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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71739 |
PTPMT1-IN-1
|
Others | Others |
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor. | |||
T14177 |
Alexidine dihydrochloride
|
Apoptosis; Others; Antifungal | Apoptosis; Microbiology/Virology; Others |
Alexidine dihydrochloride 对多种真菌病原体具有抗真菌和抗生物膜活性。它是一种抗癌剂,可靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶 PTPMT1,并导致线粒体凋亡。 | |||
T63500 |
Alexidine
|
Others | Others |
Alexidine 是一种双双胍,对多种真菌病原体具有抗真菌 (antifungal) 和抗生物膜作用。Alexidine 靶向哺乳动物细胞中的线粒体酪氨酸磷酸酶PTPMT1,能够导致线粒体凋亡 (apoptosis),表现出抗肿瘤作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02602 |
PTPMT1 Protein, Human, Recombinant (His)
protein tyrosine phosphatase, mitochondrial 1,MOSP,... |
Human | E. coli |
PTPMT1 (PTP localized to the Mitochondrion 1) is a member of the protein tyrosine phosphatase superfamily that is localized exclusively to the mitochondrion. It has been recently reported that PTPMT1 dephosphorylates phosphatidylglycerol phosphate, an essential intermediate of cardiolipin biosynthesis. PTPMT1 deficiency in mouse embryonic fibroblasts compromises mitochondrial respiration and results in abnormal mitochondrial morphology. Lipid analysis of PTPMT1-deficient fibroblasts reveals an a... |