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Cat. No. | Product Name | ||
---|---|---|---|
L9100 | 磷酸酶抑制剂化合物库 | 79 compounds | |
79 种已知活性的磷酸酶抑制剂的集合,可用于化合物筛选、化学基因组学、药理分析等方面; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0002 |
Phosphatase Inhibitor Cocktail I (100× ddH2O)
磷酸酶抑制剂 Cocktail I (100× ddH2O) |
Solution (100× in ddH2O) | Acid <em>Phosphatase</em>, Alkaline <em>phosphatase</em>, PTPs, ATPases |
C0004 |
Phosphatase Inhibitor Cocktail III (2 Tubes, 100x)
磷酸酶抑制剂 Cocktail III (2 Tubes, 100x) |
2 Tube Solution (100×) | Each Tube has different specificity of inhibition |
C0003 |
Phosphatase Inhibitor Cocktail II (100× DMSO)
磷酸酶抑制剂 Cocktail II (100× DMSO) |
Solution (100× in DMSO) | Alkaline <em>phosphatase</em>s, Ser/Thr <em>phosphatase</em>s, Acid and PP1 and PP2A |
C0045 |
RIPA Lysis Buffer (Strong)
RIPA裂解液(强) |
Solution in bottle | |
C0046 |
RIPA Lysis Buffer (Medium)
RIPA裂解液(中) |
Solution in bottle | |
C0047 |
RIPA Lysis Buffer (Weak)
RIPA裂解液(弱) |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4671 |
BN82002
CDC25 Phosphatase Inhibitor I |
Phosphatase | Metabolism |
BN82002 (CDC25 Phosphatase Inhibitor I) 是一种CDC25 phosphatase 家族的有效的、不可逆的、选择性的泛抑制剂。它显示出比 CD45 酪氨酸磷酸酶高约 20 倍的选择性。 | |||
T78835 |
Phosphatase-IN-1
|
Antifungal | Microbiology/Virology |
Phosphatase-IN-1(compound II-8)是Propranolol的衍生物,充当磷脂酸磷酸酶(Pah)的抑制剂。Phosphatase-IN-1能够与 MoPah1结合,展现出19.8 μM的亲和常数。Phosphatase-IN-1能够抑制植物病原体的生长,并显示出抗真菌特性,同时对稻苗和麦穗表现出无毒性。 | |||
T67036 |
Acid phosphatase
|
Others | Others |
Acid phosphatase 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67036,CAS号为 9001-77-8。 | |||
T10877 |
CPDA
|
Phosphatase | Metabolism |
CPDA 是新型 SH2 domain-containing inositol phosphatase 2 抑制剂,能够作用于3T3-L1脂肪细胞,改善胰岛素抗性。 | |||
T7150 |
BTdCPU
|
Apoptosis; Phosphatase; PERK | Apoptosis; Metabolism |
BTdCPU 是一种血红素调节的 eIF2α 激酶激活剂,可促进耐药细胞中 eIF2α磷酸化并诱导凋亡。 | |||
T81550 |
PAP 248–286
Prostatic Acid Phosphatase(248-286) |
||
PAP 248–286是一种精液衍生的生物活性肽,也称为前列腺酸性磷酸酶 (248-286) 或PAP (248-286) 肽,属于精液中的精液衍生病毒感染增强子 (SEVI) 因子。该肽能显著增强HIV病毒颗粒与靶细胞间的附着,从而增加HIV感染率。 | |||
T7820 |
Raphin1
|
Phosphatase | Metabolism |
Raphin1 是一种口服具有活力的、可透过血脑屏障的、选择性调节性磷酸酶 PPP1R15B(R15B) 抑制剂。它与 R15B-PP1c 全磷酸酶强烈结合 (Kd=33 nM),与 R15A-PP1c 相比,结合 R15B-PP1c 约为其 30 倍的选择性。它可减少蛋白质错误折叠疾病的小鼠模型中的生物和分子缺陷。 | |||
T10486 |
BCI
(E)-BCI |
Phosphatase | Metabolism |
BCI ((E)-BCI) 是双重特异性磷酸酶的变构抑制剂。它特异性抑制 DUSP6和 DUSP1的 EC50分别为 13.3 和 8.0 μM,但不能够抑制 DUSP5。 | |||
T2417 |
Sal003
|
Apoptosis; Phosphatase; PERK | Apoptosis; Metabolism |
Sal003 是 salubrinal 的衍生物,是一种高效特异性的细胞渗透性 eIF2α 磷酸酶抑制剂。 | |||
T3045 |
Salubrinal
|
Apoptosis; Phosphatase; PERK; Autophagy; HSV | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Salubrinal 是一种磷酸酶抑制剂 ,对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂,抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性,并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。 | |||
T7381 |
TCS 401
|
Phosphatase | Metabolism |
TCS 401 是一种选择性的蛋白酪氨酸磷酸酶 1B 抑制剂。 | |||
T16762 |
RMC-4550
|
Phosphatase | Metabolism |
RMC-4550 是选择性的蛋白酪氨酸磷酸酶 2 的变构抑制剂,其IC50=0.583 nM。 | |||
T2747 |
Endothall
|
Phosphatase; Others | Metabolism; Others |
Endothall 是蛋白磷酸酶 2A (PP2A) 抑制剂,能够抑制PP2A (IC50: 90 nM) 和 PP1 (IC50: 5 uM) 。它可作为除草剂,在癌症化疗过程中也能够发挥作用。 | |||
T6521 |
GSK 2830371
GSK2830371 |
Phosphatase | Metabolism |
GSK 2830371 是 Wip1磷酸酶 (Wip1 phosphatase)选择性抑制剂,IC50=6 nM。 | |||
T4256 |
PTP1B-IN-2
|
Phosphatase | Metabolism |
PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂,IC50=50 nM。 | |||
T4308 |
F1063-0967
|
Phosphatase | Metabolism |
F1063-0967 是双特异性磷酸酶 26 抑制剂,其IC50=11.62 μM。 | |||
T16859 |
SBI-425
|
Others | Others |
SBI-425 是一种有效且具有口服生物利用度的 TNAP 抑制剂。 SBI-425 有效抑制脉管系统中的 TNAP,改善心血管参数和存活率,而骨骼没有检测到变化。 | |||
T1927 |
CCT007093
|
Apoptosis; Phosphatase; Autophagy | Apoptosis; Autophagy; Metabolism |
CCT007093 是蛋白磷酸酶 1D(PPM1D Wip1)的抑制剂,IC50值为8.4 μM。Wip1 抑制可激活 mTORC1 通路,增强肝切除手术后肝细胞的增殖。 | |||
T7078 |
NSC 95397
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
