47
2
4
6
Cat. No. | Product Name | ||
---|---|---|---|
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; | |||
L3300 | 组胺&褪黑色素化合物库 | 153 compounds | |
153 种生物活性小分子化合物,用于高通量、高内涵筛选; | |||
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24656 |
PQ-10
A844337,PQ 10,A-844337,A 844337 |
PDE | Metabolism |
PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂,其IC50=4.6 nM,ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式,这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。 | |||
T7706 |
LY-404187
N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺 |
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
LY404187 是一种选择性的、有效的,中枢活性的AMPA 受体的正变构调节剂,作用于GluR1i,GluR2i,GluR2o,GluR3i 和GluR4i 的EC50值分别为 5.65、0.15、1.44、1.66 和 0.21 µM。它用于许多精神疾病和神经退行性疾病的研究潜力。 | |||
T28368 |
PF-04859989 HCl
PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 |
Others | Others |
PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂,可透过血脑屏障,抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。 | |||
T0024 |
Primidone
Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360 |
GABA Receptor; Sodium Channel; GluR; AChR | Membrane transporter/Ion channel; Neuroscience |
Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂,在癫痫、原发性震颤和精神疾病的研究中具有价值。 | |||
T22016 |
A-582941 dihydrochloride
A 582941 |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
A-582941 dihydrochloride (A 582941) 是选择性和可透过血脑屏障的 α7 nAChR 的部分激动剂,在大鼠脑膜和人额叶皮层的Ki 值分别为 10.8 和 16.7 nM。它与人5-HT3受体结合,Ki 值为 150 nM,具有与各种神经退行性疾病和精神疾病相关的认知缺陷的研究潜力。 | |||
T7165 |
Basmisanil
RG1662,RO5186582,巴米沙尼 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Basmisanil (RG1662) 是高度选择性GABAAα5负调节剂,用于治疗与唐氏综合症相关的认知障碍。 | |||
T0678 |
Amitriptyline hydrochloride
Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin |
Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂,还与多巴胺再摄取转运体结合,其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂,具有强神经营养活性和有抗抑郁作用。 | |||
T20324 |
Butyrophenone
苯丁酮,NSC8463,NSC 8463,NSC-8463 |
Others | Others |
Butyrophenone (NSC-8463) 是一种化合物。它的一些衍生物用于治疗各种精神疾病。 | |||
T83974 |
OPC18750 HCl
|
PDE | Metabolism |
OPC18750 HCl 是一种潜在的磷酸二酯酶抑制剂,具有正肌力作用,可用于研究哮喘、癌症、糖尿病和精神疾病。 | |||
T50054 |
Opromazine hydrochloride
|
Others | Others |
Opromazine hydrochloride 属于吩噻嗪类抗精神病药物,通过阻断大脑中的多巴胺受体而降低多巴胺能通路的活性,主要用于治疗精神分裂症和精神病等精神疾病。 | |||
T31079 |
CP-810123
CP 810123,UNII-E6G4550EC4,CP810123 |
AChR | Neuroscience |
CP-810123 是一种新的α 7 nAChR 激动剂,可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。 | |||
T23066 |
NGD 94-1
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
NGD 94-1 是一种选择性的 D4 受体拮抗剂,对D4受体的亲和力为3 nM,而对D1、D2、D3和D5受体的亲和力大于2 pM。NGD 94-1 可用研究认知障碍等精神性疾病。 | |||
T50061 |
[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine
|
Others | Others |
[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine 是一种哌嗪衍生物,它是血清素和多巴胺受体的部分激动剂,使其成为治疗抑郁症和精神分裂症等精神疾病的候选药物。 | |||
T5444 |
CLP290
CLP-290 |
Potassium Channel | Membrane transporter/Ion channel |
CLP-290 是一种神经特异性 K+-Cl−共转运体 KCC2的口服激活剂,在多种神经和精神疾病方面具有研究潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。 | |||
T1292 |
Tiapride hydrochloride
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Tiapride 是一种大脑中 D2/3 多巴胺受体的选择性阻滞剂。 它用于治疗各种精神和神经系统疾病,包括运动障碍、酒精戒断综合征、精神病的阴性症状以及老年人的攻击和激动。 | |||
T77597 |
SXC 2023
(S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid |
Others | Others |
SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) 是一种可治疗中枢神经疾病和神经认知障碍的N-乙酰-L-半胱氨酸的前药,可用于治疗谷氨酸能功能障碍和氧化应激起关键作用的精神疾病。 | |||
T67811 |
Tefludazine
|
Others | Others |
Tefludazine 一种具有苯茚酮结构的新型神经抑制剂, 是一种具有良好口服活性且与多巴胺和5-羟色胺受体有拮抗作用的化合物。Tefludazine 在小鼠、大鼠和狗的体外和体内测试模型中表现出强大的多巴胺(DA)拮抗活性。Tefludazine 是一种用来治疗精神类疾病的潜在化合物。 | |||
