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Search Results for " protein deacetylase hdac3 "

Targets Recommended: Epigenetic Reader Domain Histone Acetyltransferase HDAC

2

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T27083	Crebinostat	Epigenetic Reader Domain; Histone Acetyltransferase; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3 和 HDAC6 有抑制作用， IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可增加在体外神经元的突触蛋白 1 斑点沿树突 (synapsin-1 punctae along dendrites) 的密度。Crebinostat 可调节染色质介导的神经可塑性，增强小鼠的记忆。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化，并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。
T36629	Givinostat	Others	Others
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...

化合物

Cat.No: T27083

Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC

Cat.No: T36629

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01473	HDAC3 Protein, Human, Recombinant (His & SUMO) Protein deacylase HDAC3,RPD3<...	Human	E. coli
	HDAC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.8 kDa and the accession number is O15379.
TMPY-03431	HDAC4 Protein, Human, Recombinant (aa 612-1084) histone deacetylase 4,HA6116,HDAC-4,HD4,BD...	Human	Baculovirus Insect Cells
	HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th...

重组蛋白

HDAC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01473

Species: Human

Expression System: E. coli

HDAC4 Protein, Human, Recombinant (aa 612-1084)

Cat.No: TMPY-03431

Species: Human

Expression System: Baculovirus Insect Cells

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