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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76138 |
Phosphodiesterase
|
Others | Others |
Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶,常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根据其对环核苷酸的特异性也可以分别不同类型,如 PDE1-PDE11,在多种疾病方面也具有一定的潜力。 | |||
T36018 |
Phosphodiesterase 4 Inhibitor
|
Others | Others |
Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme. | |||
T76156 |
Sphingomyelin phosphodiesterase
|
Others | Others |
Sphingomyelinphosphodiesterase 是一种水解酶,参与鞘磷脂代谢过程。Sphingomyelinphosphodiesterase 水解鞘磷脂,使其向磷酸胆碱和神经酰胺转化。Sphingomyelinphosphodiesterase 还在细胞分化、各种免疫和炎症反应以及细胞内胆固醇运输和代谢中发挥重要作用。 | |||
T76133 |
Phosphodiesterase II
|
Others | Others |
PhosphodiesteraseII,即磷酸二酯酶 2,主要参与水解重要的第二信使环磷酸腺苷 (cAMP) 和环磷酸鸟苷 (cGMP),常用于生化研究。PhosphodiesteraseII 表达于多种组织,如肾上腺髓质、脑、心脏、血小板、巨噬细胞和内皮细胞,可参与调节许多不同的细胞内过程。 | |||
T10676 |
Carbodenafil
|
PDE | Metabolism |
Carbodenafil 是在健康食品中发现的 Sildenafil 相关化合物。其中Sildenafil 是磷酸二酯酶 5 (PDE5) 抑制剂(IC50:5.22 nM)。 | |||
T27172 |
Difamilast
|
PDE | Metabolism |
Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂,对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。 | |||
T12150 |
N-Methylbenzamide
|
PDE | Metabolism |
N-Methylbenzamide 是磷酸二酯酶 10A 抑制剂,具有抗癌作用。 | |||
T6462 |
Deltarasin
|
PDE; Ras | GPCR/G Protein; MAPK; Metabolism |
Deltarasin 是一种 KRAS-PDEδ 相互作用的小分子抑制剂,与纯化的 PDEδ 结合,Kd 值为 38 nM。 | |||
T27475 |
GSK356278
GSK-356278,GSK 356278 |
PDE | Metabolism |
GSK356278 是一种有效的特异性磷酸二酯酶 4 (PDE4) 抑制剂,对人 PDE4A、PDE4B 和 PDE4D 的 pIC50 分别为 8.6、8.8 和 8.7。 GSK356278 具有抗炎、抗焦虑和增强认知的作用。 | |||
T2129 |
Zaprinast
|
PDE | Metabolism |
Zaprinast 是一种 cGMP 选择性的磷酸二酯酶(PDE)抑制剂,是一种 GPR35激动剂,对大鼠 GPR35 有很强的激活作用,对人 GPR35 有一定的激活作用。它通过抗增殖和促凋亡作用,减少血管的重构。 | |||
T6054 |
GSK256066
|
PDE | Metabolism |
GSK256066 是高亲和力的、选择性的PDE4抑制剂,IC50=3.2 pM,被开发用于慢性阻塞性肺病的研究。 | |||
T7954 |
YM976
|
PDE | Metabolism |
YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应,并有抗炎的作用。 | |||
T21965 |
MBCQ
|
PDE | Metabolism |
MBCQ 是选择性 cGMP 特异性磷酸二酯酶 (PDE V; PDE5) 抑制剂,IC50=19 nM。它通过特异性抑制 cGMP-PDE 来扩张冠状动脉。它对其他 PDE 同工酶没有抑制活性,IC50均大于 100 µM。 | |||
T0160 |
Anagrelide
Anagrelida,Xagrid,Anagrelidum,阿那格雷 |
PDE | Metabolism |
Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM),是咪唑喹唑啉衍生物。它能够抑制血小板生成,以及抗血栓形成作用,可用作血小板聚集抑制剂。 | |||
T4695 |
CP671305
|
PDE | Metabolism |
CP671305 是口服具有活力的 phosphodiesterase-4-D 选择性抑制剂,具有很高的活性。 | |||
T2646 |
HA130
|
PDE | Metabolism |
HA130 是选择性 autotaxin 抑制剂,IC50=28 nM。 | |||
T7888 |
Enpp-1-IN-1
|
PDE | Metabolism |
Enpp-1-IN-1 是enpp-1(核苷酸焦磷酸酶-磷酸二酯酶 1) 选择性抑制剂。 | |||
T5496 |
ML-030
|
PDE | Metabolism |
ML-030 是 PDE4抑制剂,对 PDE4A (IC50=6.7 nM),PDE4A1 (IC50=12.9 nM),PDE4B1 (IC50=48.2 nM),PDE4B2 (IC50=37.2 nM),PDE4C1 (IC50=452 nM) 和 PDE4D2 (IC50=49.2 nM)。 | |||
T6649 |
(S)-(+)-Rolipram
(S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram |
Apoptosis; PDE | Apoptosis; Metabolism |
(S)-(+)-Rolipram ((+)-Rolipram) 是一种 cAMP 依赖性磷酸二酯酶 4 (PDE4) 抑制剂,IC50=1100 nM。它能够抑制人单核细胞产生的肿瘤坏死因子 α (TNFα)。 | |||
T4462 |
Roflumilast N-oxide
|
PDE | Metabolism |
Roflumilast N-oxide 是一种 PDE 4 型抑制剂。 | |||
T10410 |
ATX inhibitor 1
|
PDE | Metabolism |
ATX inhibitor 1是一种 ATX(IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) 抑制剂。 | |||
T13448 |
(R)-(-)-Rolipram
(R)-Rolipram,(-)-Rolipram |
DNA-PK; Others | DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling |
(R)-(-)-Rolipram ((-)-Rolipram) 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。 | |||
T12267 |
NSP-805
|
PDE | Metabolism |
NSP-805 是一种强心剂,是一种选择性的 phosphodiesterase 3 抑制剂,具有舒张血管的作用。 | |||
