首页工具

登录

搜索结果

Search Results for " prostaglandin e synthase "

Targets Recommended: Others PGE Synthase

27

抑制剂 & 化合物

4

天然产物

9

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T1866	AT-56	Others; PGE Synthase	Immunology/Inflammation; Others
	AT56 是口服有活性的脂钙蛋白型前列腺素 D 合酶 (L-PGDS) 选择性抑制剂，其IC50=95 μM，Ki=75 μM。它能够特异性地抑制L-PGDS 催化的 PGD2介导的嗜睡或疼痛反应。
T2681	hPGDS-IN-1	PGE Synthase	Immunology/Inflammation
	hPGDS-IN-1是 hPGDS 抑制剂，使用荧光偏振检测或通过 EIA 法测得的 IC50值为12 nM。
T0159	Pranoprofen 普拉洛芬,Pyranoprofen	Apoptosis; COX; PGE Synthase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pranoprofen (Pyranoprofen) 可抑制COX1/2酶，阻断花生四烯酸转化为二十烷醇，减少前列腺素的合成。它是一种用于眼科的非甾体抗炎试剂。
T5843L	(S)-Flurbiprofen esflurbiprofen,(S)-氟比洛芬	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Esflurbiprofen 是 Flurbiprofen 的活性对映体，是 COX-1 和 COX-2 的抑制剂，对 COX-1和 COX-2的 IC50分别为0.48 和 0.47 μM。
T7948	HPGDS inhibitor 2 GSK-2894631A	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 2 (GSK-2894631A) 是高效的造血前列腺素 D 合成酶(H-PGDS)选择性抑制剂(IC50:9.9 nM)。
T10098	PGS-IN-1 KME-4	Lipoxygenase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	PGS-IN-1 (KME-4)是一种前列腺素合成酶抑制剂，IC50=0.28 μM。它也可抑制5-脂肪氧合酶的活性，IC50=1.05 μM。
T1804	HPGDS inhibitor 1 HPGDS-inhibitor-1	PGE Synthase	Immunology/Inflammation
	HPGDS inhibitor 1 是口服具有活性的HPGDS 选择性抑制剂，在酶和细胞分析中的IC50值分别为 0.6 nM 和 32 nM，但对 L-PGDS、mPGES、COX-1、COX-2 、5-LOX 无抑制作用。
T0726	Benzydamine hydrochloride Benzydamine HCl,盐酸苄达明,AF864	COX; PGE Synthase; Antibacterial	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Benzydamine hydrochloride (AF864) 是一种局部作用的非甾体抗炎药，具有局部麻醉和镇痛作用。它也是前列腺素合成酶抑制剂，有抗细菌活性。
T0264	Zomepirac sodium salt Zomepirac Sodium,佐美酸钠,McN-2783-21-98	PGE Synthase; PDE	Immunology/Inflammation; Metabolism
	Zomepirac sodium salt (McN-2783-21-98) 是前列腺素合成酶抑制剂。它是一种非甾体抗炎药，但能够导致免疫介导的肝损伤。
T6687	Suprofen Maldocil,Suprol,TN-762,舒洛芬,Profenal	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Suprofen (Suprol) 是一种非甾体抗炎化合物，对前列腺素合成具有抑制作用。
T23861	CAY10526 CAY-10526,BTH,CAY 10526	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂，可抑制 NF-κB 信号通路。
T0424	Bismuth Subsalicylate Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋	COX; PGE Synthase	Immunology/Inflammation; Neuroscience
	Bismuth Subsalicylate (Bismuth subsalicylat) 是口服抗酸和止泻试剂。它能够抑制体内前列腺素合成，抑制胃和肠道黏膜炎症反应。它广泛用于研究腹泻疾病，如恶心、消化不良、腹泻等。
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T15757	Limaprost 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206	PGE Synthase	Immunology/Inflammation
	Limaprost (17α,20-dimethyl-δ2-PGE1) 是PGE1类似物，也是口服具有活性的血管舒张剂。它能够增加血流量以及减少血小板聚集。它具有抗心绞痛的功能，可用于疼痛的缓解，以及用于研究缺血性症状。
T28089	mPGES-1 Inhibitor-1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	mPGES-1 Inhibitor-1 是一种新型的微粒体前列腺素 E 合酶-1（mPGES-1）选择性抑制剂，具有抗炎镇痛活性，可用于研究急性肝损伤。
T21738	PF-9184	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-9184 是一种有效且高度选择性的人微粒体前列腺素 E 合酶 1 (mPGES-1) 的抑制剂，IC50 值为 16.5 nM。PF-9184 体外抑制 IL-1β 诱导的 PGE2 合成。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T16504	PF-4693627	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).
T70874	Vipoglanstat	Others	Others
	Vipoglanstat is a prostaglandin E synthase inhibitor and an anti-inflammatory. Vipoglanstat ameliorates leukocyte infiltration and lung injury resulting from both endotoxin-induced and sepsis-induced lung injury.
T79846	Friluglanstat	PGE Synthase	Immunology/Inflammation
	Friluglanstat为一种mPGES-1抑制剂，表现出抗炎作用。
T39000	Zaloglanstat GRC-27864,ISC-27864	Others	Others
	Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain, and neurodegenerative diseases.
T74781	UT-11	Others	Others
	UT-11是一种有效且具有脑渗透性的mPGES-1抑制剂，能够降低人类(SK-N-AS)和小鼠(BV2)细胞内PGE2的生成，其IC50s分别是0.10 μM和2.00 μM。
T68334	AF3442	Others	Others
	AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional re...
T68738	(±)-γ-Tocopherol	Others	Others
	(±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated...
T84654	5-trans Prostaglandin D2 5,6-trans PGD2	Others	Others
	Prostaglandin D2 (PGD2) is one of the five principal prostaglandins enzymatically derived from PGH2. It is abundantly generated in the cerebrospinal fluid (CSF) by lipocalin-type PGD synthase and in peripheral regions by myeloid cells, such as mast cells and basophils, via leukocyte-type PGD synthase. The compound 1,25-trans-PGD2 is an isomer of PGD2, characterized by the alteration of the double bond between carbons 5 and 6 from cis(Z) to trans(E). This trans isomer, found as a 2-5% impurity in...
T83773	Prostaglandin E2 Inhibitor 3 PGE2 Inhibitor 3	Others	Others
	Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂，相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH)，在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下，该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中，LPS诱导的IL-6和PGE2生成。同时，它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成，包括白三烯B4 (LTB4) 和5-H(p)ETE（IC50s分别为4.9和5.2 µM）。在体内，10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。

