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Search Results for " plasmodium "

Targets Recommended: Dehydrogenase Parasite

103

抑制剂 & 化合物

36

天然产物

13

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T12438	PfDHODH-IN-1	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物，具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。
T1491	Atovaquone Atavaquone,阿托伐醌	Others; P450; Dehydrogenase; Antibiotic; Parasite	Metabolism; Microbiology/Virology; Others
	Atovaquone (Atavaquone) 是具有口服活性的选择性寄生虫线粒体细胞色素bc1复合物的抑制剂。它抑制人类和P. falciparum 细胞色素bc1活性，IC50值分别为 460 nM 和 2.0 nM。它有抗疟作用，有潜力用于疟疾、弓形体病、肺孢子虫肺炎和巴贝斯虫病的相关研究。
T12909	SID 26681509	Cysteine Protease; Parasite	Microbiology/Virology; Proteases/Proteasome
	SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。
T8767	PfDHODH-IN-2	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-2 是一种二氢噻吩酮衍生物，是一种有效的恶性疟原虫二氢乳清酸脱氢酶抑制剂，其IC50值为 1.11 µM。它具有抗疟作用，可研究疟疾。
T5421	KDU691	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	KDU691 是一种咪唑吡嗪类药物，对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性，它是 PI4K 抑制剂，选择性抑制双氢青蒿素预处理的恶性疟原虫。
T16269	Nanaomycin A	DNA Methyltransferase; Dehydrogenase; Parasite	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的特异性抑制剂 (IC50 = 500 nM)。
T10356	AQ-13 dihydrochloride	Parasite	Microbiology/Virology
	AQ-13 dihydrochloride 是一种氨基喹啉类抗疟药，对耐药型菌株 Plasmodium falciparum 有抑制作用。
T13246	UCT943	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	UCT943是恶性疟原虫PI4K 的抑制剂（IC50 = 23 nM）。
T67694	ZY-19489	Parasite	Microbiology/Virology
	ZY-19489是一种具有抗疟作用的化合物，是一种潜在的单剂量根治性恶性疟原虫和间日疟原虫疟疾的药物，已获得美国 FDA 的孤儿药认定。
T40087	DSM502	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	DSM502 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，具有抗疟活性，抑制 Plasmodium DHODH，可作为抗疟化合物的先导物。
T40417	Ethylhydrocupreine hydrochloride Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐	Antibacterial; Parasite	Microbiology/Virology
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T10378	Artelinic acid	Parasite	Microbiology/Virology
	Artelinic acid 是水溶性青蒿素类似物，具有抗疟活性，用于治疗恶性疟原虫多重耐药菌株。
T27400L	Ganaplacide phosphate Ganaplacide phosphate (1261113-96-5 Free base)	Others	Others
	Ganaplacide phosphate 对疟原虫症状性无性血期感染具有多阶段抗疟活性，并且能够在动物模型中预防传播和阻断感染。
T16125	MMV390048	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	MMV390048 是一种抗疟药，是一种新型化学疟原虫 PI4K 抑制剂。它与疟原虫 PI4K 的 ATP 结合位点结合，不与除人类 PIP4K2C 外的其他恶性疟原虫和人类激酶结合。
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T14766	BPH-715	Others; Parasite	Microbiology/Virology; Others
	BPH-715 抑制恶性疟原虫的肝脏阶段生长，对 HepG2 细胞中的恶性疟原虫外红细胞的形成的 IC50 为 10 μM。
T79535	Antimalarial agent 30	Parasite	Microbiology/Virology
	Antimalarial agent 30 具有抗伯氏疟原虫肝期寄生虫活性和抗疟活性，可用于研究疟感染。
T11027	DHODH-IN-4	Dehydrogenase	Metabolism
	DHODH-IN-4 是人和 Plasmodium falciparum 二氢乳清酸脱氢酶 (DHODH) 的抑制剂，其对 PfDHODH 和 HsDHODH 的IC50 值分别为 4 μM 和 0.18 μM。DHODH-IN-4 (compound 17) 具有抗疟疾活性。
T21022	Deacylketoconazole Deacyl ketoconazole,脱乙酰酮康唑	Antifungal	Microbiology/Virology
	Deacylketoconazole (Deacyl ketoconazole) 是一种酮康唑衍生物，也是一种抗真菌剂。脱酰基酮康唑对恶性疟原虫的活性是酮康唑的 15 至 50 倍。
T10903	CWHM-1552	Parasite	Microbiology/Virology
	CWHM-1552 是一种有效的恶性疟原虫抑制剂。对于 3D7 和 Dd2 菌株，IC50 分别为 51 nM 和 53 nM。
T4220	BQR-695 BQR695,NVP-BQR695	PI3K; Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂，对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。
T11558	Hexyl gallate 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate	Antibacterial	Microbiology/Virology
	Hexyl gallate (Gallic acid hexyl ester) 是没食子酸的烷基酯衍生物，对恶性疟原虫具有很强的抗疟活性，IC50为 0.11 mM。它具有抗菌活性，通过抑制 RhlR 抑制鼠李糖脂和绿脓杆菌素的产生。
T74696	SpdSyn binder-1	Parasite	Microbiology/Virology
	SpdSyn binder-1 是一种弱结合剂，结合在恶性疟原虫亚精胺合酶的活性位点，对疟疾有部分抑制作用，可用于研究疟疾。
T15276	Ferroquine SSR97193,Ferrochloroquine	Others	Others
	Ferroquine (Ferrochloroquine) 是 Chloroquine 的二茂铁基类似物，具有抗疟疾活性。Ferroquine 具有杀疟原虫作用，机制是通过诱导氧化应激和随后的膜破坏。
