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Search Results for " pthr1 "

Targets Recommended: Thyroid hormone receptor(THR)

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11101	DS08210767	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	DS08210767 是一种高效的，具有生物口服可利用 PTHR1 拮抗剂，IC50 值为 90 nM。
T23673	AH-3960 AH3960	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	AH-3960 是一种甲状腺激素受体 1 (PTHR1) 激动剂。
TP1215L	Abaloparatide acetate(247062-33-5 free base)	Others	Others
	Abaloparatide acetate(247062-33-5 free base) 是一种甲状旁腺激素受体 1 PTHR1 类似物，是 PTHR1 信号通路的有效和选择性激活剂。
T28891	SW106	Others	Others
	SW106 is a selective antagonist of PTHR1-mediated cAMP signaling, not functioning as an inverse agonist on either PTHR1-T410P or PTHR1-H223R, which have activating mutations at the cytoplasmic ends of TMD helices-2 and -6, respectively.
T76663	pTH-Related Protein (1-40) (human, mouse, rat)
	pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα/β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体（PTHR1）表达，提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。
T73690	Abaloparatide
	Abaloparatide (BA 058) 是一种甲状旁腺激素受体 1 (PTHR1) 类似物。Abaloparatide 也是一种选择性 PTHR1激活剂。Abaloparatide 增强 Gs/cAMP 信号和β-arrestin 募集。Abaloparatide 可增强小鼠的骨形成和皮质结构。Abaloparatide 具有用于骨质疏松症研究的潜力。
T73132	DS69910557	Others	Others
	DS69910557为高效、选择性的hPTHR1拮抗剂，口服有效。其对PTHR1的拮抗IC50值为0.08 μM。适用于甲状旁腺功能亢进症、恶性肿瘤引起的高钙血症及骨质疏松症研究。

化合物

DS08210767

Cat.No: T11101

Synonym:

Target: Thyroid hormone receptor(THR)

AH-3960

Cat.No: T23673

Synonym: AH3960

Target: Thyroid hormone receptor(THR)

Abaloparatide acetate(247062-33-5 free base)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02236	PTH1R Protein, Human, Recombinant (His) PFE,PTHR1,MGC138452,parathyroid h...	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane protein which belongs to the G-protein coupled receptor 2 family. PTH1R is expressed in most tissues. It is most abundant in kidney, bone and liver. PTH1R is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase an...