化合物

Cat.No: T1866

Target: Others, PGE Synthase

Cat.No: T2681

Target: PGE Synthase

Cat.No: T0159

Synonym: 普拉洛芬,Pyranoprofen

Target: Apoptosis, COX, PGE Synthase, Prostaglandin Receptor

(S)-Flurbiprofen

Cat.No: T5843L

Synonym: esflurbiprofen,(S)-氟比洛芬

Target: COX, PGE Synthase

HPGDS inhibitor 2

Cat.No: T7948

Synonym: GSK-2894631A

Target: PGE Synthase

Cat.No: T10098

Synonym: KME-4

Target: Lipoxygenase, Prostaglandin Receptor

HPGDS inhibitor 1

Cat.No: T1804

Synonym: HPGDS-inhibitor-1

Target: PGE Synthase

Benzydamine hydrochloride

Cat.No: T0726

Synonym: Benzydamine HCl,盐酸苄达明,AF864

Target: COX, PGE Synthase, Antibacterial

Zomepirac sodium salt

Cat.No: T0264

Synonym: Zomepirac Sodium,佐美酸钠,McN-2783-21-98

Target: PGE Synthase, PDE

Cat.No: T6687

Synonym: Maldocil,Suprol,TN-762,舒洛芬,Profenal

Target: COX, PGE Synthase

Cat.No: T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Bismuth Subsalicylate

Cat.No: T0424

Synonym: Bismuth subsalicylat,Bismuth(III) salicylate basic,Bismuth oxysalicylate,碱式水杨酸铋,次水杨酸铋

