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Search Results for " peptidylarginine deiminase "

Targets Recommended: PAD

8

抑制剂 & 化合物

1

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8861	GSK199	PAD	Chromatin/Epigenetic
	GSK199 是可逆的 PAD4选择性抑制剂，当缺少钙离子时，其 IC50值为 200 nM。
T24105	GSK121 GSK-121,GSK 121	PAD	Chromatin/Epigenetic
	GSK121 Trifluoroacetate 是PAD4的选择性抑制剂。
T22277	BMS-P5	PAD	Chromatin/Epigenetic
	BMS-P5 是一种特异性具有口服活性的肽精氨酸二亚胺酶 4抑制剂。它可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T10831L	Cl-amidine hydrochloride	Apoptosis; PAD	Apoptosis; Chromatin/Epigenetic
	Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。
T22277L	BMS-P5 free base	PAD	Chromatin/Epigenetic
	BMS-P5 free base 是一种特异性，可口服的肽精氨酸二亚胺酶抑制剂，可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
TQ0067	GSK484 hydrochloride GTPL8577,AOB6992,GSK484盐酸盐	PAD	Chromatin/Epigenetic
	GSK484 hydrochloride (GTPL8577) 是一种可逆的肽酰基精氨酸脱亚氨酶 4 (PAD4) 抑制剂。它高亲和力与 PAD4 结合，在存在 2 mM 钙和不存在钙的情况下，IC50分别为 250 和 50 nM。
T36107	YW3-56 YW3-56	Others	Others
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...
T36108	YW3-56 (hydrochloride) (technical grade) YW3-56 (hydrochloride) (technical grade)	Others	Others
	YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept...

化合物

Cat.No: T8861

Target: PAD

Cat.No: T24105

Synonym: GSK-121,GSK 121

Target: PAD

Cat.No: T22277

Target: PAD

Cl-amidine hydrochloride

Cat.No: T10831L

Target: Apoptosis, PAD

BMS-P5 free base

Cat.No: T22277L

Target: PAD

GSK484 hydrochloride

Cat.No: TQ0067

Synonym: GTPL8577,AOB6992,GSK484盐酸盐

Target: PAD

Cat.No: T36107

Synonym: YW3-56

Target: Others

YW3-56 (hydrochloride) (technical grade)

Cat.No: T36108

Synonym: YW3-56 (hydrochloride) (technical grade)

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2205	Acefylline Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。

天然产物

Cat.No: T2205

Synonym: Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03158	PAD Protein, Porphyromonas gingivalis, Recombinant (His) Peptidylarginine deiminase	Porphyromonas gingivalis	E. coli
	Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth. PAD Protein, Porphyromonas gingivalis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weig...
TMPH-01967	PADI3 Protein, Human, Recombinant (His) Protein-arginine deiminase type III,Peptidylarg...	Human	P. pastoris (Yeast)
	PADI3 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01966	PADI2 Protein, Human, Recombinant (His & SUMO) Peptidylarginine deiminase II,Protein-argi...	Human	E. coli
	PADI2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPJ-00532	PADI4 Protein, Human, Recombinant (E. coli, His) PDI5,PADI4,Protein-arginine Deiminase type IV,HL-60...	Human	E. coli
	Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune fe...
TMPH-01965	PADI2 Protein, Human, Recombinant (His & Myc) Protein-arginine deiminase type-2,PADI2,Peptidy...	Human	HEK293 Cells
	PADI2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPY-00021	PADI4 Protein, Human, Recombinant (His) PADI5,PAD4,PDI4,peptidyl arginine deiminase, type I...	Human	Baculovirus Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPK-00501	PADI4 Protein, Cynomolgus, Recombinant (His) Protein-arginine deiminase type-4,HL60 PAD,PAD,PDI5...	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expres...
TMPK-00502	PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated PDI5,HL-60,PAD,PADI5,Protein-arginine deiminase typ...	Cynomolgus	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biot...
TMPK-01238	PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated PDI5,Protein-arginine deiminase type-4,HL-60,PAD4,H...	Human	E. coli
	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinyla...

重组蛋白

PAD Protein, Porphyromonas gingivalis, Recombinant (His)

Cat.No: TMPH-03158

Species: Porphyromonas gingivalis

Expression System: E. coli

PADI3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01967

Species: Human

Expression System: P. pastoris (Yeast)

PADI2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01966

Species: Human

Expression System: E. coli

PADI4 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00532

Species: Human

Expression System: E. coli

PADI2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01965

Species: Human

Expression System: HEK293 Cells

PADI4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00021

Species: Human

Expression System: Baculovirus Insect Cells

PADI4 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00501

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00502

Species: Cynomolgus

Expression System: E. coli

PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-01238

Species: Human

Expression System: E. coli

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