T5106 |
BRL-50481
|
PDE | Metabolism |
BRL 50481 是一种新型的、选择性的 PDE7 的抑制剂,对 PDE7A,PDE7B,PDE4和 PDE3的 IC50值分别为 0.15,12.1,62 和 490 μM。 | |||
T3631 |
PF-8380
|
PDE | Metabolism |
PF8380 是有效的autotaxin 抑制剂,在体外酶实验和人类全血细胞实验中的IC50分别为 2.8 nM 和 101 nM。 | |||
T10590 |
Zatolmilast
BPN14770 |
Others; PDE | Metabolism; Others |
Zatolmilast (BPN14770) 是选择性磷酸二酯酶 4D(PDE4D)变构抑制剂,能够抑制 PDE4D7 (IC50:7.8 nM) 与 PDE4D3 (IC50:7.4 nM)。 | |||
T7346 |
Lodenafil
Hydroxyhomosildenafil,羟基豪莫西地那非 |
PDE | Metabolism |
Lodenafil (Hydroxyhomosildenafil) 是一种有效的磷酸二酯酶 5 型(PDE5)抑制剂,可用于勃起功能障碍的研究。 | |||
T6548 |
Irsogladine
Dicloguamine,伊索拉定 |
PDE; AChR | Metabolism; Neuroscience |
Irsogladine (Dicloguamine) 是抗胃溃疡剂,通过 M1 毒蕈碱乙酰胆碱受体结合促进间隙连接细胞间通讯。 | |||
T1618 |
Dipyridamole
Persantin,Dypyridamole,Dipyridamol,双嘧达莫,NSC-515776,Dipyudamine |
PDE | Metabolism |
Dipyridamole (Persantin) 是一种磷酸二酯酶抑制剂,能阻断红细胞和血管内皮细胞对腺苷的吸收和代谢。 | |||
T6445 |
Cilomilast
SB-207499,西洛司特,Ariflo |
PDE | Metabolism |
Cilomilast (SB-207499) 是选择性的、口服具有活性的磷酸二酯酶 4 抑制剂。 它对 PDE4 的选择性高于 PDE1,PDE2,PDE3 和 PDE5 (IC50=74,65,>100,83 µM)。它具有抗炎和免疫调节功能,可用于研究哮喘和慢性阻塞性肺疾病。 | |||
T1096 |
Milrinone
Win 47203,米力农 |
PDE | Metabolism |
Milrinone (Win 47203) 是一种 PDE3抑制剂,也是一种强心药、血管舒张药。 | |||
T8515 |
Osoresnontrine
BI-409306 |
PDE | Metabolism |
Osoresnontrine (BI-409306) 是选择性的PDE9A 抑制剂,IC50=52 nM,对其他 PDE 的活性较弱。它可用于中枢神经系统障碍疾病中提高记忆力的研究。 | |||
T5474 |
D159687
D 159687 |
PDE | Metabolism |
D159687 是一种PDE4D 选择性抑制剂。 | |||
T3465 |
Vesnarinone
维司力农,OPC-8212,Arkin,Piteranometozine |
HIV Protease; PDE | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Vesnarinone (Arkin) 是一种喹啉酮衍生物,可抑制磷酸二酯酶III 活性,增加钙通量和减小钾通量。 | |||
T4041 |
Ziritaxestat
GLPG1690 |
PDE | Metabolism |
Ziritaxestat (GLPG1690) 是一种创新的 autotaxin (ATX)抑制剂,其 IC50=131 nM,Ki=15 nM。 | |||
T6147 |
Nortadalafil
Demethyl Tadalafil,去甲基他达那非 |
PDE | Metabolism |
Nortadalafil (Demethyl Tadalafil) 是 demethyl Tadalafil,是一种 PDE5 抑制剂。 | |||
T23154 |
Piclamilast
RPR 73401,RP 73401,吡拉米司特 |
PDE | Metabolism |
Piclamilast (RP 73401) 是一种有效的磷酸二酯酶 4(PDE4)的抑制剂,对猪主动脉和可溶性嗜酸性粒细胞中的 IC50值分别为 16 nM 和 2 nM。 | |||
T24656 |
PQ-10
A844337,PQ 10,A-844337,A 844337 |
PDE | Metabolism |
PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂,其IC50=4.6 nM,ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式,这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。 | |||
T8919 |
Homo Sildenafil
蒙莫西地那非,豪莫西地那非 |
PDE | Metabolism |
Homo Sildenafil 是一种 Sildenafil 的类似物,是一种磷酸二酯酶抑制剂。 | |||
T21865 |
BC 11-38
|
PDE | Metabolism |
BC 11-38是一种有效的PDE11生物活性抑制剂,可提高PKA 介导的 ATF-1 磷酸化、 H295R 细胞 cAMP 水平和皮质醇生成。 | |||
T12913 |
Siguazodan
SKF 94836 |
PDE | Metabolism |
Siguazodan (SKF 94836) 是选择性的,口服有效的磷酸二酯酶 III 抑制剂,IC50为 117 nM。它可增加完整血小板中 cAMP 的积累,EC50为 18.88 μM。它也抑制苯肾上腺素诱导的 5-HT 释放,IC50为 4.2 μM。 | |||
T7542 |
Amino Tadalafil
氨基他达那非,氨基他达拉非 |
PDE | Metabolism |
Amino Tadalafil 是一种 Tadalafil 的类似物,是一种磷酸二酯酶 5 抑制剂,可用于多种疾病,如勃起功能障碍,肺动脉高压和下尿路功能障碍。 | |||
T21389 |
Enprofylline
Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱 |
Others | Others |
Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ,也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。 | |||
T5033 |
Olprinone
奥普力农,Loprinone |
PDE | Metabolism |
Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂,对 PDE1,PDE2,PDE3,PDE4 的IC50分别为 150、100、0.35 和 14 μM,具有抗炎活性。它具有正性肌力和血管扩张作用,可用于心力衰竭的研究。 | |||
T9805 |
BAY 2666605
|
PDE | Metabolism |
BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂,IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。 | |||
T8506 |
THPP-1
|
PDE | Metabolism |
THPP-1 是一种 SGC 推荐的化学探针, 是一种口服具有活性的磷酸二酯酶10A 抑制剂,其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。 | |||
