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Search Results for " ppi "

Targets Recommended: Beta Amyloid

79

抑制剂 & 化合物

4

天然产物

4

化合物库

19

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L9400	PPI抑制剂库		485 compounds
	485 种已知活性的 PPI 相关的抑制剂，可用于高通量、高内涵筛选；
DP1000	PPI计算机辅助药物设计库		230000 compounds
	ChemDiv’s Protein-Protein Interaction Library contains 210,000 compounds. 陶术生物针对小规模PPI 药物筛选，基于结构多样性构建PPI 多样性子库，包含10397种小分子化合物。
L9610	环肽库		80 compounds
	80 种环肽分子，可用于高通量和高内涵筛选；
L9300	大环化合物库		210 compounds
	210 种活性已知的大环化合物，用于高通量、高内涵筛选；

化合物库

PPI抑制剂库

Cat.No: L9400

Compounds: 485

PPI计算机辅助药物设计库

Cat.No: DP1000

Compounds: 230000

Cat.No: L9610

Compounds: 80

大环化合物库

Cat.No: L9300

Compounds: 210

Cat. No.	Product Name	Target	Signaling Pathways
T28441	PPI-1019 PPI1019,Apan	Beta Amyloid	Neuroscience
	PPI-1019 是一种 APP( β -淀粉状蛋白 A4 )抑制剂，可用于治疗神经系统疾病和研究阿尔茨海默病（AD）。
T62447	Paltimatrectinib PBI-200,PPI-5278	Trk receptor; Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Paltimatrectinib (PBI-200) 是一种高效的酪氨酸激酶 (tyrosine kinase) 抑制剂，具有抗癌活性，抑制肌球蛋白相关激酶 A (TrkA) 。Paltimatrectinib 可用于研究膀胱癌、乳腺癌和结直肠癌。
T10217L	Abarelix R3827,阿巴瑞克,PPI 149	GNRH Receptor	GPCR/G Protein
	Abarelix (PPI 149) 是一种促性腺激素释放激素 (GnRH) 拮抗剂，用于前列腺癌研究。
T69258	PPI-2458	Others	Others
	PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class.
T7387	Ceftaroline fosamil TAK-599,头孢罗林酯,PPI0903	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftaroline fosamil (TAK-599) 是一种头孢菌素衍生物，是抗甲氧西林金黄色葡萄球菌 (MRSA) T-91825 的 N-膦酰基前药，可研究 MRSA 感染。
T72785	PRMT5:MEP50 PPI	Others	Others
	PRMT5:MEP50 PPI是一款新型的抑制剂，专门针对PRMT5:MEP50蛋白-蛋白相互作用，展现了抗肿瘤活性，并对肺癌及前列腺癌细胞具有显著的抗增殖效果。
T10217	Abarelix Acetate (183552-38-7 free base) PPI 149 Acetate,Abarelix Acetate	Others	Others
	Abarelix (PPI 149; R 3827) Acetate is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.
T8784	IGS-1.76	Others	Others
	IGS-1.76对hNCS-1有显著的亲和力，并有效调节hNCS-1与Ric8a之间的相互作用。此外，IGS-1.76还能熟练抑制由human NCS-1和Ric8a形成的复合物。
T6889	MI-136	Apoptosis; Epigenetic Reader Domain; Androgen Receptor	Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones
	MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂，其 IC50值为31 nM，Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达，有用于去势抵抗性肿瘤的潜能。
T79457	PEX5-PEX14 PPI-IN-1	Others	Others
	PEX5-PEX14 PPI-IN-1(Compound 8)为PEX14-PEX5 PPI 抑制剂，其通过破坏PEX5-TbPEX14 PPI的作用并表现出53 μM的Ki值。该化合物还能抑制T. b. brucei的bloodstream形式，EC50为5 μM。
T81503	PEX5-PEX14 PPI-IN-2	Others	Others
	PEX5-PEX14 PPI-IN-2（化合物 12）是一种抑制PEX14-PEX5蛋白质-蛋白质相互作用（PPI）的化合物，其在T. b. brucei细胞和HepG2细胞中的EC50值分别为5 µM和17 µM。该化合物适用于研究与锥虫感染有关的疾病。
T4647	M2I-1 M2I 1	Others	Others
	M2I-1 是Mad2抑制剂，靶向的 Mad2 与 Cdc20 的结合，该结合是纺锤体装配检查点内必不可少的蛋白-蛋白相互作用。
T26859	BMS-8	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-8 抑制PD-1/PD-L1相互作用(IC50:7.2 μM)。它能够直接与 PD-L1 结合，促使形成 PD-L1 同源二聚体，进而阻断 PD-L1 与 PD-1 的相互作用。