T5420	Cycloguanil hydrochloride Chloroguanide Triazine,环氯胍盐酸盐	Parasite; Drug Metabolite	Metabolism; Microbiology/Virology
	Cycloguanil hydrochloride (Chloroguanide Triazine) 是抗疟化合物氯胍的活性代谢物。它作为二氢叶酸还原酶的抑制剂，对于疟原虫和人类形式的 Kis 值分别为 0.3 和 1.5 nM。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T17257L	WR99210 hydrochloride(47326-86-3 free base) WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others	Others
	WR99210 hydrochloride 是恶性疟原虫二氢叶酸还原酶 (pfDHFR) 的有效抑制剂，pfDHFR 是主要的疟疾药物靶点。它对野生型、双突变体和四突变体二氢叶酸还原酶具有亚纳摩尔效力。
T11030	DHODH-IN-8	Dehydrogenase	Metabolism
	DHODH-IN-8 是一种人和恶性疟原虫二氢乳清酸脱氢酶的抑制剂，IC50 分别为 0.13 μM 和 47.4 μM，Ki 分别为 0.016 μM 和 5.6 μM。DHODH-IN-8 具有抗疟疾能力。
T28824	SNX0723 SNX 0723,SNX- 0723	HSP	Cytoskeletal Signaling; Metabolism
	SNX0723 是一种 Hsp90 抑制剂，具有抗疟原虫活性。SNX0723 对 HsHsp90 和 PfHsp90 具有高结合亲和力，Ki 分别为 4.4 和 47 nM。SNX0723 抑制肝期伯氏疟原虫 ANKA 寄生虫，EC50 为 3.3 μM。
T5493	Pyronaridine	Others	Others
	Pyronaridine 是一种具有口服活性的、含甘露醇的抗疟疾化合物，通过干扰红细胞内疟疾寄生虫(疟原虫)的复制而起作用。Pyronaridine 常与其他药联用来治疗疟疾，对对 P. falciparum 和 Echinococcus granulosus 具有抗感染活性。
T4382	Proguanil hydrochloride Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil	Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others
	Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T0049	Azlocillin sodium salt Sodium azlocillin,Azlocillin sodium,阿洛西林钠	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Azlocillin sodium salt 是一种半合成青霉素，是内酰胺类广谱抗生素。它具有抗假单胞杆菌的活性，并对抗寄生虫Plasmodium falciparum 有效。
T0850	Primaquine diphosphate Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹	Antibiotic; Parasite	Microbiology/Virology
	Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物，具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。
T30612	Bulaquine	Others	Others
	Bulaquine is a derivative of 8-aminoquinoline and has effective activity against the liver stage of plasmodium falciparum and the dormant bodies of Plasmodium vivax and Plasmodium ovale.
T33457	MMV007839 MMV-007839,MMV 007839	Others	Others
	MMV007839 is a potent Plasmodium lactate transporter PfFNT.
T24490	MMV666693 MMV-666693,MMV 666693	Others	Others
	MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor.
T23935	D44 D 44,D-44	Others	Others
	D44 is a Plasmodium FKBPs inhibitor.
T25448	Genz-669178	Others	Others
	Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T68421	MMV019662	Others	Others
	MMV019662 is a novel inhibitor of Plasmodium falciparum.
T71061	DSM267	Others	Others
	DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor.
T25524	IDI-3783	Others	Others
	IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T20910	Dibemethine Dibemetina,DBMA,AI3-26795,Dibemethinum	Others	Others
	Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT).
T40291	DSM705 DSM705	Others	Others
	DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHODHs. DSM705 shows significant efficacy as an antimalarial compound.
T31178	Dabequin dabechin,G 800	Others	Others
	Dabequin is a derivative of aminoquinoline. It is said to have pharmacological activity against Plasmodium fukiparum.
T11331L	FTI 276	Others	Others
	FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human).
T120656	N004-0015	Others	Others
	Plasmodium falciparum, EC50: 7.21 nM
T71841	MMV085203	Others	Others
	MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites.
T71771	Supradamal	Others	Others
	Supradamal is a potent Inhibitor of Plasmodium FK506 Binding Protein 35 (FKBD35). It also acts as an HIV inhibitor.
T25815	Mirincamycin HCl U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride	Others	Others
	Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.
T23625	ACT-451840 ACT451840	Others	Others
	ACT-451840 is a drug of antimalarial activity. It has effective activity against sensitive and resistant Plasmodium falciparum strains.