NSC 95397 是一种选择性的Cdc25双特异性磷酸酶抑制剂。它抑制丝裂原活化蛋白激酶磷酸酶-1(MKP-1),通过 MKP-1 和 ERK1/2 途径抑制结肠癌细胞的增殖并诱导细胞凋亡。 | |||
T9156 |
CDC25B-IN-2
|
Phosphatase; mTOR | Metabolism; PI3K/Akt/mTOR signaling |
BIA 是一种 cdc25B 抑制剂。 | |||
T12901 |
SHIP2-IN-1
|
Phosphatase | Metabolism |
SHIP2-IN-1 是一种 SHIP2 抑制剂,IC50=2 µM。它能够使 GSK3β 的 Ser9 位点磷酸化,抑制 GSK3β 的活化。它可用于研究阿尔滋海默症。 | |||
T3962 |
TPI-1
TPI 1,TPI1 |
Phosphatase; Glucocorticoid Receptor | Endocrinology/Hormones; Metabolism |
TPI-1 是一种 SHP-1的抑制剂,其 IC50=40 nM。 | |||
T8519 |
Raphin1 acetate
|
Phosphatase | Metabolism |
Raphin1 acetate 是具有口服活性的、可透过血脑屏障的、选择性调节性磷酸酶PPP1R15B 抑制剂。它与 R15B-PP1c 全磷酸酶强烈结合 (Kd=33 nM),与 R15A-PP1c 相比,结合 R15B-PP1c 约为其 30 倍的选择性。它可减少蛋白质错误折叠疾病的小鼠模型中的生物和分子缺陷。 | |||
T0827 |
Cefsulodin sodium
Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素,对缘脓杆菌和肠杆菌有活性。 | |||
T14177 |
Alexidine dihydrochloride
|
Apoptosis; Others; Antifungal | Apoptosis; Microbiology/Virology; Others |
Alexidine dihydrochloride 对多种真菌病原体具有抗真菌和抗生物膜活性。它是一种抗癌剂,可靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1,并导致线粒体凋亡。 | |||
T6667 |
SF1670
PTP CD45 Inhibitor,PTPase CD45 Inhibitor |
Phosphatase; PTEN; Autophagy | Autophagy; Metabolism; PI3K/Akt/mTOR signaling |
SF1670 (PTPase CD45 Inhibitor) 是一种特异性 PTEN 抑制剂,IC50 为 2 μM。 | |||
T7323 |
BCI-215
|
Phosphatase | Metabolism |
BCI-215 是高效肿瘤细胞选择性的双重特异性磷酸酶DUSP-MKP 抑制剂。它对肿瘤细胞有细胞毒性,但对正常细胞无毒性。 | |||
T14841 |
BVT948
|
Phosphatase; P450; Histone Methyltransferase | Chromatin/Epigenetic; Metabolism |
BVT948 是一种蛋白酪氨酸磷酸酶抑制剂,还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。 | |||
T16350 |
NSC-87877
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
NSC-87877 是一种Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂,IC50值分别为0.318 μM 和0.355 μM。它还抑制双特异性磷酸酶26。 | |||
T4340 |
SPI-112
|
Phosphatase | Metabolism |
SPI 112 是一种选择性的、有效的、竞争性的SHP2 (PTPN11)抑制剂,对SHP2,蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的IC50分别为 1 μM,18.3 μM 和 14.5 μM。 | |||
T7411 |
Rbin-1
Ribozinoindole-1 |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Rbin-1 (Ribozinoindole-1) 是一种选择性 Midasin 抑制剂,是一种可逆的、特异性真核核糖体生物合成抑制剂,GI50=136 nM。 | |||
TQ0032 |
Rosiptor
洛司普托,AQX-1125 |
Phosphatase | Metabolism |
Rosiptor (AQX-1125) 是一种选择性,具有口服活性的磷酸酶 SHIP1激活剂。它在体外抑制 Akt 磷酸化、炎症介质生成和白细胞趋化,具有抗炎作用。 | |||
T13013 |
Sodium stibogluconate
Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠 |
Phosphatase | Metabolism |
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 是一种有效的蛋白酪氨酸磷酸酶 (phosphatase) 抑制剂。 它在10,100 和 100 μg/mL 时分别抑制 99% 的 SHP-1,SHP-2 和 PTP1B 活性。 | |||
T50103 |
NFAT Inhibitor-2
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
NFAT Inhibitor-2 是是钙调磷酸酶 NFAT 信号传导的强效抑制剂。 | |||
T41298 |
LMPTP INHIBITOR 1 dihydrochloride
|
Phosphatase | Metabolism |
LMPTP INHIBITOR 1 dihydrochloride 是选择性的低分子量蛋白酪氨酸磷酸酶(LMPTP)抑制剂,抑制 LMPTP-A 活性的IC50为 0.8 μM。 | |||
T3544 |
SHP099 hydrochloride
|
Phosphatase; Others | Metabolism; Others |
SHP099 hydrochloride 是一种有效的、选择性的、口服生物可利用的、有效的 SHP2 抑制剂。 | |||
T16724 |
Razuprotafib
AKB-9778 |
Phosphatase; Others | Metabolism; Others |
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。 | |||
T7012 |
VO-Ohpic trihydrate
VO-Ohpic |
PTEN; Autophagy | Autophagy; PI3K/Akt/mTOR signaling |
VO-Ohpic trihydrate (VO-Ohpic) 是一种有效的磷酸酶和张力蛋白同源物(PTEN)抑制剂,IC50 为 35 nM。 | |||
T9744 |
MP07-66
|
Phosphatase | Metabolism |
MP07-66 是 FTY720 的一种类似物,没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。 | |||
T7953 |
BpV(HOpic)
bpV (HOpic) |
PTEN | PI3K/Akt/mTOR signaling |
BpV(HOpic) (bpV (HOpic)) 是 PTEN 选择性抑制剂,IC50=14 nM。BpV(HOpic) 具有神经保护作用。 | |||
T22215 |
1-Naphthyl phosphate potassium salt
|
Phosphatase | Metabolism |
1-Naphthyl phosphate potassium salt 是非特异性磷酸酶 (phosphatase) 抑制剂,能够降低剪接校正作用。 | |||
T8985 |
NSC45586
|
Others | Others |
NSC45586 是一种蛋白磷酸酶 PHLPP 抑制剂,对 PHLPP1 和 PHLPP2 具有选择性。 | |||
T7704 |
KY-226
|
Phosphatase | Metabolism |
KY-226 是选择性的,口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂,IC50=0.25 μM,且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。 | |||
