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7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1595 |
Human Papillomavirus (HPV) E7 protein (49-57)
Human Papillomavirus (HPV) E7 protein 49-57 |
||
Human Papillomavirus (HPV) E7 protein (49-57) is the H-2d-restricted human papillomavirus (HPV) E749-57 epitope. | |||
T12711 |
Retro-2 cycl
RN 1-001 |
Virus Protease | Microbiology/Virology |
Retro-2 cycl 是一种抗病毒剂,是一种逆行运输抑制剂,抑制 JCPyV(IC50s:54 μM)和 HPV16 假病毒(IC50s:160 μM)。 | |||
T8350 |
TPCK
|
Proteasome | Proteases/Proteasome; Ubiquitination |
TPCK 是丝氨酸蛋白酶抑制剂,通过与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心发生反应,并能够消除其 RB 结合能力。将它添加到培养基内,可修饰活角质形成细胞中的 E7 蛋白。 | |||
T1583 |
Vorinostat
MK0683,伏立诺他,suberoylanilide hydroxamic acid,SAHA |
Apoptosis; Mitophagy; Virus Protease; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
Vorinostat (SAHA) 是一种泛的组蛋白脱乙酰酶 (HDAC) 抑制剂 (IC50=10 nM),对 HDAC1/2/3/6/7/11 均有抑制活性。 Vorinostat 具有抗肿瘤活性,可以诱导细胞分化,阻滞细胞周期,诱导细胞凋亡。 | |||
T4326 |
AG 555
Tyrphostin B46,Tyrphostin AG 555 |
EGFR; Reverse Transcriptase | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂,可阻断Cdk2活化。它是一种抗逆转录病毒药。 | |||
T0134 |
Imiquimod
咪喹莫特,R 837,IMQ,S-26308 |
SARS-CoV; TLR; Autophagy; HSV | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Imiquimod (R 837) 是一种免疫反应修饰剂,可作为 toll 样受体7 激动剂。它有抗病毒和抗肿瘤作用,可研究外生殖器、肛周疣、癌症和 COVID-19。 | |||
T31648 |
Epetirimod
S 30563,S-30563,S30563 |
Antiviral | Immunology/Inflammation |
Epetirimod (S-30563) 是一种小分子免疫调节剂,具有抗肿瘤和抗感染活性,可用于研究乳头状瘤病毒感染。 | |||
T36432 |
A2ti-1
|
Virus Protease | Microbiology/Virology |
A2ti-1 是一种具有高选择性的附件蛋白 A2/S100A10 杂四聚体(A2t)抑制剂(IC50 : 24 μM), 抑制ARV介导的Src和p38丝裂原活化蛋白激酶(MAPK)的激活。A2ti-1 可用于研究人类乳头瘤病毒 16 型(HPV16)感染。 | |||
T67786 |
ABI-1968 PM
|
Others | Others |
ABI-1968 PM 是ABI-1968的一种衍生物。ABI-1968是一种细胞凋亡刺激剂,是一种病毒复制抑制剂。ABI-1968可用于研究宫颈上皮内瘤样病变、乳头状瘤病毒感染和鳞状上皮内病变。 | |||
T36433 |
A2ti-2
A2ti-2 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂(IC50 : 230 μM)。A2ti-2 具有抗病毒活性,可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用,可防止人乳头瘤病毒 16 型 (HPV16) 感染。 | |||
T15172 |
DSHS00884
SSYA10-001 |
Others | Others |
DSHS00884 is a potent inhibitor of human papillomavirus E6 (IC50: 10 μM). | |||
T28534 |
RH02007
CCG 40788,RH-02007,CCG40788,CCG-40788,RH 02007 |
Others | Others |
RH02007 is an inhibitor of the human papillomavirus (HPV) E6 oncoprotein. | |||
T71941 |
Lig3
|
Others | Others |
Lig3 is an inhibitor against high-risk strains of human papillomavirus (HPV) E6 oncoprotein. | |||
T76960 |
Verpasep caltespen
|
Others | Others |
Verpasep caltespen (HspE7) 是一种重组融合蛋白,来源于Mycobacterium bovis Calmette-Guérin 热休克蛋白 65 (Hsp65),其 C 末端与HPV16 的 E7 蛋白共价连接。Verpasep caltespen 可用于人乳头瘤病毒 (HPV)引起的癌前病变和癌性病变研究。 | |||
T36858 |
C12 Galactosylceramide (d18:1/12:0)
|
Others | Others |
C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4417 |
Larixyl acetate
|
Others | Others |
Larixyl acetate 是一种生物活性化学物质。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01466 |
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer Protein, Human, MHC (His & Avi)
Human papillomavirus type 16,E6,HPV16 |
Human | HEK293 Cells |
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer. | |||
TMPK-01467 |
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)
HPV16,E6,Human papillomavirus type 16 |
Human | HEK293 Cells |
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer. | |||
TMPH-01584 |
KRT7 Protein, Human, Recombinant (His & SUMO)
KRT7,Keratin, type II cytoskeletal 7,Sarcolectin,Keratin-7,T... |
Human | E. coli |
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7). | |||
TMPK-00479 |
AGER Protein, Cynomolgus, Recombinant (His)
AGER,RAGE,SCARJ1 |
Cynomolgus | HEK293 Cells |
The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer. | |||
TMPY-00575 |
ULBP-6 Protein, Human, Recombinant (His)
RAET1L,retinoic acid early transcript 1L,ULBP6 |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel... | |||
TMPY-00190 |
ULBP-6 Protein, Human, Recombinant (hFc)
retinoic acid early transcript 1L,RAET1L,ULBP6 |
Human | HEK293 Cells |
ULBP6/RAET1L, is a polymorphic locus that expresses a functional transcript. ULBP6 had a more restricted expression profile in cell lines and primary human tissues than other NKG2D ligands, but expression was detected in several human papillomavirus-positive cervical carcinoma cell lines and was inducible on infection with human CMV. Expression of ULBP6 on target cells induced a significant increase in NK-cell killing. ULBP-6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cel... | |||
TMPH-02301 |
VPS35 Protein, Human, Recombinant (His & Myc)
VPS35,Vacuolar protein sorting-associated protein 35,Vesicle... |
Human | E. coli |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of... |