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Search Results for " plc "

Targets Recommended: Others

28

抑制剂 & 化合物

5

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23101	o-3M3FBS	Others	Others
	o-3M3FBS 是 m-3M3FBS 的阴性对照。它以独立于 PLC 的机制及拮抗方式抑制内向和外向电流。它以与 m-3M3FBS 竞争的方式增加 [Ca2+]i 增加。
T15044	D609	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	D609 (Tricyclodecan-9-yl-Xanthogenate) 具有广泛的生物活性，包括抗氧化、抗凋亡、抗胆碱能、抗肿瘤、抗炎、抗病毒、抗增殖和神经保护活性。D609 通过引起磷脂酰胆碱 (PC) 特异性磷脂酶 C (PC-PLC) 和鞘磷脂合酶 (SMS) 的竞争性抑制来发挥作用。
TQ0159	U-73343 U 73343	Phospholipase	Metabolism
	U-73343 是一种 U-73122 的无活性类似物，能够剂量依赖性的抑制酸分泌，可作为 U-73122 的阴性对照。其中 U 73122 是一种有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂，对磷脂酶 C 的 IC50值约为 1-2.1 µM。
T6243	U-73122 U73122	Phospholipase; Ferroptosis; Lipoxygenase	Apoptosis; Metabolism
	U-73122 (U73122) 是一种磷脂酶 C 和 5-脂氧合酶抑制剂，对磷脂酶 C 的 IC50值约为 1-2.1 µM。它是一种 PLC 抑制剂，可减少激动剂诱导的血小板和 PMN 中的 Ca2+ 增加。
T8531	m-3M3FBS 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺	Apoptosis; Phospholipase	Apoptosis; Metabolism
	m-3M3FBS 是一种有效的磷脂酶C 激活剂，刺激人中性粒细胞产生超氧物，上调细胞内钙离子浓度，刺激多种细胞产生磷酸肌醇。它诱导单核细胞白血病细胞凋亡。
T14903	CCT129957	Calcium Channel; Phospholipase	Membrane transporter/Ion channel; Metabolism
	CCT129957 是一种新型有效的磷脂酶 C-γ (PLC-γ) 抑制剂，IC50 约为 3 μM，GC50 为 15 μM。CCT129957 具有抗癌活性，在鳞状细胞中抑制 Ca2+ 的释放。
T3132	SC66	Apoptosis; Akt	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	SC66 是一种Akt 抑制剂，可降低细胞活力。它以剂量和时间依赖性地抑制肝癌细胞的集落形成和诱导凋亡。
T21815	ONO-RS-082	Others	Others
	ONO-RS-082 是磷脂酶 A 抑制剂。它抑制PLA2的IC50值为1.0 μM，但即使浓度达到 100 μM 也不抑制 PLC。
T10115	3-Nitrocoumarin 3-nitrochromen-2-one	Phospholipase	Metabolism
	3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。
T68752	Manoalide	Others	Others
	Manoalide，一种类萜化合物，有效抑制磷脂酶A2（PLA2）和磷脂酶C（PLC），具有抗炎和抗菌活性。
T37434	p-Nitrophenylphosphorylcholine	Others	Others
	p-Nitrophenylphosphorylcholine is a chromogenic substrate that is used to measure phospholipase C (PLC) activity. Hydrolysis of p-nitrophenylphosphorylcholine by PLC results in the liberation of p-nitrophenol, which can be measured at 405 nm at pH 7.2-7.5.
T74068	WH-15	Others	Others
	WH-15 是一种荧光 PLC 报告基因，对 PLC-γ1、PLC-δ1、PLC-β2 的 Km 值分别为 49、30、86.1 μM。WH-15 可在级联反应中裂解，生成荧光 6-氨基喹啉。WH-15 可用于响应活细胞中的 PLC 成像。
TP1950	PEN(mouse) PEN (mouse)
	Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide. Activates phospholipase C (PLC)-mediated signaling cascade in mouse hypothalamus.
T35934	D-myo-Inositol-1,4,5-triphosphate (potassium salt)	Others	Others
	D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.
T85301	ABO hydrochloride	Others	Others
	ABO acts as an annexin A7 modulator, specifically binding to Thr286 to inhibit its phosphorylation on threonine (not on serine or tyrosine) residues within human umbilical vein endothelial cells (HUVECs). This compound furthers the annexin A7 interaction with the EF-hand protein GCA, leading to reduced GCA phosphorylation, lowered intracellular calcium levels, and enhanced autophagy in COS-7 cells. Moreover, ABO lessens phosphorylation of the microtubule-associated protein 1 light chain (LC3) in...
T35936	D-myo-Inositol-1,4,6-triphosphate (sodium salt)	Others	Others
	D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in int...
T35938	D-myo-Inositol-4-phosphate (ammonium salt)	Others	Others
	D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intr...
T37060	D-myo-Inositol-1,3-diphosphate (sodium salt)	Others	Others
	D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in in...
T37691	Phosphatidic Acids (egg) (ammonium salt)	Others	Others
	Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others. It has roles in shaping cellular membranes, cellular ...
T36668	Geranylgeranoic Acid	Others	Others
	Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also...
T37057	D-myo-Inositol-1,2-diphosphate (sodium salt)	Others	Others
	Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2)P2 (te...
T37028	PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)	Others	Others
	The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal ...
T36907	1-Oleoyl Lysophosphatidic Acid Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid	Others	Others
	1-Oleoyl lysophosphatidic acid is a species of lysophosphatidic acid (LPA) containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of phospholipase D (PLD) or through a two step process involving liberation of diacylglycerol (DAG) by phospholipase C (PLC) followed by phosphorylation of DAG by diglycerol kinase.[1] Hydrolysis of the fatty acid at the sn-2 position by phospholipase A2 (PLA2) yields bioactive LPA. LPA binds to one of five differe...
T36939	PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)	Others	Others
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd...
T6345	Tirbanibulin KX2-391,KX-01	Microtubule Associated; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tirbanibulin (KX2-391) 是一种高度选择性的 Src 激酶抑制，靶向 Src 的多肽底物结合位点，对多种癌症有疗效。
T36844	Inostamycin A	Others	Others
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...
T15675	Tirbanibulin Mesylate KX2-391 Mesylate,KX01 Mesylate	Microtubule Associated; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tirbanibulin Mesylate (KX01 Mesylate) 是一种 Src 抑制剂，靶向 Src 的肽底物位点。在肿瘤细胞中，GI50值为 9-60 nM。
T15674	Tirbanibulin dihydrochloride KX-01 (dihydrochloride),KX2-391 (dihydrochloride)	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

