38
3
1
18
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0003 |
Phosphatase Inhibitor Cocktail II (100× DMSO)
磷酸酶抑制剂 Cocktail II (100× DMSO) |
Solution (<em>1</em>00× in DMSO) | Alkaline phosphatases, Ser/Thr phosphatases, Acid and <em>PP</em><em>1</em> and <em>PP</em>2A |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6196 |
PP1
EI 275,AGL 1872 |
Apoptosis; EGFR; Bcr-Abl; Src; c-Kit | Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
PP1 (AGL 1872) 是一种选择性有效 Src 家族抑制剂,抑制 Lck 和Fyn,IC50分别为 5 和 6 nM。 | |||
T2153 |
1-NM-PP1
PP1 Analog II,1 nM-PP1 |
Serine/threonin kinase; CDK; Src | Angiogenesis; Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
1-NM-PP1 (PP1 Analog II) 是一种有效的Src 家族激酶抑制剂,是一种细胞渗透性 PP1 类似物,对 v-Src-as1 与 c-Fyn-as1 的IC50值分别为 4.3 nM、3.2 nM。 | |||
T3935 |
1-Naphthyl PP1
4 -氨基- 1 -叔丁基- 3 -(1' -萘基)吡唑并[3,4 - D]嘧啶,1-NA-PP 1 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
1-Naphthyl PP1 (1-NA-PP 1) 是选择性的src 家族激酶抑制剂,能够抑制 v-Src (IC50:1.0 μM)、c-Fyn (IC50:0.6 μM)、c-Abl (IC50:0.6 μM)、CDK2 (IC50:18 μM) 和 CAMK II (IC50:22 μM)。 | |||
T7371 |
1-Naphthyl PP1 hydrochloride
1-叔丁基-3-(1-萘基)-1H-吡唑并[3,4-D]嘧啶-4-胺盐酸盐,1-NA-PP 1 hydrochloride |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) 是选择性的 src 家族激酶抑制剂,能够抑制 v-Src (IC50:1.0 μM)、c-Fyn (IC50:0.6 μM)、c-Abl (IC50:0.6 μM)、CDK2 (IC50:18 μM)、CAMK II (IC50:22 μM)。 | |||
T21678 |
3MB-PP1
|
PLK | Cell Cycle/Checkpoint |
3MB-PP1是嘌呤类似物,是一种 Polo 样激酶 1 (Plk1) 抑制剂。在表达类似物敏感的 Plk1 等位基因的细胞中,3MB-PP1 通过靶向 Plk1 阻断有丝分裂进程和细胞分裂。3MB-PP1 特异性抑制类似物敏感的 Ssn3 (Cdk8)。3MB-PP1 抑制 Leu93 突变 Zipper-interacting protein kinase(Leu93-ZIPK),IC50为2 μM。3MB-PP1 可用于细胞分裂和白色念珠菌 (Candida albicans) 菌丝形成的研究。 | |||
T41113 |
3BrB-PP1
3BrB-PP1 |
Others | Others |
3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase. It is effective in inhibiting protein kinase with mutations in the ATP-binding pocket, specifically the mutation of Thr97 within Sty1's ATP-binding pocket. | |||
T60718 |
3-IN-PP1
|
Others | Others |
3-IN-PP1是一种针对蛋白激酶D(PKD)家族成员PKD1、PKD2和PKD3具有高效抑制作用的抑制剂,IC50值分别为108、94和108 nM。此外,3-IN-PP1作为一种广谱抗癌剂,能抑制多种肿瘤细胞的生长,适用于癌症研究领域。 | |||
T14022 |
2OH-BNPP1
|
Others | Others |
2OH-BNPP1 是BUB1 kinase 抑制剂,可用于研究癌症。 | |||
T28818 |
SMAPP1
|
Others | Others |
SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells. | |||
TMAZ-0259P |
Anti-TPP1 Monoclonal Antibody-PE
|
||
Anti-TPP1 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-PE can be used ELISA, FACS. | |||
TP1963 |
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide |
||
Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo. | |||
T61782 |
NPP1-IN-1
|
Others | Others |
NPP1-IN-1 is a highly potent inhibitor of NPP enzymes, effectively inhibiting NPP1 with an IC 50 value of 0.15 μM and NPP3 with an IC 50 value of 40 μM [1]. | |||
TMAZ-0259B |
Anti-TPP1 Monoclonal Antibody-Biotin
|
||
Anti-TPP1 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-Biotin can be used ELISA, FACS. | |||
TMAZ-0259A5 |
Anti-TPP1 Monoclonal Antibody-AF555
|
||
Anti-TPP1 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-AF555 can be used ELISA, FACS. | |||
T80291 |
PP113
|
||
PP113是一种具有广谱抗菌性的抗菌肽,能有效作用于多种革兰氏阴性及革兰氏阳性细菌。对E.coli (MIC: 73.3 uM)、B. subtilis (MIC: 23.3 uM)、S. aureus (MIC: 13 uM)、S. lutea (MIC: 16.7 uM)及B. pumilus (MIC: 23.3 uM)表现出不同程度的最小抑菌浓度(MIC)。 | |||
T37431 |
ENPP1 Inhibitor C
ENPP1 Inhibitor C |
Others | Others |
ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM. |1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant brea... | |||
T69560 |
ENPP1 inhibitor 43
|
Others | Others |
ENPP1 inhibitor 43 is a novel small molecule for cancer immunotherapy. | |||
TMAZ-0259A |
Anti-TPP1 Monoclonal Antibody-APC
|
||
Anti-TPP1 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-APC can be used ELISA, FACS. | |||
TMAZ-0259A4 |
Anti-TPP1 Monoclonal Antibody-AF488
|
||
Anti-TPP1 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-AF488 can be used ELISA, FACS. | |||
T80288 |
