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Targets Recommended: Others

217

抑制剂 & 化合物

10

天然产物

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化合物库

12

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；
L2630	神经元分化化合物库		672 compounds
	672 种与神经元分化相关的化合物，可以用于神经系统疾病药物研发

化合物库

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

神经元分化化合物库

Cat.No: L2630

Compounds: 672

Cat. No.	Product Name	Target	Signaling Pathways
T1880	P7C3	Others	Others
	P7C3 是一种 aminopropyl carbazole 类化合物，具有口服活性，可透过血脑屏障，具有神经保护作用。它可用于神经退行性疾病，如帕金森病的研究。
T3464	PHCCC (-) PHCCC	GluR	Neuroscience
	PHCCC ((-) PHCCC) 是 I 组代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。它对 mGluR2 和 mGluR8 也有很强的拮抗作用，具有抗帕金森病作用。
TQ0289	LY450108	iGluR	Membrane transporter/Ion channel; Neuroscience
	LY450108 是有效的AMPA 受体增强剂，在抑郁和帕金森氏病中有研究的潜力。
T7729	PF-06454589	LRRK2	Autophagy
	PF-06447475 是LRRK2激酶选择性抑制剂，可通透血脑屏障，能够抑制 WT LRRK (IC50:3 nM) 和 G2019S LRRK2 (IC50:11 nM) 。它可用于研究帕金森病 (PD) 。
T21667	FAUC-365	Dopamine Receptor	GPCR/G Protein; Neuroscience
	FAUC-365 是一种高度选择性的多巴胺D3受体拮抗剂，能够作用于 D3 受体(Ki:0.5 nM)、D4.4 受体(Ki:340 nM)、D2short 受体(Ki:2600 nM)和 D2Long 受体(Ki:3600 nM)。它可用于研究帕金森病、精神分裂症等疾病。
T1770	GNE-9605	LRRK2	Autophagy
	GNE-9605 是一个高效，选择性和能脑渗透的LRRK2抑制剂，IC50为19 nM。
T2216	Entacapone OR-611,恩他卡朋	Transferase	Metabolism
	Entacapone (OR-611) 是可逆的、具有口服活性的、外周作用的儿茶酚-O-甲基转移酶抑制剂。它对大鼠脑、红细胞和肝脏 COMT 有抑制作用。它对 COMT 的选择性优于其他儿茶酚胺代谢酶。它抑制 FTO 去甲基化活性，可用于研究代谢紊乱。它可用于研究帕金森病。
T22026	AGK7	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	AGK7 是 sirtuin 2 (SIRT2) 抑制剂。它在体外和帕金森病果蝇模型中均能抑制多巴胺能细胞的凋亡。在帕金森病细胞模型中，它改善了 α-突触核蛋白毒性和修饰的包涵体形态
T3278	Piribedil EU-4200,Trivastan,ET-495,Trivastal	Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	Piribedil (Trivastan) 是多巴胺 D2受体激动剂，对 hα1A-肾上腺素受体也显示出拮抗作用。
T8737	GR 125743	5-HT Receptor	GPCR/G Protein; Neuroscience
	GR 125743 是选择性的5-HT1B/1D 受体拮抗剂，与野生型的人 h5-HT1B 和 5-HT1D 结合的pKi 分别为 8.85 和 8.31，可用于帕金森病和心血管疾病的研究。
T3053	CZC-25146 CHEMBL2397014	LRRK2	Autophagy
	CZC-25146 (CHEMBL2397014) 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂，对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。
T5139	CZC-25146 hydrochloride	LRRK2	Autophagy
	CZC-25146 hydrochloride 是一种有效、特异性和代谢稳定的 LRRK2 抑制剂，对野生型 LRRK2 和 G2019S LRRK2 的 IC50 分别为 4.76 和 6.87 nM。
T1476	Pramipexole SND 919,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole (SND 919) 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂，对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。
T1308	Orphenadrine hydrochloride Mebedrol,Mephenamin,盐酸邻甲苯海拉明	Sodium Channel; NMDAR; Norepinephrine; iGluR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T6726	VU0361737 ML-128,VU 0361737	GluR	Neuroscience
	VU0361737 (ML-128) 是一种高效选择性的，中枢神经系统渗透性的代谢型谷氨酸受体 4(mGluR4)正变构调节剂，对人类和大鼠 mGluR4作用的EC50值分别为 240 和 110 nM。它具有神经保护作用，有用于帕金森氏病的研究潜力。
T4473	Ibiglustat Venglustat,SAR402671,GZ402671	Transferase	Metabolism
	Ibiglustat (GZ402671) 是一种可透过血脑屏障的、具有口服活性的葡萄糖神经酰胺合成酶(GCS)抑制剂。它可用于戈谢病 3 型、法布瑞氏症、与 GBA 突变相关的帕金森病、GM2 神经节苷脂病和常染色体显性多囊肾病的研究。