T2923 |
Apremilast
阿普斯特,CC-10004,阿普司特 |
Apoptosis; TNF; PDE | Apoptosis; Metabolism |
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂,IC50为 74 nM。它抑制脂多糖释放TNF-α,IC50为 104 nM。 | |||
T16499 |
Mardepodect
PF-2545920 |
PDE | Metabolism |
Mardepodect (PF-2545920) 是一种有效的、口服具有活性的、可透过血脑屏障的、选择性的 PDE10A 抑制剂,IC50=0.37 nM,比作用于其他 PDE 选择性高 1000 多倍。 | |||
T11689 |
ITI-214
ITI214 |
PDE | Metabolism |
ITI-214 是一种中枢神经系统活性抑制剂,具有口服生物活性的PDE1抑制剂 (Kiof 58 pM),对其他 PDE 家族成员和一系列酶、受体、转运体和离子通道具有良好的选择性,在各种运动和认知功能的动物模型中显示出有效性。 | |||
T1745 |
Balipodect
TAK063,TAK-063,TAK 063 |
PDE | Metabolism |
Balipodect (TAK063) 是一种高效的、口服具有活性、选择性的 PDE10A 抑制剂,IC50=0.3nM,对其他PDEs 无抑制作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1266 |
3-O-Methylquercetin
|
IL Receptor; cAMP; PDE | GPCR/G Protein; Immunology/Inflammation; Metabolism |
3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物,可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。 | |||
T8787 |
Drotaverine hydrochloride
|
PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
TN2159 |
Robustine
大叶桉亭,8-羟基白鲜碱,4-甲氧基呋喃并[2,3-B]喹啉-8-醇 |
PDE | Metabolism |
Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱,在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。 | |||
TN1416 |
Ayanin
|
IL Receptor; P450; PARP; PDE | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂,在呼吸道疾病中有研究的价值,如过敏性哮喘等。 | |||
T1681 |
Aminophylline
氨茶碱,Phyllocontin |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Aminophylline (Phyllocontin) 是一种竞争性非选择性磷酸二酯酶抑制剂,具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂,有用于哮喘研究的潜力。 | |||
T7027 |
EURYCOMANONE
东革阿里提取物,Pasakbumin A |
Others | Others |
Eurycomanone (Pasakbumin A) 能够抑制雌激素生成过程中磷酸二酯酶和芳香酶的活性,促进精子生成。它对 HepG2 细胞具有细胞毒性,能够上调 p53 和 Bax 以及下调 Bcl-2 ,诱导细胞凋亡。它具有抗癌活性,在浓度范围内以剂量依赖性方式抑制 A549 肺癌细胞增殖 从 5 到 20 微克/毫升。 | |||
T0892 |
Diphylline
二羟丙茶碱,Dyphylline,Diprophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂,也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物,具有支气管扩张和血管扩张作用,有用于治疗慢性支气管炎和肺气肿的潜力。 | |||
T2855 |
Icariin
淫羊藿苷,Ieariline,淫羊藿甙 |
PDE; PPAR; Autophagy | Autophagy; DNA Damage/DNA Repair; Metabolism |
Icariin (Ieariline) 是一种黄酮醇苷,可抑制PDE5和PDE4活性,IC50分别为 432 nM 和 73.50 μM。它也是PPARα激活剂。 | |||
T3783 |
Fraxin
Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙 |
OAT; transporter; PDE | Membrane transporter/Ion channel; Metabolism |
Fraxin (Fraxoside) 是一种白蜡树内酯的糖苷,可从Acer tegmentosum,F. ornus 和A. hippocastanum 等分离得到,具有抗氧化、抗炎和抗转移活性。它能够抑制环腺苷酸磷酸二酯酶,具有抗氧化作用。 | |||
T0480 |
Doxofylline
Doxophylline,多索茶碱 |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Doxofylline (Doxophylline) 是腺苷 A1 受体拮抗剂,且能抑制磷酸二酯酶 IV,用于治疗哮喘。 | |||
T1083 |
Theophylline
Theo-24,1,3-Dimethylxanthine,茶碱 |
Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。 | |||
T6427 |
Butein
2’,3,4,4’-tetrahydroxy Chalcone,紫铆因 |
Apoptosis; EGFR; Others; PDE; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors |
Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂,也是蛋白酪氨酸激酶抑制剂,还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路,靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T2205 |
Acefylline
Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid |
TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。 | |||
T0167 |
Vinpocetine
长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate |
IκB/IKK; NF-κB; Sodium Channel; PDE | Membrane transporter/Ion channel; Metabolism; NF-κB |
Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物,是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂,并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应,已被广泛用于研究脑血管疾病。 | |||