PP13
|
||
PP13是一种具有广谱抗菌活性的抗菌肽,有效针对多种革兰氏阴性及革兰氏阳性细菌,包括E.coli (MIC: 16.7 uM)、B. subtilis (MIC: 13.3 uM)、S. aureus (MIC: 23.3 uM)、S. lutea (MIC: 8.0 uM)以及B. pumilu (MIC: 9.0 uM)。 | |||
T75913 |
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
|
||
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 为高效且选择性的神经肽 YY5 受体激动剂,其与 hY5 受体的结合 IC50 值为 0.24 nM,已知可促进饮食摄入。 | |||
T80290 |
PP102
|
||
PP102为一种抗菌肽,针对革兰氏阴性及革兰氏阳性细菌展现出抗菌效能,具体作用于B. subtilis(MIC: 25 uM)、S. aureus(MIC: 13 uM)、S. lutea(MIC: 63 uM)和B. pumilu(MIC: 23 uM)。 | |||
T2415 |
PP121
|
Apoptosis; VEGFR; Bcr-Abl; PDGFR; Src; mTOR; Hck | Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
PP121是一种多靶点激酶抑制剂,抑制 PDGFR、Hck、mTOR、VEGFR2、Src、Abl、DNK-PK 的 IC50值分别为2、8、10、12、14、18、60 nM。 | |||
TMAZ-0259A6 |
Anti-TPP1 Monoclonal Antibody-AF647
|
||
Anti-TPP1 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting TPP1. Anti-TPP1 Monoclonal Antibody-AF647 can be used ELISA, FACS. | |||
T3045 |
Salubrinal
|
Apoptosis; Phosphatase; PERK; Autophagy; HSV | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Salubrinal 是一种磷酸酶抑制剂 ,对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂,抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性,并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。 | |||
T32108 |
HXJ42
HXJ-42,HXJ 42 |
Others | Others |
HXJ42 是一种 PP1 类似物,可选择性地有效作用于野生型 ZAP-70 (AS)。 | |||
T2747 |
Endothall
|
Phosphatase; Others | Metabolism; Others |
Endothall 是蛋白磷酸酶 2A (PP2A) 抑制剂,能够抑制PP2A (IC50: 90 nM) 和 PP1 (IC50: 5 uM) 。它可作为除草剂,在癌症化疗过程中也能够发挥作用。 | |||
T14859 |
Calyculin A
(-)-Calyculin A |
Others | Others |
Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM). | |||
T13095 |
Tautomycin
|
Others | Others |
Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus. | |||
T70441 |
1E7-03
|
Others | Others |
1E7-03 is an inhibitor of HIV-1 transcription, by targeting host Protein Phosphatase-1 (PP1). | |||
T68749 |
EBOV-IN-C31
|
Others | Others |
EBOV-IN-C31 is a novel PP1-targeting Ebola Virus (EBOV) inhibitor with improved pharmacological properties. | |||
TP2054 |
Calcineurin Autoinhibitory Peptide
|
||
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). | |||
TP1698 |
Microcystin-LA
|
||
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively. | |||
T39183 |
Okadaic acid ammonium salt
|
Others | Others |
Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation. | |||
T68458 |
Fostriecin (free base)
|
Others | Others |
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM, respectively) and does not inhibit PP2B. Through its effects on protein phosphatases, fostriecin increases the level of histone H3 phosphorylation and may alter epigenetic regulation of cell proliferation. On a related note, fostriecin was first identified as an antitumor antib... | |||
T68721 |
Cantharidin imide
|
Others | Others |
Cantharidin imide is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity of osteoclasts. This compound can produce severe skin inflammation, and is extremely toxic if ingested orally. | |||
T35613 |
Cytostatin (sodium salt)
|
Others | Others |
Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect agai... | |||
T35777 |
Nodularin
|
Others | Others |
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory eff... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
T16381 |
Okadaic acid
|
Others | Others |
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halic | |||
T37055 |
Cytostatin
|
Others | Others |
Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00499 |
PPP1CA Protein, Canine, Recombinant (His & Myc)
PPP1CA,Serine/threonine-protein phosphatas... |
Canine | E. coli |
PPP1CA Protein, Canine, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-02098 |
PPP1CB Protein, Human, Recombinant (His)
PPP1CB,Serine/threonine-protein phosphatas... |
Human | E. coli |
PPP1CB Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00944 |
PPP1CC Protein, Human, Recombinant (His)
