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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T4408 |
Elafibranor
GFT505 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Elafibranor (GFT505) 是过氧化物酶体增殖物激活受体-α (PPAR-α) 和过氧化物酶体增殖物激活受体-δ (PPAR-δ) 的激动剂,EC50 值分别为 45 和 175 nM。 | |||
T15575 |
Indeglitazar
PPM 204 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Indeglitazar (PPM 204) 是 PPAR 的泛激动剂,包括亚型 alpha (α)、delta (δ) 和 gamma (γ)。 | |||
T8486 |
GW6471
GW 6471 |
PPAR | DNA Damage/DNA Repair; Metabolism |
GW6471 是一种 PPARα 的拮抗剂 (IC50=0.24 μM),具有选择性,可以增强 PPAR α 配体结合结构域与共抑制蛋白 SMRT 和 NCoR 的结合亲和力。GW6471 具有抗肿瘤活性,可以抑制细胞增殖,诱导细胞凋亡。 | |||
T21587 |
Muraglitazar
Pargluva,BMS-298585 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Muraglitazar (BMS-298585) 是一种 PPAR α/γ的双激动剂,用于治疗2型糖尿病及相关血脂异常。Muraglitazar 对人 PPARα (EC50 = 320 nM)和 PPARγ(EC50 = 110 nM)具有较强的体外活性。 | |||
T27706 |
K-111
BM 170744,K111,K 111,BM170744,BM-170744 |
PPAR | DNA Damage/DNA Repair; Metabolism |
K-111 (BM-170744) 是一种可口服的过氧化物酶体增殖物激活受体 (PPAR)-α 激动剂和胰岛素增强剂,可用于研究肥胖型糖尿病和代谢综合征。 | |||
T17044 |
Tesaglitazar
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Tesaglitazar 是一种有效且具有选择性的过氧化物 PPAR α / γ受体双重激动剂,对 PPARγ的亲和力比 PPARα更有效,对大鼠PPARα和人PPARα的EC50分别为13.4 μM 和3.6 μM,对大鼠PPARγ和人类 PPARγ的EC50都是0.2 μM。Tesaglitazar 诱导大鼠皮下组织间质间充质细胞DNA 合成和纤维肉瘤形成。 | |||
T1415 |
Gemfibrozil
吉非罗齐,CI-719,Jezil,Decrelip,Lopid |
P450; Adrenergic Receptor; PPAR | DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience |
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。 | |||
T10506 |
PPAR agonist 1
|
PPAR | DNA Damage/DNA Repair; Metabolism |
PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol. | |||
T12278 | NXT629 | Estrogen/progestogen Receptor | Endocrinology/Hormones |
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM). | |||
T33415 |
MK 0767
MK0767,MK-0767 |
Others | Others |
MK 0767 is a dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist that has been investigated as a potential treatment for type 2 diabetes and dyslipidemia. | |||
T60432 |
NAAA-IN-3
|
Others | Others |
NAAA-IN-3 (Compound 17a) 是一种有效的、选择性的 NAAA 抑制剂,IC50为 50 nM。NAAA 是一种半胱氨酸酰胺酶,它优先水解内源性生物脂棕榈酰乙醇酰胺 (PEA) 和油酰乙醇酰胺 (OEA)。PEA 是核过氧化物酶体增殖物激活受体-α (PPAR-α) 的内源性激动剂,PPAR-α 是炎症和疼痛的关键调节因子。 NAAA-IN-3 的潜在作用是作为炎症和疼痛的治疗剂。 | |||
T79454 |
Anti-NASH agent 1
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Anti-NASH agent 1 (compound 3d),Elafibranor衍生物,高效PPAR-α/δ激动剂,针对非酒精性脂肪性肝炎(NASH)。以3-10 mg/kg剂量,连续4周处理,能显著改善蛋氨酸胆碱缺乏(MCD)诱导的NASH小鼠高脂血症、肝脏脂肪变性及炎症状况,展现出低肝毒性和良好肝脏保护效能。 | |||
T35813 |
CAY10592
|
Others | Others |
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2824 |
Pedunculoside
|
Others; Fatty Acid Synthase | Metabolism; Others |
Pedunculoside 是从 Ilex rotunda Thunb 中提取的,通过对脂质形成和脂肪酸 β-氧化的调节而发挥降脂作用。 | |||
TN1990 |
Norathyriol
芒果苷元 |
Akt; DNA/RNA Synthesis; AMPK; PPAR | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Norathyriol 是来自芒果的芒果苷代谢物,具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶,IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ,IC50分别为 92.8、102.4 和 153.5 µM。 | |||
T12296 |
Oleoylethanolamide
油酰单乙醇胺,N-Oleoylethanolamide,Oleamide MEA,Oleic acid monoethanolamide |
Endogenous Metabolite; PPAR | DNA Damage/DNA Repair; Metabolism |
Oleoylethanolamide (N-Oleoylethanolamide) 是一种PPAR-α 的高亲和力内源性激动剂,可用于肥胖和动脉硬化的相关研究。 | |||
T2932 |
Ginsenoside Rh1
Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1 |
IL Receptor; TNF; Endogenous Metabolite; PPAR; Interleukin | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Ginsenoside Rh1 (Sanchinoside B2) 是人参的一种主要成分,具有抗炎作用,抑制PPAR-γ,TNF-α,IL-6和IL-1β的表达。 | |||
T2985 |
Gypenoside XLIX
绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX |
PPAR | DNA Damage/DNA Repair; Metabolism |
Gypenoside XLIX 是一种达玛烷型糖苷,是绞股蓝的主要成分。它是选择性过氧化物酶体增殖物激活受体 (PPAR)-α激活剂,可抑制细胞因子诱导的血管细胞粘附分子-1 (VCAM-1) 在人体内皮细胞中过度活跃和表达。 | |||
T2S0633 |
Raspberry ketone
Oxyphenalon,Rasketone,Aloenin,4-(4-Hydroxyphenyl)-2-butanone,p-Hydroxybenzyl acetone,Frambinone,覆盆子酮 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Raspberry ketone (p-Hydroxybenzyl acetone) 是覆盆子中主要的芳香族天然产物,主要用作化妆品的香料和食品增味剂,也可作 PPAR-α激动剂。 | |||
TN3219 |
7,8-Didehydrocimigenol
|
ERK; IκB/IKK; TNF; NF-κB; Akt; PPAR | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression. | |||
TN3655 |
Cimiside E
|
ERK; TNF; ROS; Akt; PI3K; PKC; PPAR | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-06837 |
PPAR alpha/PPARA Protein, Mouse, Recombinant (His)
PPARα,PPAR-alpha,peroxisome proli... |
Mouse | E. coli |
PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204. | |||
TMPY-06830 |
PPAR alpha/PPARA Protein, Human, Recombinant (His)
NR1C1,PPARα,peroxisome proliferator-activa... |
Human | E. coli |
PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869. |