化合物

Cat.No: T12438

Target: Dehydrogenase, Parasite

Cat.No: T1491

Synonym: Atavaquone,阿托伐醌

Target: Others, P450, Dehydrogenase, Antibiotic, Parasite

Cat.No: T12909

Target: Cysteine Protease, Parasite

Cat.No: T8767

Target: Dehydrogenase, Parasite

Cat.No: T5421

Target: Parasite, PI4K

Cat.No: T16269

Target: DNA Methyltransferase, Dehydrogenase, Parasite

AQ-13 dihydrochloride

Cat.No: T10356

Target: Parasite

Cat.No: T13246

Target: Parasite, PI4K

Cat.No: T67694

Target: Parasite

Cat.No: T40087

Target: Dehydrogenase, Parasite

Ethylhydrocupreine hydrochloride

Cat.No: T40417

Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

Target: Antibacterial, Parasite

Cat.No: T10378

Target: Parasite

Ganaplacide phosphate

Cat.No: T27400L

Synonym: Ganaplacide phosphate (1261113-96-5 Free base)

Target: Others

Cat.No: T16125

Target: Parasite, PI4K

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Cat.No: T14766

Target: Others, Parasite

Antimalarial agent 30

Cat.No: T79535

Target: Parasite

Cat.No: T11027

Target: Dehydrogenase

Deacylketoconazole

Cat.No: T21022

Synonym: Deacyl ketoconazole,脱乙酰酮康唑

Target: Antifungal

Cat.No: T10903

Target: Parasite

Cat.No: T4220

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

Cat.No: T11558

Synonym: 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate

Target: Antibacterial

SpdSyn binder-1

Cat.No: T74696

Target: Parasite

Cat.No: T15276

Synonym: SSR97193,Ferrochloroquine

Target: Others

Cycloguanil hydrochloride

Cat.No: T5420

Synonym: Chloroguanide Triazine,环氯胍盐酸盐

Target: Parasite, Drug Metabolite

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

WR99210 hydrochloride(47326-86-3 free base)

Cat.No: T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

Cat.No: T11030

Target: Dehydrogenase

Cat.No: T28824

Synonym: SNX 0723,SNX- 0723

Target: HSP

Cat.No: T5493

Target: Others

Proguanil hydrochloride

Cat.No: T4382

Synonym: Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Azlocillin sodium salt