T17199 |
Udenafil
3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非 |
PDE | Metabolism |
Udenafil 是一种选择性的,有效的,具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解,可用于研究勃起功能障碍的。 | |||
T0070 |
Pentoxifylline
Oxpentifylline,PTX,己酮可可碱,BL-191 |
HIV Protease; PDE; Adenosine Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂,具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。 | |||
T4S0792 |
Pinoresinol 4-O-β-D-glucopyranoside
(+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside |
Others; Antioxidant | Others; oxidation-reduction |
(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。 | |||
TN2217 |
Sophoflavescenol
槐苦参醇,槐黄醇 |
Others; Beta-Secretase; BACE; PDE; AChR; AChE | Metabolism; Neuroscience; Others |
Sophoflavescenol 是异戊烯基黄酮类化合物,能够抑制PDE5的活性,IC50=0.013 μM。它也抑制 RLAR,HRAR,BACE1,AChE 和 BChE,IC50值分别为 0.30 µM,0.17 µM,10.98 µM,8.37 µM 和 8.21 µM。 | |||
TN4510 |
(+)-Medioresinol Di-O-β-D-glucopyranoside
(+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside |
PDE | Metabolism |
(+)-Medioresinol Di-O-β-D-glucopyranoside 对环 AMP 磷酸二酯酶具有很强的抑制活性。 | |||
TN3091 |
5,7-Diacetoxy-8-methoxyflavone
ZINC77031696 |
PDE | Metabolism |
5,7-Diacetoxy-8-methoxyflavone 源自黄芩的根,可抑制 cAMP 磷酸二酯酶。 | |||
T10822 |
Cirsimarin
Cirsitakaoside |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Cirsimarin (Cirsitakaoside) 是一种从 Microtea debilis 中分离出来的黄酮类化合物。它具有很强的抗脂肪生成作用,能减少小鼠脂肪组织的沉积。Cirsimarin 对腺苷 A1 受体有拮抗作用,对磷酸二酯酶有抑制作用 | |||
T5940 |
Proxyphylline
羟丙茶碱,7-(2-Hydroxypropyl)theophylline |
PDE; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Proxyphylline (7-(2-Hydroxypropyl)theophylline) 是甲基黄嘌呤衍生物,可用作心脏活化剂、血管扩张剂和支气管扩张剂。 | |||
TN6120 |
Nauclefine
Parvine |
PDE | Metabolism |
Nauclefine (Parvine) 是一种植物吲哚生物碱天然产物,可通过 PDE3A-SLFN12 依赖性死亡途径诱导多种癌细胞的凋亡。 Nauclefine 结合 PDE3A 但不抑制 PDE3A 的磷酸二酯酶活性。 | |||
TN1950 |
Moracin M
|
PDE | Metabolism |
Moracin M 是桑白皮中的一种酚类成分,有效的磷酸二酯酶 4 (PDE4) 抑制剂,对于 PDE4D2,PDE4B2,PDE5A1 和 PDE9A2 的 IC50 分别为 2.9 μM,4.5 μM,> 40 μM 和 > 100 μM。Moracin M 具有抗炎活性。 | |||
T4973 |
Paraxanthine
1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE |
Endogenous Metabolite | Metabolism |
Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物,能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。 | |||
TN3466 |
Atherosperminine
|
cAMP; Calcium Channel; AChR; Parasite | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Atherosperminine 是一种天然生物碱,在体外表现出抗疟原虫活性,IC50为 5.80 μM。它具有DPPH 自由基清除活性,其IC50值为 29.56 µg/mL。它对气管有非特异性的弛缓作用。它是一种良好的还原剂,具有螯合金属的能力。 | |||
TN3013 |
4,5-Dimethoxycanthin-6-one
Methylnigakinone |
P450; Antibacterial; PDE | Metabolism; Microbiology/Virology |
4,5-Dimethoxycanthin-6-one 从 Picrasma quassioides BENNET (Simaroubaceae)是一种从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到生物碱。4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂(IC50 : 1.7 μM, Ki : 2.6 μM),对环磷酸腺苷(cAMP)磷酸二酯酶有很强的抑制作用。4,5-Dimethoxycanthin-6-one 具有抗菌活性,对金黄色葡萄球菌及其耐药菌株有抑制作用。4,5-Dimethoxycanthin-6-one 对肿瘤细胞株 U937 和 HepG2 具有细胞毒性。 | |||
T28019 |
(-)-Mesembrine
Mesembrin,Mesembrine,Mesembranone |
Others | Others |
Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4). | |||
T27436 |
GS 389
GS-389,GS389 |
Others | Others |
GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta. | |||
TN1843 |
Kushenol K
|
PDE; HSV | Metabolism; Microbiology/Virology |
Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II. | |||
TN4397 |
Kuraridine
|
PDE; Parasite | Metabolism; Microbiology/Virology |
Kuraridine is measured against cGMP PDE5 to identify potent cGMP specific phosphodiesterase type 5 inhibitory constituents. | |||
