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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T85150 |
Dihydropleuromutilin
(+)-19,20-Dihydropleuromutilin |
Others | Others |
Dihydropleuromutilin, a semisynthetic antibiotic derived from pleuromutilin, exhibits antimicrobial efficacy against S. aureus, M. hominis, M. gallisepticum, and M. hyorhinis, with minimum inhibitory concentrations (MICs) of 0.5, 0.3, 0.3, and 2 µg/ml, respectively. | |||
T6638 |
Retapamulin
瑞他莫林,SB-275833 |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Retapamulin (SB-275833) 是一种能结合金黄色葡萄球菌和大肠杆菌核糖体的局部抗生素,Kd 为3 nM。 | |||
T11836 |
Lefamulin acetate
BC-3781 acetate,醋酸来法莫林 |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Lefamulin acetate (BC-3781 acetate) 是具有口服活性的抗生素。它是用于人体细菌感染的全身研究的半合成截短侧耳素。它与 50S 细菌核糖体的肽基转移酶peptidyl transferase 中心结合抑制蛋白质合成,并阻止了转移RNA 与肽转移的结合。 | |||
T63695 |
Antibacterial agent 90
|
Others | Others |
Antibacterial agent 90 (6n) 是抗细菌 (antibacterial) 的 pleuromutilin 衍生物,对 Gram-positive pathogens (GPPs) 和Mycoplasma pneumoniae 表现出抗菌活性。 | |||
T84389 |
Valnemulin
|
Others | Others |
Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyl transferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae. | |||
T83871 |
Ferroptocide
|
Others | Others |
Ferroptocide是一种抑制剂,可抑制硫氧还蛋白(Trx)活性,并且是pleuromutilin的衍生物。在20 µM的浓度下,Ferroptocide能够抑制ES-2卵巢癌细胞中的Trx活性,并对ES-2细胞具有细胞毒性(IC50 = 1.6 µM)。5 µM的Ferroptocide能够诱导ES-2细胞发生铁死亡,这一效应可以通过铁螯合剂去铁胺(DFO)、抗氧化剂Trolox或铁死亡抑制剂ferrostatin-1来阻断。在使用免疫完整但非免疫缺陷小鼠的4T1小鼠乳腺癌模型中,每周两次以50 mg/kg剂量给药时,Ferroptocide能够减少肿瘤体积。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16552 |
Pleuromutilin
Mutilin 14-glycolate,Drosophilin B,截短侧耳素 |
Antibacterial; Antibiotic | Microbiology/Virology |
Pleuromutilin (Drosophilin B) 通过与细菌的 50S 核糖体亚基结合来抑制细菌蛋白质的合成。 | |||
T8065 |
Tiamulin
Thiamutilin,泰妙菌素 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Tiamulin (Thiamutilin) 是一类二萜,广泛用于控制猪的传染疾病,包括猪痢疾和地方性肺炎等。 |