Cat.No: T0049

Synonym: Sodium azlocillin,Azlocillin sodium,阿洛西林钠

Target: Antibacterial, Antibiotic, Parasite

Primaquine diphosphate

Cat.No: T0850

Synonym: Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹

Target: Antibiotic, Parasite

Cat.No: T30612

Target: Others

Cat.No: T33457

Synonym: MMV-007839,MMV 007839

Target: Others

Cat.No: T24490

Synonym: MMV-666693,MMV 666693

Target: Others

Cat.No: T23935

Synonym: D 44,D-44

Target: Others

Cat.No: T25448

Target: Others

Cat.No: T68421

Target: Others

Cat.No: T71061

Target: Others

Cat.No: T25524

Target: Others

Cat.No: T20910

Synonym: Dibemetina,DBMA,AI3-26795,Dibemethinum

Target: Others

Cat.No: T40291

Synonym: DSM705

Target: Others

Cat.No: T31178

Synonym: dabechin,G 800

Target: Others

Cat.No: T11331L

Target: Others

Cat.No: T120656

Target: Others

Cat.No: T71841

Target: Others

Cat.No: T71771

Target: Others

Mirincamycin HCl

Cat.No: T25815

Synonym: U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride

Target: Others

Cat.No: T23625

Synonym: ACT451840

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0084	Tuberostemonine 对叶百部碱,Tuberstemonine	Parasite	Microbiology/Virology
	Tuberostemonine (Tuberstemonine) 是一种生物碱，可作为抗疟疾剂，有较高的肠道通透性。
TN7103	13,21-Dihydroeurycomanone Pasakbumin C	Anti-infection; Parasite	Microbiology/Virology
	13,21-Dihydroeurycomanone (Pasakbumin C) 是从 Eurycoma longifolia 根部分离得到的一种天然产物，有抗寄生虫活性。
TN2027	Oxysanguinarine 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine	Parasite	Microbiology/Virology
	Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。
T3682	(-)-Catechin gallate (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate	Others; COX	Immunology/Inflammation; Neuroscience; Others
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) 是绿茶儿茶素中的微量组分，可抑制COX-1和COX-2活性。它抑制人 Beta-secretase，对氯喹敏感的恶性疟原虫 NF54 和耐氯喹的恶性疟原虫 K1 具有抗疟原虫活性。
TN1190	14,15 β-Dihydroxyklaineanone 14,15beta-Dihydroxyklaineanone	Parasite	Microbiology/Virology
	14,15 β-Dihydroxyklaineanone（14,15beta-Dihydroxyklaineanone）从 Eurycoma longifolia 中分离得到的苦味素类化合物，具有抗肿瘤促进、抗血吸虫和杀疟原虫活性。
TN3790	Dehydroabietinol Pomiferin A,Dehydroabietyl alcohol	Antifection	Microbiology/Virology
	Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫，IC50为26-27 μM.
T0392	Artemisinin Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine	HCV Protease; Ferroptosis; Akt; Parasite	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Artemisinin (Qinghaosu) 是一种倍半萜烯内酯，是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。
T3327	Artemotil SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether	CXCR; CCR; Parasite	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Artemotil (SM-227) 是一种新型的速效抗疟药，可研究耐Plasmodium falciparum 的恶性疟原虫疟疾，IC50值为 1.61 nM。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。
TN3466	Atherosperminine	cAMP; Calcium Channel; AChR; Parasite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Atherosperminine 是一种天然生物碱，在体外表现出抗疟原虫活性，IC50为 5.80 μM。它具有DPPH 自由基清除活性，其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂，具有螯合金属的能力。
TN4314	Isonardoperoxide	Antifection	Microbiology/Virology
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).
T11681	Isochondrodendrine Isochondrodendrin	Others	Others
	Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.
TN3583	Canophyllal	Antifection	Microbiology/Virology
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.
TN4717	Oplopanone	Antifection	Microbiology/Virology
	Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.
TN2485	1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Antifection	Microbiology/Virology
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
T11509	Guanfu base H Atisinium chloride	Others	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
TN3563	Caesalmin B	Antifection	Microbiology/Virology
	Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E	Antifection	Microbiology/Virology
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.
TN1930	Methylenetanshinquinone	Antifection	Microbiology/Virology
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
TN4666	Norcaesalpinin E	Antifection	Microbiology/Virology
	Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.
TN1442	Betulinic acid methyl ester	Antifection	Microbiology/Virology
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN4202	(-)-Heraclenol	Antifection	Microbiology/Virology
	(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.
TN3124	5-Hydroxysophoranone	Antibacterial; Parasite; Antifection	Microbiology/Virology
	5-Hydroxysophoranone 从 Erythrina subumbrans 茎中提取，对恶性疟原虫具有高抗疟原虫活性 (IC50 = 2.5 μg/mL)。
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H
TN2738	2,6-Dimethoxy-1-acetonylquinol	Antifection	Microbiology/Virology
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
T75568	Z-Antiepilepsirine	Others	Others
	Z-Antiepilepsirine 是一种酰胺生物碱，存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性，对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。
T1235L	Lincomycin U 10149,U10149,U-10149	Others	Others
	Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis. Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effective against other organisms including
T75450	P-orlandin	Others	Others
	P-orlandin，一种真菌代谢产物，具有阻止FREP1与其配子体或[卵动细胞]结合的功能。该化合物能有效抑制蚊子体内的恶性疟原虫感染。
T11802	L-Canaline	Others	Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase.
T75447	Asperaculane B	Others	Others
	Asperaculane B，一种真菌代谢产物，以IC50 7.89 µM抗恶性疟原虫传播，同时以IC50 3 µM抑制无性恶性疟原虫的发育，对人类细胞无毒。
TN4113	Garcinone E	Antifection	Microbiology/Virology
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
TN4449	Longistylin C	Antifection	Microbiology/Virology
	Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vitro activity against the chloroquine
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
TN4683	Nyasol	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly

天然产物

Tuberostemonine

Cat.No: T6S0084

Synonym: 对叶百部碱,Tuberstemonine

Target: Parasite

13,21-Dihydroeurycomanone

Cat.No: TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Oxysanguinarine

Cat.No: TN2027

Synonym: 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine

Target: Parasite

(-)-Catechin gallate

Cat.No: T3682

Synonym: (-)-Catechin 3-O-gallate,儿茶素没食子酸酯,几茶素没食子酸酯,(-)-Catechin 3-gallate

Target: Others, COX

14,15 β-Dihydroxyklaineanone

Cat.No: TN1190

Synonym: 14,15beta-Dihydroxyklaineanone

Target: Parasite

Dehydroabietinol

Cat.No: TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

Cat.No: T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Cat.No: T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Atherosperminine

Cat.No: TN3466

Target: cAMP, Calcium Channel, AChR, Parasite

Isonardoperoxide

Cat.No: TN4314

Target: Antifection

Isochondrodendrine

Cat.No: T11681

Synonym: Isochondrodendrin

Target: Others

Cat.No: TN3583

Target: Antifection

Cat.No: TN4717

Target: Antifection

1,2-Dihydrotanshinone

Cat.No: TN2485

Synonym: 1,2-Dihydrotanshinquinone

Target: Antifection

Cat.No: T11509

Synonym: Atisinium chloride

Target: Others

Cat.No: TN3563

Target: Antifection

2-Acetoxy-3-deacetoxycaesaldekarin E

Cat.No: TN2747

Target: Antifection

Methylenetanshinquinone

Cat.No: TN1930

Target: Antifection

Norcaesalpinin E

Cat.No: TN4666

Target: Antifection

Betulinic acid methyl ester

Cat.No: TN1442

Target: Antifection

Cat.No: TN4202

Target: Antifection

5-Hydroxysophoranone

Cat.No: TN3124

Target: Antibacterial, Parasite, Antifection

Cat.No: TN5657

2,6-Dimethoxy-1-acetonylquinol

Cat.No: TN2738

Target: Antifection

Cat.No: TN4716

Target: Influenza Virus

Z-Antiepilepsirine

Cat.No: T75568

Target: Others

Cat.No: T1235L

Synonym: U 10149,U10149,U-10149

Target: Others

Cat.No: T75450

Target: Others

Cat.No: T11802

Target: Others

Cat.No: T75447

Target: Others

Cat.No: TN4113

Target: Antifection

Cat.No: TN4449

Target: Antifection

Cat.No: TN5474

Cat.No: TN4683

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03143	PFD0110w Protein, Plasmodium falciparum, Recombinant Normocyte-binding protein 1,Reticulocyte-binding protein hom...	Plasmodium falciparum	E. coli
	PFD0110w Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.1 kDa and the accession number is P86148.
TMPH-03144	SEY1 Protein, Plasmodium knowlesi, Recombinant (His) SEY1,Protein SEY1 homolog	Plasmodium knowlesi	E. coli
	Probable GTP-binding protein that may be involved in cell development. SEY1 Protein, Plasmodium knowlesi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 103.5 kDa and the accession number is B3LAJ9.
TMPH-03139	MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) Chloroquine resistance protein,MDR1,Multidrug resistance pro...	Plasmodium falciparum	E. coli
	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.2 kDa and the accession number is P13568.
TMPH-03137	PFS230 Protein, Plasmodium falciparum, Recombinant PFS230,Gametocyte surface protein P230	Plasmodium falciparum	E. coli
	Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes. PFS230 Protein, Plasmodium falciparum, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.9 kDa and the accession number is P68874.
TMPH-03138	GST Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	P. pastoris (Yeast)
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin). GST Protein, Plasmodium falciparum, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 27.3 kDa and the accession number is Q8MU52.
TMPH-03140	Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His) Plasmepsin I,Aspartic hemoglobinase I,Plasmepsin 1,PMI	Plasmodium falciparum	E. coli
	During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.0 k...
