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Search Results for " pk 3 "

Targets Recommended: Others

35

抑制剂 & 化合物

64

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T24646	PK-3 CID-20959075,CID 20959075,CID20959075	Others	Others
	PK-3 is a cancer cell growth inhibitor. It also has microtubule-binding activity.
T4459	PK11000	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型p53的 DNA 结合结构域。
T2461	PIK-90	DNA-PK; PI3K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK90 PIK-90 是一种 DNA-PK 和 PI3K 抑制剂，抑制 p110α、p110γ和DNA-PK，IC50分别为 11、18 和 13 nM。
T3986	SF2523	DNA-PK; Epigenetic Reader Domain; PI3K; mTOR	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	SF2523 是一种选择性PI3K 抑制剂，抑制DNA-PK、PI3Kα、PI3Kγ、BRD4 和 mTOR，IC50分别为 9 nM、34 nM、158 nM、241 nM 和 280 nM。
T6557	KU-0060648 KU0060648	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	KU-0060648 是一种 PI3K 和 DNA-PK 的双重抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 DNA-PK 的 IC50值分别为 4 nM、0.5 nM、0.1 nM、0.59 nM 和 8.6 nM。
T6143	PI-103 PI103,PI 103	Apoptosis; DNA-PK; PI3K; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI-103 是一种 PI3K 和 mTOR 抑制剂，抑制 p110α、p110β、p110δ、p110γ、mTORC1和 mTORC2，IC50分别为 8 nM、88 nM、48 nM、150 nM、20 nM 和 83 nM。它可诱导自噬，还抑制 DNA-PK，IC50为 2 nM。
T25399	ETP-45658 ETP45658,ETP 45658	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ETP-45658 (ETP45658) 是一种PI3K 抑制剂，抑制PI3Kα、PI3Kδ、PI3Kβ和PI3Kγ的IC50值分别为 22.0、39.8、129.0 和 717.3 nM。它可研究癌症，还抑制DNA-PK 和mTOR，IC50分别为70.6 和 152 nM。
T2667	PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK75 是一种可逆的DNA-PK 和p110α-选择性的抑制剂，抑制 DNA-PK、p110α 和 p110γ，IC50分别为 2、5.8 和 76 nM。它诱导凋亡，抑制 p110α 效果比抑制 p110β 高 200 多倍，p110β的IC50为 1.3 μM。
T7122	AZD-7648	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂，在酶试验中 IC50 为 0.63 nM，具有抗肿瘤活性。
T6883	Samotolisib GTPL8918,LY3023414	DNA-PK; PI3K; mTOR; Autophagy	Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Samotolisib (LY3023414) 在低纳摩尔浓度下，有效抑制mTORC1/2。它选择性地有效抑制PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ、DNA-PK 和mTOR，IC50分别为 6.07 nM、77.6 nM、38 nM、23.8 nM、4.24 nM 和 165 nM。它可用于多种肿瘤和癌症的试验。
T61751	DNA-PK-IN-3	Others	Others
	DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].
T13017	STL127705 Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione	DNA-PK; Others	DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling
	STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂，抑制 Ku70/80-DNA 相互作用，IC50 为 3.5 μM。它抑制 Ku 依赖性 DNA-PKCS 激酶的激活，IC50 为 2.5 μM。
T2008	LY294002 LY 294002,NSC 697286,SF 1101	Apoptosis; DNA-PK; Casein Kinase; PI3K; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	LY294002 (SF 1101) 是一种 PI3K 的广谱抑制剂，抑制 PI3Kα、PI3Kδ 和 PI3Kβ (IC50=0.5/0.57/0.97 μM)。LY294002 也是 DNA-PK 抑制剂 (IC50=1.4 μM) 和 CK2 抑制剂 (IC50=98 nM)。LY294002 可以激活凋亡和自噬。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T2287	PIK-75 hydrochloride PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂，抑制 DNA-PK，p110α和 p110γ，可诱导凋亡。
T12672	(Rac)-Nedisertib (Rac)-M3814	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	(Rac)-Nedisertib is a racemate of Nedisertib, a potent inhibitor of DNA-PK(IC50 of <3 nM).
T6283	Wortmannin SL-2052,渥曼青霉素,KY-12420	ATM/ATR; DNA-PK; Serine/threonin kinase; PLK; PI3K; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Wortmannin (SL-2052) 是一种 PI3K 抑制剂 (IC50=3 nM)，具有共价性和不可逆性。Wortmannin 也是一种 PlK1 和 PlK3 的抑制剂 (IC50=5.8/48 nM)，可以阻断自噬。
T24648	PK-THPP	Others	Others
	PK-THPP is a channel blocker of TASK-3.
T32007	GSK256471 GSK 256471,GSK-256471	Others	Others
	GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment showed that GSK256471 reduced the E(Ma
T11381	Pictilisib dimethanesulfonate GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt	Apoptosis; DNA-PK; PI3K; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) 是一种 PI3Kα/δ抑制剂，IC50值为 3 nM。对 p110β 和 p110γ的选择性分别为11倍和25倍。
T32004	GSK172981 GSK 172981,GSK-172981	Others	Others
	GSK172981 is a non-peptide tachykinin NK3 receptor antagonist with a high affinity for the recombinant human (PK (I) value 7.7) and native guinea pig (PK (I) value 7.8) tachykinin NK3 receptor. In vitro, the functional evaluation showed that GSK172981 was
T72999	PF-06455943	Others	Others
	PF-06455943, 作为一种LRRK2 (富含亮氨酸的重复激酶 2) 抑制剂，具有3 nM的IC50值，主要用于帕金森病（PD）的研究。
T75880	GR 94800 TFA
	GR 94800 TFA 是有效的、选择性的神经激肽 2(NK2)受体的肽类拮抗剂，其对 NK2、NK1和 NK3受体的 pKB 值分别为 9.6、6.4 和 6.0。
T78975	IDO1-IN-22	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-22（Compound 3）是一种效能显著的IDO1抑制剂，具备低纳摩尔级生化活性（hIDO1 IC50：67.4 nM）以及显著的细胞内抑制效果（HeLa细胞中hIDO1 IC50：17.6 nM）。在小鼠LLC异种移植模型中表现出卓越的抗肿瘤效果，并表现出有利的药代动力学（PK）特性。
T72591	Sp-5,6-DCl-cBIMPS	Others	Others
	Sp-5,6-DCl-cBIMPS 为一种高效特异的 cAMP 依赖性蛋白激酶(cAMP-PK)激活剂，能够促进胰岛素释放，并抑制U46619引起的血小板Rho、Gq及G12/G13的激活[3]。
T76431	GR 83074
	GR 83074 是一种有效的选择性 NK-2(Neurokinin Receptor) 拮抗剂，pKB 为 8.23。GR 83074 对 NK-3 没有活性，并表现出 340 倍的 NK-2/NK-1 选择性。
T6143L	PI-103 Hydrochloride	Others	Others
	PI-103 Hydrochloride 是一种有效的PI3K 和mTOR 双重抑制剂，抑制p110α，p110β，p110δ，p110γ，mTORC1和mTORC2，IC50分别为 8 nM，88 nM，48 nM，150 nM，20 nM 和 83 nM。PI-103 Hydrochloride 也可抑制DNA-PK，IC50为 2 nM。PI-103 Hydrochloride 诱导细胞自噬 (autophagy)。
T75245	Canfosfamide	Others	Others
	Canfosfamide (TLK-286) 是一种谷胱甘肽类似物前体药物，由谷胱甘肽 S-转移酶 P1-1 激活，诱导细胞凋亡 (apoptosis)。Canfosfamide 还抑制 DNA 依赖性蛋白激酶 (DNA-PK) 的催化激酶活性。Canfosfamide 在活化后产生一种抗癌烷基化剂和谷胱甘肽衍生物。Canfosfamide 可用于恶性肿瘤的研究。
T75248	Pasireotide (diaspartate)	Others	Others
	Pasireotide (SOM230) diaspartate 是一种长效的环己肽生长激素抑制素类似物，可以提高生长抑素受体的激动剂活性，对sst1/2/3/4/5的pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide diaspartate 具有抗分泌、抗增殖和促凋亡活性。
T73301	ATR-IN-20	Others	Others
	ATR-IN-20是一种高效的ATR(ATM/ATR)抑制剂, IC50值仅为3 nM。该化合物还能抑制mTOR(IC50值为18 nM)，并展示出对PI3Kα(100 nM)、ATM(100 nM)和DNA-PK(662 nM)的良好选择性。ATR-IN-20具备优秀的药代动力学属性(F=30%)，同时显示了其抗癌潜力。
T71510	MF-592	Others	Others
	MF-592 is a potent and selective antagonists of the EP4 receptor. MF-592 demonstrated good functional potency (hEP4 IC50 = 3 nM) and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB) (IC50 = 78nM). In addition, it showed an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model (ED50 = 0.1 mg/kg/day).. MF-592 has a desirable overall preclinical profile that suggests it is suitable for further de...
T38298	Tuberculosis inhibitor 3	Others	Others
	Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].
T27595	Imarikiren HCl TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272	Others	Others
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 >
T84998	QLT0267	Others	Others
	QLT0267 is an inhibitor targeting integrin-linked kinase (ILK; IC50= 26 nM), showing over 10-fold selectivity against cyclin-dependent kinases 1, 2, and 5 (Cdk1, Cdk2, and Cdk5), and over 1,000-fold selectivity against C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2) at a concentration of 10 mg/ml. This compound effectively inhibits the proliferation of NPA187 papillary thyroid cancer cells with an IC50 of approximately 3 µM and induces apoptosis in NPA187, DRO, an...
T10396	ATM Inhibitor-1	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM).