TN2974 |
3-O-Methylquercetin tetraacetate
|
IL Receptor; TNF; PDE | Apoptosis; Immunology/Inflammation; Metabolism |
Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness. | |||
TN1841 |
Kushenol A
苦参新醇 A,Leachianone E |
cAMP | GPCR/G Protein |
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). | |||
TN1504 |
Citreorosein
羟基大黄素 |
cAMP; NF-κB; PI3K | GPCR/G Protein; NF-κB; PI3K/Akt/mTOR signaling |
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation. | |||
TN4886 |
Quinovic acid 3-O-alpha-L-rhamnopyranoside
|
Others | Others |
Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I. | |||
T79957 |
4'-Methoxyisoagarotetrol
|
Others | Others |
4'-Methoxyisoagarotetrol 是一种色素衍生物,表现出中等强度的PDE3A抑制活性,其半抑制浓度(IC50)为54 μM。 | |||
TN4433 |
Licoarylcoumarin
|
cAMP; HIV Protease; Antifection | GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase. | |||
T16397 |
Ophiobolin A
|
Others | Others |
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity. | |||
T28522 |
Reticulol
|
Others | Others |
Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10. | |||
TN3537 |
Braylin
|
IL Receptor; TNF; NF-κB | Apoptosis; Immunology/Inflammation; NF-κB |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also a phosphodiesterase-4 inhibitor, it could represent an ideal prototype of glucocorticoid receptor ligand, able to induce synergic immunomodulatory effects. | |||
T4700 |
1,3,5-Trihydroxy-4-prenylxanthone
|
||
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu | |||
T75486 |
Toddacoumalone
|
Others | Others |
Toddacoumalone 是一种天然PDE4 (磷酸二酯酶 4) 抑制剂,效力中等,活性分子特性不完善。具有研究银屑病等炎症性疾病潜力。 | |||
T73857 |
Mesembrine
|
Others | Others |
Mesembrine ((+)-Mesembrine) 一种主要的生物碱,具有芳基八氢吲哚骨架。Mesembrine 是一种5-HT 转运蛋白抑制剂,Ki 为 1.4 nM。Mesembrine 还抑制磷酸二酯酶 4B (PDE4B),IC50为 7.8 μM。 | |||
TN4551 | Methyl orsellinate | Phosphatase; cAMP; Antifection | GPCR/G Protein; Metabolism; Microbiology/Virology |
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential ... | |||
T38108 |
Fulvic Acid
|
Antioxidant; PDE | Metabolism; oxidation-reduction |
Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物,是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化,破坏预先形成的AB17-42三聚体,并结合到磷酸二酯酶5A (PDE5A)的催化位点,可以调节机体免疫系统,影响细胞的氧化状态,改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂, 具有研究糖尿病等慢性炎症性疾病的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04006 |
ENPP3 Protein, Rhesus, Recombinant (His)
ectonucleotide pyrophosphatase/phosphodiesterase 3,... |
Rhesus | Baculovirus Insect Cells |
ENPP3 Protein, Rhesus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 97.2 kDa and the accession number is XP_001103528.1. | |||
TMPY-00463 |
ENPP2 Protein, Cynomolgus, Recombinant (His)
ENPP2,ectonucleotide pyrophosphatase/phosphodiesterase |
Cynomolgus | HEK293 Cells |
ENPP2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is XP_005564040.1. | |||
TMPY-02585 |
Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiester... |
Mouse | Baculovirus Insect Cells |
Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome... | |||
TMPH-00571 |
ACP phosphodiesterase Protein, E. coli, Recombinant (His & Myc)
yajB,acpH,Acyl carrier protein phosphodiesterase |
E. coli | E. coli |
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP. | |||
TMPY-02778 |
ENPP2 Protein, Human, Recombinant (His)
ATX,ectonucleotide pyrophosphatase/phosphodiesterase |
Human | HEK293 Cells |
ENPP2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is AAH34961.1. | |||
TMPY-01922 |
PDE9A Protein, Human, Recombinant (His & GST)