T4979	Procyclidine hydrochloride (±)-Procyclidine hydrochlorid,丙环定盐酸盐	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) 是具有NMDA 拮抗剂特性的抗胆碱能试剂。
T0957	Isradipine PN 200-110,伊拉地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂，具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂，也是一种潜在可行的帕金森病神经保护剂。
T3217	PF-CBP1 hydrochloride PF-CBP1 HCl	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂，抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达，也可下调皮质神经元 RGS4 的表达，可用于癫痫和帕金森病等神经疾病的研究。
T6618	Orphenadrine Citrate Flexon,Flexoject,Banflex,枸酸芬那君,奥芬那君	AChR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Orphenadrine Citrate (Flexon) 是NMDA 受体拮抗剂，Ki 为6.0μM，还是HERG 钾离子通道阻断剂。它是一种骨骼肌松弛剂，它作用于中枢神经系统以产生肌肉松弛作用。
T0218	Biperiden Bipariden,Akineton,KL 373,比哌立登,Biperidine	AChR	Neuroscience
	Biperiden (Bipariden) 是中枢 M1胆碱受体阻断剂，有抗帕金森症活性。
T2592	Ropinirole hydrochloride SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl,盐酸罗匹尼罗	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Ropinirole hydrochloride (SKF-101468A) 是D3/D2受体激动剂，对 D2受体的Ki=29 nM。它对 hD2，hD3和 hD4受体的pEC50分别为 7.4、8.4 和 6.8。它对 D1受体没有亲和力。它对帕金森氏病具有潜在的研究价值。
T9235	GW604714X 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-	Mitochondrial Metabolism	Metabolism
	GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂，Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运，但浓度比 MPC 的大 4 个数量级。
T1336	Benztropine mesylate Benzotropine mesylate,苯扎托品,Benzatropine mesylate,Benztropine methanesulfonate,甲磺酸苯扎托品	Dopamine Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Benztropine mesylate (Benztropine methanesulfonate) 是一种可口服的中枢性抗胆碱能剂，用于帕金森氏病的研究。它是抗组胺剂，抑制多巴胺的吸收。它也是人 D2多巴胺受体的变构拮抗剂，具有抗癌症干细胞的作用。
T2226	Pergolide mesylate 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Pergolide mesylate salt(LY127809) 是一种有效的，具有口服活性的多巴胺 D1和 D2受体激动剂，是一种 Ergoline 衍生物，可用于帕金森氏病和高泌乳素血症的研究。
T0229	Rivastigmine SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明	AChE	Neuroscience
	Rivastigmine (Exelon) 是具有口服活性的、有效的、可透过血脑屏障的胆碱酯酶抑制剂，可抑制丁酰胆碱酯酶和乙酰胆碱酯酶，IC50分别为 0.037 μM 和 4.15 μM。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T6951	Pramipexole dihydrochloride hydrate Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的，具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂，对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM，可用于研究帕金森综合症和腿多动综合征。
T1628	Rivastigmine tartrate SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀	AChR; AChE	Neuroscience
	Rivastigmine tartrate (SDZ-ENA 713) 是一种具有口服活性的、可透过血脑屏障的胆碱酯酶抑制剂，能够抑制丁酰胆碱酯酶和乙酰胆碱酯酶。它是一种拟副交感神经剂或胆碱能剂，用于研究轻度至中度阿尔茨海默氏型痴呆和帕金森氏病引起的痴呆。
T1406	Amantadine hydrochloride 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T81632	Nurr1 agonist 8	Others	Others
	Nurr1 agonist 8 是一种低亲和力的 Nurr1 激动剂，可用于研究帕金森等神经系统疾病。
T31773	Fenlean FLZ	Beta Amyloid; Src	Angiogenesis; Neuroscience; Tyrosine Kinase/Adaptors
	Fenlean (FLZ) 是酪氨酸激酶 Src 抑制剂，是来自Annona glabra的鳞甲酰胺的合成环状衍生物，具有细胞保护活性，在帕金森病慢性 MPTP/丙磺舒类小鼠模型中保护酪氨酸羟化酶功能。Fenlean 可以抑制线粒体中Aβ的产生，可用于研究年龄相关性黄斑变性和帕金森。
T40018	SY2-062 4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others	Others
	4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 具有抗癌、治疗帕金森病的前药和抗炎药的潜力。