T39658 |
RMC-4630
SHP2-IN-7,RMC-4630 |
Phosphatase | Metabolism |
RMC-4630 (SHP2-IN-7) 是 SHP2 的抑制剂。 | |||
T13176 |
TNO155
Batoprotafib |
Phosphatase | Metabolism |
TNO155 是具有口服活性野生型SHP2的选择性变构抑制剂 (IC50= 0.011 µM)。它有研究 RTK 依赖性恶性肿瘤(尤其是晚期实体瘤)的潜力。 | |||
T6911 |
NSC-87877 disodium
NSC87877 |
Apoptosis; Phosphatase | Apoptosis; Metabolism |
NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂,IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。 | |||
T23133 |
Pentamidine
|
Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology |
Pentamidine 是抗微生物剂,会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究,有抗肿瘤活性,抗菌活性。 | |||
T8478 |
SC-43
|
Apoptosis; Phosphatase; STAT | Apoptosis; JAK/STAT signaling; Metabolism; Stem Cells |
SC-43 是一种具有口服活性的SHP-1 (PTPN6)激动剂。它是Sorafenib 的衍生物,可抑制STAT3的磷酸化并诱导细胞凋亡,具有抗纤维化和抗癌作用。 | |||
T9205 |
NCGC00378430
|
Phosphatase; Others | Metabolism; Others |
NCGC00378430 是一种 SIX1/EYA2 相互作用抑制剂。它部分逆转 SIX1 过表达介导的转录和代谢谱,并逆转 SIX1 诱导的 TGF-β 信号传导和上皮-间质转化。在小鼠模型中,它能够抑制 SIX1 介导的乳腺癌转移。 | |||
T2189 |
Sodium orthovanadate
Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate |
ATPase; Phosphatase | Membrane transporter/Ion channel; Metabolism |
Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶,碱性磷酸酶和一些ATP 酶的抑制剂,有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35951 |
Alkaline Phosphatase
|
Others | Others |
Alkaline phosphatase 是一种膜结合糖蛋白,在碱性条件下可催化磷酸单酯的水解。它可用于分子生物学和酶免分析。 | |||
TN1859 |
Licoflavone A
|
Phosphatase | Metabolism |
Licoflavone A 是分离自甘草根的黄酮类化合物,可以抑制酪氨酸磷酸酶 1B 的活性,IC50为 54.5 μM。 | |||
TN1305 |
Ethoxysanguinarine
乙氧基血根碱,6-Ethoxydihydrosanguinarine |
Apoptosis; AChR | Apoptosis; Neuroscience |
Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) 是存在于龙葵中的一种苯并菲啶生物碱天然产物,通过抑制蛋白磷酸酶 2A,可抑制结直肠癌细胞活力,诱导细胞凋亡。 | |||
T3880 |
Silydianin
水飞蓟宁,Silidianin |
Phosphatase | Metabolism |
Silydianin (Silidianin) 是一种水飞蓟的活性成分,具有抗胶原酶和抗弹性酶作用,对氧化产物的体外产生和释放具有抑制作用 。它是一种天然蛋白酪氨酸磷酸酶 1B 抑制剂,其IC50=17.38 μM。 | |||
T6S2116 |
Ginkgolic acid C17:1
银杏酸 C17:1,银杏酸C17:1 |
Phosphatase; PTEN | Metabolism; PI3K/Akt/mTOR signaling |
Ginkgolic acid C17:1 是分离自银杏叶中,通过诱导PTEN 和SHP-1酪氨酸磷酸酶抑制组成型和诱导型 STAT3 活化。它具有抗癌活性。 | |||
TN1124 |
Neoeriocitrin
|
AChE | Neuroscience |
Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂,分离于自百日草,在 MC3T3-E1 中显示出对增殖和成骨分化的活性。 | |||
T3780 |
Oroxin B
Hypocretin-2,木蝴蝶苷B |
Apoptosis; PTEN; Antioxidant; PI3K; Autophagy | Apoptosis; Autophagy; oxidation-reduction; PI3K/Akt/mTOR signaling |
Oroxin B (Hypocretin-2) 是从传统中草药木蝴蝶中分离出来的黄酮类天然产物,在恶性淋巴瘤细胞中诱导肿瘤抑制性 ER 应激。它通过上调 PTEN,下调 COX-2,VEGF,PI3K 和 p-AKT,对肝癌细胞具有明显的抑制作用,诱导细胞早期凋亡。 | |||
T4915 |
β-Glycerophosphate disodium salt hydrate
|
Phosphatase; Endogenous Metabolite | Metabolism |
β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂,是内源性代谢产物的一种。 | |||
T0945 |
Cyclosporin A
环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素 |
Phosphatase; Antibiotic; Complement System | Immunology/Inflammation; Metabolism; Microbiology/Virology |
Cyclosporin A 属于天然产物,是一种真菌的活性代谢产物,一种环状多肽。Cyclosporin A 是一种能与亲环素结合的免疫抑制剂,可以抑制 calcineurin (IC50=7 nM)。 | |||
TN1362 |
Afzelin
阿福豆苷,Kaempferol-3-O-rhamnoside |
PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性,例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性,并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤,增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。 | |||
TN2111 |
Prunin
Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷 |
Phosphatase; Anti-infection; Virus Protease | Metabolism; Microbiology/Virology |
Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B,IC50值为 5.5 μM。 | |||
T2144 |
Tacrolimus
他克莫司,Fujimycin,FK506,FR900506 |
Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling |
Tacrolimus (Fujimycin) 属于大环内酯类抗生素,可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM),抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂,通过抑制 IL-2 的释放,全面抑制 T 淋巴细胞的作用。 | |||
T5891 |
D-ERYTHRO-SPHINGOSINE
trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇 |
Phosphatase; Endogenous Metabolite; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
D-erythro-Sphingosine (trans-4-Sphingenine) 是一种非常有效的p32激酶活化剂,EC50为 8 μM。它也是一种PP2A 激活剂,抑制蛋白激酶 C (PKC)。 | |||
T4852 |
Trimyristin
Trimyristoylglycerol,Tritetradecanoin,三肉豆蔻酸甘油酯,Glyceryl trimyristate,甘油三肉豆蔻酸酯,1,2,3-Tritetradecanoylglycerol |
Phosphatase; Endogenous Metabolite; AChE | Metabolism; Neuroscience |
Trimyristin (Tritetradecanoin) 是一种 Myristica fragransHoutt 的有效成分,能够显著抑制乙酰胆碱酯酶 (AChE),酸性和碱性磷酸酶 (ACP/ALP) 特性。它对 AChE,ACP 和 ALP 的 IC50分别为 0.11、0.16 和 0.18 mM。 | |||
TN1053 |
Aloe-emodin-8-O-β-D-glucopyranoside
Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷 |
Phosphatase | Metabolism |
Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) 是一种分离自Saussrurea lappa 中的化合物,是一种温和的人类蛋白酪氨酸磷酸酶 1B 抑制剂,其IC50=26.6 μM。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T2185 |
L-Ascorbic acid 2-phosphate trisodium
L-抗坏血酸-2-磷酸三钠盐(维生素C),L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐 |
Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物,能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达,因此,能够促进人脂肪干细胞的成骨分化。 | |||
T3827 |
Rhein-8-glucoside calcium
大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt |
Phosphatase; Antibacterial | Metabolism; Microbiology/Virology |
Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中,分离得到的蒽醌类 hPTP1B 抑制剂,IC50值为11.5 μM,具有抗菌作用。 | |||
T8103 |
H-HoArg-OH
|
Endogenous Metabolite; Phosphorylase | Metabolism |
H-HoArg-OH 是人骨和肝脏碱性磷酸酶(alkaline phosphatase)的强效抑制剂,是一种精氨酸的同系物。 | |||
T3938 |
H-HomoArg-OH.HCl
NSC 145416,L-Homoarginine hydrochloride,L-高精氨酸盐酸盐,L(+)-Homoarginine hydrochloride |
Endogenous Metabolite; Phosphorylase | Metabolism |
H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) 是内源性代谢产物的一种。 | |||
T3855 |
Tracheloside
|
Estrogen Receptor/ERR; Phosphorylase | Endocrinology/Hormones; Metabolism |
Tracheloside 是抗雌激素木质素,利用 ERK1/2 刺激促进角质形成细胞增殖,是一种良好的促进伤口愈合的药物。 | |||
TN1906 |
Magnoloside A
Magloside A |
Antifection | Microbiology/Virology |
Magnoloside A (Magloside A) 是 M. obovata Thunb 中的苯乙醇苷,是一种可口服且具有选择性的钙调磷酸酶抑制剂。 Magnoloside A 可用于研究腹胀和功能性消化不良 (FD) 。 | |||
T3804 |
Neomangiferin
Mangiferin 7-glucoside,新芒果苷 |
Phosphatase | Metabolism |
Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone,分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。 | |||
T65128 |
Tartaric acid disodium dihydrate
Disodium L-(+)-Tartrate Dihydrate |
Phosphatase; Endogenous Metabolite | Metabolism |
Tartaric acid disodium dihydrate (Disodium L-(+)-Tartrate Dihydrate) 常用来制作分子生物学和细胞培养中的缓冲液,。Tartaric acid disodium dihydrate 是酸性磷酸酶抑制剂, 可增加秋水仙碱结合 tubulin1的概率。 | |||
TN1470 |
Cassiaside B2
决明子苷B2 |
Phosphatase; MAO; 5-HT Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂, 具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物(NRE)的有效成分之一。 | |||
T2481 |
Ascomycin
FK520,Immunomycin,子囊霉素,FR-900520 |
Phosphatase; Others; Antibiotic; Parasite; Antifungal | Metabolism; Microbiology/Virology; Others |
Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物,具有免疫抑制特性。它也是一种大环聚酮类抗生素,具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥,并具有用于各种皮肤病研究的潜力。 | |||
T2133 |
Adenosine monophosphate
5'-Adenylic acid,5'-腺嘌呤核苷酸,AMP,Adenosine 5'-monophosphate |
Endogenous Metabolite; AMPK | Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling |
Adenosine monophosphate (AMP) 是一种嘌呤核糖核苷5'-单磷酸腺苷,是信号转导和调节能量稳态的关键细胞代谢物。它具有EC 3.1.3.11(果糖-二磷酸酶)抑制剂、EC 3.1.3.1(碱性磷酸酶)抑制剂和腺苷A1受体激动剂的作用。 | |||
T2P2923 |
Stearic acid
硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid |
Phosphatase; Endogenous Metabolite | Metabolism |
Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
T10109 |
3-Carene
Delta-3-Carene |
COX; Antifungal | Immunology/Inflammation; Microbiology/Virology; Neuroscience |
3-Carene(Delta-3-Carene) 是西部落叶松和花旗松中提取的双环单萜烯,可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用,能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。 | |||