HSPDE9A2,phosphodiesterase 9A |
Human | Baculovirus Insect Cells |
PDE9A Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.5 kDa and the accession number is O76083-2. | |||
TMPY-01921 |
PDE9A Protein, Human, Recombinant (His)
phosphodiesterase 9A,HSPDE9A2 |
Human | E. coli |
PDE9A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 40 kDa and the accession number is O76083-2. | |||
TMPH-02575 |
PDE5A Protein, Mouse, Recombinant (His & Myc)
cGMP-specific 3',5'-cyclic phosphodiesterase,Pde5a,... |
Mouse | E. coli |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. PDE5A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.1 kDa and the accession number is Q8CG03. | |||
TMPH-02425 |
ENPP3 Protein, Cynomolgus, Recombinant (His)
Phosphodiesterase I beta |
Cynomolgus | HEK293 Cells |
ENPP3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 98.7 kDa and the accession number is A0A2K5TKP4. | |||
TMPY-01819 |
PDE1B Protein, Human, Recombinant (His & GST)
PDES1B,phosphodiesterase 1B, calmodulin-dependent,P... |
Human | Baculovirus Insect Cells |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b... | |||
TMPY-02081 |
PDE2A Protein, Human, Recombinant (aa 215-900, His)
phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4... |
Human | Baculovirus Insect Cells |
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ... | |||
TMPY-03278 |
SMPDL3A Protein, Human, Recombinant (His)
yR36GH4.1,sphingomyelin phosphodiesterase, acid-lik... |
Human | HEK293 Cells |
SMPDL3A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.3 kDa and the accession number is Q92484. | |||
TMPY-02977 |
PDE1C Protein, Human, Recombinant (His & GST)
hCam-3,phosphodiesterase 1C, calmodulin-dependent 7... |
Human | Baculovirus Insect Cells |
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s... | |||
TMPY-02253 |
ENPP7 Protein, Mouse, Recombinant (His)
ectonucleotide pyrophosphatase/phosphodiesterase 7,... |
Mouse | HEK293 Cells |
ENPP7 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q3TIW9. | |||
TMPY-02880 |
ENPP5 Protein, Human, Recombinant (His)
NPP-5,ectonucleotide pyrophosphatase/phosphodiesterase |
Human | HEK293 Cells |
ENPP5 is a member of the nucleotide pyrophosphatase/phosphodiesterase family (NPP). It is a family comprised of dimeric enzymes that catalyze the hydrolysis of phosphate diester bonds. There are seven isoforms in NPP family, some of which prefer nucleotide substrates, some of which prefer phospholipid substrates, and others of which prefer substrates that have not yet been determined. NPP also belongs to the alkaline phosphatase (AP) superfamily of enzymes and they are located in the cell membra... | |||
TMPH-02706 |
PDE9A Protein, Mouse, Recombinant (His)
High affinity cGMP-specific 3',5'-cyclic phosphodiestera... |
Mouse | E. coli |
PDE9A Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPY-04512 |
SMPDL3A Protein, Mouse, Recombinant (His)
AI529588,ASML3,ASM3A,0610010C24Rik,ASML3A,sphingomyelin ... |
Mouse | HEK293 Cells |
SMPDL3A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.1 kDa and the accession number is P70158. | |||
TMPY-01070 |
ENPP7 Protein, Human, Recombinant (His)
ectonucleotide pyrophosphatase/phosphodiesterase 7,... |
Human | HEK293 Cells |
ENPP7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49 kDa and the accession number is Q6UWV6. | |||
TMPH-01467 |
PDE9A Protein, Human, Recombinant (His & Myc)
PDE9A,High affinity cGMP-specific 3',5'-cyclic phosphodi... |
Human | E. coli |
PDE9A Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-03254 |