T34616	Seridopidine ACR-343,ACR 343,ACR343	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Seridopidine (ACR343) 是一种多巴胺能活性调节剂，可作为精神分裂症、帕金森病和抽动秽语综合征的口服疗法。
T68026	(Rac)-GSK 372475	Others	Others
	(Rac)-GSK 372475 可用于研究治疗帕金森综合征、抑郁症和肥胖。
T6946	Pimavanserin tartrate ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin,匹莫范色林	5-HT Receptor	GPCR/G Protein; Neuroscience
	Pimavanserin tartrate (Nuplazid) 是一种有效的5-HT 2A 受体反向激动剂，pIC50和 pKi 值分别为8.73和9.3，用于治疗与帕金森病相关的精神病。
T71707L	Romergoline 2HCl Romergoline 2HCl(107052-56-2 Free base),FCE 23884 2HCl	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Romergoline 2HCl 是一种 D1 激动剂和 D2 拮抗剂，可用于研究帕金森病。
T71934	Atibeprone	MAO	Metabolism; Neuroscience
	Atibeprone 是 MAO-B 抑制剂，具有抗抑郁活性，可用于研究帕金森病。
T4081	MPTP hydrochloride MPTP-hydrochloride	Apoptosis; Dopamine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	MPTP hydrochloride 是 MPP+ 的前体，是一种多巴胺神经毒素，具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒，可以导致帕金森症，被广泛应用于帕金森动物模型的构建。
T62304	Minzasolmin (R)-NPT200-11,UCB0599,DLX-313	Others	Others
	Minzasolmin（DLX-313）是一种 α-突触核蛋白错误折叠抑制剂，可用于研究帕金森疾病。
T13248	UK-240455	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	UK-240455是一种有效的且具有选择性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸受体拮抗剂，具有神经保护作用和改善帕金森病模型的运动的功能，是治疗帕金森病的潜在候选化合物。
T24064	Fipamezole JP-1730,BVF-025,JP 1730,JP1730	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fipamezole 是一种有效的 α2肾上腺素能受体拮抗剂，可能用于研究帕金森病自主神经功能障碍。
T77333L	(Iso)-BMT-124110 Formate (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）	AAK1 (AP2 associated kinase 1)	Neuroscience
	(Iso)-BMT-124110 Formate 对蛋白丝氨酸/苏氨酸激酶AAK 有抑制作用，可用于治疗帕金森病、精神分裂症、神经性疼痛和阿尔茨海默病。
T69188	Aloisine B AloisineB	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiviral activity and can be used to study Alzheimer's, diabetes, HIV and Parkinson's.
T19922	L-m-Tyrosine L(-)mTyrosine,3-羟基-L-苯基丙氨酸,L (-) m Tyrosine,LmTyrosine,3-Hydroxy-L-Phenylalanine,L-(-)-m-Tyrosine	Others	Others
	L-m-Tyrosine (3-Hydroxy-L-Phenylalanine) 是一种非天然氨基酸。L-m-Tyrosine 在治疗帕金森病、关节炎和阿尔茨海默病方面显示出潜力。
T26878	BN-82451 2HCl BN-82451B 2HCl,BN 82451B 2HCl	COX	Immunology/Inflammation; Neuroscience
	BN-82451 2HCl是 COX-1和COX-2 双重抑制剂，可用于研究亨廷顿舞蹈病和帕金森病。
T22638	CBiPES hydrochloride CBiPES HCl	GluR	Neuroscience
	CBiPES hydrochloride(CBiPES HCl) 是一种高效的 mGlu2 受体正变构调节剂，EC50值为 92.8 nM。CBiPES hydrochloride 可阻断 WT 和 mGlu（3）受体的作用。CBiPES hydrochloride 可用于研究像癫痫和帕金森综合征类的神经系统疾病。
T9970	mGluR3 modulator-1 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈	GluR	Neuroscience
	mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) 是 mGluR3 的正变构调节剂，可用于治疗帕金森病的研究。
T13267	USP30 inhibitor 11 USP30-IN-11	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP30 inhibitor 11 (USP30-IN-11) 是一个选择性的 USP30 抑制剂(IC50 ： 0.01 µΜ)，抑制 SVA，可用于研究癌症、线粒体功能障碍和帕金森。
T30098	Aplindore Fumarate Aplindore,DAB-452 Fumarate,DAB-452	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Aplindore Fumarate （DAB-452）是一种小分子多巴胺 D2 受体部分激动剂，Aplindore Fumarate 对多巴胺D2 和D3 受体表现出高亲和力，对多巴胺D4、5-羟色胺（5-HT2）和α1-肾上腺素受体表现出低亲和力。Aplindore Fumarate 可用于研究帕金森和精神分裂症。

