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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4570 |
Pipobroman
Vercyte,A-8103,Amedel,哌泊溴烷 |
Others; DNA Alkylator/Crosslinker | DNA Damage/DNA Repair; Others |
Pipobroman (Vercyte) 是一种烷基化剂,是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性,可用于癌症研究。 | |||
T60927 |
Ranimustine
|
Others | Others |
Ranimustine (MCNU) 是一种可用于真性红细胞增多症和慢性粒细胞白血病研究的亚硝基脲烷基化剂。 | |||
T76943 | Cepeginterferon alfa-2b | ||
Cepeginterferon alfa-2b是一种聚乙二醇化干扰素, 其聚乙二醇基由分子量为20 kDa的PEG构成。该化合物广泛应用于丙型肝炎病毒(HCV)、真性红细胞增多症(PV)和原发性血小板增多症(ET)等疾病的研究中。 | |||
T73567 |
ZT55
|
Others | Others |
ZT55 是一种口服有效并具有高选择性的JAK2抑制剂,其IC50值为 0.031 μM。ZT55 能抑制表达JAK2V617F 的 HEL 细胞系的增殖,并诱导细胞凋亡和周期停滞。ZT-55 还可有效抑制小鼠模型体内 HEL 异种移植肿瘤的生长。ZT-55 可用于骨髓增生性肿瘤、多血症以及原发性血小板增多症的研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00541 |
CD177 Protein, Human, Recombinant (His)
PRV-1,HNA-2a,Human Neutrophil Alloantigen 2a,CD177,Polyc... |
Human | HEK293 Cells |
CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors,and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phospha... | |||
TMPH-01070 |
CD177 Protein, Human, Recombinant (GST & His)
Human neutrophil alloantigen 2a,CD177,PRV1,Polycythemia<... |
Human | E. coli |
CD177 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 63.6 kDa and the accession number is Q8N6Q3. |