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
TN6926 |
Paeonoside
|
Others | Others |
Paeonoside 发现与P. suffruticosa 中,具有生物活性,可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性,可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用,以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶(ALP)染色及其活性。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
T23421 |
Tautomycetin
|
Others | Others |
protein phosphatase (PP)1 inhibitor | |||
TN5400 |
Aerugidiol
|
||
Aerugidiol inhibits protein tyrosine phosphatase 1B (PTP1B). | |||
T19885 |
Methyllucidone
|
||
Methyllucidone is an inhibitor of STAT3 that acts by regulating the expression of the protein tyrosine phosphatase MEG2. | |||
T70221 |
Dibefurin
|
Others | Others |
Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes. | |||
TN3335 |
Abyssinone V
|
Phosphatase | Metabolism |
Abyssinone V 是一种从刺桐茎皮中分离的天然化合物,是蛋白质酪氨酸磷酸酶 1B (PTP1B) 的抑制剂。 | |||
T11203 |
Enocyanin
|
Others | Others |
Enocyanin, an anthocyanin extracted from grapes, exhibits inhibitory effects on leucine aminopeptidase, acid phosphatase, γ-glutamyl transpeptidase, and esterase activity. | |||
TN7362 |
Hederagenin 3-O-(2-O-acetyl-alpha-L-arabinopyranoside)
|
Others | Others |
Hederagenin 3-O-(2-O-acetyl-α-L-arabinopyranoside) significantly elevated alkaline phosphatase (ALP) activity and enhanced the protein expression levels of bone sialoprotein (BSP) and osteocalcin (OC). | |||
T13740 |
Isotanshinone IIA
|
Others | Others |
Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite. | |||
T70725 |
Motuporin
|
Others | Others |
Motuporin is an inhibitor of type-1 and type-2A protein phosphatase catalytic subunits (PP-1c and PP-2Ac). | |||
TN2887 |
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
|
Phosphatase | Metabolism |
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM. | |||
T73073 |
PTP1B-IN-21
|
Others | Others |
PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50>100 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
T39219 |
Ficusonolide
|
Others | Others |
Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase. | |||
TN2913 |
3-Acetoxy-11-ursen-28,13-olide
|
Phosphatase | Metabolism |
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |||
TN5207 |
Ursolic aldehyde
|
Others | Others |
Ursolic aldehyde can inhibit phosphatase of regenerating liver-3, with the IC(50) value of 50 +/- 0.3 mu M. | |||
TN3505 | Beta-Peltoboykinolic acid | Phosphatase | Metabolism |
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity. | |||
TN1775 |
Isocryptotanshinone
|
ERK; JNK; STAT | JAK/STAT signaling; MAPK; Stem Cells |
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |||
T73072 |
PTP1B-IN-20
|
Others | Others |
PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50=78.0 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02650 |
Alkaline phosphatase Protein, Human, Recombinant (His)
IAP,alkaline phosphatase, intestinal |
Human | HEK293 Cells |
Alkaline phosphatase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is P09923. | |||
TMPK-00639 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Rat, Recombinant (His)
GCAP,ALP-1,Alkaline Phosphatase,ALPPL2,PLAP-like,AL... |
Rat | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Rat, Recombinant (His) is expressed in HEK293... | |||
TMPY-00663 |
Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His)
alkaline phosphatase, liver/bone/kidney,TNSALP,AP-T... |
Human | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is A0A024RAB4. | |||
TMPY-00570 |
Alkaline Phosphatase/PLAP Protein, Human, Recombinant (His)
ALPI,PALP,PLAP,PLAP-1,alkaline phosphatase, placent... |
Human | P. pastoris (Yeast) |
Most importantly, placental alkaline phosphatase (ALPP), an ectoenzyme that locates on cell surface with catalytic domains outside the plasma membrane and is overexpressed on many cancer cells, dephosphorylate the d-tyrosine phosphates on the surface of the magnetic nanoparticle and enable the magnetic nanoparticles to adhere selectively to the cancer cells, such as HeLa cells. Placental alkaline phosphatase (PLAP), encoded by the ALPP gene, is produced by the fetal side of the placenta. | |||