化合物

Cat.No: T1880

Target: Others

Cat.No: T3464

Synonym: (-) PHCCC

Target: GluR

Cat.No: TQ0289

Target: iGluR

Cat.No: T7729

Target: LRRK2

Cat.No: T21667

Target: Dopamine Receptor

Cat.No: T1770

Target: LRRK2

Cat.No: T2216

Synonym: OR-611,恩他卡朋

Target: Transferase

Cat.No: T22026

Target: Others, Sirtuin

Cat.No: T3278

Synonym: EU-4200,Trivastan,ET-495,Trivastal

Target: Dopamine Receptor, Histone Methyltransferase, Adrenergic Receptor

Cat.No: T8737

Target: 5-HT Receptor

Cat.No: T3053

Synonym: CHEMBL2397014

Target: LRRK2

CZC-25146 hydrochloride

Cat.No: T5139

Target: LRRK2

Cat.No: T1476

Synonym: SND 919,普拉克索

Target: Dopamine Receptor

Orphenadrine hydrochloride

Cat.No: T1308

Synonym: Mebedrol,Mephenamin,盐酸邻甲苯海拉明

Target: Sodium Channel, NMDAR, Norepinephrine, iGluR, Histamine Receptor

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T6726

Synonym: ML-128,VU 0361737

Target: GluR

Cat.No: T4473

Synonym: Venglustat,SAR402671,GZ402671

Target: Transferase

Procyclidine hydrochloride

Cat.No: T4979

Synonym: (±)-Procyclidine hydrochlorid,丙环定盐酸盐

Target: NMDAR, iGluR

Cat.No: T0957

Synonym: PN 200-110,伊拉地平

Target: Calcium Channel, Autophagy

PF-CBP1 hydrochloride

Cat.No: T3217

Synonym: PF-CBP1 HCl

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Orphenadrine Citrate

Cat.No: T6618

Synonym: Flexon,Flexoject,Banflex,枸酸芬那君,奥芬那君

Target: AChR, iGluR

Cat.No: T0218

Synonym: Bipariden,Akineton,KL 373,比哌立登,Biperidine

Target: AChR

Ropinirole hydrochloride

Cat.No: T2592

Synonym: SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl,盐酸罗匹尼罗

Target: Dopamine Receptor

Cat.No: T9235

Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Target: Mitochondrial Metabolism

Benztropine mesylate

Cat.No: T1336

Synonym: Benzotropine mesylate,苯扎托品,Benzatropine mesylate,Benztropine methanesulfonate,甲磺酸苯扎托品