化合物

Cat.No: T24646

Synonym: CID-20959075,CID 20959075,CID20959075

Target: Others

Cat.No: T4459

Target: DNA Alkylator/Crosslinker

Cat.No: T2461

Target: DNA-PK, PI3K

Cat.No: T3986

Target: DNA-PK, Epigenetic Reader Domain, PI3K, mTOR

Cat.No: T6557

Synonym: KU0060648

Target: DNA-PK, PI3K, mTOR

Cat.No: T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T25399

Synonym: ETP45658,ETP 45658

Target: DNA-PK, PI3K, mTOR

Cat.No: T2667

Target: Apoptosis, DNA-PK, PI3K

Cat.No: T7122

Target: DNA-PK

Cat.No: T6883

Synonym: GTPL8918,LY3023414

Target: DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T61751

Target: Others

Cat.No: T13017

Synonym: Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

Target: DNA-PK, Others

Cat.No: T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

PIK-75 hydrochloride

Cat.No: T2287

Synonym: PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75

Target: Apoptosis, DNA-PK, PI3K

(Rac)-Nedisertib

Cat.No: T12672

Synonym: (Rac)-M3814

Target: DNA-PK

Cat.No: T6283

Synonym: SL-2052,渥曼青霉素,KY-12420

Target: ATM/ATR, DNA-PK, Serine/threonin kinase, PLK, PI3K, Antibiotic, Autophagy

Cat.No: T24648

Target: Others

Cat.No: T32007

Synonym: GSK 256471,GSK-256471

Target: Others

Pictilisib dimethanesulfonate

Cat.No: T11381

Synonym: GDC-0941 dimethanesulfonate,GDC-0941 2 MeSO3H salt

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Cat.No: T32004

Synonym: GSK 172981,GSK-172981

Target: Others

Cat.No: T72999

Target: Others

Cat.No: T75880

Cat.No: T78975

Target: Indoleamine 2,3-Dioxygenase (IDO)

Sp-5,6-DCl-cBIMPS

Cat.No: T72591

Target: Others

Cat.No: T76431

PI-103 Hydrochloride

Cat.No: T6143L

Target: Others

Cat.No: T75245

Target: Others

Pasireotide (diaspartate)

Cat.No: T75248

Target: Others

Cat.No: T73301

Target: Others

Cat.No: T71510

Target: Others

Tuberculosis inhibitor 3

Cat.No: T38298

Target: Others

Cat.No: T27595

Synonym: TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl |,TAK272,TAK 272,TAK-272