Target: COX, PGE Synthase

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Cat.No: T15757

Synonym: 17α,20-dimethyl-δ2-PGE1,利马前列素,OP1206,ONO1206

Target: PGE Synthase

mPGES-1 Inhibitor-1

Cat.No: T28089

Target: Prostaglandin Receptor

Cat.No: T21738

Target: Prostaglandin Receptor

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T16504

Target: Prostaglandin Receptor

Cat.No: T70874

Target: Others

Cat.No: T79846

Target: PGE Synthase

Cat.No: T39000

Synonym: GRC-27864,ISC-27864

Target: Others

Cat.No: T74781

Target: Others

Cat.No: T68334

Target: Others

(±)-γ-Tocopherol

Cat.No: T68738

Target: Others

5-trans Prostaglandin D2

Cat.No: T84654

Synonym: 5,6-trans PGD2

Target: Others

Prostaglandin E2 Inhibitor 3

Cat.No: T83773

Synonym: PGE2 Inhibitor 3

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2S2335	Dehydroevodiamine DHED,去氢吴茱萸碱	Others; NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB; Others
	Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。
T4S0227	Sinensetin Pedalitin permethyl ether,甜橙素	TNF; PGE Synthase	Apoptosis; Immunology/Inflammation
	Sinensetin (Pedalitin permethyl ether) 是从水果中发现的一种甲基化黄酮，有很强的抗血管和抗炎症的能力。
T5727	CAFESTOL 咖啡醇,咖啡油醇	ERK; NF-κB; COX; PGE Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Cafestol 是咖啡特有的一种二萜，可靶向 AP-1 抑制ERK，有化学预防、抗肿瘤、保肝、抗氧化和抗炎作用。它通过抑制NF-kB 活化途径强烈的抑制 PGE2的产生，还抑制 LGE 激活的 RAW264.7 细胞中的PGE2产生和环氧合酶(COX-2)的 mRNA 表达。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。

天然产物

Dehydroevodiamine

Cat.No: T2S2335

Synonym: DHED,去氢吴茱萸碱

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Cat.No: T4S0227

Synonym: Pedalitin permethyl ether,甜橙素

Target: TNF, PGE Synthase

Cat.No: T5727

Synonym: 咖啡醇,咖啡油醇

Target: ERK, NF-κB, COX, PGE Synthase

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01926	PTGES3 Protein, Human, Recombinant (His) Prostaglandin E synthase 3,Cytosolic p...	Human	P. pastoris (Yeast)
	PTGES3 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01925	PTGES3 Protein, Human, Recombinant (E. coli, His) Telomerase-binding protein p23,Hsp90 co-chaperone,Cytosolic ...	Human	E. coli
	PTGES3 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli.
TMPK-01424	Peptide Ready HLA-E01:03&B2M Monomer Protein, Human, MHC (His & Avi) MHC,HLA-E01:03,Peptide Ready	Human	HEK293 Cells
	HLA-E01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01545	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated sHLA-E,MHC,MHC class I antigen E,HLAE,MHC HLA-E alpha-1,MHC ...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01423	Peptide Ready HLA-E01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,Peptide Ready,HLA-E01:03	Human	HEK293 Cells
	HLA-E01:03&B2M&Peptide ready Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-E01:03. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01541	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated QA1,MHC HLA-E alpha-2.1,MHC,HLAE,MHC class I antigen E,MHC H...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01544	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi) MHC class I antigen E,HLAE,sHLA-E,QA1,MHC HLA-E alpha-2.1,MH...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01452	HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi) HLAE,MHC class I antigen E,MHC,QA1,sHLA-E	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...
TMPK-01514	HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi) sHLA-E,MHC class I antigen E,MHC HLA-E alpha-1,MHC,HLAE,QA1,...	Human	HEK293 Cells
	HLA-E is a nonclassical member of the major histocompatibility complex class I gene locus. HLA-E protein shares a high level of homology with MHC Ia classical proteins: it has similar tertiary structure, associates with β2-microglobulin, and is able to present peptides to cytotoxic lymphocytes. The main function of HLA-E under normal conditions is to present peptides derived from the leader sequences of classical HLA class I proteins, thus serving for monitoring of expression of these molecules ...

重组蛋白

PTGES3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01926

Species: Human

Expression System: P. pastoris (Yeast)

PTGES3 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01925

Species: Human

Expression System: E. coli

Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01424

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01545

Species: Human

Expression System: HEK293 Cells

Peptide Ready HLA-E*01:03&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01423

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01541

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01544

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPKTLVL) Monomer Negative Control Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01452

Species: Human

Expression System: HEK293 Cells

HLA-E*01:03&B2M&Peptide (VMAPRTLVL) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01514

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