Target: Dopamine Receptor, AChR, Histamine Receptor

Pergolide mesylate

Cat.No: T2226

Synonym: 甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T0229

Synonym: SDZ-ENA 713,卡巴拉汀,S-Rivastigmine,Exelon,利凡斯的明

Target: AChE

Pramipexole dihydrochloride hydrate

Cat.No: T6951

Synonym: Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索

Target: Dopamine Receptor

Rivastigmine tartrate

Cat.No: T1628

Synonym: SDZ-ENA 713,ENA 713,酒石酸卡巴拉汀

Target: AChR, AChE

Amantadine hydrochloride

Cat.No: T1406

Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

Nurr1 agonist 8

Cat.No: T81632

Target: Others

Cat.No: T31773

Synonym: FLZ

Target: Beta Amyloid, Src

Cat.No: T40018

Synonym: 4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others

Cat.No: T34616

Synonym: ACR-343,ACR 343,ACR343

Target: Dopamine Receptor

(Rac)-GSK 372475

Cat.No: T68026

Target: Others

Pimavanserin tartrate

Cat.No: T6946

Synonym: ACP-103,ACP-103 tartrate,Nuplazid,Pimavanserin,匹莫范色林

Target: 5-HT Receptor

Romergoline 2HCl

Cat.No: T71707L

Synonym: Romergoline 2HCl(107052-56-2 Free base),FCE 23884 2HCl

Target: Dopamine Receptor

Cat.No: T71934

Target: MAO

MPTP hydrochloride

Cat.No: T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Cat.No: T62304

Synonym: (R)-NPT200-11,UCB0599,DLX-313

Target: Others

Cat.No: T13248

Target: NMDAR, iGluR

Cat.No: T24064

Synonym: JP-1730,BVF-025,JP 1730,JP1730

Target: Adrenergic Receptor

(Iso)-BMT-124110 Formate

Cat.No: T77333L

Synonym: (R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base）

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T69188

Synonym: AloisineB

Target: GSK-3, CDK

Cat.No: T19922

Synonym: L(-)mTyrosine,3-羟基-L-苯基丙氨酸,L (-) m Tyrosine,LmTyrosine,3-Hydroxy-L-Phenylalanine,L-(-)-m-Tyrosine

Target: Others

Cat.No: T26878

Synonym: BN-82451B 2HCl,BN 82451B 2HCl

Target: COX

CBiPES hydrochloride

Cat.No: T22638

Synonym: CBiPES HCl

Target: GluR

mGluR3 modulator-1

Cat.No: T9970

Synonym: 1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈

Target: GluR

USP30 inhibitor 11

Cat.No: T13267

Synonym: USP30-IN-11

Target: DUB

Aplindore Fumarate

Cat.No: T30098

Synonym: Aplindore,DAB-452 Fumarate,DAB-452

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T0437	Inosine INO 495,NSC 20262,肌苷	ROS; Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Inosine (NSC-20262) 是由腺苷分解代谢产生的一种内源性嘌呤核苷，是腺苷受体A1R 和A2AR 的激动剂，具有抗炎免疫调节，抗伤害和神经保护作用。
T6830	Epoxomicin BU-4061T,BU-4061T,Aids010837,环氧酶素	Apoptosis; Proteasome	Apoptosis; Proteases/Proteasome; Ubiquitination
	Epoxomicin (BU-4061T,Aids010837) 是一种含环氧酮的天然产物，可穿越血脑屏障，并具有很强的抗肿瘤和抗炎活性。它是一种选择性不可逆的蛋白酶体抑制剂，抑制类胰凝乳蛋白酶的活性。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T0848	L-DOPA 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	L-DOPA (Levodopa) 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa 具有抗痛觉过敏作用。Levodopa 还具有帕金森氏病的研究潜力。
T5S0754	Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷	NF-κB; Wnt/beta-catenin; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells
	Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T4954L	Smilagenin PYM50028,Cogane,AI3-44895,PYM 50028
	Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.
T15255	Etilevodopa Levodopa ethyl ester,L-DOPA ethyl ester	Others	Others
	Etilevodopa is an ethyl-ester prodrug of Levodopa which is used for the treatment of Parkinson's disease (PD). It is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Levodopa is the direct precursor of dop

