical antipsychotic. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and bipolar disorder. Olanzapine is structurally similar to clozapine and quetiapine. It is a dopamine antagonist and is classified as a thienobenzodiazepine.

化合物

Quetiapine

Cat.No: T0162

Synonym: ICI204636,Quetiapin,喹硫平

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

Quetiapine hemifumarate

Cat.No: T6241

Synonym: Quetiapine Fumarate,ICI-204636,富马酸喹硫平

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Quetiapine sulfoxide

Cat.No: T12619

Synonym: Quetiapine S-oxide

Target: Others

Quetiapine sulfoxide dihydrochloride

Cat.No: T12619L

Synonym: Quetiapine S-oxide dihydrochloride,喹硫平亚砜双盐酸盐

Target: Others

Quetiapine sulfoxide hydrochloride

Cat.No: T12619L2

Synonym: Quetiapine S-oxide hydrochloride,Quetiapine sulfoxide hydrochloride (329216-63-9 free base)

Target: Others

Quetiapine hydroxy impurity

Cat.No: T125035

Synonym:

Target: Others

Desethoxy Quetiapine hydrochloride

Cat.No: T84947

Synonym: O-Desalkylquetiapine

Cat. No.	Product Name	Target	Signaling Pathways
T12618	Quetiapine-d4 fumarate Quetiapine D4 fumarate,富马酸奎硫平 D4	Others	Others
	Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic.
T12618L	Quetiapine-d4 hemifumarate 半富马酸奎硫平 D4	Others	Others
	Quetiapine D4 hemifumarate is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with ntidepressant and anxiolytic.
TMID-0025	Quetiapine-d8 Hemifumarate
	Quetiapine-d8 Hemifumarate 是 Quetiapine Hemifumarate 的氘代化合物。Quetiapine Hemifumarate 的 CAS 号为 111974-72-2。Quetiapine Fumarate 是5-HT受体激动剂和多巴胺受体拮抗剂，对人5-HT1A和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。
TMIJ-0315	Quetiapine-d8 Fumarate
	Quetiapine-d8 Fumarate 是 Quetiapine Fumarate 的氘代化合物。Quetiapine Fumarate 的 CAS 号为 111974-72-2。Quetiapine Fumarate 是5-HT受体激动剂和多巴胺受体拮抗剂，对人5-HT1A和人D2的pEC50值分别为 4.77 和 6.33，具有抗抑郁和抗焦虑作用。