TMPY-02713 |
Alkaline phosphatase Protein, Human, Recombinant (hFc)
alkaline phosphatase, intestinal,IAP |
Human | HEK293 Cells |
Alkaline phosphatase Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.5 kDa and the accession number is P09923. | |||
TMPK-00855 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Mouse, Recombinant (His)
Alkaline Phosphatase,Alppl2,Akp5,Alpg,Alkaline ... |
Mouse | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Mouse, Recombinant (His) is expressed in HEK2... | |||
TMPJ-00784 |
Alkaline Phosphatase Protein, Human, Recombinant (aa 23-506, His)
Alkaline phosphatase Regan isozyme,placental type,P... |
Human | HEK293 Cells |
ALPP is a membrane protein and exits as a homodimer. ALPP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It has been shown to play a role in a number of processes including cell signaling, long-term potentiation, and cell adhesion, however, the best known and most commonly studied role is implicated in Alzheimer's research. | |||
TMPY-02131 |
Acid Phosphatase/ACP1 Protein, Human, Recombinant (GST)
acid phosphatase 1, soluble,HAAP |
Human | E. coli |
The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1/LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphoryl... | |||
TMPK-00804 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (mFc)
GCAP,Alkaline Phosphatase,PLAP-like,Alkaline ph... |
Human | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (mFc) is expressed in HEK2... | |||
TMPY-00446 |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His)
TNSALP,Akp2,alkaline phosphatase, liver/bone/kidney... |
Mouse | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is B7XGA6. | |||
TMPY-02672 |
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His)
5'-NT,9.104100899-104272570.1,Ppal,A030005E02Rik,PAP,Lap,aci... |
Mouse | HEK293 Cells |
Prostatic Acid Phosphatase Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is Q8CE08-1. | |||
TMPY-02155 |
Prostatic Acid Phosphatase Protein, Human, Recombinant (His)
5'-NT,acid phosphatase, prostate,PAP,ACP-3,ACP3 |
Human | HEK293 Cells |
Prostatic Acid Phosphatase Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is P15309-2. | |||
TMPK-00803 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (His)
ALPG,ALPPL,Alkaline phosphatase, placental-like,Alk... |
Human | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (His) is expressed in HEK2... | |||
TMPK-00802 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (hFc)
GCAP,ALPPL,Alkaline phosphatase, placental-like,Alk... |
Human | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (hFc) is expressed in HEK2... | |||
TMPK-01326 |
Alkaline Phosphatase (Placental type) /ALPP Protein, Cynomolgus, Recombinant (His)
Alkaline phosphatase,PLAP,PLAP-1,ALPP |
Cynomolgus | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Placental type) /ALPP Protein, Cynomolgus, Recombinant (His) is express... | |||
TMPY-00594 |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc)
Akp-2,TNSALP,TNAP,alkaline phosphatase, liver/bone/... |
Mouse | HEK293 Cells |
Alkaline Phosphatase/ALPL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.3 kDa and the accession number is B7XGA6. | |||
TMPY-04125 |
PTP1B Protein, Human, Recombinant (His)
protein tyrosine phosphatase, non-receptor type 1,P... |
Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p... | |||
TMPK-00801 |
Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (His & Avi), Biotinylated
ALPPL2,PLAP-like,GCAP,ALPG,Alkaline phosphatase, pl... |
Human | HEK293 Cells |
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Human, Recombinant (His & Avi), Biotinylated ... | |||
TMPY-03548 |
PTPN12 Protein, Human, Recombinant
