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Search Results for " protein deacetylase hdac6 "
Targets Recommended: Epigenetic Reader Domain Histone Acetyltransferase HDAC

2

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T27083 Crebinostat

Epigenetic Reader Domain; Histone Acetyltransferase; HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂,对 HDAC1、HDAC2、HDAC3 和 HDAC6 有抑制作用, IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可增加在体外神经元的突触蛋白 1 斑点沿树突 (synapsin-1 punctae along dendrites) 的密度。Crebinostat 可调节染色质介导的神经可塑性,增强小鼠的记忆。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化,并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。
T38381 CAY17c

Others Others
CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,...

化合物

Crebinostat
Cat.No: T27083
Synonym:
Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC
CAY17c
Cat.No: T38381
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPH-01474 HDAC6 Protein, Human, Recombinant (His)

Protein deacetylase HDAC6

Human E. coli
HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.

重组蛋白

HDAC6 Protein, Human, Recombinant (His)
Cat.No: TMPH-01474
Species: Human
Expression System: E. coli
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