T82758	CDK9-Cyclin T1 PPI-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-Cyclin T1 PPI-IN-1 (Compound B19) 是CDK9-Cyclin T1蛋白-蛋白相互作用的选择性抑制剂。该化合物能够有效抑制TNBC MDA-MB-231细胞系的细胞增殖(IC50: 0.044 μM)，诱导细胞凋亡，同时降低CDK9的转录活性并减少RNA Pol II CTD ser2的磷酸化，有效地抑制了4T1移植瘤模型小鼠中肿瘤的生长。
T9039	HIV-1 Nef-IN-1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 Nef-IN-1 是 HIV-1 Nef 蛋白的抑制剂。它有效地竞争 Nef-SH3Hck 相互作用，Kd 值为 6.7 μM。
T9044	SORT-PGRN interaction inhibitor 1	Neurotensin Receptor	GPCR/G Protein
	SORT-PGRN interaction inhibitor 1 是一种 sortilin-progranulin 相互作用抑制剂，IC50为 2 μM。
T13018	SU3327 halicin	JNK	MAPK
	SU3327 (halicin) 是具有底物竞争性的 JNK 选择性抑制剂，IC50为 0.7 μM。它还抑制 JNK 和 JIP 之间的蛋白相互作用，IC50值为 239 nM。
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T8216	T-1101 tosylate TAI-95 tosylate	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	T-1101 tosylate (TAI-95 tosylate) 是一种具有抗肿瘤活性的 Hec1/Nek2抑制剂。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T71022	GI-129471	Others	Others
	GI-129471 is a metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo.
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T6929	Pantoprazole sodium Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc	Apoptosis; Others; Proton pump; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others
	Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T16421	p-MPPI hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	p-MPPI hydrochloride 是一种选择性的，具有高亲和力的5-HT1A 受体拮抗剂，能穿过血脑屏障，具有抗抑郁和抗焦虑样作用。
T22135	PPIase-Parvulin Inhibitor	Others	Others
	PPIase-Parvulin Inhibitor 是一种抑制剂，可以抑制PPlase Pin1 和Pin4的细胞渗透。
T8873	Bractoppin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂，IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募，进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
T22747	DPPI 1c hydrochloride	Others	Others
	DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (IC50 = 104 nM) that shows selectivity over enzymes with DPP-like activity (IC50 > 30 μM).
T37893	3-MPPI	Others	Others
	3-MPPI 是一种高亲和力非选择性 α1 拮抗剂。
T24652	Poloppin	Others	Others
	Poloppin is a protein-protein interactions modulator of the mitotic polo-like kinases that acts by targeting mutant KRAS. It works synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.
T9202	DDO-5936	HSP	Cytoskeletal Signaling; Metabolism
	DDO-5936 是一种特异性Hsp90-Cdc37 PPI 抑制剂，可研究大肠癌。
T10601	BRCA1-IN-2	Others	Others
	BRCA1-IN-2 是一种可穿过细胞膜的 BRCA1 蛋白-蛋白相互作用（PPI）抑制剂，具有抗肿瘤活性，通过破坏 BRCA1 (BRCT)2 与蛋白质的相互作用来发挥作用。
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T9642	ZW4864 free base	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	ZW4864 free base 是口服有效的，选择性的 β catenin/ B-Cell lymphoma 9 蛋白-蛋白相互作用 (β catenin/BCL9 PPI) 抑制剂 (Ki= 0.76 μM, IC50= 0.87 μM)。