protein tyrosine phosphatase, non-receptor type 12,... |
Human | Baculovirus Insect Cells |
PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1. | |||
TMPY-03484 |
TCPTP Protein, Human, Recombinant
TCPTP,protein tyrosine phosphatase, non-receptor ty... |
Human | Baculovirus Insect Cells |
TCPTP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.8 kDa and the accession number is P17706-1. | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphatase, recep... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05748 |
CD45 Protein, Human, Recombinant (aa 26-577, His)
L-CA,T200,LCA,B220,protein tyrosine phosphatase, re... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3. | |||
TMPJ-01390 |
MINPP1 Protein, Human, Recombinant (His)
3,4,5)-Tetrakisphosphate 3-Phosphatase,2,5)P(4) 3-<... |
Human | HEK293 Cells |
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re... | |||
TMPY-02576 |
PHOSPHO1 Protein, Human, Recombinant (His)
phosphatase, orphan 1 |
Human | E. coli |
PHOSPHO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.5 kDa and the accession number is Q8TCT1-1. | |||
TMPH-00075 |
At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (E. coli, His)
Multiple inositol polyphosphate phosphatase 1,2,3-b... |
Arabidopsis thaliana | E. coli |
At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q941B2. | |||
TMPJ-00996 |
VHR Protein, Human, Recombinant (His)
DUSP3,VHR,Dual specificity protein phosphatase VHR,... |
Human | E. coli |
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ... | |||
TMPH-01389 |
G6PC Protein, Human, Recombinant (His)
Glucose-6-phosphatase,Glucose-6-phosphatase |
Human | P. pastoris (Yeast) |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 5.6 kDa and the accession number is P35575. | |||
TMPH-01008 |
PNKP Protein, Human, Recombinant (His & SUMO)
Polynucleotide kinase-3'-phosphatase,PNKP,DNA 5'-ki... |
Human | E. coli |
Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. PNKP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The ... | |||
TMPH-03021 |
PstP Protein, Mycobacterium tuberculosis, Recombinant (His)
Mycobacterial Ser/Thr phosphatase,PP2C-family Ser/T... |
Mycobacterium tuberculosis | E. coli |
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. | |||
TMPH-01390 |
G6PC Protein, Human, Recombinant (His & SUMO)
Glucose-6-phosphatase alpha,G6PC1,Glucose-6-pho... |
Human | E. coli |
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.1 kDa and the accession number i... | |||
TMPH-02870 |
PDXP Protein, Mouse, Recombinant (His & SUMO)
Pdxp,Pyridoxal phosphate phosphatase,Chronophin,Pyr... |
Mouse | E. coli |
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskel... | |||
TMPH-00076 |
At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His)
2,3-bisphosphoglycerate 3-phosphatase,Multiple inos... |
Arabidopsis thaliana | Baculovirus Insect Cells |
At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is Q941B2. | |||
TMPH-02097 |
PPP5C Protein, Human, Recombinant (His & Myc)
Serine/threonine-protein phosphatase 5,Protein ... |
Human | E. coli |
PPP5C Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-02869 |
PDXP Protein, Mouse, Recombinant (His)
Chronophin,Pdxp,Pyridoxal phosphate phosphatase,Pyr... |
Mouse | P. pastoris (Yeast) |
PDXP Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 33.5 kDa and the accession number is P60487. | |||
TMPY-02766 |
PSPH Protein, Human, Recombinant
PSP,phosphoserine phosphatase,PSPHD |
Human | E. coli |
Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine ... | |||
TMPH-03022 |
PstP Protein, Mycobacterium tuberculosis, Recombinant
PP2C-family Ser/Thr phosphatase,pstP,Serine/threoni... |
Mycobacterium tuberculosis | E. coli |
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. PstP Protein, Mycobacterium tuberculosis, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.3 kDa and the accession number is P9WHW4. | |||
TMPH-01703 |
CDC25C Protein, Human, Recombinant (His)