TMPH-03141	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc) Plasmepsin II,Aspartic hemoglobinase II,PMII,Plasmepsin 2,Pf...	Plasmodium falciparum	Baculovirus Insect Cells
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predict...
TMPH-03136	L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) LDH,L-lactate dehydrogenase	Plasmodium berghei	E. coli
	N/A. L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.4 kDa and the accession number is Q7SI97.
TMPH-00990	ACKR1 Protein, Human, Recombinant (His) Glycoprotein D,Duffy antigen/chemokine receptor,Atypical che...	Human	E. coli
	ACKR1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 41.1 kDa and the accession number is Q16570.
TMPH-03142	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc) PMII,PfAPD,Plasmepsin 2,PfPM1,Aspartic hemoglobinase II,Plas...	Plasmodium falciparum	E. coli
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable). Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. T...
TMPY-04180	PfLDH Protein, P. falciparum, Recombinant (His) PfLDH,L-lactate dehydrogenase	P. falciparum	E. coli
	Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR assays to detect <1 parasite/microL suggests that improvements of bound antibody sensor technology may greatly increase the sensitivity of malaria rapid diagnostic tests. The PfLDH test could be used to detect failures and, therefore, to assess anti-malarial efficacy.
TMPY-04765	PKLR Protein, Human, Recombinant (His) PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc) FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece...

重组蛋白

PFD0110w Protein, Plasmodium falciparum, Recombinant

Cat.No: TMPH-03143

Species: Plasmodium falciparum

Expression System: E. coli

SEY1 Protein, Plasmodium knowlesi, Recombinant (His)

Cat.No: TMPH-03144

Species: Plasmodium knowlesi

Expression System: E. coli

MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)

Cat.No: TMPH-03139

Species: Plasmodium falciparum

Expression System: E. coli

PFS230 Protein, Plasmodium falciparum, Recombinant

Cat.No: TMPH-03137

Species: Plasmodium falciparum

Expression System: E. coli

GST Protein, Plasmodium falciparum, Recombinant (His)

Cat.No: TMPH-03138

Species: Plasmodium falciparum

Expression System: P. pastoris (Yeast)

Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His)

Cat.No: TMPH-03140

Species: Plasmodium falciparum

Expression System: E. coli

Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc)

Cat.No: TMPH-03141

Species: Plasmodium falciparum

Expression System: Baculovirus Insect Cells

L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc)

Cat.No: TMPH-03136

Species: Plasmodium berghei

Expression System: E. coli

ACKR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00990

Species: Human

Expression System: E. coli

Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03142

Species: Plasmodium falciparum

Expression System: E. coli

PfLDH Protein, P. falciparum, Recombinant (His)

Cat.No: TMPY-04180

Species: P. falciparum

Expression System: E. coli

PKLR Protein, Human, Recombinant (His)

Cat.No: TMPY-04765

Species: Human

Expression System: E. coli

CD36 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00292

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0072	Lumefantrine-d9
	Lumefantrine-d9 是 Lumefantrine 的氘代化合物。Lumefantrine 的 CAS 号为 82186-77-4。Lumefantrine是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether联用，可提高疗效。
TMIH-0457	Proguanil-d6 HCl
	Proguanil-d6 HCl 是 Proguanil HCl 的氘代化合物。Proguanil HCl 的 CAS 号为 637-32-1。Proguanil hydrochloride 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。

同位素标记化合物

Lumefantrine-d9

Cat.No: TMIJ-0072

Proguanil-d6 HCl

Cat.No: TMIH-0457

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