Target: Others

Cat.No: T84998

Target: Others

ATM Inhibitor-1

Cat.No: T10396

Target: ATM/ATR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04766	PKM2 Protein, Mouse, Recombinant (His) AL024424,AA414905,Pk3,Pk-3	Mouse	Baculovirus Insect Cells
	PKM2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60 kDa and the accession number is P52480-2.
TMPY-04553	AKT3 Protein, Human, Recombinant (GST) PRKBG,RAC-γ,RAC-PK-γ,MPPH,PKB-γ,PK	Human	Baculovirus Insect Cells
	AKT3 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 81 kDa and the accession number is Q9Y243-1.
TMPY-04465	PKM2 Protein, Human, Recombinant (His) pyruvate kinase, muscle,OIP3,CTHBP,PK3...	Human	E. coli
	PKM2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 59 kDa and the accession number is P14618-1.
TMPY-06986	FGF-8b Protein, Human, Recombinant NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-00132	Mesothelin Protein, Human, Recombinant MPF,SMRP,Mesothelin	Human	HEK293 Cells
	Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.
TMPY-04935	CD47 Protein, Human, Recombinant (aa 1-139, His) MER6,CD47 molecule,IAP,OA3	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3.
TMPY-03763	Neuropilin-2 Protein, Human, Recombinant (hFc) Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP2	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.
TMPY-05191	CD47 Protein, Human, Recombinant, Biotinylated CD47 molecule,MER6,OA3,IAP	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-00072	GITR/TNFRSF18 Protein, Human, Recombinant (His) AITR,GITR-D,tumor necrosis factor receptor superfamily, memb...	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
TMPY-04683	CD47 Protein, Human, Recombinant MER6,CD47 molecule,OA3,IAP	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-00892	Neuropilin-2 Protein, Human, Recombinant (His) NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-2	Human	HEK293 Cells
	Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3.
TMPY-01897	PRSS3 Protein, Human, Recombinant (His) PRSS4,TRY4,TRY3,RP11-176F3.3,T9,M...	Human	HEK293 Cells
	Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His) PN,OSF-2,OSF2,periostin,periostin, osteoblast specific facto...	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc) ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa...	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP) Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPY-04142	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re...	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
TMPY-05748	CD45 Protein, Human, Recombinant (aa 26-577, His) L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72	Human	HEK293 Cells
	CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3.
TMPJ-01099	IL-15RA Protein, Human, Recombinant (hFc, Human Cells) interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...	Human	HEK293 Cells
	Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPY-00357	HNT/NTM Protein, Human, Recombinant (His) HNT,NTRI,IGLON2,neurotrimin	Human	HEK293 Cells
	HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3.
TMPY-04298	CDCP1 Protein, Human, Recombinant (His) TRASK,CD318,CUB domain containing protein 1,SIMA1	Human	HEK293 Cells
	CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3.
TMPY-00480	NCAM1 Protein, Human, Recombinant (His) neural cell adhesion molecule 1,CD56,MSK39,NCAM	Human	HEK293 Cells
	NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
TMPY-03621	EphB2 Protein, Mouse, Recombinant (hFc) Tyro5,Erk,Qek5,ETECK,Hek5,Drt,EPH receptor B2,Nuk,Prkm5,Sek<...	Mouse	HEK293 Cells
	EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.6 kDa and the accession number is P54763-3.
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST) SET and MYND domain containing 3,ZMYND1,KMT3	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg...
TMPY-03149	CDCP1 Protein, Human, Recombinant (mFc) TRASK,SIMA135,CD318,CUB domain containing ...	Human	HEK293 Cells
	CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3.
TMPY-04386	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) PCBC,CAPB,Hek5,EK5,EPHT3,EPH receptor B2,Tyro5,DRT,...	Human	Baculovirus Insect Cells
	EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.2 kDa and the accession number is P29323-3.
TMPK-00447	CD45 Protein, Human, Recombinant (aa 26-577, hFc) CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3....	Human	HEK293 Cells
	PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577...
TMPJ-01288	KLF6 Protein, Human, Recombinant CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige...	Human	E. coli
	Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul...
