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Search Results for " polycythemia vera "
Targets Recommended: Others DNA Alkylator/Crosslinker

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T4570 Pipobroman

Vercyte,A-8103,Amedel,哌泊溴烷

Others; DNA Alkylator/Crosslinker DNA Damage/DNA Repair; Others
Pipobroman (Vercyte) 是一种烷基化剂,是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性,可用于癌症研究。
T60927 Ranimustine

Others Others
Ranimustine (MCNU) 是一种可用于真性红细胞增多症和慢性粒细胞白血病研究的亚硝基脲烷基化剂。
T76943 Cepeginterferon alfa-2b

Cepeginterferon alfa-2b是一种聚乙二醇化干扰素, 其聚乙二醇基由分子量为20 kDa的PEG构成。该化合物广泛应用于丙型肝炎病毒(HCV)、真性红细胞增多症(PV)和原发性血小板增多症(ET)等疾病的研究中。
T73567 ZT55

Others Others
ZT55 是一种口服有效并具有高选择性的JAK2抑制剂,其IC50值为 0.031 μM。ZT55 能抑制表达JAK2V617F 的 HEL 细胞系的增殖,并诱导细胞凋亡和周期停滞。ZT-55 还可有效抑制小鼠模型体内 HEL 异种移植肿瘤的生长。ZT-55 可用于骨髓增生性肿瘤、多血症以及原发性血小板增多症的研究。

化合物

Pipobroman
Cat.No: T4570
Synonym: Vercyte,A-8103,Amedel,哌泊溴烷
Target: Others, DNA Alkylator/Crosslinker
Ranimustine
Cat.No: T60927
Synonym:
Target: Others
Cepeginterferon alfa-2b
Cat.No: T76943
Synonym:
Target:
ZT55
Cat.No: T73567
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPJ-00541 CD177 Protein, Human, Recombinant (His)

PRV-1,HNA-2a,Human Neutrophil Alloantigen 2a,CD177,Polyc...

Human HEK293 Cells
CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors,and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phospha...
TMPH-01070 CD177 Protein, Human, Recombinant (GST & His)

Human neutrophil alloantigen 2a,CD177,PRV1,Polycythemia<...

Human E. coli
CD177 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 63.6 kDa and the accession number is Q8N6Q3.

重组蛋白

CD177 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00541
Species: Human
Expression System: HEK293 Cells
CD177 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-01070
Species: Human
Expression System: E. coli
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