T11666	IPR-803	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	IPR-803 是一种有效的 uPAR·uPA 蛋白-蛋白相互作用抑制剂，具有抗肿瘤活性。 IPR-803 直接与 uPAR 结合，Ki 为 0.2 μM。
T60217	TAS1553	Others	Others
	TAS1553是一种高效的可口服蛋白质-蛋白质相互作用(PPI)抑制剂，其IC50值为0.0396 μM。TAS1553 有效地阻碍DNA复制并减少细胞内dATP池。此外，TAS1553诱导凋亡，[1]使其在癌症研究中极具价值。
T60657	(R)-STU104	TNF; MAPK	Apoptosis; MAPK
	(R)-STU104 是一种新型 TAK1-MKK3 蛋白-蛋白相互作用（PPI）抑制剂，抑制 TNF-α，通过与 MKK3 结合并破坏TAK1磷酸化MKK3来抑制TAK1/MKK3/p38/MnK1/MK2/elF4E信号通路。(R)-STU104 是治疗溃疡性结肠炎的候选化合物。
T10138	4-Desmethoxy Omeprazole	Drug Metabolite	Metabolism
	4-Desmethoxy Omeprazole 是 Omeprazole 的活性代谢物。Omeprazole 是质子泵抑制剂。Omeprazole 竞争性抑制 CYP2C19 活性，Ki=2 - 6 μM。Omeprazole 还抑制革兰氏阴性菌和革兰氏阳性菌生长。
T6700	Tenatoprazole 泰妥拉唑,TU-199	Proton pump	Membrane transporter/Ion channel
	Tenatoprazole (TU-199) 是一种口服有效的，基于咪唑吡啶的质子泵抑制剂。它抑制猪胃H+/K+-ATP 酶活性，IC50为6.2 μM。它阻断泛素与 ESCRT-1 因子 Tsg101 的相互作用，抑制几种包膜病毒的产生，包括 EBV。
T22391	Omeprazole Sodium	P450; Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Omeprazole 是有效的质子泵抑制剂，在胃肠道疾病的研究中具有价值。它竞争性抑制CYP2C19活性，Ki 为 2 到 6 μM。它还抑制革兰氏阴性菌和革兰氏阳性菌生长。它是中性鞘磷脂酶的外泌体抑制剂。
T12906	SI-2 hydrochloride EPH 116 hydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	SI-2 hydrochloride (EPH 116 hydrochloride) 是 SRC-3 的抑制剂，诱导乳腺癌细胞死亡的 IC50 值为 3-20 nM。SI-2 hydrochloride 具有良好的药代动力学特征和改善的毒性，以及可接受的口服可用性。
T10221	Abeprazan hydrochloride DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump	Membrane transporter/Ion channel
	Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂，通过竞争性的与钾离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI)，通过减少胃酸的产生而起作用，可用于治疗胃酸相关疾病，如胃食管反流病(GERD)和消化性溃疡。
T0757	Omeprazole Losec,Prilosec,奥美拉唑,奥美拉挫,H 16868,Antra	Proton pump; Phospholipase; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Omeprazole (Losec) 是一种质子泵抑制剂，有研究胃肠道疾病的潜力。它竞争性抑制 CYP2C19活性，Ki 为 2 到 6 μM。它还抑制革兰氏阳性菌和革兰氏阴性菌生长。它是中性鞘磷脂酶的外泌体抑制剂。
T11096	DRI-C21045	NF-κB	NF-κB
	DRI-C21045 是一种有效的 CD40-CD40L 协同刺激蛋白-蛋白质相互作用的选择性抑制剂，IC50 为 0.17 μM。它显示对 CD40L 诱导的 NF-κB 活化和 B 细胞增殖的浓度依赖性抑制，IC50分别为 17.1 μM 和 4.5 μM。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T35841	5-Benzyloxygramine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体，可拮抗 5-HT 对大鼠子宫和兔耳的作用。
T27077	CPUY192018 Disodium CPUY-192018,CPUY192018,CPUY192018disodium,CPUY192018 Na2,CPUY192018-disodium	Others	Others
	CPUY192018 Disodium is a potent inhibitor of the Keap1-Nrf2 PPI. The inhibition of the Keap1-Nrf2 PPI may be beneficial as a treatment for ulcerative colitis.
T23693	AKCI	Others	Others
	AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction.
T32200	ISIR-005 ISIR 005	Others	Others
	ISIR-005 is a natural stabilizer of the 14-3-3/Gab2 protein-protein interaction (PPI) interface.
T8731	BCL6-IN-7	Others	Others
	BCL6-IN-7 是一种有效的 BCL6 蛋白-蛋白相互作用(PPI)抑制剂。