Dual specificity phosphatase Cdc25C,M-phase inducer... |
Human | E. coli |
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307. | |||
TMPJ-00908 |
LMW-PTP Protein, Human, Recombinant (His)
Low Molecular Weight Cytosolic Acid Phosphatase,Adi... |
Human | E. coli |
Low Molecular Weight Phosphotyrosine Protein Phosphatase (LMW-PTP) is a member of the low molecular weight phosphotyrosine protein phosphatase family. LMW-PTP serves as an acid phosphatase and a protein tyrosine phosphatase (PTPase) by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. LMW-PTP can be detected in all human tissues, including adipocytes. LMW-PTP is a cytosolic enzyme that regulate cell proliferation and growth of leiomyomas during dephosphorylation of t... | |||
TMPJ-01057 |
PSP Protein, Human, Recombinant (His)
PSPH,L-3-Phosphoserine Phosphatase,PSPase,Phosphose... |
Human | E. coli |
Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial fea... | |||
TMPY-03482 |
DUSP3 Protein, Human, Recombinant
dual specificity phosphatase 3,VHR |
Human | Baculovirus Insect Cells |
DUSP3 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 20.6 kDa and the accession number is P51452. | |||
TMPH-03320 |
IAP-1 Protein, Rat, Recombinant (His)
Intestinal alkaline phosphatase I,Intestinal-type a... |
Rat | HEK293 Cells |
Alkaline phosphatase that can hydrolyze various phosphate compounds. IAP-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 55.9 kDa and the accession number is P15693. | |||
TMPH-03236 |
Alkaline phosphatase/ALPL Protein, Rat, Recombinant (His & SUMO)
ALPase,PiALP |
Rat | E. coli |
Alkaline phosphatase/ALPL Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 69.5 kDa and the accession number is P08289. | |||
TMPH-02278 |
PTPN5 Protein, Human, Recombinant (His & SUMO)
PTPN5,Neural-specific protein-tyrosine phosphatase,... |
Human | E. coli |
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P54829. | |||
TMPY-02127 |
DUSP3 Protein, Human, Recombinant (His & GST)
VHR,dual specificity phosphatase 3 |
Human | Baculovirus Insect Cells |
DUSP3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 48.3 kDa and the accession number is P51452. | |||
TMPJ-00465 |
PTP1C Protein, Human, Recombinant (His)
HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase... |
Human | E. coli |
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter... | |||
TMPH-02010 |
PTPRB Protein, Human, Recombinant (His)
Vascular endothelial protein tyrosine phosphatase,P... |
Human | P. pastoris (Yeast) |
PTPRB Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-03516 |
NPTase Protein, S. aureus, Recombinant (His & SUMO)
30 kDa neutral phosphatase |
Staphylococcus aureus | E. coli |
Highly cationic enzyme that can bind human or rat immunoglobulins as well as serum albumin, and could therefore be involved in post-infectious sequelae. NPTase Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.7 kDa and the accession number is P21222. | |||
TMPH-02277 |
PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)
Protein-tyrosine phosphatase 1D,Tyrosine-protein |
Human | E. coli |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. | |||
TMPH-02011 |
PTPRB Protein, Human, Recombinant (His & SUMO)
PTPRB,Receptor-type tyrosine-protein phosphatase be... |
Human | E. coli |
PTPRB Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-03161 |
Alkaline Phosphatase Protein, Prevotella intermedia, Recombinant (GST & His & Myc)
PiALP,ALPase |
Prevotella intermedia | E. coli |
Acts against tyrosine-phosphatases. Alkaline Phosphatase Protein, Prevotella intermedia, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 32.1 kDa and the accession number is P81800. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0178 |
Stearic acid-18,18,18-d3
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Stearic acid-18,18,18-d3 是 Stearic acid 的氘代化合物。Stearic acid 的 CAS 号为 57-11-4。Stearic acid是长链饱和脂肪酸,存在于许多动植物油脂中。 |