化合物

Cat.No: T23101

Target: Others

Cat.No: T15044

Target: Apoptosis, Antioxidant

Cat.No: TQ0159

Synonym: U 73343

Target: Phospholipase

Cat.No: T6243

Synonym: U73122

Target: Phospholipase, Ferroptosis, Lipoxygenase

Cat.No: T8531

Synonym: 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺

Target: Apoptosis, Phospholipase

Cat.No: T14903

Target: Calcium Channel, Phospholipase

Cat.No: T3132

Target: Apoptosis, Akt

Cat.No: T21815

Target: Others

3-Nitrocoumarin

Cat.No: T10115

Synonym: 3-nitrochromen-2-one

Target: Phospholipase

Cat.No: T68752

Target: Others

p-Nitrophenylphosphorylcholine

Cat.No: T37434

Target: Others

Cat.No: T74068

Target: Others

Cat.No: TP1950

Synonym: PEN (mouse)

D-myo-Inositol-1,4,5-triphosphate (potassium salt)

Cat.No: T35934

Target: Others

ABO hydrochloride

Cat.No: T85301

Target: Others

D-myo-Inositol-1,4,6-triphosphate (sodium salt)

Cat.No: T35936

Target: Others

D-myo-Inositol-4-phosphate (ammonium salt)

Cat.No: T35938

Target: Others

D-myo-Inositol-1,3-diphosphate (sodium salt)

Cat.No: T37060

Target: Others

Phosphatidic Acids (egg) (ammonium salt)

Cat.No: T37691

Target: Others

Geranylgeranoic Acid

Cat.No: T36668

Target: Others

D-myo-Inositol-1,2-diphosphate (sodium salt)