化合物

Cat.No: T28441

Synonym: PPI1019,Apan

Target: Beta Amyloid

Paltimatrectinib

Cat.No: T62447

Synonym: PBI-200,PPI-5278

Target: Trk receptor, Tyrosine Kinases

Cat.No: T10217L

Synonym: R3827,阿巴瑞克,PPI 149

Target: GNRH Receptor

Cat.No: T69258

Target: Others

Ceftaroline fosamil

Cat.No: T7387

Synonym: TAK-599,头孢罗林酯,PPI0903

Target: Antibacterial, Antibiotic

PRMT5:MEP50 PPI

Cat.No: T72785

Target: Others

Abarelix Acetate (183552-38-7 free base)

Cat.No: T10217

Synonym: PPI 149 Acetate,Abarelix Acetate

Target: Others

Cat.No: T8784

Target: Others

Cat.No: T6889

Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor

PEX5-PEX14 PPI-IN-1

Cat.No: T79457

Target: Others

PEX5-PEX14 PPI-IN-2

Cat.No: T81503

Target: Others

Cat.No: T4647

Synonym: M2I 1

Target: Others

Cat.No: T26859

Target: PD-1/PD-L1

CDK9-Cyclin T1 PPI-IN-1

Cat.No: T82758

Target: CDK

Cat.No: T9039

Target: HIV Protease

SORT-PGRN interaction inhibitor 1

Cat.No: T9044

Target: Neurotensin Receptor

Cat.No: T13018

Synonym: halicin

Target: JNK

Cat.No: T8421

Target: YAP

T-1101 tosylate

Cat.No: T8216

Synonym: TAI-95 tosylate

Target: Apoptosis, Microtubule Associated

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Cat.No: T71022

Target: Others

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

Cat.No: T6929

Synonym: Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

p-MPPI hydrochloride

Cat.No: T16421

Target: 5-HT Receptor

PPIase-Parvulin Inhibitor

Cat.No: T22135

Target: Others

Cat.No: T8873

Target: Others, DNA/RNA Synthesis

DPPI 1c hydrochloride

Cat.No: T22747

Target: Others

Cat.No: T37893

Target: Others

Cat.No: T24652

Target: Others

Cat.No: T9202

Target: HSP

Cat.No: T10601

Target: Others

Cat.No: T20626

Target: Proton pump, Cysteine Protease

ZW4864 free base

Cat.No: T9642

Target: Wnt/beta-catenin

Cat.No: T11666

Target: Serine/threonin kinase

Cat.No: T60217

Target: Others

Cat.No: T60657

Target: TNF, MAPK

4-Desmethoxy Omeprazole

Cat.No: T10138

Target: Drug Metabolite

Cat.No: T6700

Synonym: 泰妥拉唑,TU-199

Target: Proton pump

Omeprazole Sodium

Cat.No: T22391

Target: P450, Proton pump, Antibacterial, Autophagy

SI-2 hydrochloride

Cat.No: T12906

Synonym: EPH 116 hydrochloride

Target: Src

Abeprazan hydrochloride

Cat.No: T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Cat.No: T0757

Synonym: Losec,Prilosec,奥美拉唑,奥美拉挫,H 16868,Antra

Target: Proton pump, Phospholipase, Antibacterial, Autophagy

Cat.No: T11096

Target: NF-κB

Cat.No: T38050

Target: Transferase

5-Benzyloxygramine

Cat.No: T35841

Target: Dopamine Receptor, 5-HT Receptor

CPUY192018 Disodium

Cat.No: T27077

Synonym: CPUY-192018,CPUY192018,CPUY192018disodium,CPUY192018 Na2,CPUY192018-disodium

Target: Others

Cat.No: T23693

Target: Others

Cat.No: T32200

Synonym: ISIR 005

Target: Others

Cat.No: T8731

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci
TN6340	Philippin A
	Philippin A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6340，CAS号为 1848254-99-8。
T21651	Lansoprazole sodium 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂，是中性鞘磷脂酶的外泌体抑制剂，能抑制胃酸生成。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。