T50111 |
6-Fluorotryptamine hydrochloride
|
Others | Others |
6-Fluorotryptamine hydrochloride 是一种用作分子结构单元的化合物,是天然色胺生物碱血清素的衍生物。它是5-HT2A 和5-HT2C 血清素受体的激动剂,使其成为开发治疗各种精神和神经疾病的新药的潜在候选者。 | |||
T39218 |
(S)-CVN424
(S)-CVN424 |
Others | Others |
(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease. | |||
T12318 |
Org-10490
|
Others | Others |
Org-10490 is an dopamine D1 receptor and dopamine D2 receptor antagonist, and treatment for psychiatric disease. | |||
T24766 |
SBI-0061869
SBI0061869 |
Others | Others |
SBI-0061869 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders. | |||
T28085 |
Moperone Hydrochloride
EN1733A,EN 1733A,EN-1733A |
Others | Others |
Moperone Hydrochloride, a dopamine D2-receptor antagonist, is used for the treatment of psychiatric disorders. | |||
T79838 |
(S)-Bexicaserin
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
(S)-Bexicaserin (化合物 2),作为一种5-HT2C受体激动剂,展现了在肥胖和精神相关疾病研究中的应用潜力。 | |||
T24767 |
SBI-0069332
|
Others | Others |
SBI-0069332 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders. | |||
T39940 |
Plazinemdor
|
Others | Others |
Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system. | |||
T7352L |
Pridopidine hydrochloride
ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride |
Others | Others |
Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor activity in a state-dependent way t | |||
T82891 |
Bexicaserin
|
Others | Others |
Bexicaserin (Compound 3)为5-HT2C受体激动剂,可研究治疗肥胖及精神疾病。 | |||
T61578 |
BRD3731
|
Others | Others |
BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, including post-traumatic stress disorder (PTSD), psychiatric disorders, diabetes, and neurodegenerative disorders [1]. | |||
T61207 |
5-HT6/5-HT2A receptor ligand-1
|
Others | Others |
5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1]. | |||
T60913 |
Aceprometazine
|
Others | Others |
Aceprometazine (1664CB) 是具有口服活性的抗精神病剂。Aceprometazine 可用于精神类疾病研究,例如抑郁症。 | |||
T38828 |
Mesdopetam
IRL790 |
Others | Others |
Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease. | |||
T70196 |
AZD1446 HCl
|
Others | Others |
AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease. | |||
T70787 |
AZD1446 tosylate
|
Others | Others |
AZD1446 tosylate, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 tosylate showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease. | |||
T60923 |
Zelquistinel
|
Others | Others |
Zelquistinel 用于研究抑郁、焦虑和其他相关精神疾病的研究。它是一种 N-甲基-D-天冬氨酸(NMDA)受体的部分激动剂。 | |||
T78920 |
HDAC-IN-58
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC-IN-58为HDAC抑制剂,特异性针对HDAC6,其IC50值达2.06 nM。适用于慢性疾病,如神经退行性和精神疾病的研究。 | |||
T60611 |
Talaglumetad hydrochloride
|
Others | Others |
Talaglumetad (hydrochloride) 是Eglumegad 的前药,Eglumegad 是II 型代谢型谷氨酸受体(mGluR2/3)有效选择性的激动剂,用于治疗焦虑等精神疾病。 | |||
T16507 |
PF-5006739
|
Casein Kinase | Metabolism; Stem Cells |
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selecti | |||
T80971 |
TNIK-IN-6
|
Others | Others |
TNIK-IN-6 (Compound 9) 是一种Traf2和Nck相互作用激酶(TNIK)的抑制剂,具有0.93 nM的IC50,对神经与精神疾病具有重要影响。 | |||
T62975 |
Haloperidol lactate
|
Others | Others |
Haloperidol lactate 是一种有效的抗精神病药。Haloperidol lactate 具有潜力进行精神障碍的研究。Haloperidol lactate 能够用于急性和慢性精神分裂症和多发性秽语综合征。 | |||
T72246 |
Bicuculline methobromide
(+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide |
Others | Others |
Bicuculline methobromide 是选择性GABAA 受体拮抗剂,具IC50值为3 μM。该化合物可引起哺乳类动物阵挛性强直性惊厥,且能阻断Ca2+激活的钾通道,用于癫痫等精神疾病研究。 | |||
T62202 |
mGluR2 modulator 1
|
Others | Others |
mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。 | |||
T60578 |
Procyclidine
|
Others | Others |