TMPY-00276	PLGF/PGF Protein, Human, Recombinant (mFc) placental growth factor,D12S1900,PLGF,SHGC-10760,PGFL,PlGF-2	Human	HEK293 Cells
	PLGF/PGF Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P49763-3.
TMPY-04015	COL9A1 Protein, Human, Recombinant (mFc) DJ149L1.1.2,STL4,collagen, type IX, alpha 1,MED,EDM6,collage...	Human	HEK293 Cells
	COL9A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 59.2 kDa and the accession number is P20849-3.
TMPY-06411	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated CD357,GITR-D,tumor necrosis factor receptor superfa...	Human	HEK293 Cells
	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3.
TMPY-05514	RANK/TNFRSF11A Protein, Human, Recombinant (mFc) OFE,RANK,OPTB7,FEO,tumor necrosis factor receptor superfamil...	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3.
TMPY-03960	COL9A1 Protein, Human, Recombinant (His) EDM6,collagen, type IX, α1,STL4,collagen, type IX, alpha 1,M...	Human	HEK293 Cells
	COL9A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is P20849-3.
TMPK-00398	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) Fibroblast growth factor receptor 2,CD332,...	Human	HEK293 Cells
	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPK-00401	FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated ECT1,K-SAM,CD332,CEK3,FGFR2 α,CFD...	Human	HEK293 Cells
	Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs.
TMPJ-00391	FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) FGF R2b,KGFR,BFR-1,FGFR2 β,FGFR2b,FGFR2,FGFR2 beta,CD3	Human	HEK293 Cells
	FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3.
TMPY-04216	EphB2 Protein, Mouse, Recombinant (His) Drt,Nuk,Qek5,Tyro5,Prkm5,Sek3,ETECK,Cek5,Hek5,EPH r...	Mouse	HEK293 Cells
	EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is P54763-3.
TMPY-00715	CD84 Protein, Human, Recombinant (His) LY9B,mCD84,CD84 molecule,hCD84,SLAMF5	Human	HEK293 Cells
	CD84 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9UIB8-3.
TMPY-03883	CD47 Protein, Human, Recombinant (hFc) OA3,CD47 molecule,IAP,MER6	Human	HEK293 Cells
	CD47 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is Q08722-3.
TMPY-02573	IL-17RC Protein, Human, Recombinant (aa 1-454, His) IL17RL,interleukin 17 receptor C,IL17-RL,UNQ6118/PRO20040/PR...	Human	Baculovirus Insect Cells
	IL-17RC Protein, Human, Recombinant (aa 1-454, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.6 kDa and the accession number is Q8NAC3-3.
TMPY-01656	VEGF183 Protein, Human, Recombinant 血管内皮生长因子,VEGF165,VPF,VEGF,vascular endothelial growth factor...	Human	Baculovirus Insect Cells
	VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3.
TMPY-03969	SUSD4 Protein, Human, Recombinant (mFc) sushi domain containing 4,PRO222	Human	HEK293 Cells
	SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical path...
TMPJ-00465	PTP1C Protein, Human, Recombinant (His) HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-PTP1,...	Human	E. coli
	Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter...
TMPY-01692	NETO1 Protein, Human, Recombinant (His) neuropilin (NRP) and tolloid (TLL)-like 1,BCTL1,BTCL1	Human	HEK293 Cells
	Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus repr...
TMPY-03705	VEGF164 Protein, Canine, Recombinant 血管内皮生长因子,vascular endothelial growth factor A	Canine	HEK293 Cells
	VEGF164 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 17 kDa and the accession number is Q9MYV3-3.
TMPY-05590	NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated NCAM,MSK39,CD56,neural cell adhesion molecule 1	Human	HEK293 Cells
	NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 67.9 kDa and the accession number is P13591-3.
TMPY-04157	RANK/TNFRSF11A Protein, Human, Recombinant (His) ODFR,OFE,CD265,PDB2,RANK,tumor necrosis factor receptor supe...	Human	HEK293 Cells
	RANK/TNFRSF11A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.5 kDa and the accession number is Q9Y6Q6-3.
TMPK-00399	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated Keratinocyte growth factor receptor,K-sam,BEK,FGFR2 β (IIIb)...	Human	HEK293 Cells
	FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3.
TMPK-00729	Siglec-6 Protein, Human, Recombinant (His & Avi) SIGLEC6,OBBP1,CD327,CD33L1,CD...	Human	HEK293 Cells
	Siglecs (Sialic acid binding Ig-like Lectins) are I-type (Ig-type) lectins that belong to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains.Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
TMPK-00400	FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated Fibroblast growth factor receptor 2,KGFR,FGFR-2,KSAM,CD3...	Human	HEK293 Cells
	FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.3 kDa and the accession number is P21802-3.
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重组蛋白