天然产物

Flemiphilippinin A

Cat.No: TN1646

Target: Others

Cat.No: TN6340

Lansoprazole sodium

Cat.No: T21651

Synonym: 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium

Target: Proton pump, Phospholipase, Antibacterial

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05824	Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 247-675, His) E Protein	DENV	HEK293 Cells
	Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 247-675, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.79 kDa and the accession number is AAA99437.1.
TMPY-04903	Dengue virus (DENV) (type 3, strain Philippines/H87/1956) NS1 Protein (His) DENV-NS1	DENV	HEK293 Cells
	Dengue virus (DENV) (type 3, strain Philippines/H87/1956) NS1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.1 kDa and the accession number is AAA99437.1.
TMPY-03413	PPIL2 Protein, Human, Recombinant (aa 280-457, His) UBOX7,Cyp-60,CYP60,CYC4,peptidylprolyl isomerase (cyclophili...	Human	E. coli
	PPIL2, is an enzyme that belongs to the cyclophilin family. The cyclophilins are peptidylprolyl isomerases and are highly conserved ubiquitous. They play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL2 interacts with the proteinase inhibitor eglin c and is localized in the nucleus. It contains 1 PPIL2 cyclophilin-type domain and 1 U-box domain. PPIL2 accelerate the folding of proteins. It catalyzes the cis-trans isomerization of pro...
TMPJ-00676	PPIH Protein, Human, Recombinant (His) Peptidyl-Prolyl Cis-Trans Isomerase H,Rotamase H,PPI	Human	E. coli
	Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the i...
TMPH-00687	PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO) ppiA,Cyclophilin A,Peptidyl-prolyl cis-trans isomer...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 38.1 kDa and the accession number is P0AFL4.
TMPY-06466	Dengue virus (DENV) (type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 579-678, His) E Protein	DENV	Baculovirus Insect Cells
	Dengue virus (DENV) (type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 579-678, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 16.48 kDa and the accession number is AAA99437.1.
TMPY-05023	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) NS1 Protein (His) DENV-NS1	DENV	HEK293 Cells
	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) NS1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is AAX48017.1.
TMPJ-01090	PPID Protein, Human, Recombinant (His) Cyclophilin-40,CYPD,Peptidyl-Prolyl Cis-Trans Isomerase D,Ro...	Human	E. coli
	Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase cyclophilin-type domain and three TPR repeats. PPID catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. PPID can bind to the immunosuppressant cyclosporine A and is known that its overexpression suppresses the apoptosis in cancer cells.
TMPH-00705	PPIase A Protein, E. coli, Recombinant (His & SUMO) Rotamase A,Cyclophilin A,ppiA,Peptidyl-prolyl cis-t...	E. coli	E. coli
	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
TMPY-03285	PPIL1 Protein, Human, Recombinant (His) CGI-124,PPIase,CYPL1,hCyPX,peptidylprolyl isomerase...	Human	E. coli
	PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of...
TMPJ-00971	PPIC Protein, Human, Recombinant (Trx & His) PPIase C,Peptidyl-Prolyl Cis-Trans Isomerase C,...	Human	E. coli
	Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so...
TMPK-00377	DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) DPP4,DPPIV,ADCP2,CD26,ADABP,TP103,EC 3.4.14.5	Cynomolgus,Rhesus	HEK293 Cells
	CD26/dipeptidyl peptidase (DPP)IV is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express DPPIV/CD26 to a variable extent.
TMPH-03405	Reston ebolavirus (REBOV) (strain Philippines-96) Nucleoprotein/NP Protein (His & SUMO) Nucleocapsid protein,Reston NP,Nucleoprotein,NP	REBOV	E. coli
	Reston ebolavirus (REBOV) (strain Philippines-96) Nucleoprotein/NP Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 53.3 kDa and the accession number is Q91DE1.
TMPY-05821	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (aa 579-679, His) E Protein	DENV	HEK293 Cells
	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (aa 579-679, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.41 kDa and the accession number is AAX48017.1.
TMPY-04800	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (His) E Protein	DENV	Baculovirus Insect Cells
	Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is AAX48017.1.
TMPY-04668	Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His) Harvey rat sarcoma viral oncogene homolog	H3N2	HEK293 Cells
	Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.9 kDa and the accession number is A0A097PF18.
TMPY-04941	Influenza A H3N2 (A/Philippines/472/2002) Hemagglutinin/HA Protein (His) Harvey rat sarcoma viral oncogene homolog	H3N2	Baculovirus Insect Cells
	Influenza A H3N2 (A/Philippines/472/2002) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.1 kDa and the accession number is A0A097PF18.
TMPJ-01389	PPIE Protein, Human, Recombinant (His) Rotamase E,PPIE,Cyclophilin E,PPIase E,CYP...	Human	E. coli
	Peptidyl-prolyl cis-trans isomerase E, also known as Cyclophilin E, Cyclophilin-33, Rotamase E, CYP33, PPIE, is an enzyme which belongs to the cyclophilin-type PPIase family of PPIase E subfamily. PPIE found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PPIE contains one PPIase cyclophilin-type domain and one RRM (RNA recognition motif) domain. PPIE accelerates the folding of proteins. It catalyzes the cis-trans isomerization of ...
TMPY-03276	BLBP Protein, Human, Recombinant fatty acid binding protein 7, brain,FABPB,MRG,B-FABP,BLBP,RP...	Human	E. coli
	BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake, transport, and metabolism. BLBP is expressed, during development, in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expre...