Cat.No: T37057

Target: Others

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

Cat.No: T37028

Synonym: PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

Target: Others

1-Oleoyl Lysophosphatidic Acid

Cat.No: T36907

Synonym: Oleoyl-sn-3-Glycerophosphate,1-Oleoyl LPA,1-Oleoyl Lysophosphatidic Acid

Target: Others

PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Cat.No: T36939

Synonym: PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)

Target: Others

Cat.No: T6345

Synonym: KX2-391,KX-01

Target: Microtubule Associated, Src

Cat.No: T36844

Target: Others

Tirbanibulin Mesylate

Cat.No: T15675

Synonym: KX2-391 Mesylate,KX01 Mesylate

Target: Microtubule Associated, Src

Tirbanibulin dihydrochloride

Cat.No: T15674

Synonym: KX-01 (dihydrochloride),KX2-391 (dihydrochloride)

Target: Src

Cat. No.	Product Name	Target	Signaling Pathways
T70955	Vinaxanthone SM-345431	Phospholipase; Antibacterial	Metabolism; Microbiology/Virology
	Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T73812	Phosphatidylinositol 4,5-bisphosphate	Others	Others
	Phosphatidylinositol 4,5-bisphosphate（L-alpha-Phosphatidylinositol-4,5-bisphosphate）为细胞膜磷脂成分，主要作为磷脂酶C（PLC）与磷酸肌醇3-激酶（PI3K）的底物，充当重要信使。
TN2685	2,3,24-Trihydroxy-12-ursen-28-oic acid	Antifection	Microbiology/Virology
	2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
T83864	Plipastatin A1 SNA-60-367-3,Fengycin IX	Others	Others
	Plipastatin A1是一种在B. cereus中发现的脂肽类化合物，具有酶抑制活性和免疫抑制活性。它能抑制磷脂酶A2（PLA2）、PLC和PLD（IC50分别为2.9、1.3和1.4 µM）。Plipastatin A1（100 µg/ml）能抑制LPS诱导的B细胞爆发生成和Concanavalin A诱导的T细胞爆发生成。在体内，Plipastatin A1（0.1 mg/动物）能抑制小鼠的迟发型超敏反应。

天然产物

Cat.No: T70955

Synonym: SM-345431

Target: Phospholipase, Antibacterial

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Phosphatidylinositol 4,5-bisphosphate

Cat.No: T73812

Target: Others

2,3,24-Trihydroxy-12-ursen-28-oic acid

Cat.No: TN2685

Target: Antifection

Cat.No: T83864

Synonym: SNA-60-367-3,Fengycin IX

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03169	PLC-H Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) Phosphatidylcholine cholinephosphohydrolase,Hemolytic phosph...	Pseudomonas aeruginosa	E. coli
	Hydrolyzes sphingomyelin in addition to phosphatidylcholine. PLC-H Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 64.3 kDa and the accession number is P06200.
TMPH-00421	Phospholipase C Protein, Clostridium perfringens, Recombinant (His) Phospholipase C,plc,Alpha-toxin,Hemolysin,Phosphati...	C.perfringens	E. coli
	Phospholipase C Protein, Clostridium perfringens, Recombinant (His) is expressed in E. coli.
TMPH-00321	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO) Rhodoaggretin subunit alpha,Aggretin alpha chain,Snaclec rho...	Calloselasma rhodostoma	E. coli
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodo...
TMPH-00320	Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His) Rhodoaggretin subunit alpha,Aggretin alpha chain,Snaclec rho...	Calloselasma rhodostoma	P. pastoris (Yeast)
	Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial. Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodo...

重组蛋白

PLC-H Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03169

Species: Pseudomonas aeruginosa

Expression System: E. coli

Phospholipase C Protein, Clostridium perfringens, Recombinant (His)

Cat.No: TMPH-00421

Species: C.perfringens

Expression System: E. coli

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His & SUMO)

Cat.No: TMPH-00321

Species: Calloselasma rhodostoma

Expression System: E. coli

Snaclec rhodocytin subunit alpha Protein, Calloselasma rhodostoma, Recombinant (His)

Cat.No: TMPH-00320

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

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