PDE1C Protein, Rat, Recombinant (His)
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic n... |
Rat | E. coli |
PDE1C Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 92.6 kDa and the accession number is Q63421. | |||
TMPY-02055 |
ENPP2 Protein, Mouse, Recombinant (His)
PD-Ialpha,Pdnp2,ectonucleotide pyrophosphatase/phosphodi... |
Mouse | HEK293 Cells |
ENPP2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96 kDa and the accession number is Q9R1E6-1. | |||
TMPY-06858 |
ENPP3 Protein, Human, Recombinant (His)
RP5-988G15.3,ectonucleotide pyrophosphatase/phosphodiest... |
Human | HEK293 Cells |
ENPP3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 96.44 kDa and the accession number is O14638. | |||
TMPK-00854 |
ENPP1 Protein, Human, Recombinant (C-His)
M6S1,E-NPP 1,PCA1,PDNP1,ENPP1,NPPase,NPPS,M6S1NPP1,PCA1ARHR2... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413. | |||
TMPH-01024 |
Calbindin Protein, Human, Recombinant (His)
Vitamin D-dependent calcium-binding protein, avian-type,D-28... |
Human | P. pastoris (Yeast) |
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937. | |||
TMPK-00853 |
ENPP1 Protein, Human, Recombinant (N-His)
PDNP1,NPP1,NPPase,PCA1ARHR2,PCA1,M6S1,Ly-41 Antigen,ENPP1,E-... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413. | |||
TMPK-00781 |
ENPP1 Protein, Mouse, Recombinant (His)
ENPP1,PC1,PCA1ARHR2,PCA1,NPP1,M6S1NPP1,PDNP1,NPPS,Ly-41 Anti... |
Mouse | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 95.99 kDa and the accession number is P06802-1. | |||
TMPH-00270 |
GNAT2 Protein, Bovine, Recombinant (His)
GNAT2,Transducin alpha-2 chain,Guanine nucleotide-binding pr... |
Bovine | E. coli |
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. GNAT2 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P04696. | |||
TMPK-00573 |
ENPP3 Protein, Canine, Recombinant (His)
gp130RB13-6,PD-Iβ,NPP3,E-NPP 3,B10,NPPase,ENPP3,PDNP3,CD203c... |
Canine | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.19 kDa and the accessio... | |||
TMPK-00852 |
ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated
E-NPP 1,NPPase,PC1,NPP1,PCA1,ENPP1,Ly-41 Antigen,PCA1ARHR2,M... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 98.29 kDa and the accession number is P22413. | |||
TMPK-00712 |
ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi)
ENPP3,E-NPP 3,PDNP3,CD203c,PD-Ibeta,NPP3,NPPase,gp130RB13-6,... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 17.21 ... | |||
TMPK-00715 |
ENPP3 Protein, Human, Recombinant (aa 558-875, His)
PD-Ibeta,B10,E-NPP 3,PDNP3,NPP3,ENPP3,gp130RB13-6,NPPase,PD-... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 558-875, His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 39.06 kDa and t... | |||
TMPK-00713 |
ENPP3 Protein, Human, Recombinant (His & Avi), Biotinylated
NPP3,B10,PDNP3,NPPase,gp130RB13-6,CD203c,PD-Iβ,PD-Ibeta,ENPP... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 99.... | |||
TMPK-00714 |
ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi), Biotinylated
CD203c,PDNP3,NPPase,E-NPP 3,NPP3,PD-Iβ,gp130RB13-6,B10,ENPP3... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (aa 48-157, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular we... | |||
TMPK-00711 |
ENPP3 Protein, Human, Recombinant (His & Avi)