重组蛋白

Dengue virus (DENV)(type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 247-675, His)

Cat.No: TMPY-05824

Species: DENV

Expression System: HEK293 Cells

Dengue virus (DENV) (type 3, strain Philippines/H87/1956) NS1 Protein (His)

Cat.No: TMPY-04903

Species: DENV

Expression System: HEK293 Cells

PPIL2 Protein, Human, Recombinant (aa 280-457, His)

Cat.No: TMPY-03413

Species: Human

Expression System: E. coli

PPIH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00676

Species: Human

Expression System: E. coli

PPIase A Protein, E. coli O6:H1, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00687

Species: E. coli

Expression System: E. coli

Dengue virus (DENV) (type 3, strain Philippines/H87/1956) E/Envelope Protein (aa 579-678, His)

Cat.No: TMPY-06466

Species: DENV

Expression System: Baculovirus Insect Cells

Dengue virus (DENV) (type 4, strain Philippines/H241/1956) NS1 Protein (His)

Cat.No: TMPY-05023

Species: DENV

Expression System: HEK293 Cells

PPID Protein, Human, Recombinant (His)

Cat.No: TMPJ-01090

Species: Human

Expression System: E. coli

PPIase A Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00705

Species: E. coli

Expression System: E. coli

PPIL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03285

Species: Human

Expression System: E. coli

PPIC Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00971

Species: Human

Expression System: E. coli

DPPIV/CD26 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00377

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

Reston ebolavirus (REBOV) (strain Philippines-96) Nucleoprotein/NP Protein (His & SUMO)

Cat.No: TMPH-03405

Species: REBOV

Expression System: E. coli

Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (aa 579-679, His)

Cat.No: TMPY-05821

Species: DENV

Expression System: HEK293 Cells

Dengue virus (DENV) (type 4, strain Philippines/H241/1956) E/Envelope Protein (His)

Cat.No: TMPY-04800

Species: DENV

Expression System: Baculovirus Insect Cells

Influenza A H3N2 (A/Philippines/472/2002) (MDCK) Hemagglutinin/HA1 Protein (His)

Cat.No: TMPY-04668

Species: H3N2

Expression System: HEK293 Cells

Influenza A H3N2 (A/Philippines/472/2002) Hemagglutinin/HA Protein (His)

Cat.No: TMPY-04941

Species: H3N2

Expression System: Baculovirus Insect Cells

PPIE Protein, Human, Recombinant (His)

Cat.No: TMPJ-01389

Species: Human

Expression System: E. coli

BLBP Protein, Human, Recombinant

Cat.No: TMPY-03276

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12308	Omeprazole-d3 奥美拉挫 D3,H 16868 D3	Others	Others
	Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)
TMIJ-0302	Esomeprazole-d3
	Esomeprazole-d3 是 Esomeprazole 的氘代化合物。Esomeprazole 的 CAS 号为 119141-88-7。Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。

同位素标记化合物

Cat.No: T12308

Synonym: 奥美拉挫 D3,H 16868 D3

Target: Others

Esomeprazole-d3

Cat.No: TMIJ-0302

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