PKM2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04766

Species: Mouse

Expression System: Baculovirus Insect Cells

AKT3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04553

Species: Human

Expression System: Baculovirus Insect Cells

PKM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04465

Species: Human

Expression System: E. coli

FGF-8b Protein, Human, Recombinant

Cat.No: TMPY-06986

Species: Human

Expression System: E. coli

Mesothelin Protein, Human, Recombinant

Cat.No: TMPY-00132

Species: Human

Expression System: HEK293 Cells

CD47 Protein, Human, Recombinant (aa 1-139, His)

Cat.No: TMPY-04935

Species: Human

Expression System: HEK293 Cells

Neuropilin-2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03763

Species: Human

Expression System: HEK293 Cells

CD47 Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-05191

Species: Human

Expression System: HEK293 Cells

GITR/TNFRSF18 Protein, Human, Recombinant (His)

Cat.No: TMPY-00072

Species: Human

Expression System: HEK293 Cells

CD47 Protein, Human, Recombinant

Cat.No: TMPY-04683

Species: Human

Expression System: HEK293 Cells

Neuropilin-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-00892

Species: Human

Expression System: HEK293 Cells

PRSS3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01897

Species: Human

Expression System: HEK293 Cells

Periostin/OSF-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01020

Species: Human

Expression System: HEK293 Cells

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04142

Species: Human

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (aa 26-577, His)

Cat.No: TMPY-05748

Species: Human

Expression System: HEK293 Cells

CD86 Protein, Human, Recombinant (His)

Cat.No: TMPY-01180

Species: Human

Expression System: HEK293 Cells

IL-15RA Protein, Human, Recombinant (hFc, Human Cells)

Cat.No: TMPJ-01099

Species: Human

Expression System: HEK293 Cells

HNT/NTM Protein, Human, Recombinant (His)

Cat.No: TMPY-00357

Species: Human

Expression System: HEK293 Cells

CDCP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04298

Species: Human

Expression System: HEK293 Cells

NCAM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00480

Species: Human

Expression System: HEK293 Cells

EphB2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03621

Species: Mouse

Expression System: HEK293 Cells

SMYD3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01268

Species: Human

Expression System: Baculovirus Insect Cells

CDCP1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03149

Species: Human

Expression System: HEK293 Cells

EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)

Cat.No: TMPY-04386

Species: Human

Expression System: Baculovirus Insect Cells

CD45 Protein, Human, Recombinant (aa 26-577, hFc)

Cat.No: TMPK-00447

Species: Human

Expression System: HEK293 Cells

KLF6 Protein, Human, Recombinant

Cat.No: TMPJ-01288

Species: Human

Expression System: E. coli

PLGF/PGF Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00276

Species: Human

Expression System: HEK293 Cells

COL9A1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04015

Species: Human

Expression System: HEK293 Cells

GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06411

Species: Human

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05514

Species: Human

Expression System: HEK293 Cells

COL9A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03960

Species: Human

Expression System: HEK293 Cells

FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)

Cat.No: TMPK-00398

Species: Human

Expression System: HEK293 Cells

FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00401

Species: Human

Expression System: HEK293 Cells

FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)

Cat.No: TMPJ-00391

Species: Human

Expression System: HEK293 Cells

EphB2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04216

Species: Mouse

Expression System: HEK293 Cells

CD84 Protein, Human, Recombinant (His)

Cat.No: TMPY-00715

Species: Human

Expression System: HEK293 Cells

CD47 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03883

Species: Human

Expression System: HEK293 Cells

IL-17RC Protein, Human, Recombinant (aa 1-454, His)

Cat.No: TMPY-02573

Species: Human

Expression System: Baculovirus Insect Cells

VEGF183 Protein, Human, Recombinant

Cat.No: TMPY-01656

Species: Human

Expression System: Baculovirus Insect Cells

SUSD4 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03969

Species: Human

Expression System: HEK293 Cells

PTP1C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00465

Species: Human

Expression System: E. coli

NETO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01692

Species: Human

Expression System: HEK293 Cells

VEGF164 Protein, Canine, Recombinant

Cat.No: TMPY-03705

Species: Canine

Expression System: HEK293 Cells

NCAM1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05590

Species: Human

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (His)

Cat.No: TMPY-04157

Species: Human

Expression System: HEK293 Cells

FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPK-00399

Species: Human

Expression System: HEK293 Cells

Siglec-6 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00729

Species: Human

Expression System: HEK293 Cells

FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00400

Species: Human

Expression System: HEK293 Cells

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