gp130RB13-6,CD203c,NPPase,PDNP3,B10,PD-Iβ,PD-Ibeta,NPP3,ENPP... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase-phosphodiesterase 3 (ENPP3), a protein detected in the human uterus, has been found to play an important role in the development and invasion of tumours. It was recently discovered that ENPP3 was upregulated during the window of implantation in the human endometrium but its functional relevance remains elusive. ENPP3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 99.97 kDa and the... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0249 |
Crisaborole-d4
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Crisaborole-d4 是 Crisaborole 的氘代化合物。Crisaborole 的 CAS 号为 906673-24-3。Crisaborole 是一种有效的 PDE4和cytokine释放抑制剂,能够抑制PDE4(IC50=0.49 μM)。 | |||
TMID-0210 |
Sildenafil-13C-d3
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Sildenafil-13C-d3 是 Sildenafil 的 13C 和氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 | |||
TMID-0117 |
Aminophylline-d6
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Aminophylline-d6 是 Aminophylline 的氘代化合物。Aminophylline 的 CAS 号为 317-34-0。Aminophylline 是一种竞争性非选择性磷酸二酯酶抑制剂,具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂,有用于哮喘研究的潜力。 | |||
TMID-0050 |
N-Desmethyl Sildenafil-d8
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N-Desmethyl Sildenafil-d8 是 N-Desmethyl Sildenafil 的氘代化合物。N-Desmethyl Sildenafil 的 CAS 号为 139755-82-1。N-Desmethyl Sildenafil是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。 | |||
TMID-0043 |
Sildenafil-d8
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Sildenafil-d8 是 Sildenafil 的氘代化合物。Sildenafil 的 CAS 号为 139755-83-2。Sildenafil 是一种磷酸二酯酶 5 抑制剂,IC50为 5.22 nM。 | |||
TMIJ-0148 |
Avanafil-13C-d3
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Avanafil-13C-d3 是 Avanafil 的 13C 和氘代化合物。Avanafil 的 CAS 号为 330784-47-9。Avanafil 是一种高活性PDE-5抑制剂,IC50=5.2 nM,对PDE1,PDE6和PDE11活性较低。 | |||
TMIH-0190 |
Difamilast-d5
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Difamilast-d5 是 Difamilast 的氘代化合物。Difamilast 的 CAS 号为 937782-05-3。Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂,对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。 | |||
T71329 |
Theophylline-d6
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Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist. Theophylline induces relaxation of isolated cat bronchial smooth muscle segments precontracted with acetylcholine. It inhibits ovalbumin-induced increases in bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma. F... | |||
TMIJ-0114 |
Vardenafil-d5
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Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。 | |||
TMID-0209 |
Tadalafil-13C-d3
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Tadalafil-13C-d3 是 Tadalafil 的 13C 和氘代化合物。Tadalafil 的 CAS 号为 171596-29-5。Tadalafil 是一种PDE5抑制剂,IC50为 1.8 nM。 | |||
TMID-0037 |
Tadalafil-d3
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Tadalafil-d3 是 Tadalafil 的氘代化合物。Tadalafil 的 CAS 号为 171596-29-5。Tadalafil 是一种PDE5抑制剂,IC50为 1.8 nM。 | |||
T70883 |
Moexipril-d5
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Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ... | |||
TMIJ-0274 |
Sulindac-d3
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Sulindac-d3 是 Sulindac 的氘代化合物。Sulindac 的 CAS 号为 38194-50-2。Sulindac 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。 | |||
TMID-0119 |
Diprophylline-d6
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Diprophylline-d6 是 Diprophylline 的氘代化合物。Diprophylline 的 CAS 号为 479-18-5。Diphylline 是一种A1/A2腺苷受体拮抗剂,也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物,具有支气管扩张和血管扩张作用,有用于治疗慢性支气管炎和肺气肿的潜力。 | |||
T71141 |
Fenspiride-d5
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Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... |