天然产物

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T0437

Synonym: INO 495,NSC 20262,肌苷

Target: ROS, Endogenous Metabolite, Adenosine Receptor

Cat.No: T6830

Synonym: BU-4061T,BU-4061T,Aids010837,环氧酶素

Target: Apoptosis, Proteasome

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

Cat.No: T0848

Synonym: 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine

Target: Dopamine Receptor, Endogenous Metabolite

Cat.No: T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷

Target: NF-κB, Wnt/beta-catenin, NO Synthase

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Cat.No: T4954L

Synonym: PYM50028,Cogane,AI3-44895,PYM 50028

Cat.No: T15255

Synonym: Levodopa ethyl ester,L-DOPA ethyl ester

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant BDNF,Abrineurin,Brain-Derived Neurotrophic Factor	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) G-α-h,HEL-S-45,TGC,transglutaminas	Human	Baculovirus Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which...
TMPK-01063	LRP-10 Protein, Mouse, Recombinant (His) Lrp10,LRP-10,Lrp9	Mouse	HEK293 Cells
	LDL receptor-related protein (LRP) 10 was recently identified as a Parkinson's disease gene through genome-wide linkage and sequencing analysis, but its role in Parkinson's disease in various populations is still unclear.
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His) DJ1,HEL-S-67p,DJ-1,parkinson prot...	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress...
TMPY-05099	GBA/glucocerebrosidase Protein, Human, Recombinant (His) glucosidase, β, acid,GLUC,GCB,GBA1,gluco	Human	HEK293 Cells
	Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD.
TMPY-03227	CISD1 Protein, Human, Recombinant (His) ZCD1,CDGSH iron sulfur domain 1,C10orf70,m...	Human	E. coli
	Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death. At the ce...
TMPY-00554	CHRNB3 Protein, Human, Recombinant (His) cholinergic receptor, nicotinic, beta 3 (neuronal),cholinerg...	Human	HEK293 Cells
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. CHRNB3 Prot...
TMPY-04195	CHRNB3 Protein, Human, Recombinant (hFc) cholinergic receptor, nicotinic, β 3 (neuronal),cholinergic ...	Human	HEK293 Cells
	Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The beta3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. CHRNB3 Prot...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His) SMT3 homolog 1,Smt3A,Small ubiqui...	Human	HEK293 Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect...
TMPY-03653	CTRL Protein, Human, Recombinant (His) CTRL1,chymotrypsin-like	Human	HEK293 Cells
	CTRL-1, also known as chymotrypsin-like protease, belongs to thepeptidase S1 family. CTRL-1 contains 1peptidase S1 domain. Its expression is increased in preeclampsia (PE). Placental-derived chymotrypsin-like protease is responsible for inducing endothelial inflammatory phenotypic changes possibly by upregulation of cell adhesion molecule expressions, activation of cellular protease, and induction of extracellular regulated kinase phosphorylation. Activated microglia have been observed in variou...
TMPJ-00684	SNCA Protein, Mouse, Recombinant (His) Snca,Non-A β component of AD amyloid,Non-A4 compone...	Mouse	E. coli
	Alpha-synuclein (Snca) belongs to a family of proteins including a-, b-, and g-synucleins. Alpha-synuclein has been found to be implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Manyneurodegenerative diseases has shown that alpha-synuclein accumulates in dystrophic neurites and in Lewy bodies. The function of alpha-synuclein is closely correlated with its three-dimensional structure, especially for proteins important...
TMPY-02759	Kallikrein 6/KLK6 Protein, Human, Recombinant (His) kallikrein-related peptidase 6,PRSS	Human	HEK293 Cells
	KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh...

重组蛋白

BDNF Protein, Human/Murine/Rat, Recombinant

Cat.No: TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01355

Species: Human

Expression System: Baculovirus Insect Cells

LRP-10 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01063

Species: Mouse

Expression System: HEK293 Cells

PARK7/DJ-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02043

Species: Human

Expression System: E. coli

GBA/glucocerebrosidase Protein, Human, Recombinant (His)

Cat.No: TMPY-05099

Species: Human

Expression System: HEK293 Cells

CISD1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03227

Species: Human

Expression System: E. coli

CHRNB3 Protein, Human, Recombinant (His)

Cat.No: TMPY-00554

Species: Human

Expression System: HEK293 Cells

CHRNB3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04195

Species: Human

Expression System: HEK293 Cells

SUMO3 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01022

Species: Human

Expression System: HEK293 Cells

CTRL Protein, Human, Recombinant (His)

Cat.No: TMPY-03653

Species: Human

Expression System: HEK293 Cells

SNCA Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00684

Species: Mouse

Expression System: E. coli

Kallikrein 6/KLK6 Protein, Human, Recombinant (His)

Cat.No: TMPY-02759

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...
T10118	3-O-Methyltolcapone D7 Ro 40-7591 D7	Transferase	Metabolism
	3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P
TMIJ-0312	L-Dopa-2,5,6-d3
	L-Dopa-2,5,6-d3 是 L-Dopa 的氘代化合物。L-Dopa 的 CAS 号为 59-92-7。Levodopa 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa具有抗痛觉过敏作用。Levodopa还具有帕金森氏病的研究潜力。
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

3-O-Methyltolcapone D7

Cat.No: T10118

Synonym: Ro 40-7591 D7

Target: Transferase

L-Dopa-2,5,6-d3

Cat.No: TMIJ-0312

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

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