Procyclidine (Tricyclamol; (±)-Procyclidine) 是一种抗胆碱能剂。它是一种毒蕈碱受体 (muscarinic receptor) 拮抗剂,也是 N-甲基-D-天冬氨酸 (NMDA) 拮抗剂。Procyclidine 可用于帕金森症和相关精神疾病的研究,如Soman 诱发的癫痫。 | |||
T74668 |
Zicronapine fumarate
|
Others | Others |
Zicronapine (Lu 31-130) fumarate 是抗精神病药,主要通过拮抗多巴胺D1/D2受体和5-HT2A受体发挥作用,在动物模型中显示出显著的前认知效果,展现出治疗多种神经和精神疾病的可能性。 | |||
T74112 |
Bicuculline methochloride
|
Others | Others |
Bicuculline ((+)-Bicuculline; d-Bicuculline) 甲基氯化物是一种惊厥生物碱,是选择性GABAA 受体 (GABAA receptor) 的拮抗剂,IC50为 3 μM。Bicuculline 甲基氯化物在哺乳动物中可以诱导阵挛性强直性惊厥,还可用于阻断 Ca2+激活的钾通道。Bicuculline 甲基氯化物可用于癫痫等相关精神疾病的研究。 | |||
T72034 |
LI-2242
|
Others | Others |
LI-2242是一种强效肌醇六磷酸激酶(IP6K)抑制剂,对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达,改善了肝脏脂肪变性,增强体外脂肪细胞和肝细胞的线粒体耗氧率(OCR)和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。 | |||
T38131 |
(E)-10-Hydroxynortriptyline
|
Others | Others |
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ... | |||
T73677 |
SR 142948 dihydrochloride
|
Others | Others |
SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂,其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中,该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成,IC50为3.9 nM。此外,SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为,且具有良好的血脑屏障通透性,适用于精神疾病研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3158 |
Harmane
Loturine,Harman,Aribine,哈尔满碱 |
Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor | GPCR/G Protein; Neuroscience |
Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱,是有效的神经毒素,可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂,具有致突变作用,对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01200 |
Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His)
NGR,NOGOR,RTN4R,NgR1,Nogo receptor,Nogo-66 receptor |
Cynomolgus | HEK293 Cells |
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes. | |||
TMPK-00621 |
CSPG5 Protein, Human, Recombinant (His)
CALEB,NGC,MGC44034,Neuroglycan C |
Human | HEK293 Cells |
Chondroitin sulfate proteoglycan 5 (CSPG-5), also known as neuroglycan C, has been previously associated to differentiation since it shapes neurite growth and synapse forming. CSPG-5 expression shifts in brain areas of the default mode network of suicide victims, which may reflect an impact in the pathogenesis of psychiatric diseases or support diagnostic power. | |||
TMPK-01125 |
FAM19A5 Protein, Mouse, Recombinant (His)
Fam19a5,QLLK5208,Tafa5,Chemokine-like protein TAFA-5,UNQ5208 |
Mouse | E. coli |
FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Mouse, Recombinant (His) is expressed in E. coli ... | |||
TMPK-00699 |
FAM19A5 Protein, Human, Recombinant (His)
Chemokine-like protein TAFA-5,UNQ5208,Tafa5,QLLK5208,Fam19a5 |
Human | E. coli |
FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Human, Recombinant (His) is expressed in E. coli ... | |||
TMPY-03991 |
DBI Protein, Human, Recombinant (His)
diazepam binding inhibitor (GABA receptor modulator, acyl-Co... |
Human | E. coli |
The diazepam binding inhibitor (DBI), alternatively known as the acyl-CoA binding protein (ACBP), is involved in multiple biological actions. The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine receptor and facilitates transport of cholesterol to the inner membrane to stimulate steroid synthesis. Through this action, DBI indirectly modulates gamma-aminobutyric acid (GABA)-mediated inhibitory neurotransmission. DBI can be postulated as a candidate gene for psychiatric phenot... | |||
TMPY-01618 |
GLO1 Protein, Mouse, Recombinant (His)
glyoxalase I,Glo-1r,GLY1,Glo1-r,2510049H23Rik,Glo1-s,AW55064... |
Mouse | E. coli |
Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellul... |