PP-1G,Serine/Threonine-Protein Phosphatase... |
Human | E. coli |
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1C... | |||
TMPJ-01261 |
PPP1R14A Protein, Human, Recombinant (His)
17 kDa PKC-Potentiated Inhibitory Protein of PP... |
Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA su... | |||
TMPY-02767 |
TPP1 Protein, Human, Recombinant (His)
tripeptidyl peptidase I,CLN2,TPP-1,SCAR7,G... |
Human | Baculovirus Insect Cells |
TPP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.7 kDa and the accession number is AAH14863.1. | |||
TMPH-01948 |
PPP1R3G Protein, Human, Recombinant (His & Myc)
PPP1R3G,Protein phosphatase 1 reg... |
Human | E. coli |
Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits. PPP1R3G Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.5 kDa and the accession number is B7ZBB8. | |||
TMPJ-00528 |
PPP1R1A Protein, Human, Recombinant (His)
PPP1R1A,I-1,IPP... |
Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein plays important function. Hormones can elevate intracellular cAMP level and elevate IPP-1 activity. PPP1R1A activation caused cAMP increase , cAMP control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium. IPP-1 is inactivated by cal... | |||
TMPK-00854 |
ENPP1 Protein, Human, Recombinant (C-His)
M6S1,E-NPP 1,PCA1,PDNP |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (C-His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413. | |||
TMPH-01947 |
PPP1R15A Protein, Human, Recombinant (His)
Growth arrest and DNA damage-inducible protein GADD34,Protei... |
Human | E. coli |
PPP1R15A Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-05215 |
TPP1 Protein, Mouse, Recombinant (His)
TPP-1,TPP-I,tripeptidyl peptidase... |
Mouse | Baculovirus Insect Cells |
TPP1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.9 kDa and the accession number is O89023. | |||
TMPK-00852 |
ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated
E-NPP 1,NPPase,PC1,N... |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 98.29 kDa and the accession number is P22413. | |||
TMPJ-01207 |
UPP1 Protein, Human, Recombinant (His)
UPP1,Uridine Phosphorylase 1,U |
Human | E. coli |
Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c... | |||
TMPJ-00984 |
INPP1 Protein, Human, Recombinant (His)
IPP,IPPase,Inositol Polyphosphate 1 |
Human | HEK293 Cells |
Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibited by Li+. Removing the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. INPP1 is involved in signal transduction and phosphatidylinositol signaling pathway. | |||
TMPY-01854 |
DPP10 Protein, Human, Recombinant (His)
DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 1 |
Human | HEK293 Cells |
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p... | |||
TMPJ-01390 |
MINPP1 Protein, Human, Recombinant (His)
3,4,5)-Tetrakisphosphate 3-Phosphatase,2,5)P(4) 3-Phosphatas... |
Human | HEK293 Cells |
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re... | |||
TMPK-00853 |
ENPP1 Protein, Human, Recombinant (N-His)
PDNP1,NPP1,NPPase,PCA |
Human | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Human, Recombinant (N-His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 96.5 kDa and the accession number is P22413. | |||
TMPK-00781 |
ENPP1 Protein, Mouse, Recombinant (His)
ENPP1,PC1,PCA1ARHR2,PCA<... |
Mouse | HEK293 Cells |
Ectonucleotide pyrophosphatase/phosphodiesterase (ENPP)-1 is a membrane-bound protein that catalyzes the hydrolysis of extracellular nucleoside triphosphates to monophosphate and extracellular inorganic pyrophosphate (ePPi). Mechanical stimulation regulates ENPP-1 expression. ENPP1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 95.99 kDa and the accession number is P06802-1. | |||
TMPJ-00870 |
NCK1 Protein, Human, Recombinant (His)
SH2/SH3 Adaptor Protein NCK-α,SH2/SH3 Adaptor Protein NCK-Al... |
Human | E. coli |
Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing... |